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The map label for this gene is wzb [C]

Identifier: 21242829

GI number: 21242829

Start: 2438930

End: 2439394

Strand: Direct

Name: wzb [C]

Synonym: XAC2090

Alternate gene names: 21242829

Gene position: 2438930-2439394 (Clockwise)

Preceding gene: 21242828

Following gene: 21242830

Centisome position: 47.12

GC content: 66.88

Gene sequence:

>465_bases
ATGAAGGTGCTGATCGTCTGCCTGGGCAATATCTGCCGGTCACCGATGGGCGAGGGTGCCTTGCGTGCGCAACTGGACAA
GGCACGGCTGTCGCGGCGCATCGAGGTCGATTCGGCCGGGACCGGGGATTGGCATGCCGGCGATCCGCCGGACCCGCGCG
CGATCCGCTGCGCGGGCGGTCACGGCGTGGATATTTCGGGTCTTCGCGCGCGCCAGGTGAAGCACTCGGATGTCGAGCAT
TTCGATTGGCTGCTATGCGCAGACGGCAGCAATCTGCGCGATCTGCAGCGGCTGGCCCCGGCAGCGCAGCGCGACAAGCT
CGCCTTGTGGCTGCCCTGGGCCGGCATCGACGCGCGCGATGAAATCCCCGACCCGTATACCGGCAGCATGGATGACTTCG
AGCAGGTATGGCAGCTGGTCGACACTGCCGCGCGCCTCACCGTTGCCAGACTCACCCGCGGCTAA

Upstream 100 bases:

>100_bases
CCGGCTATCGCATCGCCGTGGCGGTGACGCCTGAGCCGTTTCCGCCAGGCATCGATACCGCGGACGATCTCGTTCGCGCG
CAGATGCGGGTGGCTTCTGC

Downstream 100 bases:

>100_bases
TCGCGCTTGGGCATAATCACCGCATGAACGCCCAGCTCACCCAGGAACTGCCGGAATTTCCCACCTGGCTCAATGCCAGG
CCCTCCACCTTGCAGGAGCA

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MKVLIVCLGNICRSPMGEGALRAQLDKARLSRRIEVDSAGTGDWHAGDPPDPRAIRCAGGHGVDISGLRARQVKHSDVEH
FDWLLCADGSNLRDLQRLAPAAQRDKLALWLPWAGIDARDEIPDPYTGSMDDFEQVWQLVDTAARLTVARLTRG

Sequences:

>Translated_154_residues
MKVLIVCLGNICRSPMGEGALRAQLDKARLSRRIEVDSAGTGDWHAGDPPDPRAIRCAGGHGVDISGLRARQVKHSDVEH
FDWLLCADGSNLRDLQRLAPAAQRDKLALWLPWAGIDARDEIPDPYTGSMDDFEQVWQLVDTAARLTVARLTRG
>Mature_154_residues
MKVLIVCLGNICRSPMGEGALRAQLDKARLSRRIEVDSAGTGDWHAGDPPDPRAIRCAGGHGVDISGLRARQVKHSDVEH
FDWLLCADGSNLRDLQRLAPAAQRDKLALWLPWAGIDARDEIPDPYTGSMDDFEQVWQLVDTAARLTVARLTRG

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=138, Percent_Identity=41.304347826087, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI4757714, Length=138, Percent_Identity=42.0289855072464, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI96304457, Length=89, Percent_Identity=42.6966292134831, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788375, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI87081812, Length=151, Percent_Identity=33.7748344370861, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325330, Length=153, Percent_Identity=30.718954248366, Blast_Score=107, Evalue=9e-25,
Organism=Drosophila melanogaster, GI78706766, Length=139, Percent_Identity=39.568345323741, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI78706768, Length=139, Percent_Identity=39.568345323741, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI78706764, Length=126, Percent_Identity=41.2698412698413, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI78706770, Length=154, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78706772, Length=154, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78711846, Length=151, Percent_Identity=33.112582781457, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16950; Mature: 16950

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIVCLGNICRSPMGEGALRAQLDKARLSRRIEVDSAGTGDWHAGDPPDPRAIRCAGG
CEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEECCC
HGVDISGLRARQVKHSDVEHFDWLLCADGSNLRDLQRLAPAAQRDKLALWLPWAGIDARD
CCCCCCCCHHHHHCCCCCCHHEEEEECCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCC
EIPDPYTGSMDDFEQVWQLVDTAARLTVARLTRG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVLIVCLGNICRSPMGEGALRAQLDKARLSRRIEVDSAGTGDWHAGDPPDPRAIRCAGG
CEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEECCC
HGVDISGLRARQVKHSDVEHFDWLLCADGSNLRDLQRLAPAAQRDKLALWLPWAGIDARD
CCCCCCCCHHHHHCCCCCCHHEEEEECCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCC
EIPDPYTGSMDDFEQVWQLVDTAARLTVARLTRG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]