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The map label for this gene is smf2

Identifier: 21242780

GI number: 21242780

Start: 2380723

End: 2382057

Strand: Reverse

Name: smf2

Synonym: XAC2036

Alternate gene names: 21242780

Gene position: 2382057-2380723 (Counterclockwise)

Preceding gene: 21242784

Following gene: 21242779

Centisome position: 46.03

GC content: 64.72

Gene sequence:

>1335_bases
ATGTCCGCCGACACCGCCGCCTCAGCGCCATCGTCAACCACCGCCATCGGCGGTCTGGGCGACCACCAAGCCAGCGTCTC
TGTGCCCAACAGCGGCCATTGGTGGTCCCGCCTACTGGCCTTCCTGGGACCGGGCTACATGGTGTCGGTGGGCTATATGG
ACCCGGGCAACTGGGCCACCGATCTGGCCGGCGGCTCGCAGTTCGGCTACCTGCTGCTGTCGGTGATCCTGTTGTCGAAC
CTGATGGCGATCGTGCTGCAAGGCCTGTCGGCGCGGCTGGGTATCGCCACCGGGCTGGACCTGGCGCAGGCCTGTCGCGC
GCGTTATCCGCGTGGCGTCAATCTGGCCTTGTGGGGCATTTGCGAGCTGGCCATCATCGCCTGCGACTTGGCAGAGGTCA
TCGGTACCGCGATTGCGTTGAAGCTGTTGTTCGGGATTCCGCTCACCATGGGCGCGATCATCACCGCGGTGGATGTGGTG
CTGGTGTTGTTGCTGATGAACCGCGGTTTCCGCGCGCTGGAAGCCTTCGTGATCGCGCTGCTGCTGATCATCTTCGCGTG
TTTCGGGATCCAGATCGCGTTGGCCGCGCCACCGATCGCGGCGGTACTGGGCGGTTTCATCCCGCGTGCGCAGGTGGTCA
CCGACCCGCAGGCGCTGTATCTGGCGATCGGCATCATCGGTGCGACGGTGATGCCGCATAACCTGTATCTGCACTCGTCG
ATCGTGCAGACGCGCGCGTATCCACGGACCGATGTCGGCCGGAAATCCGCGCTGCGTTGGGCGGTCACCGACAGCACGGT
GGCGTTGATGTTCGCGCTGTTCATCAATGCCTCGATCCTGATCCTGGCCGCGGCGGTGTTCCATGCGCAGGGCCGCACCG
ACGTGCAGGAGATCGAACAGGCGCATGCGTTGCTGGCGCCGATGCTGGGCGTCGGCCTGGCCTCGACGCTGTTTGCGGTG
GCGCTGCTCGCCTCGGGCATCAACTCCACCGTGACCGCAACGCTGGCCGGGCAGATCGTGATGGAAGGCTTCCTGCAATT
ACGCCTGCCGCCATGGATACGGCGCTTGCTCACCCGCGGCATCGCGATCGTGCCGGTGGTCATCGTGACCTGGCTGTATG
GCGAAGCCGGTACCGCGCGGTTGTTGGTACTCAGCCAGGTGGTGTTGTCGATGCAGCTGCCGTTTGCGGTGATTCCGCTG
GTGCGCTTCGTGTCCGATCGGCAGTTGATGGGCGCGCTGGTAGCGCCAGCATGGCTGGTACGCATCGCGTGGGTGATCGC
TGCGGTGATCGTATGCCTCAATCTGAAGCTGCTGTGGGATACCGCGCTGCATTGA

Upstream 100 bases:

>100_bases
TAGTTTGAAGCACACAGCAGATCAATACGATTGAAATTGCCAATGCTCAACAGCATAGCAACTGCTATATCATGCGCTTA
ACCCGTTTCGACCCGAGTGC

Downstream 100 bases:

>100_bases
GATGCGGCATCGGCGCGGGTATTGCGCCAGCGTTCGATCAATTGTTTCGTATCGCCCGGACAAGTGGAAGACGATGTCGC
GCTTTCTTCCCTTCAACGCG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSADTAASAPSSTTAIGGLGDHQASVSVPNSGHWWSRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSN
LMAIVLQGLSARLGIATGLDLAQACRARYPRGVNLALWGICELAIIACDLAEVIGTAIALKLLFGIPLTMGAIITAVDVV
LVLLLMNRGFRALEAFVIALLLIIFACFGIQIALAAPPIAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAV
ALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRGIAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPL
VRFVSDRQLMGALVAPAWLVRIAWVIAAVIVCLNLKLLWDTALH

Sequences:

>Translated_444_residues
MSADTAASAPSSTTAIGGLGDHQASVSVPNSGHWWSRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSN
LMAIVLQGLSARLGIATGLDLAQACRARYPRGVNLALWGICELAIIACDLAEVIGTAIALKLLFGIPLTMGAIITAVDVV
LVLLLMNRGFRALEAFVIALLLIIFACFGIQIALAAPPIAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAV
ALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRGIAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPL
VRFVSDRQLMGALVAPAWLVRIAWVIAAVIVCLNLKLLWDTALH
>Mature_443_residues
SADTAASAPSSTTAIGGLGDHQASVSVPNSGHWWSRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSNL
MAIVLQGLSARLGIATGLDLAQACRARYPRGVNLALWGICELAIIACDLAEVIGTAIALKLLFGIPLTMGAIITAVDVVL
VLLLMNRGFRALEAFVIALLLIIFACFGIQIALAAPPIAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSSI
VQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAVA
LLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRGIAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLV
RFVSDRQLMGALVAPAWLVRIAWVIAAVIVCLNLKLLWDTALH

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI295293167, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI295293171, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI295293169, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI295293175, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI295293173, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI10835169, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI295293178, Length=466, Percent_Identity=36.2660944206009, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI109255241, Length=427, Percent_Identity=37.9391100702576, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1788736, Length=406, Percent_Identity=41.871921182266, Blast_Score=283, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI193210616, Length=454, Percent_Identity=32.8193832599119, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71999499, Length=446, Percent_Identity=32.9596412556054, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17569473, Length=367, Percent_Identity=35.6948228882834, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71993856, Length=229, Percent_Identity=37.9912663755458, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323062, Length=414, Percent_Identity=42.0289855072464, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6324450, Length=420, Percent_Identity=38.0952380952381, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321841, Length=405, Percent_Identity=42.2222222222222, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24648607, Length=416, Percent_Identity=35.8173076923077, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI281362176, Length=416, Percent_Identity=35.8173076923077, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24648609, Length=416, Percent_Identity=35.8173076923077, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI45553443, Length=416, Percent_Identity=35.8173076923077, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_XANAC (Q8PKX1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642362.1
- GeneID:   1156107
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2036
- NMPDR:   fig|190486.1.peg.2006
- HOGENOM:   HBG312498
- OMA:   KFGYALL
- ProtClustDB:   PRK00701
- BioCyc:   XAXO190486:XAC2036-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 46976; Mature: 46844

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfe4e528)-; HASH(0xe44e654)-; HASH(0xff00e10)-; HASH(0xf906e90)-; HASH(0xf0ad8c8)-; HASH(0xf82864c)-; HASH(0xff8e910)-; HASH(0xf770fd0)-; HASH(0xb9eb410)-; HASH(0xf82ef3c)-; HASH(0xffacda0)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADTAASAPSSTTAIGGLGDHQASVSVPNSGHWWSRLLAFLGPGYMVSVGYMDPGNWAT
CCCCCCCCCCCCCCEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHH
DLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRARYPRGVNLALWGI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHH
CELAIIACDLAEVIGTAIALKLLFGIPLTMGAIITAVDVVLVLLLMNRGFRALEAFVIAL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLIIFACFGIQIALAAPPIAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
HHHHHHHHHHEEHCCCCCHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQ
HHHHCCCCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AHALLAPMLGVGLASTLFAVALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVSDRQLMGALVAPAWLV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RIAWVIAAVIVCLNLKLLWDTALH
HHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SADTAASAPSSTTAIGGLGDHQASVSVPNSGHWWSRLLAFLGPGYMVSVGYMDPGNWAT
CCCCCCCCCCCCCEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHH
DLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRARYPRGVNLALWGI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHH
CELAIIACDLAEVIGTAIALKLLFGIPLTMGAIITAVDVVLVLLLMNRGFRALEAFVIAL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLIIFACFGIQIALAAPPIAAVLGGFIPRAQVVTDPQALYLAIGIIGATVMPHNLYLHSS
HHHHHHHHHHEEHCCCCCHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
IVQTRAYPRTDVGRKSALRWAVTDSTVALMFALFINASILILAAAVFHAQGRTDVQEIEQ
HHHHCCCCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AHALLAPMLGVGLASTLFAVALLASGINSTVTATLAGQIVMEGFLQLRLPPWIRRLLTRG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IAIVPVVIVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVSDRQLMGALVAPAWLV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RIAWVIAAVIVCLNLKLLWDTALH
HHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217