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The map label for this gene is moeA [H]

Identifier: 21242776

GI number: 21242776

Start: 2376627

End: 2377880

Strand: Direct

Name: moeA [H]

Synonym: XAC2032

Alternate gene names: 21242776

Gene position: 2376627-2377880 (Clockwise)

Preceding gene: 21242774

Following gene: 21242777

Centisome position: 45.92

GC content: 69.3

Gene sequence:

>1254_bases
ATGATCAGCTATGCCGAAGCACTCGCGCTGGTCCACGCGCACGTCGCAACCCTGTCCAGCGAGTGGGTGGCAAGCGACGA
TGCCGAGGGCCGCGTGCTCGCCGACGCCTTGTCGAGCCAGGCAGAGTTGCCGCCCTTCGACAACAGCGCAATGGATGGGT
TTGCACTGGCGACCGCGGGCATGGGTGCGTTGGCAGACAGCGAGCACGTGGTGAGCGGCACCGTTGCGGCAGGGCAGGAT
GCCGGTGCGGCCGCGATCGGCGCGGCCTGGGAAATCATGACCGGTGCCGGCGTGCCCCCGGGTGCCGATGCGGTGGTGCC
GATCGAGCAAGTGCAGATCCTCGAACACGACGGCGAGCGCCCCAGCCGCATCCGCCTGCATCGGCCGGTGCGTGCGGGCC
AGCACATCCGTCGTCGCGGCGAAGACGTGCGCTTGCACGATCGCGTGATCGATGCCGGCACCGTACTGCGCGGTGCGCAT
CTGATGCTGCTCGCCGGCCTGGGCTGCGCGCAGGTGCAGGTGCTGCGGCGACCGCGCGTGGCCTTGATTGCCACGGGACG
CGAGCTGATCGGCGACCCCGCACAACCTCTGCAGCCGGGCCAGATCCGCGACGGCACCAGCAGTTATCTGCTGGCTCGGT
TGCGTGCCGCCGGCGCCGATGTCGTGTGGCGTGGGCAGGTGGGCGACGACGATGCTGCCTTCGATGCGGCACTGGCCCAG
GCCCGCCATGCCGGTGCCGATCTCATCCTGAGCACCGGCGCCGTTTCGCGCGGTCGTTACGATTTCATCCCGGATGCGTT
GGCACGCCACGCTGCGGAAGTGCTGTTTCATAAGGTCGCGGTGCGACCGGGCAAACCGGTACTGTTTGCACGCTTCGGCG
ATGGCGCGCTGTACGCGGGCTTGCCCGGCAACCCGATGGCCAGTGCGGCCGGGCTGCGCTTTTTTGTCGAGCCGGCATTG
CGCGGTTTGTTGGGCATGCCGGTCGAGCGTGGCTTGCGCGTCGCGTTGGAGGCGCCGATGCAGGCCCGGCCGCTCTGGCG
GCAGCATCTGCGGGCACGGCTGCTGTGCAGCGTGGCCGGCGAGTTGTCGGTGCAGATCCTGCCGCAGCAGGAATCCTTTC
GTGTGGCGCCGTTGCTGCAGGCCAACGTCTGGGCCGTGCTGGAGCCGCAGGACGAAGGCGCCGCAGCGAGCACGCATGCC
GAGGTCTTCGGCTTGGGCCATCTGCAACCGGCCGCGCCGGCCATCGCGCCATGA

Upstream 100 bases:

>100_bases
CGCTAGATACACGACGGCGCCGCATTAGCCACGCCTGTACCTGCTGCGCCAGGGGCCGGTATCCTAGCCGGGTCATCCAT
TGGTCGGCACTGTCCTGCAC

Downstream 100 bases:

>100_bases
ACCTGCCTGTGCGTGCCATCCATCCTGGGGCTGTTGCATGACGCTGCTGCGGCCGTGGACGGGCGTAGTGCTGGCCGGTG
GACGTTCGTCGCGCATGGGG

Product: molybdopterin biosynthesis

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MISYAEALALVHAHVATLSSEWVASDDAEGRVLADALSSQAELPPFDNSAMDGFALATAGMGALADSEHVVSGTVAAGQD
AGAAAIGAAWEIMTGAGVPPGADAVVPIEQVQILEHDGERPSRIRLHRPVRAGQHIRRRGEDVRLHDRVIDAGTVLRGAH
LMLLAGLGCAQVQVLRRPRVALIATGRELIGDPAQPLQPGQIRDGTSSYLLARLRAAGADVVWRGQVGDDDAAFDAALAQ
ARHAGADLILSTGAVSRGRYDFIPDALARHAAEVLFHKVAVRPGKPVLFARFGDGALYAGLPGNPMASAAGLRFFVEPAL
RGLLGMPVERGLRVALEAPMQARPLWRQHLRARLLCSVAGELSVQILPQQESFRVAPLLQANVWAVLEPQDEGAAASTHA
EVFGLGHLQPAAPAIAP

Sequences:

>Translated_417_residues
MISYAEALALVHAHVATLSSEWVASDDAEGRVLADALSSQAELPPFDNSAMDGFALATAGMGALADSEHVVSGTVAAGQD
AGAAAIGAAWEIMTGAGVPPGADAVVPIEQVQILEHDGERPSRIRLHRPVRAGQHIRRRGEDVRLHDRVIDAGTVLRGAH
LMLLAGLGCAQVQVLRRPRVALIATGRELIGDPAQPLQPGQIRDGTSSYLLARLRAAGADVVWRGQVGDDDAAFDAALAQ
ARHAGADLILSTGAVSRGRYDFIPDALARHAAEVLFHKVAVRPGKPVLFARFGDGALYAGLPGNPMASAAGLRFFVEPAL
RGLLGMPVERGLRVALEAPMQARPLWRQHLRARLLCSVAGELSVQILPQQESFRVAPLLQANVWAVLEPQDEGAAASTHA
EVFGLGHLQPAAPAIAP
>Mature_417_residues
MISYAEALALVHAHVATLSSEWVASDDAEGRVLADALSSQAELPPFDNSAMDGFALATAGMGALADSEHVVSGTVAAGQD
AGAAAIGAAWEIMTGAGVPPGADAVVPIEQVQILEHDGERPSRIRLHRPVRAGQHIRRRGEDVRLHDRVIDAGTVLRGAH
LMLLAGLGCAQVQVLRRPRVALIATGRELIGDPAQPLQPGQIRDGTSSYLLARLRAAGADVVWRGQVGDDDAAFDAALAQ
ARHAGADLILSTGAVSRGRYDFIPDALARHAAEVLFHKVAVRPGKPVLFARFGDGALYAGLPGNPMASAAGLRFFVEPAL
RGLLGMPVERGLRVALEAPMQARPLWRQHLRARLLCSVAGELSVQILPQQESFRVAPLLQANVWAVLEPQDEGAAASTHA
EVFGLGHLQPAAPAIAP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=361, Percent_Identity=31.8559556786704, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI10880983, Length=361, Percent_Identity=31.8559556786704, Blast_Score=158, Evalue=8e-39,
Organism=Escherichia coli, GI1787049, Length=395, Percent_Identity=35.1898734177215, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=341, Percent_Identity=28.4457478005865, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=333, Percent_Identity=24.024024024024, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136978, Length=379, Percent_Identity=26.6490765171504, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=379, Percent_Identity=26.6490765171504, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43799; Mature: 43799

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYAEALALVHAHVATLSSEWVASDDAEGRVLADALSSQAELPPFDNSAMDGFALATAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHCC
MGALADSEHVVSGTVAAGQDAGAAAIGAAWEIMTGAGVPPGADAVVPIEQVQILEHDGER
CCCCCCCCCEEECEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCC
PSRIRLHRPVRAGQHIRRRGEDVRLHDRVIDAGTVLRGAHLMLLAGLGCAQVQVLRRPRV
CCEEEEECCHHHHHHHHHCCCCEEEHHHHHCHHHHHHHHHEEHHHCCCHHHHHHHHCCCE
ALIATGRELIGDPAQPLQPGQIRDGTSSYLLARLRAAGADVVWRGQVGDDDAAFDAALAQ
EEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
ARHAGADLILSTGAVSRGRYDFIPDALARHAAEVLFHKVAVRPGKPVLFARFGDGALYAG
HHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECC
LPGNPMASAAGLRFFVEPALRGLLGMPVERGLRVALEAPMQARPLWRQHLRARLLCSVAG
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
ELSVQILPQQESFRVAPLLQANVWAVLEPQDEGAAASTHAEVFGLGHLQPAAPAIAP
CEEEEEECCCCCCEEEEEECCCEEEEECCCCCCCCCCCCHHHEECCCCCCCCCCCCC
>Mature Secondary Structure
MISYAEALALVHAHVATLSSEWVASDDAEGRVLADALSSQAELPPFDNSAMDGFALATAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHCC
MGALADSEHVVSGTVAAGQDAGAAAIGAAWEIMTGAGVPPGADAVVPIEQVQILEHDGER
CCCCCCCCCEEECEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCC
PSRIRLHRPVRAGQHIRRRGEDVRLHDRVIDAGTVLRGAHLMLLAGLGCAQVQVLRRPRV
CCEEEEECCHHHHHHHHHCCCCEEEHHHHHCHHHHHHHHHEEHHHCCCHHHHHHHHCCCE
ALIATGRELIGDPAQPLQPGQIRDGTSSYLLARLRAAGADVVWRGQVGDDDAAFDAALAQ
EEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHH
ARHAGADLILSTGAVSRGRYDFIPDALARHAAEVLFHKVAVRPGKPVLFARFGDGALYAG
HHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECC
LPGNPMASAAGLRFFVEPALRGLLGMPVERGLRVALEAPMQARPLWRQHLRARLLCSVAG
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
ELSVQILPQQESFRVAPLLQANVWAVLEPQDEGAAASTHAEVFGLGHLQPAAPAIAP
CEEEEEECCCCCCEEEEEECCCEEEEECCCCCCCCCCCCHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9495759 [H]