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The map label for this gene is fdh [H]

Identifier: 21242772

GI number: 21242772

Start: 2372839

End: 2374008

Strand: Direct

Name: fdh [H]

Synonym: XAC2028

Alternate gene names: 21242772

Gene position: 2372839-2374008 (Clockwise)

Preceding gene: 21242771

Following gene: 21242774

Centisome position: 45.85

GC content: 62.22

Gene sequence:

>1170_bases
ATGCGAGCACTTTGCTGGAATGGCGTTAACGATTTGCGCGTGGAAACCGTGCCCGACCCGGCGCTGGTCAACCCACGCGA
TGTGATCCTGAAAGTCGGGCTTACCACCACCTGTGGTTCTGATCTGCATTTCATCGACGGCTACCTGCCAACCATGCGCG
AGGGCGATGTCATCGGCCACGAATTCATGGGTACGGTCGTGGAGATAGGCACCGCGGTGAAGAACGTGCGTGTGGGTCAG
CGCGTGGTGGTACCGTCGTTTATCTCCTGTGGCGGTTGCTGGCATTGCGAGCGCAAGGAATTTTCGCTGTGCGACAACAC
CAACCCTAACTGGGAGATGCAGGAGCCGCTGCTTGGGCATCCAACTGCCGGCATTTACGGCTATACGCACGCCTTTGGCG
GCTACGCAGGGTCGCACGCCACCTACATCCGCGTGCCGCACGCGGATGTCGGGTGTTTCGAGGTGCCTGATGGTGTGTCC
GATGAGGACGCGCTATTTCTGTCGGATGCGGGGCCGACCGGTTTCATGGGCGCAGACTTCTGCGATATCCAGTCCGGCGA
CACGGTGGCGGTCTGGGGTTGTGGTGGGGTGGGGCTGATGGCGCAGCAAAGCGCACGCATCCTGGGCGCAGAGCGGGTGA
TCGGCATCGACCGGTTACCTGAGCGTCTGGCGATGGCGCGCGATGTGTTAGGTGTGGAAGTGATCGACTATTCGGCGGTC
GACAGCGTGGTGGATGTCCTGCGCGAAATGACCGGAGGGCGTGGTCCGGATGCGTGTATCGATGCGGTCGGCATGGAGGC
GCATGGCACCGGCATCGGCCACACCTACGATCGGGTCAAGCAGGCCTTGCACTTGCACACCGATCGCGGCCAGGCGCTGC
GCGAGGCCATCCTCGCCTGCCGCAAAGGCGGCATCCTGTCGGTTCTGGGCGTGTACGGGGTGATGGACAAGTTTCCGCTG
GGTGCGGTGATGAACAAGGGCCTGACGGTACGGACCGCGCAGCAGCATGGGCAGCGATACGTGCCCAAGTTGCTGGACCT
GGCGCAGGCTGGACGATTGAAATCCGGCTTTCTGCTGACCCATAAGATGCCGTTGGAAGACGCCGTGCGGGGCTACGACA
TGTTCAAGCACAAGCACGATGGGTGCGTGCGCGCGGGGTTTGTTCCCTAG

Upstream 100 bases:

>100_bases
CGACTGCGCGCATGGCTGGAAGCCGGCGAGGTGCCGACCTTGTTGCATACCCCAGCGGCGCGTGCGTCGACGCACGCGCA
TTCTTAAGGAGGGCTTTTCC

Downstream 100 bases:

>100_bases
CGCCAGAGGCCTTGGCAGCACCGAGTTGCCCTGCGAGCGCGGCAGGGAATCGCTTGCCATCTGCGTGCGTAACAAGCGCA
TGGTGCGCGCATGCTGCCAG

Product: glutathione-dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MRALCWNGVNDLRVETVPDPALVNPRDVILKVGLTTTCGSDLHFIDGYLPTMREGDVIGHEFMGTVVEIGTAVKNVRVGQ
RVVVPSFISCGGCWHCERKEFSLCDNTNPNWEMQEPLLGHPTAGIYGYTHAFGGYAGSHATYIRVPHADVGCFEVPDGVS
DEDALFLSDAGPTGFMGADFCDIQSGDTVAVWGCGGVGLMAQQSARILGAERVIGIDRLPERLAMARDVLGVEVIDYSAV
DSVVDVLREMTGGRGPDACIDAVGMEAHGTGIGHTYDRVKQALHLHTDRGQALREAILACRKGGILSVLGVYGVMDKFPL
GAVMNKGLTVRTAQQHGQRYVPKLLDLAQAGRLKSGFLLTHKMPLEDAVRGYDMFKHKHDGCVRAGFVP

Sequences:

>Translated_389_residues
MRALCWNGVNDLRVETVPDPALVNPRDVILKVGLTTTCGSDLHFIDGYLPTMREGDVIGHEFMGTVVEIGTAVKNVRVGQ
RVVVPSFISCGGCWHCERKEFSLCDNTNPNWEMQEPLLGHPTAGIYGYTHAFGGYAGSHATYIRVPHADVGCFEVPDGVS
DEDALFLSDAGPTGFMGADFCDIQSGDTVAVWGCGGVGLMAQQSARILGAERVIGIDRLPERLAMARDVLGVEVIDYSAV
DSVVDVLREMTGGRGPDACIDAVGMEAHGTGIGHTYDRVKQALHLHTDRGQALREAILACRKGGILSVLGVYGVMDKFPL
GAVMNKGLTVRTAQQHGQRYVPKLLDLAQAGRLKSGFLLTHKMPLEDAVRGYDMFKHKHDGCVRAGFVP
>Mature_389_residues
MRALCWNGVNDLRVETVPDPALVNPRDVILKVGLTTTCGSDLHFIDGYLPTMREGDVIGHEFMGTVVEIGTAVKNVRVGQ
RVVVPSFISCGGCWHCERKEFSLCDNTNPNWEMQEPLLGHPTAGIYGYTHAFGGYAGSHATYIRVPHADVGCFEVPDGVS
DEDALFLSDAGPTGFMGADFCDIQSGDTVAVWGCGGVGLMAQQSARILGAERVIGIDRLPERLAMARDVLGVEVIDYSAV
DSVVDVLREMTGGRGPDACIDAVGMEAHGTGIGHTYDRVKQALHLHTDRGQALREAILACRKGGILSVLGVYGVMDKFPL
GAVMNKGLTVRTAQQHGQRYVPKLLDLAQAGRLKSGFLLTHKMPLEDAVRGYDMFKHKHDGCVRAGFVP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=394, Percent_Identity=25.3807106598985, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156523966, Length=380, Percent_Identity=23.9473684210526, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=372, Percent_Identity=23.9247311827957, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565154, Length=384, Percent_Identity=22.3958333333333, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=41.9847328244275, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI87082125, Length=270, Percent_Identity=31.8518518518519, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=25.2124645892351, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787863, Length=393, Percent_Identity=24.6819338422392, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790045, Length=372, Percent_Identity=26.6129032258064, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788075, Length=284, Percent_Identity=28.5211267605634, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI226510992, Length=348, Percent_Identity=22.7011494252874, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=373, Percent_Identity=24.9329758713137, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=264, Percent_Identity=29.1666666666667, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=387, Percent_Identity=25.5813953488372, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=388, Percent_Identity=25.2577319587629, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=369, Percent_Identity=24.6612466124661, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=384, Percent_Identity=22.9166666666667, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=402, Percent_Identity=26.1194029850746, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=285, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=256, Percent_Identity=28.515625, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=288, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=25.5813953488372, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=252, Percent_Identity=26.984126984127, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137530, Length=390, Percent_Identity=24.8717948717949, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17737897, Length=390, Percent_Identity=25.1282051282051, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 41921; Mature: 41921

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALCWNGVNDLRVETVPDPALVNPRDVILKVGLTTTCGSDLHFIDGYLPTMREGDVIGH
CCCCCCCCCCCCEEEECCCCCCCCHHHEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCHH
EFMGTVVEIGTAVKNVRVGQRVVVPSFISCGGCWHCERKEFSLCDNTNPNWEMQEPLLGH
HHHHHHHHHHHHHHHHHCCCEEECCHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCC
PTAGIYGYTHAFGGYAGSHATYIRVPHADVGCFEVPDGVSDEDALFLSDAGPTGFMGADF
CCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCE
CDIQSGDTVAVWGCGGVGLMAQQSARILGAERVIGIDRLPERLAMARDVLGVEVIDYSAV
EECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEECHHHH
DSVVDVLREMTGGRGPDACIDAVGMEAHGTGIGHTYDRVKQALHLHTDRGQALREAILAC
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
RKGGILSVLGVYGVMDKFPLGAVMNKGLTVRTAQQHGQRYVPKLLDLAQAGRLKSGFLLT
CCCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHCCCCCCEEEE
HKMPLEDAVRGYDMFKHKHDGCVRAGFVP
ECCCHHHHHHHHHHHHHCCCCCEECCCCC
>Mature Secondary Structure
MRALCWNGVNDLRVETVPDPALVNPRDVILKVGLTTTCGSDLHFIDGYLPTMREGDVIGH
CCCCCCCCCCCCEEEECCCCCCCCHHHEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCHH
EFMGTVVEIGTAVKNVRVGQRVVVPSFISCGGCWHCERKEFSLCDNTNPNWEMQEPLLGH
HHHHHHHHHHHHHHHHHCCCEEECCHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCC
PTAGIYGYTHAFGGYAGSHATYIRVPHADVGCFEVPDGVSDEDALFLSDAGPTGFMGADF
CCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCE
CDIQSGDTVAVWGCGGVGLMAQQSARILGAERVIGIDRLPERLAMARDVLGVEVIDYSAV
EECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEECHHHH
DSVVDVLREMTGGRGPDACIDAVGMEAHGTGIGHTYDRVKQALHLHTDRGQALREAILAC
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
RKGGILSVLGVYGVMDKFPLGAVMNKGLTVRTAQQHGQRYVPKLLDLAQAGRLKSGFLLT
CCCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHCCHHHHHHHHHHHHHCCCCCCEEEE
HKMPLEDAVRGYDMFKHKHDGCVRAGFVP
ECCCHHHHHHHHHHHHHCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]