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The map label for this gene is ndk [H]

Identifier: 21242759

GI number: 21242759

Start: 2358466

End: 2358891

Strand: Direct

Name: ndk [H]

Synonym: XAC2015

Alternate gene names: 21242759

Gene position: 2358466-2358891 (Clockwise)

Preceding gene: 21242755

Following gene: 21242760

Centisome position: 45.57

GC content: 62.68

Gene sequence:

>426_bases
ATGGCGCTGGAGCGCACCCTGTCCATCATCAAGCCCGACGCCGTTGCCAAGAACGTCATCGGCGAAATCTACAGCCGCTT
CGAAAAGGCTGGCCTGAAGGTCGTGGCCGCCAAGTACAAGCAGCTGTCGCGTCGTGAAGCCGAAGGCTTCTACGCCGTTC
ATCGCGAGCGTCCGTTCTTCAACGCGCTGGTCGAGTTCATGATTTCCGGCCCGGTGATGATCCAGGCGCTGGAAGGCGAG
AACGCCGTCGCCGCACACCGTGACCTGCTGGGCGCGACCAATCCCAAGGACGCTGCGCCGGGCACCATCCGCGCCGACTT
CGCCGATTCGATCGATGCCAATGCTGCCCACGGCTCGGATTCGGTCGAGAACGCTGCCAACGAAGTCGCGTATTTCTTTG
CCGCCACCGAAGTGGTCTCGCGCTGA

Upstream 100 bases:

>100_bases
AGAATTGACCATCGCAAAGAAGCCTAAGCCCGCGTTTTGTCGCGGGTTTTTTTCATGATAACCTCGGGCCTTCAGTGGCC
CGCCCAACGGAGAACTTCCC

Downstream 100 bases:

>100_bases
GGCCGAGTGAGTCGAATCGTGAATGAGGTCGTGATCCCTTCCGTGCTGCAGGACGGCTCCGTCCGTACCCCGGAGCCGCG
CAAGCAGAACCTGCTCGACC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MALERTLSIIKPDAVAKNVIGEIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFFNALVEFMISGPVMIQALEGE
NAVAAHRDLLGATNPKDAAPGTIRADFADSIDANAAHGSDSVENAANEVAYFFAATEVVSR

Sequences:

>Translated_141_residues
MALERTLSIIKPDAVAKNVIGEIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFFNALVEFMISGPVMIQALEGE
NAVAAHRDLLGATNPKDAAPGTIRADFADSIDANAAHGSDSVENAANEVAYFFAATEVVSR
>Mature_140_residues
ALERTLSIIKPDAVAKNVIGEIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFFNALVEFMISGPVMIQALEGEN
AVAAHRDLLGATNPKDAAPGTIRADFADSIDANAAHGSDSVENAANEVAYFFAATEVVSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=139, Percent_Identity=48.2014388489209, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=45.2554744525547, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=45.2554744525547, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=45.2554744525547, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=45.2554744525547, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=45.2554744525547, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=45.2554744525547, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=45.2554744525547, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=42.3357664233577, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=39.7058823529412, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=39.7058823529412, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.7647058823529, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.1167883211679, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=31.8518518518519, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=29.9270072992701, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=63.1205673758865, Blast_Score=189, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=43.7037037037037, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=44.8529411764706, Blast_Score=127, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=46.7153284671533, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=31.3432835820896, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15257; Mature: 15126

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTLSIIKPDAVAKNVIGEIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFF
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHCCCCHH
NALVEFMISGPVMIQALEGENAVAAHRDLLGATNPKDAAPGTIRADFADSIDANAAHGSD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
SVENAANEVAYFFAATEVVSR
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALERTLSIIKPDAVAKNVIGEIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFF
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEHHCCCCHH
NALVEFMISGPVMIQALEGENAVAAHRDLLGATNPKDAAPGTIRADFADSIDANAAHGSD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCCCC
SVENAANEVAYFFAATEVVSR
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA