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The map label for this gene is clpA [H]

Identifier: 21242745

GI number: 21242745

Start: 2335584

End: 2337866

Strand: Direct

Name: clpA [H]

Synonym: XAC2001

Alternate gene names: 21242745

Gene position: 2335584-2337866 (Clockwise)

Preceding gene: 21242744

Following gene: 21242750

Centisome position: 45.13

GC content: 62.77

Gene sequence:

>2283_bases
ATGTTCAGCAAAGACCTAGAGCAAACCATCGGCCAGTGCTACAAGCGAGCACGCGAGGCGCGTCATGAGTTCATGACCGT
CGAGCACCTGCTGCTCTCGCTGCTGGACAATCCTTCCGCCCAGGCCGTGCTCAAGGCCTGTGGCGCAGACCAGGTGCGCC
TGCACAATGACCTGGAGCAGGCAATCGAGGCCTCGGTCTCGCGCCTGGCCGAGGACGACGGGCGCGACACGCAGCCTACC
CTGGGATTCCAGCGGGTGTTGCAACGCGCCGTCTACCACGTGCAGTCCTCGGGCAAGAAGGAAGTCACCGGCGCCAACGT
GCTGGTCGCCATCTTCGGCGAGAAGGACTCGCACGCGGTGTACTTCCTGAACCAACAGGACATCACCCGTCTCGATATCG
TCAATTACCTTTCGCACGGCATTGCCAAGCTGGGTGAAGACGGCGAACAGCCGTCCGCGCCGGACGGCGAGTCCAAGAGC
GAAGGTGGAGAGGGCGAGGCCAAGGGCGACGCGCTGGCCGAGTTCGCCAGCAATCTCAACGAGCAGGCGCGCAACGGCAA
GATCGACCCGTTGGTCGGCCGCAGCGACGAGATCGAGCGCACCATCCAGGTCCTGTGCCGCCGGCGCAAGAACAATCCGC
TGTACGTGGGCGAGGCCGGCGTCGGCAAGACCGCGATTGCCGAAGGTCTGGCCAAGCGCATCGTCGACAACGACGTGCCG
GAAGTGCTTGCCGATGCAGTGATTTACTCGCTGGATCTGGGCGCACTGGTGGCTGGCACCAAGTATCGAGGCGATTTCGA
AAAGCGTCTCAAGGGCGTGCTGGCCGCGTTGAAGAAGGTGCCGAATGCGGTGCTGTTCATCGACGAGATCCACACCATCA
TCGGTGCCGGCTCGGCGTCGGGCGGCACCATGGACGCCTCCAACCTGATCAAGCCCGCGCTGTCCTCGGGCGAGCTGCGC
TGCATCGGCTCGACCACGTTCCAGGAATATCGCGGCATCTTCGAGAAGGACCGTGCGCTGGCGCGTCGGTTCCAGAAGAT
CGATATCGTCGAGCCGACGGTGGGCGAAACCTTCGAGATCCTGCAGGGCCTCAAGCCCAAGTACGAGGCGCATCATGGCG
TGACCTACGCCGACGACGCGCTACAGGCGGCCGTTGACCTGTCGGTGAAGCATATCGGCGACCGCTTGCTGCCGGACAAG
GCGATCGATGTGATCGACGAGGCCGGTGCGCGTCAGCGTCTGCTGCCGGAAGGCACGCGCAAGGAGCTGATCGATATCGA
AGAGATCGAGACCATCGTGGCCAAGATGGCGCGGATTCCGGCCAAGCAGGTCAGCGCGACCGACAAGGACGTGCTGCAGC
ACCTGGAGCGCAATCTGAAGATGGTGATTTTCGGGCAAAACCCGGCGATCGAAACGCTGGCCGGTTCGATCAAGCTGGCA
CGCTCGGGCCTGGCGAACCCCGAAAAGCCGATCGGCAATTTCCTGTTCGCCGGTCCCACCGGTGTCGGCAAGACGGAGGT
CACCAAGCAGCTCGCGCTGCAGCTGGGGATTGAACTGGTGCGCTTCGACATGTCCGAGTACATGGAAGCGCATTCGATCA
GCCGTCTCATCGGTGCTCCCCCGGGCTACGTCGGTTTCGACCAGGGCGGTTTGTTGACCGAGAAAATCGTCAAGACGCCG
CACTGCGTGCTGCTGTTGGACGAAGTGGAGAAGGCGCACCCGGACATCTTCAACATCCTGTTGCAGGTCATGGACCGCGG
CATCCTCACCGATACCAACGGGCGCGAGGCCAACTTCAAGAACGTGATCCTGGTAATGACGACCAATGCCGGCGCCACGC
AGGCGTCGCGGCGTTCGATCGGCTTTACCAAGCAGGATCATTCCACCGATGCGATGGAATCGATCCGTCGCGGCTTCACG
CCCGAGTTCCGCAACCGTCTGGATGCGATCGTGCAGTTCCAACCGCTGGCGTTCGACCACATCCTGCGGGTGGTGGACAA
GTTCATCATTGAGCTGGAAATGCTGTTGCAGGAAAAGCACGTCTCCCTGTCGGCCACCCCGACCGCGCGCGACTGGCTGG
CACAGCATGGCTTCGATCCGCTGATGGGTGCGCGGCCGATGTCGCGGGTGATCCAGGAAAAGATCAAGCGCCCGCTCGCC
GACGAACTGCTGTTCGGCAAGTTAGTGGACGGTGGCCGGGTCAACATCGACGTCAAGGATGGCGAATTGGTGGTCGAGGC
GCATCCGGAACCGGAGCGCCTGCTGCCCGCGACGGTGGACTGA

Upstream 100 bases:

>100_bases
GATCACGTGCTAACGCTGTCTGAACATGCCTATCCGATAGGGTTGTGGAAAATCCCAACAAAAGCCGCATATTGTTGGCA
ACAGCCGTGCGGAGTTACCA

Downstream 100 bases:

>100_bases
TCGCCATAGGATGTTTGGCAGGTAAGAAAAGCCGCTCGAGAGAGCGGCTTTTTACGTTTTCAGCGGCCCTCGCAATCACG
CGTGCCGACGATGGCAGTGC

Product: ATP-dependent Clp protease subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MFSKDLEQTIGQCYKRAREARHEFMTVEHLLLSLLDNPSAQAVLKACGADQVRLHNDLEQAIEASVSRLAEDDGRDTQPT
LGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLNQQDITRLDIVNYLSHGIAKLGEDGEQPSAPDGESKS
EGGEGEAKGDALAEFASNLNEQARNGKIDPLVGRSDEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLAKRIVDNDVP
EVLADAVIYSLDLGALVAGTKYRGDFEKRLKGVLAALKKVPNAVLFIDEIHTIIGAGSASGGTMDASNLIKPALSSGELR
CIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETFEILQGLKPKYEAHHGVTYADDALQAAVDLSVKHIGDRLLPDK
AIDVIDEAGARQRLLPEGTRKELIDIEEIETIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQNPAIETLAGSIKLA
RSGLANPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEAHSISRLIGAPPGYVGFDQGGLLTEKIVKTP
HCVLLLDEVEKAHPDIFNILLQVMDRGILTDTNGREANFKNVILVMTTNAGATQASRRSIGFTKQDHSTDAMESIRRGFT
PEFRNRLDAIVQFQPLAFDHILRVVDKFIIELEMLLQEKHVSLSATPTARDWLAQHGFDPLMGARPMSRVIQEKIKRPLA
DELLFGKLVDGGRVNIDVKDGELVVEAHPEPERLLPATVD

Sequences:

>Translated_760_residues
MFSKDLEQTIGQCYKRAREARHEFMTVEHLLLSLLDNPSAQAVLKACGADQVRLHNDLEQAIEASVSRLAEDDGRDTQPT
LGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLNQQDITRLDIVNYLSHGIAKLGEDGEQPSAPDGESKS
EGGEGEAKGDALAEFASNLNEQARNGKIDPLVGRSDEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLAKRIVDNDVP
EVLADAVIYSLDLGALVAGTKYRGDFEKRLKGVLAALKKVPNAVLFIDEIHTIIGAGSASGGTMDASNLIKPALSSGELR
CIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETFEILQGLKPKYEAHHGVTYADDALQAAVDLSVKHIGDRLLPDK
AIDVIDEAGARQRLLPEGTRKELIDIEEIETIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQNPAIETLAGSIKLA
RSGLANPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEAHSISRLIGAPPGYVGFDQGGLLTEKIVKTP
HCVLLLDEVEKAHPDIFNILLQVMDRGILTDTNGREANFKNVILVMTTNAGATQASRRSIGFTKQDHSTDAMESIRRGFT
PEFRNRLDAIVQFQPLAFDHILRVVDKFIIELEMLLQEKHVSLSATPTARDWLAQHGFDPLMGARPMSRVIQEKIKRPLA
DELLFGKLVDGGRVNIDVKDGELVVEAHPEPERLLPATVD
>Mature_760_residues
MFSKDLEQTIGQCYKRAREARHEFMTVEHLLLSLLDNPSAQAVLKACGADQVRLHNDLEQAIEASVSRLAEDDGRDTQPT
LGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAVYFLNQQDITRLDIVNYLSHGIAKLGEDGEQPSAPDGESKS
EGGEGEAKGDALAEFASNLNEQARNGKIDPLVGRSDEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLAKRIVDNDVP
EVLADAVIYSLDLGALVAGTKYRGDFEKRLKGVLAALKKVPNAVLFIDEIHTIIGAGSASGGTMDASNLIKPALSSGELR
CIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETFEILQGLKPKYEAHHGVTYADDALQAAVDLSVKHIGDRLLPDK
AIDVIDEAGARQRLLPEGTRKELIDIEEIETIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQNPAIETLAGSIKLA
RSGLANPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEAHSISRLIGAPPGYVGFDQGGLLTEKIVKTP
HCVLLLDEVEKAHPDIFNILLQVMDRGILTDTNGREANFKNVILVMTTNAGATQASRRSIGFTKQDHSTDAMESIRRGFT
PEFRNRLDAIVQFQPLAFDHILRVVDKFIIELEMLLQEKHVSLSATPTARDWLAQHGFDPLMGARPMSRVIQEKIKRPLA
DELLFGKLVDGGRVNIDVKDGELVVEAHPEPERLLPATVD

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=329, Percent_Identity=31.6109422492401, Blast_Score=158, Evalue=2e-38,
Organism=Escherichia coli, GI1787109, Length=740, Percent_Identity=63.7837837837838, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=407, Percent_Identity=44.2260442260442, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=254, Percent_Identity=53.9370078740158, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6323002, Length=333, Percent_Identity=42.6426426426426, Blast_Score=263, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83384; Mature: 83384

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKDLEQTIGQCYKRAREARHEFMTVEHLLLSLLDNPSAQAVLKACGADQVRLHNDLEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHH
AIEASVSRLAEDDGRDTQPTLGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAV
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLNQQDITRLDIVNYLSHGIAKLGEDGEQPSAPDGESKSEGGEGEAKGDALAEFASNLN
EEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EQARNGKIDPLVGRSDEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLAKRIVDNDVP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHH
EVLADAVIYSLDLGALVAGTKYRGDFEKRLKGVLAALKKVPNAVLFIDEIHTIIGAGSAS
HHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCC
GGTMDASNLIKPALSSGELRCIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETFEI
CCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LQGLKPKYEAHHGVTYADDALQAAVDLSVKHIGDRLLPDKAIDVIDEAGARQRLLPEGTR
HHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCCCCH
KELIDIEEIETIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQNPAIETLAGSIKLA
HHHCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
RSGLANPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEAHSISRLIGAP
HHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEKIVKTPHCVLLLDEVEKAHPDIFNILLQVMDRGILTDTNGREANFK
CCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCC
NVILVMTTNAGATQASRRSIGFTKQDHSTDAMESIRRGFTPEFRNRLDAIVQFQPLAFDH
CEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
ILRVVDKFIIELEMLLQEKHVSLSATPTARDWLAQHGFDPLMGARPMSRVIQEKIKRPLA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHH
DELLFGKLVDGGRVNIDVKDGELVVEAHPEPERLLPATVD
HHHHHHHHCCCCEEEEEEECCEEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MFSKDLEQTIGQCYKRAREARHEFMTVEHLLLSLLDNPSAQAVLKACGADQVRLHNDLEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHH
AIEASVSRLAEDDGRDTQPTLGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAV
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLNQQDITRLDIVNYLSHGIAKLGEDGEQPSAPDGESKSEGGEGEAKGDALAEFASNLN
EEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EQARNGKIDPLVGRSDEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLAKRIVDNDVP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHH
EVLADAVIYSLDLGALVAGTKYRGDFEKRLKGVLAALKKVPNAVLFIDEIHTIIGAGSAS
HHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCC
GGTMDASNLIKPALSSGELRCIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETFEI
CCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LQGLKPKYEAHHGVTYADDALQAAVDLSVKHIGDRLLPDKAIDVIDEAGARQRLLPEGTR
HHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCCCCH
KELIDIEEIETIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQNPAIETLAGSIKLA
HHHCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
RSGLANPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEAHSISRLIGAP
HHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEKIVKTPHCVLLLDEVEKAHPDIFNILLQVMDRGILTDTNGREANFK
CCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCC
NVILVMTTNAGATQASRRSIGFTKQDHSTDAMESIRRGFTPEFRNRLDAIVQFQPLAFDH
CEEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
ILRVVDKFIIELEMLLQEKHVSLSATPTARDWLAQHGFDPLMGARPMSRVIQEKIKRPLA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHH
DELLFGKLVDGGRVNIDVKDGELVVEAHPEPERLLPATVD
HHHHHHHHCCCCEEEEEEECCEEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]