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The map label for this gene is carA

Identifier: 21242605

GI number: 21242605

Start: 2156012

End: 2157187

Strand: Direct

Name: carA

Synonym: XAC1861

Alternate gene names: 21242605

Gene position: 2156012-2157187 (Clockwise)

Preceding gene: 21242604

Following gene: 161485715

Centisome position: 41.66

GC content: 64.71

Gene sequence:

>1176_bases
GTGACCCAACCCGCAATCCTTGTCCTCGAAGACGGCACCGTGTTCGAGGGCGAATCCGTAGGCGCCAACGGGCTTTCCGT
CGGTGAAGTGGTGTTCAACACCGCCATGACCGGCTATCAGGAAGTCCTGACCGATCCCTCCTACGCCCGCCAGATGGTCA
CGCTGACCTATCCGCATATCGGCAACACGGGCTTCACCGATCAGGACGACGAAGCCCGCAAGATCTGGGCGGCCGGCCTG
ATCGTGCGCGATGTGCCGCGCCGCCCCAGCAACTGGCGCAGCCAGGTGGCCTTGCCGGAATGGCTGCAGGCCCGCGGTGT
GGTCGCCATCTCCGGCATCGACACCCGCAAGCTGACCCGCCTGCTGCGGCAGAAGGGCGCCCAGAACGGTGCGCTGATGG
CCGGCGACATCGACGTCGAAAAAGCGCTGGAAGCCGCACGCAAATTCCCCGGCCTGAAAGGCATGGATCTGGCCAAGGTG
GTCTCGACCGAGAGCACGTACAACTGGAAGGAAGGCTCGCTGGATCTGAACTCAGACAGCTTTTTGGGTCTGGGTGCGTT
GAATATTGGAAAGTCCGCACATGCAAGTGCGGGCTCTGGCGAGGAACTCGCATTCAAGGTCGTGGCCTACGACTACGGCG
TGAAGCTCAACATCCTGCGCATGCTGGCCGAGCGCGGCTGCGACGTCACCGTGGTACCGGCGCGCACGCCGGTGGCCGAG
GTGTTGGCGCTGCAACCCGATGGCGTGTTCCTGTCCAACGGCCCGGGCGACCCGGAGCCGTGCGACTACGCGATCGATGC
GATCAAGGAACTGATCGCGCAGAAGGTGCCGACCTTCGGCATCTGCCTGGGCCATCAGCTGCTGGCGCTGGCCGCTGGCG
CCAAGACGCTCAAGATGACCACCGGCCATCACGGCGCCAACCACCCGGTGCAGGATCTGGACGGCGGCCGGGTGATGATC
ACCTCGCAGAACCATGGTTTTGCAGTGGATGAAAGCACCTTGCCGGCCAATGTGCGGGTGACCCATCGGTCGCTGTTCGA
TGGCACCAACCAGGGCATCGCGCTGACCGACGCACCGGCGTTCTCGTTCCAGGGCCATCCGGAAGCCTCGCCCGGCCCGC
GCGATGTGGGGCCGTTGTTCGATCGGTTCGTGGATCTGATGGCGGCACGCGCCTGA

Upstream 100 bases:

>100_bases
AGCGTCGGACCGGTCCCCAGCACCGCGTCCGCGCTTTGCTGCAACCGGAATTTGGCCGGGAGCGCATCGGAGTCCCAGGC
AGCCAGAGCGAGACCCCCAC

Downstream 100 bases:

>100_bases
TGAAAACAGGGCTGGCCTCGCTGCCGCGCACACGCCATTGGCGGGTGTTTGCGTTGGCGATGCTGGCGCTGTCGATGTAT
CCGGCGTTCGTGTTGATTGC

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTQPAILVLEDGTVFEGESVGANGLSVGEVVFNTAMTGYQEVLTDPSYARQMVTLTYPHIGNTGFTDQDDEARKIWAAGL
IVRDVPRRPSNWRSQVALPEWLQARGVVAISGIDTRKLTRLLRQKGAQNGALMAGDIDVEKALEAARKFPGLKGMDLAKV
VSTESTYNWKEGSLDLNSDSFLGLGALNIGKSAHASAGSGEELAFKVVAYDYGVKLNILRMLAERGCDVTVVPARTPVAE
VLALQPDGVFLSNGPGDPEPCDYAIDAIKELIAQKVPTFGICLGHQLLALAAGAKTLKMTTGHHGANHPVQDLDGGRVMI
TSQNHGFAVDESTLPANVRVTHRSLFDGTNQGIALTDAPAFSFQGHPEASPGPRDVGPLFDRFVDLMAARA

Sequences:

>Translated_391_residues
MTQPAILVLEDGTVFEGESVGANGLSVGEVVFNTAMTGYQEVLTDPSYARQMVTLTYPHIGNTGFTDQDDEARKIWAAGL
IVRDVPRRPSNWRSQVALPEWLQARGVVAISGIDTRKLTRLLRQKGAQNGALMAGDIDVEKALEAARKFPGLKGMDLAKV
VSTESTYNWKEGSLDLNSDSFLGLGALNIGKSAHASAGSGEELAFKVVAYDYGVKLNILRMLAERGCDVTVVPARTPVAE
VLALQPDGVFLSNGPGDPEPCDYAIDAIKELIAQKVPTFGICLGHQLLALAAGAKTLKMTTGHHGANHPVQDLDGGRVMI
TSQNHGFAVDESTLPANVRVTHRSLFDGTNQGIALTDAPAFSFQGHPEASPGPRDVGPLFDRFVDLMAARA
>Mature_390_residues
TQPAILVLEDGTVFEGESVGANGLSVGEVVFNTAMTGYQEVLTDPSYARQMVTLTYPHIGNTGFTDQDDEARKIWAAGLI
VRDVPRRPSNWRSQVALPEWLQARGVVAISGIDTRKLTRLLRQKGAQNGALMAGDIDVEKALEAARKFPGLKGMDLAKVV
STESTYNWKEGSLDLNSDSFLGLGALNIGKSAHASAGSGEELAFKVVAYDYGVKLNILRMLAERGCDVTVVPARTPVAEV
LALQPDGVFLSNGPGDPEPCDYAIDAIKELIAQKVPTFGICLGHQLLALAAGAKTLKMTTGHHGANHPVQDLDGGRVMIT
SQNHGFAVDESTLPANVRVTHRSLFDGTNQGIALTDAPAFSFQGHPEASPGPRDVGPLFDRFVDLMAARA

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI18105007, Length=392, Percent_Identity=38.265306122449, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI169790915, Length=397, Percent_Identity=35.264483627204, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI21361331, Length=397, Percent_Identity=35.264483627204, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI1786215, Length=388, Percent_Identity=61.8556701030928, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI1789760, Length=132, Percent_Identity=29.5454545454545, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193204318, Length=394, Percent_Identity=39.5939086294416, Blast_Score=255, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6324878, Length=396, Percent_Identity=38.6363636363636, Blast_Score=245, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6322331, Length=401, Percent_Identity=37.4064837905237, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI45555749, Length=398, Percent_Identity=38.9447236180905, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=38.9447236180905, Blast_Score=231, Evalue=7e-61,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CARA_XANAC (P58895)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642187.1
- ProteinModelPortal:   P58895
- SMR:   P58895
- GeneID:   1155932
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1861
- NMPDR:   fig|190486.1.peg.1831
- HOGENOM:   HBG286341
- OMA:   FTYPELG
- ProtClustDB:   PRK12564
- BioCyc:   XAXO190486:XAC1861-MONOMER
- BRENDA:   6.3.5.5
- HAMAP:   MF_01209_B
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- PANTHER:   PTHR11405:SF4
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR01368

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase; SSF52021 CP_synthsmall

EC number: =6.3.5.5

Molecular weight: Translated: 41701; Mature: 41570

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 282-282 ACT_SITE 366-366 ACT_SITE 368-368

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPAILVLEDGTVFEGESVGANGLSVGEVVFNTAMTGYQEVLTDPSYARQMVTLTYPHI
CCCCEEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCEEEEEECCCC
GNTGFTDQDDEARKIWAAGLIVRDVPRRPSNWRSQVALPEWLQARGVVAISGIDTRKLTR
CCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCHHCCCCHHHHHHCCEEEEECCCHHHHHH
LLRQKGAQNGALMAGDIDVEKALEAARKFPGLKGMDLAKVVSTESTYNWKEGSLDLNSDS
HHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCC
FLGLGALNIGKSAHASAGSGEELAFKVVAYDYGVKLNILRMLAERGCDVTVVPARTPVAE
EEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCHHH
VLALQPDGVFLSNGPGDPEPCDYAIDAIKELIAQKVPTFGICLGHQLLALAAGAKTLKMT
HEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEE
TGHHGANHPVQDLDGGRVMITSQNHGFAVDESTLPANVRVTHRSLFDGTNQGIALTDAPA
CCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCEEEEEEHHHHCCCCCCEEEECCCC
FSFQGHPEASPGPRDVGPLFDRFVDLMAARA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQPAILVLEDGTVFEGESVGANGLSVGEVVFNTAMTGYQEVLTDPSYARQMVTLTYPHI
CCCEEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCEEEEEECCCC
GNTGFTDQDDEARKIWAAGLIVRDVPRRPSNWRSQVALPEWLQARGVVAISGIDTRKLTR
CCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCHHCCCCHHHHHHCCEEEEECCCHHHHHH
LLRQKGAQNGALMAGDIDVEKALEAARKFPGLKGMDLAKVVSTESTYNWKEGSLDLNSDS
HHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCC
FLGLGALNIGKSAHASAGSGEELAFKVVAYDYGVKLNILRMLAERGCDVTVVPARTPVAE
EEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCHHH
VLALQPDGVFLSNGPGDPEPCDYAIDAIKELIAQKVPTFGICLGHQLLALAAGAKTLKMT
HEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEE
TGHHGANHPVQDLDGGRVMITSQNHGFAVDESTLPANVRVTHRSLFDGTNQGIALTDAPA
CCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCEEEEEEHHHHCCCCCCEEEECCCC
FSFQGHPEASPGPRDVGPLFDRFVDLMAARA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217