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The map label for this gene is avtA [H]

Identifier: 21242602

GI number: 21242602

Start: 2152651

End: 2153934

Strand: Direct

Name: avtA [H]

Synonym: XAC1858

Alternate gene names: 21242602

Gene position: 2152651-2153934 (Clockwise)

Preceding gene: 21242601

Following gene: 21242603

Centisome position: 41.59

GC content: 66.28

Gene sequence:

>1284_bases
GTGCCGGGCGAGGCAAGCGGTCAGCGATCCGTCGCTGCACTGCACAGCGCCGCAGCCACTTGCGTTCGCTATGCTTGCGC
CATGACAACTTCCTTCCAGATCTCCCGACGTGCGCAGGCGCTGACCAGTTCGGCGATTCGCGAAATCCTCAAGGTGACCG
AACGGCCGGAGGTCATTTCCTTCGCCGGCGGCCTGCCGTCGCCGGCCACCTTTCCCGTGGAGCGCATGCGCGCAGCCAGC
GACCAGGTGCTGCGCGACGCCCCGCAGGCGGCACTGCAATACGGCCCAACCGAAGGTTATGCGCCGCTGCGCGAATGGGT
GGCCGCGCGGCTGAGTCGCGATGGCGCCAGCATCCGGCCCAGCCAGGTGCTGATCACCACCGGCTCGCAACAAGGCCTGG
ACCTGCTCGGCAAGGTCTTCATCGACGAAGGCAGCAAGGTGTTGGTGGAAACGCCGAGCTACCTGGGCGCATTGCAGGCG
TTTTCGTTGTTCCAGCCGGCATTCGTCGGCATGCCTTCGGACGAGGGCGGCGTGGTGGTGGATGCGCTGGATCCGTCGCT
GCTGGCCGATGCGCGCTTTCTGTATTGCCTGCCGAATTTCCAGAATCCCACTGGCCGGCGCTTGCCGTTGGCGCGTCGCC
AGGCCTTGGTGGCACGCGCGGCCGAGGCAGGCGTGCCGATCGTCGAAGACGACCCGTATGGCGAGCTGTACTACAGCGGG
CAACCGTTGCCGAGTCTGTTGTCGATGAACCCGGAAGGCGTCATCTACATGGGCTCCTTTTCCAAGGTGCTCGCGCCCGG
CCTGCGGCTGGGCTATGTGGTGGCGCCCGAAACGGTGCTGGGAAAACTGATCCAGGCCAAGCAGGCGGCCGATCTGCACA
CTCCATCGTTCACGCAGCGCGTGGTGTACCAGACGCTGCAGGACGATTTTCTCCAGACCCATATTCCGCAGATCCGTGCG
CTGTATGCGCGTCAGTGCAGCCTGATGCTGGAGGCGCTGGACCGGCACTTCCCGCCGCAGGTGCAGTGGAATCGCCCGGA
GGGCGGCATGTTCTTGTGGGTGACCTTGCCGCCGGGTCTGGACGGGACCGCGTTGCTGGCGCGGGCCATCGCGCGCAATG
TCGCGTTCGTTCCCGGCGCGCCGTTCTTCGCCACCTTGCCGCAGACCAATACGCTGCGCCTGTCGTTCGTCACCGTGCCC
GGCGAGAAGATCGATGCCGGCATCCAGGTGCTGGGGGAGCTGTTGCGCGAGGCGCTGGCCGAGTCGCCAGGGTTGGGCGG
GTGA

Upstream 100 bases:

>100_bases
TCGCTGGTTGCGGCTTGTGTCGTGCGGCCAGGGCAGCTGCAGTGCACCCTGCACGGTTGCCTGGTGATGGCCGGCGACGT
GCTGCCGGCCTTTGGACTCC

Downstream 100 bases:

>100_bases
CGGTGGCGACGGCGGAGCAGGGTGCGCCGATCGCGATCAGGATCGATCATGTTGCCATCGGCAGCGCGCGCGACTTCACT
CGCCCTGGCAGCCGCAGCGC

Product: valine-pyruvate aminotransferase

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MPGEASGQRSVAALHSAAATCVRYACAMTTSFQISRRAQALTSSAIREILKVTERPEVISFAGGLPSPATFPVERMRAAS
DQVLRDAPQAALQYGPTEGYAPLREWVAARLSRDGASIRPSQVLITTGSQQGLDLLGKVFIDEGSKVLVETPSYLGALQA
FSLFQPAFVGMPSDEGGVVVDALDPSLLADARFLYCLPNFQNPTGRRLPLARRQALVARAAEAGVPIVEDDPYGELYYSG
QPLPSLLSMNPEGVIYMGSFSKVLAPGLRLGYVVAPETVLGKLIQAKQAADLHTPSFTQRVVYQTLQDDFLQTHIPQIRA
LYARQCSLMLEALDRHFPPQVQWNRPEGGMFLWVTLPPGLDGTALLARAIARNVAFVPGAPFFATLPQTNTLRLSFVTVP
GEKIDAGIQVLGELLREALAESPGLGG

Sequences:

>Translated_427_residues
MPGEASGQRSVAALHSAAATCVRYACAMTTSFQISRRAQALTSSAIREILKVTERPEVISFAGGLPSPATFPVERMRAAS
DQVLRDAPQAALQYGPTEGYAPLREWVAARLSRDGASIRPSQVLITTGSQQGLDLLGKVFIDEGSKVLVETPSYLGALQA
FSLFQPAFVGMPSDEGGVVVDALDPSLLADARFLYCLPNFQNPTGRRLPLARRQALVARAAEAGVPIVEDDPYGELYYSG
QPLPSLLSMNPEGVIYMGSFSKVLAPGLRLGYVVAPETVLGKLIQAKQAADLHTPSFTQRVVYQTLQDDFLQTHIPQIRA
LYARQCSLMLEALDRHFPPQVQWNRPEGGMFLWVTLPPGLDGTALLARAIARNVAFVPGAPFFATLPQTNTLRLSFVTVP
GEKIDAGIQVLGELLREALAESPGLGG
>Mature_426_residues
PGEASGQRSVAALHSAAATCVRYACAMTTSFQISRRAQALTSSAIREILKVTERPEVISFAGGLPSPATFPVERMRAASD
QVLRDAPQAALQYGPTEGYAPLREWVAARLSRDGASIRPSQVLITTGSQQGLDLLGKVFIDEGSKVLVETPSYLGALQAF
SLFQPAFVGMPSDEGGVVVDALDPSLLADARFLYCLPNFQNPTGRRLPLARRQALVARAAEAGVPIVEDDPYGELYYSGQ
PLPSLLSMNPEGVIYMGSFSKVLAPGLRLGYVVAPETVLGKLIQAKQAADLHTPSFTQRVVYQTLQDDFLQTHIPQIRAL
YARQCSLMLEALDRHFPPQVQWNRPEGGMFLWVTLPPGLDGTALLARAIARNVAFVPGAPFFATLPQTNTLRLSFVTVPG
EKIDAGIQVLGELLREALAESPGLGG

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=419, Percent_Identity=31.0262529832936, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI33469970, Length=419, Percent_Identity=31.0262529832936, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1787710, Length=389, Percent_Identity=28.5347043701799, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790797, Length=344, Percent_Identity=30.2325581395349, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI48994949, Length=401, Percent_Identity=27.1820448877805, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788722, Length=316, Percent_Identity=24.6835443037975, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321000, Length=249, Percent_Identity=28.5140562248996, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356535, Length=397, Percent_Identity=26.1964735516373, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 45927; Mature: 45796

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGEASGQRSVAALHSAAATCVRYACAMTTSFQISRRAQALTSSAIREILKVTERPEVIS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
FAGGLPSPATFPVERMRAASDQVLRDAPQAALQYGPTEGYAPLREWVAARLSRDGASIRP
ECCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCC
SQVLITTGSQQGLDLLGKVFIDEGSKVLVETPSYLGALQAFSLFQPAFVGMPSDEGGVVV
CEEEEECCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCHHHCCCCCCCCCEEE
DALDPSLLADARFLYCLPNFQNPTGRRLPLARRQALVARAAEAGVPIVEDDPYGELYYSG
ECCCCHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCEEECC
QPLPSLLSMNPEGVIYMGSFSKVLAPGLRLGYVVAPETVLGKLIQAKQAADLHTPSFTQR
CCCHHHHCCCCCCEEEECCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHH
VVYQTLQDDFLQTHIPQIRALYARQCSLMLEALDRHFPPQVQWNRPEGGMFLWVTLPPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCC
DGTALLARAIARNVAFVPGAPFFATLPQTNTLRLSFVTVPGEKIDAGIQVLGELLREALA
CHHHHHHHHHHHCCEECCCCCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
ESPGLGG
CCCCCCC
>Mature Secondary Structure 
PGEASGQRSVAALHSAAATCVRYACAMTTSFQISRRAQALTSSAIREILKVTERPEVIS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
FAGGLPSPATFPVERMRAASDQVLRDAPQAALQYGPTEGYAPLREWVAARLSRDGASIRP
ECCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCC
SQVLITTGSQQGLDLLGKVFIDEGSKVLVETPSYLGALQAFSLFQPAFVGMPSDEGGVVV
CEEEEECCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCHHHCCCCCCCCCEEE
DALDPSLLADARFLYCLPNFQNPTGRRLPLARRQALVARAAEAGVPIVEDDPYGELYYSG
ECCCCHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCEEECC
QPLPSLLSMNPEGVIYMGSFSKVLAPGLRLGYVVAPETVLGKLIQAKQAADLHTPSFTQR
CCCHHHHCCCCCCEEEECCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHH
VVYQTLQDDFLQTHIPQIRALYARQCSLMLEALDRHFPPQVQWNRPEGGMFLWVTLPPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCC
DGTALLARAIARNVAFVPGAPFFATLPQTNTLRLSFVTVPGEKIDAGIQVLGELLREALA
CHHHHHHHHHHHCCEECCCCCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
ESPGLGG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA