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The map label for this gene is mtnC

Identifier: 21242582

GI number: 21242582

Start: 2134130

End: 2134828

Strand: Reverse

Name: mtnC

Synonym: XAC1838

Alternate gene names: 21242582

Gene position: 2134828-2134130 (Counterclockwise)

Preceding gene: 21242583

Following gene: 21242581

Centisome position: 41.25

GC content: 63.95

Gene sequence:

>699_bases
ATGACACGACCGCAAGCGATCCTCACCGATATCGAAGGTACGACCAGCAGCATTTCGTTCGTCAAGGACGTCTTGTTCCC
GTATGCGCGCCGTGCAATGCCGGCCTACGTGCGCGACCACGGCAATCATCCGCAGGTGCGCCATTGGCTCAACCAGGTGG
CCGATGAAATCGGCGAGGACGTGCCGGACGAGGTGCTGATCACCACGCTGCAGACCTGGATCGACGAGGACCGCAAGCAC
ACCGCGCTCAAGGCCTTGCAGGGCCTGATCTGGGGCGACGGCTACAAGACGGCCGACTTCACTGCGCATATCTACGCCGA
TGCCGCGATCCAGCTCAAAGCCTGGCACGCAGCGGGCATCCCGCTGTATGTGTATTCGTCCGGCTCGGTGCCGGCGCAAA
AATTGTTCTTCGCGCACAGCGACGCGGGCGACCTGAGCGGACTGATCACCGACTGGTTCGATACCGAAGTCGGCCCCAAG
CGCGAAAGCGCCAGCTACCGCCGCATCGCCGAGCGCATTGGCGTGCCGGGGCCGGAGATCCTGTTTCTGTCGGATGTGAT
CGAAGAGCTCGATGCCGCCAAGCGTGCCGGCATGCGCACCGCGCTGCTGGATCGCCTGGACGACTACCCCACGCCGCGTT
CGGCCGACGAGGTCGGCAGCCACCAGCGCGTGGAGAGTTTCAGCCAGCTGGTGCTGTAA

Upstream 100 bases:

>100_bases
TCACCGAGCCGGACGGCTGGGTCGGGCACTTCACCGGCACCGAAATCGCCAAACAATTCCCCCGCTACGCCCCCAAGAAA
CCTCACAAGGCCAGCTGACG

Downstream 100 bases:

>100_bases
GCACGATCTGCAAGCCGATTGCGCTCCTGGCCGTTTGAGCGCGATCGGGCGTTGGCGCTGCGCAGGCCGCTGAGATGTTC
CAGCTGCTATGCGCCGCATG

Product: enolase-phosphatase

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTRPQAILTDIEGTTSSISFVKDVLFPYARRAMPAYVRDHGNHPQVRHWLNQVADEIGEDVPDEVLITTLQTWIDEDRKH
TALKALQGLIWGDGYKTADFTAHIYADAAIQLKAWHAAGIPLYVYSSGSVPAQKLFFAHSDAGDLSGLITDWFDTEVGPK
RESASYRRIAERIGVPGPEILFLSDVIEELDAAKRAGMRTALLDRLDDYPTPRSADEVGSHQRVESFSQLVL

Sequences:

>Translated_232_residues
MTRPQAILTDIEGTTSSISFVKDVLFPYARRAMPAYVRDHGNHPQVRHWLNQVADEIGEDVPDEVLITTLQTWIDEDRKH
TALKALQGLIWGDGYKTADFTAHIYADAAIQLKAWHAAGIPLYVYSSGSVPAQKLFFAHSDAGDLSGLITDWFDTEVGPK
RESASYRRIAERIGVPGPEILFLSDVIEELDAAKRAGMRTALLDRLDDYPTPRSADEVGSHQRVESFSQLVL
>Mature_231_residues
TRPQAILTDIEGTTSSISFVKDVLFPYARRAMPAYVRDHGNHPQVRHWLNQVADEIGEDVPDEVLITTLQTWIDEDRKHT
ALKALQGLIWGDGYKTADFTAHIYADAAIQLKAWHAAGIPLYVYSSGSVPAQKLFFAHSDAGDLSGLITDWFDTEVGPKR
ESASYRRIAERIGVPGPEILFLSDVIEELDAAKRAGMRTALLDRLDDYPTPRSADEVGSHQRVESFSQLVL

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=251, Percent_Identity=37.8486055776892, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI115533232, Length=221, Percent_Identity=44.7963800904977, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320797, Length=214, Percent_Identity=37.3831775700935, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281360080, Length=213, Percent_Identity=41.7840375586854, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24644163, Length=213, Percent_Identity=41.7840375586854, Blast_Score=160, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_XANAC (Q8PLG2)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642164.1
- HSSP:   Q9UHY7
- ProteinModelPortal:   Q8PLG2
- SMR:   Q8PLG2
- GeneID:   1155909
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1838
- NMPDR:   fig|190486.1.peg.1808
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- ProtClustDB:   CLSK866737
- BioCyc:   XAXO190486:XAC1838-MONOMER
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- InterPro:   IPR006439
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- TIGRFAMs:   TIGR01691
- TIGRFAMs:   TIGR01549

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 25848; Mature: 25717

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPQAILTDIEGTTSSISFVKDVLFPYARRAMPAYVRDHGNHPQVRHWLNQVADEIGED
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHCCC
VPDEVLITTLQTWIDEDRKHTALKALQGLIWGDGYKTADFTAHIYADAAIQLKAWHAAGI
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEEEECCCC
PLYVYSSGSVPAQKLFFAHSDAGDLSGLITDWFDTEVGPKRESASYRRIAERIGVPGPEI
EEEEEECCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCE
LFLSDVIEELDAAKRAGMRTALLDRLDDYPTPRSADEVGSHQRVESFSQLVL
EHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
TRPQAILTDIEGTTSSISFVKDVLFPYARRAMPAYVRDHGNHPQVRHWLNQVADEIGED
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHCCC
VPDEVLITTLQTWIDEDRKHTALKALQGLIWGDGYKTADFTAHIYADAAIQLKAWHAAGI
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEEEECCCC
PLYVYSSGSVPAQKLFFAHSDAGDLSGLITDWFDTEVGPKRESASYRRIAERIGVPGPEI
EEEEEECCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCE
LFLSDVIEELDAAKRAGMRTALLDRLDDYPTPRSADEVGSHQRVESFSQLVL
EHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217