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The map label for this gene is thrA [H]

Identifier: 21242564

GI number: 21242564

Start: 2114170

End: 2116677

Strand: Direct

Name: thrA [H]

Synonym: XAC1820

Alternate gene names: 21242564

Gene position: 2114170-2116677 (Clockwise)

Preceding gene: 21242563

Following gene: 161485716

Centisome position: 40.85

GC content: 65.79

Gene sequence:

>2508_bases
ATGTCATCGCATGCTGTTTCGTTCGAACCCGCTGCTGTTCTTGCGTCCTCTGCGCGCACTGTCGTGCACAAATTCGGCGG
CACCTCGGTGGCAGATGCCGAGCGTTATCGGCATGTGGCGCAGCTGCTGCTTGCACGCGACGAGACGGTGCAGGTCACCG
TGGTCTCGGCGATGAAGGGCGTCACCGATGCCTTGATCGAACTGGCCGAACTGGCGGCGAAGAATCGCCCCGAATGGCGC
GAGCGGTGGCACGAAACGCGCGCACGCCATCGCGGTGCGGCGGTCGCCTTGCTCGGCGAGCATTCCGGGCCAACGGTGGA
GTGGCTGGACGAACGCTTCGCGCATCTGTCGCAGATCCTCGGCGCGCTGGCGGTCATCGGGGAATTGCCGCGCGAAGTGC
TCGACCGCGTGCAAGGACTGGGCGAGGTGTATTCGGCGCAGTTGCTGGGCGATCACTTTCGCGCGATCGGCGAAGACTGC
GCAGTGCTGGACGCGCGCGATGTGCTGGTGGTCAATCGCGGCGAACTCGGTGTGGATGTGGACTGGGAGGCGAGTGCGCA
GCGCCTCGCAACCTGGCGGCAAGCGCATCCGCAGACGCGCGTGGTGGTGACCGGATTCGTGGCGCGCGACCGTGCCGACC
GCGTCACCACGCTGGGCCGCAACGGCAGCGATTATTCGGGTGCCATCTTCGCTGCATTGTTCGATGCAGACGAACTGCAT
ATCTGGACCGATGTGGATGGCGTGCTGTCGGCCGACCCGCGCGTGGTGCCCGAAGCGGTGCAACTGGAAACACTGAGCTA
CGACGAGGCCTGCGAGCTGGCATATTTCGGTGCGAAGGTGGTGCACCCGCAAACGATGTCGCCGGCGATCGAGCGCGGCC
TGCCGATCATCATCCGCAACACCTTCCAGCCCGAGCATCCCGGCACGCGCATTACTGCCAGTAGCGCGGTGAGCGGGCCG
ATCAAGGGTCTGACGTTGAGCCCGGATCTGGCGGTGCTGAATCTGGAAGGCACCGGTCTGATCGGTGTGCCGGGCACGGC
CGAGCGCGTGTTCGCCGCGCTGCGCACCGCGCAGGTGTCGGTGGTGATGATCTCGCAGGGTTCGTCGGAACATTCGATCT
GCTGCGTGGTCAAGCAGCACGAGTCCGAGCGTGCACGCAACGCATTGTTGCAAGCGTTCGCGCATGAACTCACGGTCGGG
CAGGTGCAGCGCGTGCAGCTGACCACCGGCATCAGCGTGCTCGCAGCAGTAGGCGATGGTATGGCCGGTCAGCCGGGTGT
GGCGGCGCGCTTGTTCGAATCGTTGGGGCGAGCCCAGGTCAATATCCTGGCAATTGCGCAGGGCTCCTCCGAACGCAATA
TCTCGGTAGCGATCGATGCGGCGCACGCCACCAAGGCGTTGCGCGCGGCGCATGCCGGTTTCTGGTTGTCGCCGCAGACG
TTTTCTGTAGGCGTGATCGGTCCGGGCAATGTGGGCGCGGCATTGCTGGACCAACTGCGCAACGCGCAACCGCAGTTGTT
AGGCAAGGCCAATCTTGATCTGCGCCTGCGCGCGGTGGTCTCACGCGGTCGCATGCTGCTGGACGAACGCGGCCTGGTCG
GCGACTGGCGCGATGCGTTTGCATCGTCCGCAACGCCCACCGATCTGGAACGCTTCACCACGCATCTGCTGTCTGCGCAT
CTGCCGCATACGGTGATCATCGATTGCAGCGGCAGCGCCGAAGTCGCAGACCGTTATGCGGGCTGGCTGGCAGCCGGCAT
CCACGTGGTGACGCCGAACAAGCAGGCGGGGTCCGGCCCGCTGGCGCGCTATGAGGCGATTCGCGCAGCGGCCGACGCCA
GTGGTGCGCGCTTCCGTTATGAAGCCACCGTGGGCGCCGGTTTGCCGGTGATCACCACACTGCGCGACCTGGTGGACACC
GGCGATGCAGTCACGTCCATCGAAGGCATCTTCTCCGGCACGTTGGCATGGTTGTTCAACAAGTACGAAGGCAGCGTGCC
CTTCGCCGAACTGGTGACGCAGGCGCGCGGCATGGGCTATACCGAACCGGATCCGCGCGACGATCTGTCCGGCGTGGACG
TGGCGCGCAAGTTGGTGATCCTGGCGCGCGAAGCAGGGCGCTCCATCAGCCTGGAAGATGTGCAGGTTGAAAGCCTGGTG
CCTGAAGCGCTGCGCCAGGCCAGCGTGGACGATTTCATGGCGCGCTTACCGGAAGTGGATGCGTCCTTCGCGCAACGTCT
GGCCCAAGCGCATGCGCGTGGCAATGTGCTGCGCTATGTCGCGCAGCTGCCGCCGGACCGCGCGCCCAGCGTGGGCCTGG
TCGAGCTGCCGGCCGATCACGCGTTCGCCAATCTGCGTCTGACCGATAACGTGGTGCAGTTCACCACGCGGCGCTACTGC
GAGAACCCGTTGGTGGTGCAGGGCCCGGGTGCCGGTCCGGAAGTGACCGCGGCAGGCGTGTTCGCCGATCTGCTGCGCGT
GGCGGCAGGCGAGGGCGCGCGGCTGTGA

Upstream 100 bases:

>100_bases
CGCGTAACTTCCGAAAACAACGGCCCCGCACCCGGATCAGGATGCGGGGGCTTCCCTCTCTCATCCGATGCGGACGGGGC
CTCCCCAACGAGGTCTGTCG

Downstream 100 bases:

>100_bases
CGCATGCTGTTGTCAGCCAGGCCGGCGTGAGCCAGGCGGCGGTGGCGCAGGGGCAGGGCAGCGATCACGCTTCCCTGGGC
AAGCACGGCTTGCACGAAGC

Product: bifunctional aspartokinase I/homeserine dehydrogenase I

Products: NA

Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MSSHAVSFEPAAVLASSARTVVHKFGGTSVADAERYRHVAQLLLARDETVQVTVVSAMKGVTDALIELAELAAKNRPEWR
ERWHETRARHRGAAVALLGEHSGPTVEWLDERFAHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDC
AVLDARDVLVVNRGELGVDVDWEASAQRLATWRQAHPQTRVVVTGFVARDRADRVTTLGRNGSDYSGAIFAALFDADELH
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRITASSAVSGP
IKGLTLSPDLAVLNLEGTGLIGVPGTAERVFAALRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVG
QVQRVQLTTGISVLAAVGDGMAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
FSVGVIGPGNVGAALLDQLRNAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAFASSATPTDLERFTTHLLSAH
LPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDT
GDAVTSIEGIFSGTLAWLFNKYEGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLV
PEALRQASVDDFMARLPEVDASFAQRLAQAHARGNVLRYVAQLPPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYC
ENPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL

Sequences:

>Translated_835_residues
MSSHAVSFEPAAVLASSARTVVHKFGGTSVADAERYRHVAQLLLARDETVQVTVVSAMKGVTDALIELAELAAKNRPEWR
ERWHETRARHRGAAVALLGEHSGPTVEWLDERFAHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDC
AVLDARDVLVVNRGELGVDVDWEASAQRLATWRQAHPQTRVVVTGFVARDRADRVTTLGRNGSDYSGAIFAALFDADELH
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRITASSAVSGP
IKGLTLSPDLAVLNLEGTGLIGVPGTAERVFAALRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVG
QVQRVQLTTGISVLAAVGDGMAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
FSVGVIGPGNVGAALLDQLRNAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAFASSATPTDLERFTTHLLSAH
LPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDT
GDAVTSIEGIFSGTLAWLFNKYEGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLV
PEALRQASVDDFMARLPEVDASFAQRLAQAHARGNVLRYVAQLPPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYC
ENPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL
>Mature_834_residues
SSHAVSFEPAAVLASSARTVVHKFGGTSVADAERYRHVAQLLLARDETVQVTVVSAMKGVTDALIELAELAAKNRPEWRE
RWHETRARHRGAAVALLGEHSGPTVEWLDERFAHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCA
VLDARDVLVVNRGELGVDVDWEASAQRLATWRQAHPQTRVVVTGFVARDRADRVTTLGRNGSDYSGAIFAALFDADELHI
WTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRITASSAVSGPI
KGLTLSPDLAVLNLEGTGLIGVPGTAERVFAALRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQ
VQRVQLTTGISVLAAVGDGMAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQTF
SVGVIGPGNVGAALLDQLRNAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAFASSATPTDLERFTTHLLSAHL
PHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTG
DAVTSIEGIFSGTLAWLFNKYEGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLVP
EALRQASVDDFMARLPEVDASFAQRLAQAHARGNVLRYVAQLPPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYCE
NPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=812, Percent_Identity=40.3940886699507, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1790376, Length=810, Percent_Identity=34.5679012345679, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1790455, Length=461, Percent_Identity=29.5010845986985, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322599, Length=363, Percent_Identity=40.2203856749311, Blast_Score=224, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6320893, Length=512, Percent_Identity=26.3671875, Blast_Score=147, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 89137; Mature: 89006

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHAVSFEPAAVLASSARTVVHKFGGTSVADAERYRHVAQLLLARDETVQVTVVSAMKG
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
VTDALIELAELAAKNRPEWRERWHETRARHRGAAVALLGEHSGPTVEWLDERFAHLSQIL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
GALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGELGVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCC
DWEASAQRLATWRQAHPQTRVVVTGFVARDRADRVTTLGRNGSDYSGAIFAALFDADELH
CCCHHHHHHHHHHHCCCCCEEEEEEEHHHCCHHHHHCCCCCCCCCCCEEEEEEECCCCEE
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRN
EEECCCCHHCCCCCCCCHHHEEEECCCCHHHHHHHHCCEEECCCCCCHHHHCCCEEEEEC
TFQPEHPGTRITASSAVSGPIKGLTLSPDLAVLNLEGTGLIGVPGTAERVFAALRTAQVS
CCCCCCCCCEEEECCCCCCCCCCEEECCCEEEEEECCCEEEECCCHHHHHHHHHHHHEEE
VVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQLTTGISVLAAVGDG
EEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCC
MAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
CCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECHHHHHHHHHHHCCCEECCCC
FSVGVIGPGNVGAALLDQLRNAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAF
EEEEEECCCCHHHHHHHHHHCCCCHHCCCCCCCEEHHHHHHCCHHEECCCCCCCCHHHHH
ASSATPTDLERFTTHLLSAHLPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGP
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
LARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDAVTSIEGIFSGTLAWLFN
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KYEGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLV
HCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
PEALRQASVDDFMARLPEVDASFAQRLAQAHARGNVLRYVAQLPPDRAPSVGLVELPADH
HHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEECCCC
AFANLRLTDNVVQFTTRRYCENPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL
CEEEEEECHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSHAVSFEPAAVLASSARTVVHKFGGTSVADAERYRHVAQLLLARDETVQVTVVSAMKG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
VTDALIELAELAAKNRPEWRERWHETRARHRGAAVALLGEHSGPTVEWLDERFAHLSQIL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
GALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGELGVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCC
DWEASAQRLATWRQAHPQTRVVVTGFVARDRADRVTTLGRNGSDYSGAIFAALFDADELH
CCCHHHHHHHHHHHCCCCCEEEEEEEHHHCCHHHHHCCCCCCCCCCCEEEEEEECCCCEE
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRN
EEECCCCHHCCCCCCCCHHHEEEECCCCHHHHHHHHCCEEECCCCCCHHHHCCCEEEEEC
TFQPEHPGTRITASSAVSGPIKGLTLSPDLAVLNLEGTGLIGVPGTAERVFAALRTAQVS
CCCCCCCCCEEEECCCCCCCCCCEEECCCEEEEEECCCEEEECCCHHHHHHHHHHHHEEE
VVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQLTTGISVLAAVGDG
EEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCC
MAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
CCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECHHHHHHHHHHHCCCEECCCC
FSVGVIGPGNVGAALLDQLRNAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAF
EEEEEECCCCHHHHHHHHHHCCCCHHCCCCCCCEEHHHHHHCCHHEECCCCCCCCHHHHH
ASSATPTDLERFTTHLLSAHLPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGP
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
LARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDAVTSIEGIFSGTLAWLFN
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KYEGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLV
HCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
PEALRQASVDDFMARLPEVDASFAQRLAQAHARGNVLRYVAQLPPDRAPSVGLVELPADH
HHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEECCCC
AFANLRLTDNVVQFTTRRYCENPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL
CEEEEEECHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]