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The map label for this gene is aarF [C]

Identifier: 21242487

GI number: 21242487

Start: 1997314

End: 1998990

Strand: Direct

Name: aarF [C]

Synonym: XAC1738

Alternate gene names: 21242487

Gene position: 1997314-1998990 (Clockwise)

Preceding gene: 21242486

Following gene: 21242488

Centisome position: 38.59

GC content: 65.71

Gene sequence:

>1677_bases
ATGTGGGAAGCGCTAGGCACGGTACGTGATCTTGGGCGTCTGCAGGAAATCGCCTCGGTCCTGATCCGCTACGGCTTCGG
CGATGTGGTGCGTCGTATCGGCCTGGCCGATGTGCTTGAGCGCGCCGGCAGGCTGTTGCATTGGCAGAATGCCGAGGGCC
GGTTGCGCATGTCCGCAGCGATGCGCGTGCGGCGTGCACTGGAAGAGCTCGGGCCAACCTTCGTCAAACTGGGCCAGGTG
TTGGCCACGCGCGTGGACCTGCTGCCGCCGGAGTGGATCGAAGAATTGAGCGAGCTGCAGAACGCGGTGCCGGCGCTGCC
ATTCGATCAGATCCGTCCGCAGCTGGTCGCCGCGCTGGGTATGGAGCCGGAAAGCGTCTTCGCGCGCCTGGACGAACAAC
CGCTGGCGGCCGCATCGCTGGCACAGACGCATCGCGCGTGGCTGGTCGATGGCACCCCGGTGGTGTTGAAGATCCGTCGT
CCCGATATCGGTGACACCATCGATGCGGATCTGCGCCTGCTCGCCCGGCTTGCTGAAATCGTCGAAACCCGCGCACCGGA
TCTCAAGCGCTACCGTCCTTCCGAGGTGGTACAGCAATTTACCGTCTCGCTGCGACGCGAGCTGGACTTCGCTGCCGAGG
GGCGCAACGCCGAACGCATCGCCGCCAACTTCGCGCACGATGCGCAGGTGGTGGTGCCGGCGGTGTACTGGGAGTGGACC
AGCGAGTCGCTCAACGTGCAGGAATTCATCGATGGGATTCCGGGGCGCGATCTGCTCGCCGTCGATGCGGCCGGCCTGGA
TCGCAGGGCGCTCGCACGTGCCGGTGCCGGCATCGTGCTCAAGATGGTGCTGCAGGACGGCTGCTTCCACGCCGACCCGC
ATCCGGGGAACATTTTTTACCTGCGCGACGGGCGCATCGCGGTCATCGATTTCGGCATGGTCGGGCGCGTCTCCGAGCAG
CGTCGGTTTCAGGTCGCACAGCTGCTGCACGGCATGGTCAGCTACGACGCCGAAGCGGTGATCGACGTCTTGCTGGAATG
GGCGGGCACCAGCCTGGAGATCGACGAGGCGCGTTTGCAGCAAGACATCGGTGCGTTCGTCGACGAGTATCGCGGCGTGC
CGCTGAAAGAATTGCGTATTGGCGCAATGCTTGGCGACGTCACCTCCATCCTGCGCGATCACGGGCTGACGCTGCCATCG
GATCTGGCACTGATGATCAAGGCCTTTCTCACCCTGGAAGGCATGGGGCGCCAACTCGATCCGGATTTCGACATGGCCAC
CGAGGCGCGCCCGTACCTGGAGCGCGTGGTGCTGCAGCGCTATGCGCCGCGCGCCATCGTGCGGCGTGGCCGGCGGACCG
TGACTGGCGCGATCGACCTGATCGGCGATCTGCCGCGCGACCTCAAGCGCCTGTTGCAAGCCGCACGCCGCGGCAAGCTG
CAGCTGCAGGTCGAAACACGCGCATTGCGCGAGTTCGGCGAGCAGGTCGACCGCGCCGCCAATCGCCTCACGATGGGGAT
CGTGACAGCCGCCTTGGTGATCGGCTCCTCGATCGTCATGAACAGCGTCGGCGGTAGCGCCAGCCGCTGGTTGCTCGCGC
TGGGCGTGGGCGGTTTCATCGGCGCGGCGCTGTGCGGCATCTGGATCTTGTTTTCGATCTGGCGAAGCCGGCGCTAG

Upstream 100 bases:

>100_bases
CGTTTCTTGCTCCTGTCCCATCGGTCGCCGCGTTGCAGGCTGCTCTGTACTGCAGTGTCACGCAGCGCCTGAGCGCAACG
CGCTCGCAGGCGGTGTGCTG

Downstream 100 bases:

>100_bases
CGCGCGACGCGTCGTCCTGATGGCGTGCGGGCAAGACGCGGCGAAATACTTGCGCAGGCGATCGTTAGTAGTAATACTAC
TAAACATGGACCTGACCGAT

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MWEALGTVRDLGRLQEIASVLIRYGFGDVVRRIGLADVLERAGRLLHWQNAEGRLRMSAAMRVRRALEELGPTFVKLGQV
LATRVDLLPPEWIEELSELQNAVPALPFDQIRPQLVAALGMEPESVFARLDEQPLAAASLAQTHRAWLVDGTPVVLKIRR
PDIGDTIDADLRLLARLAEIVETRAPDLKRYRPSEVVQQFTVSLRRELDFAAEGRNAERIAANFAHDAQVVVPAVYWEWT
SESLNVQEFIDGIPGRDLLAVDAAGLDRRALARAGAGIVLKMVLQDGCFHADPHPGNIFYLRDGRIAVIDFGMVGRVSEQ
RRFQVAQLLHGMVSYDAEAVIDVLLEWAGTSLEIDEARLQQDIGAFVDEYRGVPLKELRIGAMLGDVTSILRDHGLTLPS
DLALMIKAFLTLEGMGRQLDPDFDMATEARPYLERVVLQRYAPRAIVRRGRRTVTGAIDLIGDLPRDLKRLLQAARRGKL
QLQVETRALREFGEQVDRAANRLTMGIVTAALVIGSSIVMNSVGGSASRWLLALGVGGFIGAALCGIWILFSIWRSRR

Sequences:

>Translated_558_residues
MWEALGTVRDLGRLQEIASVLIRYGFGDVVRRIGLADVLERAGRLLHWQNAEGRLRMSAAMRVRRALEELGPTFVKLGQV
LATRVDLLPPEWIEELSELQNAVPALPFDQIRPQLVAALGMEPESVFARLDEQPLAAASLAQTHRAWLVDGTPVVLKIRR
PDIGDTIDADLRLLARLAEIVETRAPDLKRYRPSEVVQQFTVSLRRELDFAAEGRNAERIAANFAHDAQVVVPAVYWEWT
SESLNVQEFIDGIPGRDLLAVDAAGLDRRALARAGAGIVLKMVLQDGCFHADPHPGNIFYLRDGRIAVIDFGMVGRVSEQ
RRFQVAQLLHGMVSYDAEAVIDVLLEWAGTSLEIDEARLQQDIGAFVDEYRGVPLKELRIGAMLGDVTSILRDHGLTLPS
DLALMIKAFLTLEGMGRQLDPDFDMATEARPYLERVVLQRYAPRAIVRRGRRTVTGAIDLIGDLPRDLKRLLQAARRGKL
QLQVETRALREFGEQVDRAANRLTMGIVTAALVIGSSIVMNSVGGSASRWLLALGVGGFIGAALCGIWILFSIWRSRR
>Mature_558_residues
MWEALGTVRDLGRLQEIASVLIRYGFGDVVRRIGLADVLERAGRLLHWQNAEGRLRMSAAMRVRRALEELGPTFVKLGQV
LATRVDLLPPEWIEELSELQNAVPALPFDQIRPQLVAALGMEPESVFARLDEQPLAAASLAQTHRAWLVDGTPVVLKIRR
PDIGDTIDADLRLLARLAEIVETRAPDLKRYRPSEVVQQFTVSLRRELDFAAEGRNAERIAANFAHDAQVVVPAVYWEWT
SESLNVQEFIDGIPGRDLLAVDAAGLDRRALARAGAGIVLKMVLQDGCFHADPHPGNIFYLRDGRIAVIDFGMVGRVSEQ
RRFQVAQLLHGMVSYDAEAVIDVLLEWAGTSLEIDEARLQQDIGAFVDEYRGVPLKELRIGAMLGDVTSILRDHGLTLPS
DLALMIKAFLTLEGMGRQLDPDFDMATEARPYLERVVLQRYAPRAIVRRGRRTVTGAIDLIGDLPRDLKRLLQAARRGKL
QLQVETRALREFGEQVDRAANRLTMGIVTAALVIGSSIVMNSVGGSASRWLLALGVGGFIGAALCGIWILFSIWRSRR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=299, Percent_Identity=33.7792642140468, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI40254938, Length=296, Percent_Identity=29.7297297297297, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI217035081, Length=222, Percent_Identity=28.3783783783784, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI34147522, Length=319, Percent_Identity=23.5109717868339, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI2367309, Length=550, Percent_Identity=31.8181818181818, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17559152, Length=257, Percent_Identity=26.4591439688716, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=252, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=24.4803695150115, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323282, Length=314, Percent_Identity=25.4777070063694, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=257, Percent_Identity=25.6809338521401, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22024280, Length=271, Percent_Identity=28.4132841328413, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24662575, Length=290, Percent_Identity=32.0689655172414, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18859849, Length=263, Percent_Identity=24.7148288973384, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61910; Mature: 61910

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEALGTVRDLGRLQEIASVLIRYGFGDVVRRIGLADVLERAGRLLHWQNAEGRLRMSAA
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
MRVRRALEELGPTFVKLGQVLATRVDLLPPEWIEELSELQNAVPALPFDQIRPQLVAALG
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
MEPESVFARLDEQPLAAASLAQTHRAWLVDGTPVVLKIRRPDIGDTIDADLRLLARLAEI
CCHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
VETRAPDLKRYRPSEVVQQFTVSLRRELDFAAEGRNAERIAANFAHDAQVVVPAVYWEWT
HHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEEEC
SESLNVQEFIDGIPGRDLLAVDAAGLDRRALARAGAGIVLKMVLQDGCFHADPHPGNIFY
CCCCCHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEE
LRDGRIAVIDFGMVGRVSEQRRFQVAQLLHGMVSYDAEAVIDVLLEWAGTSLEIDEARLQ
EECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHH
QDIGAFVDEYRGVPLKELRIGAMLGDVTSILRDHGLTLPSDLALMIKAFLTLEGMGRQLD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
PDFDMATEARPYLERVVLQRYAPRAIVRRGRRTVTGAIDLIGDLPRDLKRLLQAARRGKL
CCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCE
QLQVETRALREFGEQVDRAANRLTMGIVTAALVIGSSIVMNSVGGSASRWLLALGVGGFI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GAALCGIWILFSIWRSRR
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWEALGTVRDLGRLQEIASVLIRYGFGDVVRRIGLADVLERAGRLLHWQNAEGRLRMSAA
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
MRVRRALEELGPTFVKLGQVLATRVDLLPPEWIEELSELQNAVPALPFDQIRPQLVAALG
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
MEPESVFARLDEQPLAAASLAQTHRAWLVDGTPVVLKIRRPDIGDTIDADLRLLARLAEI
CCHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
VETRAPDLKRYRPSEVVQQFTVSLRRELDFAAEGRNAERIAANFAHDAQVVVPAVYWEWT
HHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEEEC
SESLNVQEFIDGIPGRDLLAVDAAGLDRRALARAGAGIVLKMVLQDGCFHADPHPGNIFY
CCCCCHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEE
LRDGRIAVIDFGMVGRVSEQRRFQVAQLLHGMVSYDAEAVIDVLLEWAGTSLEIDEARLQ
EECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHH
QDIGAFVDEYRGVPLKELRIGAMLGDVTSILRDHGLTLPSDLALMIKAFLTLEGMGRQLD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
PDFDMATEARPYLERVVLQRYAPRAIVRRGRRTVTGAIDLIGDLPRDLKRLLQAARRGKL
CCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCE
QLQVETRALREFGEQVDRAANRLTMGIVTAALVIGSSIVMNSVGGSASRWLLALGVGGFI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GAALCGIWILFSIWRSRR
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA