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The map label for this gene is folP [H]

Identifier: 21242482

GI number: 21242482

Start: 1992383

End: 1993285

Strand: Direct

Name: folP [H]

Synonym: XAC1733

Alternate gene names: 21242482

Gene position: 1992383-1993285 (Clockwise)

Preceding gene: 21242481

Following gene: 21242483

Centisome position: 38.5

GC content: 67.88

Gene sequence:

>903_bases
ATGTTCGAGACCGCCCTCACGCTGGATTGCGCCGGCCGCAGCCTGCGACTGGATGCGCCGCAGGTGATGGGTATCGTCAA
TGTCACGCCCGATTCGTTCTCCGACGGCGGCCAGCATGCGACCTGCGCAGCGGCGATCGCCCATGGGTTGGTACTGGTTG
AGCAGGGCGCTGCGGTGCTGGATATCGGTGGTGAGTCCACCCGCCCGGGCGCTGCGGCGGTCTCGGTTGAAGAAGAATTG
CAGCGGGTCATCCCGGTCATCGAAGCGCTGGCGCAACGTACCAGCGTGCCGATCAGCGTGGACACGTTCAAACCGGAGGT
CATGCGCGCGGCGGTCGCAGCCGGCGCCGGCATGATCAACGACGTCTATGCCCTGCGTTCGCCCGGTGCGCTGGAAGCGG
CGTCGGATCTGCGCGTGCCGGTGGTCTTGATGCATGCGCGCAGCGCGCCGCATGCCATGCAGGACGCGCCGCACTACGAC
GATGTCGTCGGCGAGGTGCACCGGTTTCTGGCCGAGCGCATCTTCGCCGCCGAGATGGCCGGAATCGACAAGCGCCGGCT
GGTCCTGGACCCGGGCTTTGGCTTCGACAAAACCACCACGCACAACCTCACCCTGCTTGCGCAGCTGCAGCGACTGCAGG
AGTTCGGTTTGCCCGTGCTGGCCGGGCTGTCGCGTAAGCGCAGCATCGGCGAGCTGACCGGGCGCGAGATCGCCGCCGAT
CGTGTGCACGGCTCGGTGGCCGCGCATCTGATCGCCGCGCAACATGGCGCGCTGCTGCTGCGCGTGCACGATGTGGCGGC
AACCGTGGATGCGTTGAAGGTGTGGAAGGCGATGGCGGCCATTCCCGTCCCGCGTGTCAGCGCGCCCGCCACGCCCGCGA
TGCGTTGGCCGGACGAGGACTGA

Upstream 100 bases:

>100_bases
CATCCATCAAGGCCGGGGAGCGATTCCCGGCCTTGATGCGTTATCGGGCTGCGTCGATGCCCACGTATGGGCGACCATAA
TCATCCAGGAGACACCGCCG

Downstream 100 bases:

>100_bases
TGGCTGTCGACCAACGCCCGCTGGCGATCGCCGTGATGGGCCCCACTGCCAGCGGCAAGACGGCGCTGGCGCTTGAGGCT
GCAGAGCGCTGGAATGGAGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MFETALTLDCAGRSLRLDAPQVMGIVNVTPDSFSDGGQHATCAAAIAHGLVLVEQGAAVLDIGGESTRPGAAAVSVEEEL
QRVIPVIEALAQRTSVPISVDTFKPEVMRAAVAAGAGMINDVYALRSPGALEAASDLRVPVVLMHARSAPHAMQDAPHYD
DVVGEVHRFLAERIFAAEMAGIDKRRLVLDPGFGFDKTTTHNLTLLAQLQRLQEFGLPVLAGLSRKRSIGELTGREIAAD
RVHGSVAAHLIAAQHGALLLRVHDVAATVDALKVWKAMAAIPVPRVSAPATPAMRWPDED

Sequences:

>Translated_300_residues
MFETALTLDCAGRSLRLDAPQVMGIVNVTPDSFSDGGQHATCAAAIAHGLVLVEQGAAVLDIGGESTRPGAAAVSVEEEL
QRVIPVIEALAQRTSVPISVDTFKPEVMRAAVAAGAGMINDVYALRSPGALEAASDLRVPVVLMHARSAPHAMQDAPHYD
DVVGEVHRFLAERIFAAEMAGIDKRRLVLDPGFGFDKTTTHNLTLLAQLQRLQEFGLPVLAGLSRKRSIGELTGREIAAD
RVHGSVAAHLIAAQHGALLLRVHDVAATVDALKVWKAMAAIPVPRVSAPATPAMRWPDED
>Mature_300_residues
MFETALTLDCAGRSLRLDAPQVMGIVNVTPDSFSDGGQHATCAAAIAHGLVLVEQGAAVLDIGGESTRPGAAAVSVEEEL
QRVIPVIEALAQRTSVPISVDTFKPEVMRAAVAAGAGMINDVYALRSPGALEAASDLRVPVVLMHARSAPHAMQDAPHYD
DVVGEVHRFLAERIFAAEMAGIDKRRLVLDPGFGFDKTTTHNLTLLAQLQRLQEFGLPVLAGLSRKRSIGELTGREIAAD
RVHGSVAAHLIAAQHGALLLRVHDVAATVDALKVWKAMAAIPVPRVSAPATPAMRWPDED

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=54.4117647058823, Blast_Score=295, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6324073, Length=343, Percent_Identity=27.9883381924198, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31749; Mature: 31749

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETALTLDCAGRSLRLDAPQVMGIVNVTPDSFSDGGQHATCAAAIAHGLVLVEQGAAVL
CCCCEEEEECCCCEEECCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEECCCEEE
DIGGESTRPGAAAVSVEEELQRVIPVIEALAQRTSVPISVDTFKPEVMRAAVAAGAGMIN
EECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCHHH
DVYALRSPGALEAASDLRVPVVLMHARSAPHAMQDAPHYDDVVGEVHRFLAERIFAAEMA
HHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
GIDKRRLVLDPGFGFDKTTTHNLTLLAQLQRLQEFGLPVLAGLSRKRSIGELTGREIAAD
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHCCHHHHHH
RVHGSVAAHLIAAQHGALLLRVHDVAATVDALKVWKAMAAIPVPRVSAPATPAMRWPDED
HHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFETALTLDCAGRSLRLDAPQVMGIVNVTPDSFSDGGQHATCAAAIAHGLVLVEQGAAVL
CCCCEEEEECCCCEEECCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEECCCEEE
DIGGESTRPGAAAVSVEEELQRVIPVIEALAQRTSVPISVDTFKPEVMRAAVAAGAGMIN
EECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCHHH
DVYALRSPGALEAASDLRVPVVLMHARSAPHAMQDAPHYDDVVGEVHRFLAERIFAAEMA
HHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
GIDKRRLVLDPGFGFDKTTTHNLTLLAQLQRLQEFGLPVLAGLSRKRSIGELTGREIAAD
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHCCHHHHHH
RVHGSVAAHLIAAQHGALLLRVHDVAATVDALKVWKAMAAIPVPRVSAPATPAMRWPDED
HHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]