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The map label for this gene is tlyC [C]

Identifier: 21242458

GI number: 21242458

Start: 1968573

End: 1969913

Strand: Reverse

Name: tlyC [C]

Synonym: XAC1709

Alternate gene names: 21242458

Gene position: 1969913-1968573 (Counterclockwise)

Preceding gene: 77748607

Following gene: 21242457

Centisome position: 38.06

GC content: 64.06

Gene sequence:

>1341_bases
GTGGTTGAGTTTTTGATCGTCATCGCCCTGATCGTGCTGAACGGCTTCTTCGCCATGTCTGAGATGTCGTTGATGACCTC
GCGCAAGAGCCGCCTGAAGCAGATGGCCGGTTCCAGCAAGCGCGCCGCGCGGGCCCTGGCCTTGGCCGAAAGCCCGGAAA
ACTTCCTGTCCACGGTCCAGATCGGCATCACCCTGATCGGCATCCTGACTGGCGTGTTCGGCGGCGAAGCGATCGGCGAA
GCCATTGCCAGCTGGCTGCAGGGTGTGTTCCCGGCCCTGGCGGGCACGTTCGAACTGGTCGGCAAGCCGCGCCCGTATTC
GGTGGTCATCGGCAGCACCCTGGCGGTGGCGCTGATCACGTTCCTGACGCTGATCTTCGGCGAGCTGGTGCCCAAACGGC
TGGCGCTGCGCAATTCCGAAGACATCGCAGGCGTTGTCGCAGTGCCGATGGCCTGGCTGGCCAAGATCGCCGCGCCCGGG
GTGTGGGTGCTGGCGCGCTCCACTCGCTTGGTCCTGCGCATGTTGGGCATGGGCAAGGACGAGTCGGCCTCGGTCACCGA
AGAAGAGATCCGCATGCTGGTGGCCGAAAGCCACGAGGCCGGGGTGATCGACGCGCACGAGCGCGACATGATGAATCGGG
TGATGCGGCTGGGCGATCGTACCGCCGACAGCCTGATGACCCCGCGCAACCGCATCGCCTGGCTGGACGCCAACGCCGAG
CCGGAACGCAATCTGCAGATCATGCGCGAGCACGAATTTTCGCGCTACCCGGTATACCGCGGCAGCGACCAGGACATCGC
CGGCGTGCTGGAAGTCAAATCGCTGGTCACGCGCATGGACGGCCACGGCGCGCACCTGTTCCAGGCGCTGCGCGACACCT
TGTTCGTATCCGAATCCACGCATGCGATGAAGCTGCTGGAAATCTTTCGCGAAGAACAGCAGTCGATGGCGCTGGTTGTC
GACGAATACGGCGAAATCCGTGGCTTGGTGACCATCAGCGACCTGATGGGCGCGGTGGTCGGCCGTCTGCAGGCGGTGGA
AAATACCGACGAAGACGCGTTGGTGGTCACGCGCGCGGACGGTTCGCTGCTGATCGATGGATCGCTGCCGGTGGAAGAAT
TGCGCGAAGTGCTCGGTGCCGAATTGCCCGACGCCGACGAAGGCGACTACCACACGCTTGCGGGCCTGTGCATTTACTAT
TTCGGGCGCATTCCACAGGCCGGCGAATTCTTCGATTGGGCCGGCTGGCGCATCGAGATCGTCGACCTGGACGGTGCGCG
CGTGGACAAGTTGCTGCTGAGCCGGGTGGGCGACGAGGACAGCGATGACATCGTCGGGTGA

Upstream 100 bases:

>100_bases
GAAGACGACCCTATCCCCCCGTGTTGCCGCCCGGCCCGTGCGCCCGCCGGTAGCTCCAGTGCTCCCCCGCCCTCCCCTTC
ACTGACCGGGGAAGACGCCC

Downstream 100 bases:

>100_bases
CGGCAGTGCGCCGCGCGATGATGCCAACGAGCAGATGCGCTACCGCAACGAAGGCATCCGCAGCCTGCTGGCAGCCTTCA
GCGAAGGTGATCCGGACCAG

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MVEFLIVIALIVLNGFFAMSEMSLMTSRKSRLKQMAGSSKRAARALALAESPENFLSTVQIGITLIGILTGVFGGEAIGE
AIASWLQGVFPALAGTFELVGKPRPYSVVIGSTLAVALITFLTLIFGELVPKRLALRNSEDIAGVVAVPMAWLAKIAAPG
VWVLARSTRLVLRMLGMGKDESASVTEEEIRMLVAESHEAGVIDAHERDMMNRVMRLGDRTADSLMTPRNRIAWLDANAE
PERNLQIMREHEFSRYPVYRGSDQDIAGVLEVKSLVTRMDGHGAHLFQALRDTLFVSESTHAMKLLEIFREEQQSMALVV
DEYGEIRGLVTISDLMGAVVGRLQAVENTDEDALVVTRADGSLLIDGSLPVEELREVLGAELPDADEGDYHTLAGLCIYY
FGRIPQAGEFFDWAGWRIEIVDLDGARVDKLLLSRVGDEDSDDIVG

Sequences:

>Translated_446_residues
MVEFLIVIALIVLNGFFAMSEMSLMTSRKSRLKQMAGSSKRAARALALAESPENFLSTVQIGITLIGILTGVFGGEAIGE
AIASWLQGVFPALAGTFELVGKPRPYSVVIGSTLAVALITFLTLIFGELVPKRLALRNSEDIAGVVAVPMAWLAKIAAPG
VWVLARSTRLVLRMLGMGKDESASVTEEEIRMLVAESHEAGVIDAHERDMMNRVMRLGDRTADSLMTPRNRIAWLDANAE
PERNLQIMREHEFSRYPVYRGSDQDIAGVLEVKSLVTRMDGHGAHLFQALRDTLFVSESTHAMKLLEIFREEQQSMALVV
DEYGEIRGLVTISDLMGAVVGRLQAVENTDEDALVVTRADGSLLIDGSLPVEELREVLGAELPDADEGDYHTLAGLCIYY
FGRIPQAGEFFDWAGWRIEIVDLDGARVDKLLLSRVGDEDSDDIVG
>Mature_446_residues
MVEFLIVIALIVLNGFFAMSEMSLMTSRKSRLKQMAGSSKRAARALALAESPENFLSTVQIGITLIGILTGVFGGEAIGE
AIASWLQGVFPALAGTFELVGKPRPYSVVIGSTLAVALITFLTLIFGELVPKRLALRNSEDIAGVVAVPMAWLAKIAAPG
VWVLARSTRLVLRMLGMGKDESASVTEEEIRMLVAESHEAGVIDAHERDMMNRVMRLGDRTADSLMTPRNRIAWLDANAE
PERNLQIMREHEFSRYPVYRGSDQDIAGVLEVKSLVTRMDGHGAHLFQALRDTLFVSESTHAMKLLEIFREEQQSMALVV
DEYGEIRGLVTISDLMGAVVGRLQAVENTDEDALVVTRADGSLLIDGSLPVEELREVLGAELPDADEGDYHTLAGLCIYY
FGRIPQAGEFFDWAGWRIEIVDLDGARVDKLLLSRVGDEDSDDIVG

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=381, Percent_Identity=26.7716535433071, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1790664, Length=439, Percent_Identity=28.9293849658314, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI145693175, Length=416, Percent_Identity=29.0865384615385, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI87082033, Length=347, Percent_Identity=29.971181556196, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1788119, Length=266, Percent_Identity=30.0751879699248, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786879, Length=245, Percent_Identity=27.7551020408163, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48835; Mature: 48835

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEFLIVIALIVLNGFFAMSEMSLMTSRKSRLKQMAGSSKRAARALALAESPENFLSTVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHH
IGITLIGILTGVFGGEAIGEAIASWLQGVFPALAGTFELVGKPRPYSVVIGSTLAVALIT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
FLTLIFGELVPKRLALRNSEDIAGVVAVPMAWLAKIAAPGVWVLARSTRLVLRMLGMGKD
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCC
ESASVTEEEIRMLVAESHEAGVIDAHERDMMNRVMRLGDRTADSLMTPRNRIAWLDANAE
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCC
PERNLQIMREHEFSRYPVYRGSDQDIAGVLEVKSLVTRMDGHGAHLFQALRDTLFVSEST
CCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
HAMKLLEIFREEQQSMALVVDEYGEIRGLVTISDLMGAVVGRLQAVENTDEDALVVTRAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GSLLIDGSLPVEELREVLGAELPDADEGDYHTLAGLCIYYFGRIPQAGEFFDWAGWRIEI
CCEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VDLDGARVDKLLLSRVGDEDSDDIVG
EECCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVEFLIVIALIVLNGFFAMSEMSLMTSRKSRLKQMAGSSKRAARALALAESPENFLSTVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHH
IGITLIGILTGVFGGEAIGEAIASWLQGVFPALAGTFELVGKPRPYSVVIGSTLAVALIT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
FLTLIFGELVPKRLALRNSEDIAGVVAVPMAWLAKIAAPGVWVLARSTRLVLRMLGMGKD
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCC
ESASVTEEEIRMLVAESHEAGVIDAHERDMMNRVMRLGDRTADSLMTPRNRIAWLDANAE
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCC
PERNLQIMREHEFSRYPVYRGSDQDIAGVLEVKSLVTRMDGHGAHLFQALRDTLFVSEST
CCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
HAMKLLEIFREEQQSMALVVDEYGEIRGLVTISDLMGAVVGRLQAVENTDEDALVVTRAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GSLLIDGSLPVEELREVLGAELPDADEGDYHTLAGLCIYYFGRIPQAGEFFDWAGWRIEI
CCEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VDLDGARVDKLLLSRVGDEDSDDIVG
EECCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]