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The map label for this gene is mtnA

Identifier: 21242380

GI number: 21242380

Start: 1877576

End: 1878640

Strand: Direct

Name: mtnA

Synonym: XAC1630

Alternate gene names: 21242380

Gene position: 1877576-1878640 (Clockwise)

Preceding gene: 21242379

Following gene: 21242381

Centisome position: 36.28

GC content: 69.3

Gene sequence:

>1065_bases
ATGAACGACAGCGCCCATATCGATTACGCCCGCTACGACCACATCCGGCCACTGCTGTGGACCGGCGATGCCCTTGAATT
GCTCGACCAACGCAAACTGCCCTTCGAGGTGGCGCATGTGCGGTGCGACAGCAGCGACGCGGTGGCCGAGGCGATCCATT
CGCTGGCCGTGCGCGGTGCGCCGGCGATCGGCATTGCGGCCGGGTGGGGCGTGGTACTGGCCGCGCGCGACATCGCTGCC
GACGACGGCAGCGCTGCGCTGCAGAAGCTCGAGCCGGCGCTGCTGCGGCTCAACGCGGCGCGTCCGACCGCCGTCAACCT
GGCCTGGGCGCTGATGCGCATGCGCCGGGTGCTGGGCGCGGCGGGCGCCGATTGGCGCGAGGTGATCGCGCGCGAGGCGC
AGGCCATCGCCGATGAAGACCTGGCCGCCAACCGCCACATGGGCGCGCTTGGCGCCGCACTGATCGCACCGGGCAGTGGC
GTGCTGACCCATTGCAACACCGGCTCGCTGGCCACCGCTGGCTTTGGCACCGCACTGGGCGTGATCCGCGCCGGCATGGC
GCAACAGCGCATTGCCAAGGTGTTCGCCGGAGAAACCCGGCCGTGGCTGCAGGGCGCGCGCCTGACCGTGTGGGAGCTGC
ATCAGGACGGTATCGACGCGACCCTGATCGCCGACTCGGCGGCCTCGCATCTGATGAAATCCGGGCTGGTGCAGTGGGTG
ATCGTCGGCGCCGATCGCATCTGCGCCAATGGCGATACCGCCAACAAGATCGGCACCTACCAGCTGGCCATCGCCGCCCG
CCACCATGGCGTGAAGTTCATGGTGGTGGCGCCGTCGTCCACGGTGGATATGGCAACGGCCAGCGGGGACCAGATCGAGA
TCGAGCAACGCGATCCCGGCGAGTTGTTCGGCGTGGGCGGGGTCAGGACGGTGGCCGATGGCATCCACGCCTGGAACCCG
GTCTTCGACGTGACCCCAGGCGATCTGATCGACGCGATCGTCACCGAACGCGGCGTGATCGCGCAGCCGGACCTGGCGCG
GATGCAGGCCGCCTTCGGCAGCTGA

Upstream 100 bases:

>100_bases
GCCGCGCCCGCCTTCCGGCTGCACAGTGGTTTGGTCGGCCGCGCCAGGGCCGCGCGGTCGTGCAGCGGCGCAGGCGCTGC
GCGCGCCTTACAATGGACGC

Downstream 100 bases:

>100_bases
GCCCGGGGCCGGCCGCCCGGCTTCCAACGCCGCCCAAACTCCCTGCAAGTGCTTGTTTCTGGCTGGTAAAGCGGAGGCGT
CGGGATGCCCTGCCGTGGTA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNDSAHIDYARYDHIRPLLWTGDALELLDQRKLPFEVAHVRCDSSDAVAEAIHSLAVRGAPAIGIAAGWGVVLAARDIAA
DDGSAALQKLEPALLRLNAARPTAVNLAWALMRMRRVLGAAGADWREVIAREAQAIADEDLAANRHMGALGAALIAPGSG
VLTHCNTGSLATAGFGTALGVIRAGMAQQRIAKVFAGETRPWLQGARLTVWELHQDGIDATLIADSAASHLMKSGLVQWV
IVGADRICANGDTANKIGTYQLAIAARHHGVKFMVVAPSSTVDMATASGDQIEIEQRDPGELFGVGGVRTVADGIHAWNP
VFDVTPGDLIDAIVTERGVIAQPDLARMQAAFGS

Sequences:

>Translated_354_residues
MNDSAHIDYARYDHIRPLLWTGDALELLDQRKLPFEVAHVRCDSSDAVAEAIHSLAVRGAPAIGIAAGWGVVLAARDIAA
DDGSAALQKLEPALLRLNAARPTAVNLAWALMRMRRVLGAAGADWREVIAREAQAIADEDLAANRHMGALGAALIAPGSG
VLTHCNTGSLATAGFGTALGVIRAGMAQQRIAKVFAGETRPWLQGARLTVWELHQDGIDATLIADSAASHLMKSGLVQWV
IVGADRICANGDTANKIGTYQLAIAARHHGVKFMVVAPSSTVDMATASGDQIEIEQRDPGELFGVGGVRTVADGIHAWNP
VFDVTPGDLIDAIVTERGVIAQPDLARMQAAFGS
>Mature_354_residues
MNDSAHIDYARYDHIRPLLWTGDALELLDQRKLPFEVAHVRCDSSDAVAEAIHSLAVRGAPAIGIAAGWGVVLAARDIAA
DDGSAALQKLEPALLRLNAARPTAVNLAWALMRMRRVLGAAGADWREVIAREAQAIADEDLAANRHMGALGAALIAPGSG
VLTHCNTGSLATAGFGTALGVIRAGMAQQRIAKVFAGETRPWLQGARLTVWELHQDGIDATLIADSAASHLMKSGLVQWV
IVGADRICANGDTANKIGTYQLAIAARHHGVKFMVVAPSSTVDMATASGDQIEIEQRDPGELFGVGGVRTVADGIHAWNP
VFDVTPGDLIDAIVTERGVIAQPDLARMQAAFGS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=342, Percent_Identity=45.6140350877193, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI23943880, Length=331, Percent_Identity=40.1812688821752, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI78000158, Length=266, Percent_Identity=25.187969924812, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI78000156, Length=266, Percent_Identity=25.187969924812, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI187607323, Length=266, Percent_Identity=25.187969924812, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557462, Length=350, Percent_Identity=38, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6325375, Length=391, Percent_Identity=36.5728900255754, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21357667, Length=352, Percent_Identity=41.1931818181818, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24651647, Length=352, Percent_Identity=41.1931818181818, Blast_Score=241, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_XANAC (Q8PM04)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641962.1
- HSSP:   Q9X013
- ProteinModelPortal:   Q8PM04
- SMR:   Q8PM04
- GeneID:   1155701
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1630
- NMPDR:   fig|190486.1.peg.1606
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   PRK05720
- BioCyc:   XAXO190486:XAC1630-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37256; Mature: 37256

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: ACT_SITE 245-245 BINDING 101-101 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSAHIDYARYDHIRPLLWTGDALELLDQRKLPFEVAHVRCDSSDAVAEAIHSLAVRGA
CCCCCCCCHHHHHCCCCEEECCHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHCCC
PAIGIAAGWGVVLAARDIAADDGSAALQKLEPALLRLNAARPTAVNLAWALMRMRRVLGA
CCEEEECCCCEEEEEHHHCCCCHHHHHHHHCHHHHEECCCCCHHHHHHHHHHHHHHHHCC
AGADWREVIAREAQAIADEDLAANRHMGALGAALIAPGSGVLTHCNTGSLATAGFGTALG
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCEECCCHHHHHH
VIRAGMAQQRIAKVFAGETRPWLQGARLTVWELHQDGIDATLIADSAASHLMKSGLVQWV
HHHHHHHHHHHHHHHCCCCCHHHCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCEEE
IVGADRICANGDTANKIGTYQLAIAARHHGVKFMVVAPSSTVDMATASGDQIEIEQRDPG
EECCCCEECCCCCCCCCCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCEEEEECCCCC
ELFGVGGVRTVADGIHAWNPVFDVTPGDLIDAIVTERGVIAQPDLARMQAAFGS
CEEECCCHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNDSAHIDYARYDHIRPLLWTGDALELLDQRKLPFEVAHVRCDSSDAVAEAIHSLAVRGA
CCCCCCCCHHHHHCCCCEEECCHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHCCC
PAIGIAAGWGVVLAARDIAADDGSAALQKLEPALLRLNAARPTAVNLAWALMRMRRVLGA
CCEEEECCCCEEEEEHHHCCCCHHHHHHHHCHHHHEECCCCCHHHHHHHHHHHHHHHHCC
AGADWREVIAREAQAIADEDLAANRHMGALGAALIAPGSGVLTHCNTGSLATAGFGTALG
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCEECCCHHHHHH
VIRAGMAQQRIAKVFAGETRPWLQGARLTVWELHQDGIDATLIADSAASHLMKSGLVQWV
HHHHHHHHHHHHHHHCCCCCHHHCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCCEEE
IVGADRICANGDTANKIGTYQLAIAARHHGVKFMVVAPSSTVDMATASGDQIEIEQRDPG
EECCCCEECCCCCCCCCCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCEEEEECCCCC
ELFGVGGVRTVADGIHAWNPVFDVTPGDLIDAIVTERGVIAQPDLARMQAAFGS
CEEECCCHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217