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The map label for this gene is iscA [H]

Identifier: 21242369

GI number: 21242369

Start: 1864621

End: 1864959

Strand: Direct

Name: iscA [H]

Synonym: XAC1619

Alternate gene names: 21242369

Gene position: 1864621-1864959 (Clockwise)

Preceding gene: 21242364

Following gene: 21242370

Centisome position: 36.03

GC content: 66.67

Gene sequence:

>339_bases
ATGGCCGTCAGCCTCACCCCCGCCGCGCTGGAGCGCGTGCAGCGTTTCGTGCAGCAGACCCCAGGTGCGTTGGGTCTGCG
CTTTGGCGTCACCAAGACCGGTTGTTCCGGCTGGGGCCATGTCACCGACCTGGCACGCGAGGTGCGTGACGACGACGCGG
TCTTCGAGCAAGACGGGGTGCGCATCTTTGTCGACCCCGCCAGCCTGCCGCTGGTGGATGGCACCTGCATCGACTTCGGC
AAGCACGGCCTGAGCGAGACCTTCACCTTCAGCAATCCCAACGCGACCGCCGAATGCGGCTGCGGTGAGAGCTTTACCAC
CGCGGACGAGCACCGCTGA

Upstream 100 bases:

>100_bases
GGCGCGTACTGCCCCCACCTATTGCAGATGCCGCAGCTCCGCGTTCTGCCTGGTTGTTGCGGCCTCGCTATACTTGCCGC
CACTGTTTCGGAGTGCCTCC

Downstream 100 bases:

>100_bases
TTCCTTCTCCCTCGGGAGAAGGTGCCCGAAGGGCGGATGAGGGGGCGCCTCGGAGATCTGCCAACGCATGTACTGACAAG
CGCGTCGCTACGCGCCGCCC

Product: hypothetical protein

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 112; Mature: 111

Protein sequence:

>112_residues
MAVSLTPAALERVQRFVQQTPGALGLRFGVTKTGCSGWGHVTDLAREVRDDDAVFEQDGVRIFVDPASLPLVDGTCIDFG
KHGLSETFTFSNPNATAECGCGESFTTADEHR

Sequences:

>Translated_112_residues
MAVSLTPAALERVQRFVQQTPGALGLRFGVTKTGCSGWGHVTDLAREVRDDDAVFEQDGVRIFVDPASLPLVDGTCIDFG
KHGLSETFTFSNPNATAECGCGESFTTADEHR
>Mature_111_residues
AVSLTPAALERVQRFVQQTPGALGLRFGVTKTGCSGWGHVTDLAREVRDDDAVFEQDGVRIFVDPASLPLVDGTCIDFGK
HGLSETFTFSNPNATAECGCGESFTTADEHR

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=104, Percent_Identity=35.5769230769231, Blast_Score=86, Evalue=6e-18,
Organism=Homo sapiens, GI160420328, Length=95, Percent_Identity=40, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787974, Length=103, Percent_Identity=47.5728155339806, Blast_Score=111, Evalue=1e-26,
Organism=Escherichia coli, GI1788877, Length=105, Percent_Identity=46.6666666666667, Blast_Score=102, Evalue=6e-24,
Organism=Escherichia coli, GI1786351, Length=108, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193209025, Length=105, Percent_Identity=34.2857142857143, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25146411, Length=105, Percent_Identity=34.2857142857143, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323001, Length=103, Percent_Identity=34.9514563106796, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642263, Length=105, Percent_Identity=40.9523809523809, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 12005; Mature: 11874

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSLTPAALERVQRFVQQTPGALGLRFGVTKTGCSGWGHVTDLAREVRDDDAVFEQDGV
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEECCCCC
RIFVDPASLPLVDGTCIDFGKHGLSETFTFSNPNATAECGCGESFTTADEHR
EEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AVSLTPAALERVQRFVQQTPGALGLRFGVTKTGCSGWGHVTDLAREVRDDDAVFEQDGV
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEECCCCC
RIFVDPASLPLVDGTCIDFGKHGLSETFTFSNPNATAECGCGESFTTADEHR
EEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA