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The map label for this gene is degU [H]

Identifier: 21242362

GI number: 21242362

Start: 1858906

End: 1859619

Strand: Direct

Name: degU [H]

Synonym: XAC1612

Alternate gene names: 21242362

Gene position: 1858906-1859619 (Clockwise)

Preceding gene: 21242361

Following gene: 21242363

Centisome position: 35.92

GC content: 60.22

Gene sequence:

>714_bases
ATGATGAAGACACGTATCGTCGTCGCTGCCGATCGCACCATCCTCGTGGAAGGGATGGTCGCTTTGCTACAAAAGGTTCC
GGGTATCGAAGTGGTAGGGCATGCGGAAGACGGGCTGGCATGTCTTCAGATCGCCGCCAGAGAACGGCCCGATATCGTCC
TGGTGGATGTCCTGCTGCCCGGCCTCAATGGTATCGATCTGACGCGGCGCTTGATGCAGCGCAGCCCCAACAGCCGGGCA
ATCTGTATAGCTCCGTCCGATGCCTGTACGCAGTCCAGCGCAGTCTTCGAAGCCGGCGCCAAAGCATATCTGGCGCGAAC
CAGCCGCTTCGCCGAATTGCTGCGGGCAATTCAATGCGTCATCCAGGATCAGACCTACATCAGTCCGCAGATGTCGCGTT
CGCTGATCGCCGGGCTGCGTCGTGCTGCCAAGGCCGATTCTGCGTACACCCGACTCACCTCGCGCGAGCGCGAAATCGTG
CAGCTCTATTCGGAGGGCCTGTCCACCAGGCAGATCGCCAACCGCTTGCACCTGAGCGTGAAAACGGTGGGGACGCATCG
CGAAAACTGTATGTTGAAGCTCAATATCCAAAGCATCGCTCAGCTGACCCGTTATGCGATCGCGCAGGGCCTTTCTCCGC
TTGAAGCAGCAATCGGCGGTAGCGGTGAGCCATCCGATGGATGCGTAGCGCGGCACATGCGCCGTGCCGGCTGA

Upstream 100 bases:

>100_bases
AGCTCGCTCAAGTGCTCCTGCCGAGCATCTGCCGATTCGCTGCAGCGCGCCGCGTGCAAGCCGCTGCGCACTCGCGGCCC
CCATTCGTGCACCAGAGCGT

Downstream 100 bases:

>100_bases
GGCGTCCTGGCTACGCGCAGCGGCACACCGGCCGCATGGACGCTGGTGCATGTACTCAGGTGCGAGGCGATGGCTTGCGC
ATATCAGCATCGCCGGTGGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MMKTRIVVAADRTILVEGMVALLQKVPGIEVVGHAEDGLACLQIAARERPDIVLVDVLLPGLNGIDLTRRLMQRSPNSRA
ICIAPSDACTQSSAVFEAGAKAYLARTSRFAELLRAIQCVIQDQTYISPQMSRSLIAGLRRAAKADSAYTRLTSREREIV
QLYSEGLSTRQIANRLHLSVKTVGTHRENCMLKLNIQSIAQLTRYAIAQGLSPLEAAIGGSGEPSDGCVARHMRRAG

Sequences:

>Translated_237_residues
MMKTRIVVAADRTILVEGMVALLQKVPGIEVVGHAEDGLACLQIAARERPDIVLVDVLLPGLNGIDLTRRLMQRSPNSRA
ICIAPSDACTQSSAVFEAGAKAYLARTSRFAELLRAIQCVIQDQTYISPQMSRSLIAGLRRAAKADSAYTRLTSREREIV
QLYSEGLSTRQIANRLHLSVKTVGTHRENCMLKLNIQSIAQLTRYAIAQGLSPLEAAIGGSGEPSDGCVARHMRRAG
>Mature_237_residues
MMKTRIVVAADRTILVEGMVALLQKVPGIEVVGHAEDGLACLQIAARERPDIVLVDVLLPGLNGIDLTRRLMQRSPNSRA
ICIAPSDACTQSSAVFEAGAKAYLARTSRFAELLRAIQCVIQDQTYISPQMSRSLIAGLRRAAKADSAYTRLTSREREIV
QLYSEGLSTRQIANRLHLSVKTVGTHRENCMLKLNIQSIAQLTRYAIAQGLSPLEAAIGGSGEPSDGCVARHMRRAG

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=207, Percent_Identity=28.0193236714976, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=30.9278350515464, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=26.5700483091787, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788546, Length=216, Percent_Identity=23.1481481481481, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=29.6703296703297, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790102, Length=195, Percent_Identity=27.1794871794872, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788712, Length=201, Percent_Identity=23.8805970149254, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25721; Mature: 25721

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTRIVVAADRTILVEGMVALLQKVPGIEVVGHAEDGLACLQIAARERPDIVLVDVLLP
CCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEHHC
GLNGIDLTRRLMQRSPNSRAICIAPSDACTQSSAVFEAGAKAYLARTSRFAELLRAIQCV
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQDQTYISPQMSRSLIAGLRRAAKADSAYTRLTSREREIVQLYSEGLSTRQIANRLHLSV
HHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
KTVGTHRENCMLKLNIQSIAQLTRYAIAQGLSPLEAAIGGSGEPSDGCVARHMRRAG
EECCCCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MMKTRIVVAADRTILVEGMVALLQKVPGIEVVGHAEDGLACLQIAARERPDIVLVDVLLP
CCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEHHC
GLNGIDLTRRLMQRSPNSRAICIAPSDACTQSSAVFEAGAKAYLARTSRFAELLRAIQCV
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQDQTYISPQMSRSLIAGLRRAAKADSAYTRLTSREREIVQLYSEGLSTRQIANRLHLSV
HHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
KTVGTHRENCMLKLNIQSIAQLTRYAIAQGLSPLEAAIGGSGEPSDGCVARHMRRAG
EECCCCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]