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The map label for this gene is fur [H]

Identifier: 21242268

GI number: 21242268

Start: 1750849

End: 1751259

Strand: Direct

Name: fur [H]

Synonym: XAC1517

Alternate gene names: 21242268

Gene position: 1750849-1751259 (Clockwise)

Preceding gene: 21242266

Following gene: 21242269

Centisome position: 33.83

GC content: 60.83

Gene sequence:

>411_bases
ATGGAAACCCACGACCTGCGCAAAGTCGGGCTCAAGGTGACCCATCCGCGCATGCGGATCCTGGAACTGCTCGAACAGAA
GAGCAATCAGCATCACCTCAGCGCAGAAGACATCTATCGCCAACTGCTCGACCACGGCGACGAGATCGGCTTGGCCACGG
TCTACCGCGTGCTGACCCAGTTCGAGGCGGCCGGCTTGGTGCTGAAGCACAATTTCGAAGGCGGGCAGGCCGTCTACGAG
CTGGATCGCGGCGGTCACCACGACCATATGGTGGACGTGGATACCGGTCACGTGATCGAGTTCGAGAGCGAGGAAATCGA
GGCGTTGCAGCGCCAGATCGCCGCCAAGCATGGCTATGAACTGGAAGAGCACTCGCTGGTGCTGTACGTGCGCAAGAAGC
GTGCGCGCTGA

Upstream 100 bases:

>100_bases
GATTAAGTGCTGAGGAAATCACGCCGATGATACACTTCCGCCGGTCGCCGCGACCCGTTTGATGGCAGCTGGCGCTAAAT
CGCCAATGAACGGAGAACGT

Downstream 100 bases:

>100_bases
GCTGGGGCGTAGCTAGCGCTAGTGCGAATGACAAGGCGGCTTCGGCCGCCTTGTCCGTTGTGGGGCGGTTGGTGGATTCG
ATGCACGGCTTCCCCCATCC

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
METHDLRKVGLKVTHPRMRILELLEQKSNQHHLSAEDIYRQLLDHGDEIGLATVYRVLTQFEAAGLVLKHNFEGGQAVYE
LDRGGHHDHMVDVDTGHVIEFESEEIEALQRQIAAKHGYELEEHSLVLYVRKKRAR

Sequences:

>Translated_136_residues
METHDLRKVGLKVTHPRMRILELLEQKSNQHHLSAEDIYRQLLDHGDEIGLATVYRVLTQFEAAGLVLKHNFEGGQAVYE
LDRGGHHDHMVDVDTGHVIEFESEEIEALQRQIAAKHGYELEEHSLVLYVRKKRAR
>Mature_136_residues
METHDLRKVGLKVTHPRMRILELLEQKSNQHHLSAEDIYRQLLDHGDEIGLATVYRVLTQFEAAGLVLKHNFEGGQAVYE
LDRGGHHDHMVDVDTGHVIEFESEEIEALQRQIAAKHGYELEEHSLVLYVRKKRAR

Specific function: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=124, Percent_Identity=61.2903225806452, Blast_Score=158, Evalue=1e-40,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 15740; Mature: 15740

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHDLRKVGLKVTHPRMRILELLEQKSNQHHLSAEDIYRQLLDHGDEIGLATVYRVLTQ
CCCCHHHHHCCEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVLKHNFEGGQAVYELDRGGHHDHMVDVDTGHVIEFESEEIEALQRQIAAKHGYE
HHHCCEEEEECCCCCCEEEEECCCCCCCCEEECCCCCEEEECHHHHHHHHHHHHHHCCCC
LEEHSLVLYVRKKRAR
CCCCCEEEEEECCCCC
>Mature Secondary Structure
METHDLRKVGLKVTHPRMRILELLEQKSNQHHLSAEDIYRQLLDHGDEIGLATVYRVLTQ
CCCCHHHHHCCEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
FEAAGLVLKHNFEGGQAVYELDRGGHHDHMVDVDTGHVIEFESEEIEALQRQIAAKHGYE
HHHCCEEEEECCCCCCEEEEECCCCCCCCEEECCCCCEEEECHHHHHHHHHHHHHHCCCC
LEEHSLVLYVRKKRAR
CCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478325; 9852033; 10984043 [H]