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The map label for this gene is mexE [H]

Identifier: 21242234

GI number: 21242234

Start: 1711521

End: 1712711

Strand: Direct

Name: mexE [H]

Synonym: XAC1482

Alternate gene names: 21242234

Gene position: 1711521-1712711 (Clockwise)

Preceding gene: 21242233

Following gene: 21242235

Centisome position: 33.07

GC content: 67.59

Gene sequence:

>1191_bases
ATGACCACGAACGCCACCCCGTTCCGTTTTCCCTTGCGTACCGTGCTGGCGGGCGCCGTGCTGGCGGTCGTGCTTGCCGG
CTGCGGCAGCAAGGCCGCCGAGACCGGCGCACCCCCGCCGCCCAGCGTCAGCGTCGCGCCGGTGTTGATGAAGCAGATCA
GCCAGTGGGACGAATTCAGCGGCCGCATCGAGCCGGTGGAAAGCGTCGAACTGCGTCCGCGCGTGTCCGGCTATATCGAC
AAGGTCAACTACACCGAAGGTGCAGAGGTGAAGAAGAGCGATGTGCTCTTCACCATCGACGAGCGTAGCTACCGTGCCGA
GTTTGCGCGTGCCAACGCTTCGCTGGTGCGTGCCCGCACCCAGGCCACATTGGCGCGTAGCGAAGCGGCGCGTGCACGCA
AACTGTCCGAGCAGCAGGCCATCTCCACCGAAACCTGGGAGCAACGCCGCGCCGCCGCCGACCAGGCCGACGCCGACCTG
CAGGCCGCCCAGGCCGCGGTGGACACCGCCAAGCTCAACCTGGATTGGACGCGCGTACGCGCTCCCATCGATGGCCGCGC
CGGGCGTGCGATGGTCACCGCCGGCAACCTGGTCACGGCCGGCGACAGCGCCAGCGTGCTGACCACCCTGGTGTCGCTGG
ACAAGGTGTTCGTCTATTTCGACGCCGACGAAGGCACCTTCCTGCGTTATTCGCAGATGGCCCGCAACGGCGAGCGCCCG
GACGAACGTGGCGGCGAGTTGCCGGTGCGGATCGGGCTGGTCGGCGAGCAGGGCTTCCCGCACACCGGACGCGTGGATTT
CCTGGACAACCAGGTGACCCGCAGCACCGGCACCATCCGGGTCCGCGCGGTGCTGGACAACGCGCAGCGACAGTTCACGC
CAGGCCTGTATGCGCATGTGCAATTGCTGGGCAGCGGCCAGTTCAAGGCGATGCTGGTCGACGAAAAGGCCGTGCTCACC
GACCAGGACCGCAAGTACGTGTACGTGGTGGACAAGGACGGCAAGGCGCAACGCCGCGACGTGGAGCTCGGCCGCAATGC
CGACGGCCTGCGCATCGTGCGTAGCGGCCTGGCCGCCGGCGACCGCGTGGTAGTCGATGGTGTGCAGAAGATCTTCATGC
CCGGCATGCCGGTGGAGGCCAAGACCGTGGCCATGGCACCGGCGACGGACAAGCGCACCGCTTCCAACTAG

Upstream 100 bases:

>100_bases
GACAAGCCATCGTGACCGTGAGTCGTCGCCCACATGCCGCACCGTCGGCGAGCCGGCTGGCCGGTCTGCACGTTTCCATC
CCCACCCGAGAGATTTCCCC

Downstream 100 bases:

>100_bases
CGATCGCCACGCCTGTTGCGCGCCGTCGCGCCTAGCTGGCGACGGCGTAACACCTGCAATGGCTGTACTGCTGTATCGCT
GCATCGCAGCCCAAGACTGC

Product: RND multidrug efflux membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTTNATPFRFPLRTVLAGAVLAVVLAGCGSKAAETGAPPPPSVSVAPVLMKQISQWDEFSGRIEPVESVELRPRVSGYID
KVNYTEGAEVKKSDVLFTIDERSYRAEFARANASLVRARTQATLARSEAARARKLSEQQAISTETWEQRRAAADQADADL
QAAQAAVDTAKLNLDWTRVRAPIDGRAGRAMVTAGNLVTAGDSASVLTTLVSLDKVFVYFDADEGTFLRYSQMARNGERP
DERGGELPVRIGLVGEQGFPHTGRVDFLDNQVTRSTGTIRVRAVLDNAQRQFTPGLYAHVQLLGSGQFKAMLVDEKAVLT
DQDRKYVYVVDKDGKAQRRDVELGRNADGLRIVRSGLAAGDRVVVDGVQKIFMPGMPVEAKTVAMAPATDKRTASN

Sequences:

>Translated_396_residues
MTTNATPFRFPLRTVLAGAVLAVVLAGCGSKAAETGAPPPPSVSVAPVLMKQISQWDEFSGRIEPVESVELRPRVSGYID
KVNYTEGAEVKKSDVLFTIDERSYRAEFARANASLVRARTQATLARSEAARARKLSEQQAISTETWEQRRAAADQADADL
QAAQAAVDTAKLNLDWTRVRAPIDGRAGRAMVTAGNLVTAGDSASVLTTLVSLDKVFVYFDADEGTFLRYSQMARNGERP
DERGGELPVRIGLVGEQGFPHTGRVDFLDNQVTRSTGTIRVRAVLDNAQRQFTPGLYAHVQLLGSGQFKAMLVDEKAVLT
DQDRKYVYVVDKDGKAQRRDVELGRNADGLRIVRSGLAAGDRVVVDGVQKIFMPGMPVEAKTVAMAPATDKRTASN
>Mature_395_residues
TTNATPFRFPLRTVLAGAVLAVVLAGCGSKAAETGAPPPPSVSVAPVLMKQISQWDEFSGRIEPVESVELRPRVSGYIDK
VNYTEGAEVKKSDVLFTIDERSYRAEFARANASLVRARTQATLARSEAARARKLSEQQAISTETWEQRRAAADQADADLQ
AAQAAVDTAKLNLDWTRVRAPIDGRAGRAMVTAGNLVTAGDSASVLTTLVSLDKVFVYFDADEGTFLRYSQMARNGERPD
ERGGELPVRIGLVGEQGFPHTGRVDFLDNQVTRSTGTIRVRAVLDNAQRQFTPGLYAHVQLLGSGQFKAMLVDEKAVLTD
QDRKYVYVVDKDGKAQRRDVELGRNADGLRIVRSGLAAGDRVVVDGVQKIFMPGMPVEAKTVAMAPATDKRTASN

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=358, Percent_Identity=32.4022346368715, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786668, Length=365, Percent_Identity=34.7945205479452, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789665, Length=385, Percent_Identity=32.2077922077922, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082036, Length=313, Percent_Identity=27.7955271565495, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87081796, Length=379, Percent_Identity=24.5382585751979, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789637, Length=139, Percent_Identity=36.6906474820144, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081951, Length=166, Percent_Identity=31.9277108433735, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42940; Mature: 42809

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNATPFRFPLRTVLAGAVLAVVLAGCGSKAAETGAPPPPSVSVAPVLMKQISQWDEFS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
GRIEPVESVELRPRVSGYIDKVNYTEGAEVKKSDVLFTIDERSYRAEFARANASLVRART
CCCCCCCCEECCCCHHHHEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHH
QATLARSEAARARKLSEQQAISTETWEQRRAAADQADADLQAAQAAVDTAKLNLDWTRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCHHEEE
APIDGRAGRAMVTAGNLVTAGDSASVLTTLVSLDKVFVYFDADEGTFLRYSQMARNGERP
CCCCCCCCEEEEEECCEEECCCCHHHHHHHHHHCEEEEEEECCCCCEEHHHHHHHCCCCC
DERGGELPVRIGLVGEQGFPHTGRVDFLDNQVTRSTGTIRVRAVLDNAQRQFTPGLYAHV
CCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCHHHHCCCCCEEEE
QLLGSGQFKAMLVDEKAVLTDQDRKYVYVVDKDGKAQRRDVELGRNADGLRIVRSGLAAG
EEECCCCEEEEEECCCEEECCCCCEEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHCCCC
DRVVVDGVQKIFMPGMPVEAKTVAMAPATDKRTASN
CEEHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TTNATPFRFPLRTVLAGAVLAVVLAGCGSKAAETGAPPPPSVSVAPVLMKQISQWDEFS
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
GRIEPVESVELRPRVSGYIDKVNYTEGAEVKKSDVLFTIDERSYRAEFARANASLVRART
CCCCCCCCEECCCCHHHHEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHH
QATLARSEAARARKLSEQQAISTETWEQRRAAADQADADLQAAQAAVDTAKLNLDWTRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCHHEEE
APIDGRAGRAMVTAGNLVTAGDSASVLTTLVSLDKVFVYFDADEGTFLRYSQMARNGERP
CCCCCCCCEEEEEECCEEECCCCHHHHHHHHHHCEEEEEEECCCCCEEHHHHHHHCCCCC
DERGGELPVRIGLVGEQGFPHTGRVDFLDNQVTRSTGTIRVRAVLDNAQRQFTPGLYAHV
CCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCHHHHCCCCCEEEE
QLLGSGQFKAMLVDEKAVLTDQDRKYVYVVDKDGKAQRRDVELGRNADGLRIVRSGLAAG
EEECCCCEEEEEECCCEEECCCCCEEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHCCCC
DRVVVDGVQKIFMPGMPVEAKTVAMAPATDKRTASN
CEEHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]