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The map label for this gene is lepB [H]

Identifier: 21242076

GI number: 21242076

Start: 1529344

End: 1530144

Strand: Direct

Name: lepB [H]

Synonym: XAC1323

Alternate gene names: 21242076

Gene position: 1529344-1530144 (Clockwise)

Preceding gene: 21242075

Following gene: 21242077

Centisome position: 29.55

GC content: 61.67

Gene sequence:

>801_bases
ATGAAATGGTTTGAGATCATCCTGGTTGTCCTGACGCTGGGCAGCGGCTTCATCTGGCTGCTGGACAAGCTGTTTCTGGC
CAAGCGGCGTGCGGCGCGTGCCGGGTTGCTGGACAGCGAGCCGGCGATCGTCGATTACTCGCGCGCCTTTTTCCCGGTGC
TGGCGGTGGTGCTGATCCTGCGCAGCTTCGTGGCCGAGCCGTACAAGATTCCGTCCAGTTCGATGATGCCCAACCTGCTG
ATCGGCGATTTCATCCTGGTCAACAAGTTCGCCTACGGTTTCCGCCTGCCGATCACCAATACCAAGTTCATTCCCACCGG
CGAGCCCAAGCGCGGCGACGTGGTGGTGTTCAAGCCGCCGCACGCGCCGGACCAGAACTGGATCAAGCGCGTGGTGGGCC
TGCCGGGCGACAAGATCGGCTTCCACGGCGATACGCTGTACATCAACGACAAGCCGATGCATTACACGGTCAAGGGCGAG
TACATCGGCAAGGGCAAGGGCGCCGAGATGACCGGCACCACGCTGCTGGTCGAGGATCTGCCGGGCCGCACGCATACCGT
GCTGGAATGGCTGGACCGCAACATGCCGGCCGGGCAGGGCGACTGGACCGTGCCGGCGGACAGCTATTTCGTGATGGGGG
ATAATCGCGACAACAGCGAGGACAGCCGGTTCTGGACCCAAACGCACTTTCTGCCGGAAGCCAATCTGCGCGGCAAGGCG
TTCCTGATCTGGCTCAATTGCGAAGGATGGTTCTGCAAGGGGAGTTTCGATCCATCGCGGATCGGGACTGGAATCCAGTA
A

Upstream 100 bases:

>100_bases
GGAATGGTGAATCGGGAATCGGGAATCGTAAGAGCCTGCGTGCTCCTGCTGTTCCTATTCCCCATTCGCGATTCTCGATT
CCCTTTCCGAAGGAACATCA

Downstream 100 bases:

>100_bases
ATGCACGCACGGCGTGCCAGGGGAAGCACAATGAAGCGCAAGCAAAGCGGTATGACGTTGACGTCGTTCGTGGTGGTGCT
GGCGGTGGTGGGATTCGGTC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKWFEIILVVLTLGSGFIWLLDKLFLAKRRAARAGLLDSEPAIVDYSRAFFPVLAVVLILRSFVAEPYKIPSSSMMPNLL
IGDFILVNKFAYGFRLPITNTKFIPTGEPKRGDVVVFKPPHAPDQNWIKRVVGLPGDKIGFHGDTLYINDKPMHYTVKGE
YIGKGKGAEMTGTTLLVEDLPGRTHTVLEWLDRNMPAGQGDWTVPADSYFVMGDNRDNSEDSRFWTQTHFLPEANLRGKA
FLIWLNCEGWFCKGSFDPSRIGTGIQ

Sequences:

>Translated_266_residues
MKWFEIILVVLTLGSGFIWLLDKLFLAKRRAARAGLLDSEPAIVDYSRAFFPVLAVVLILRSFVAEPYKIPSSSMMPNLL
IGDFILVNKFAYGFRLPITNTKFIPTGEPKRGDVVVFKPPHAPDQNWIKRVVGLPGDKIGFHGDTLYINDKPMHYTVKGE
YIGKGKGAEMTGTTLLVEDLPGRTHTVLEWLDRNMPAGQGDWTVPADSYFVMGDNRDNSEDSRFWTQTHFLPEANLRGKA
FLIWLNCEGWFCKGSFDPSRIGTGIQ
>Mature_266_residues
MKWFEIILVVLTLGSGFIWLLDKLFLAKRRAARAGLLDSEPAIVDYSRAFFPVLAVVLILRSFVAEPYKIPSSSMMPNLL
IGDFILVNKFAYGFRLPITNTKFIPTGEPKRGDVVVFKPPHAPDQNWIKRVVGLPGDKIGFHGDTLYINDKPMHYTVKGE
YIGKGKGAEMTGTTLLVEDLPGRTHTVLEWLDRNMPAGQGDWTVPADSYFVMGDNRDNSEDSRFWTQTHFLPEANLRGKA
FLIWLNCEGWFCKGSFDPSRIGTGIQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=302, Percent_Identity=39.4039735099338, Blast_Score=181, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 29943; Mature: 29943

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWFEIILVVLTLGSGFIWLLDKLFLAKRRAARAGLLDSEPAIVDYSRAFFPVLAVVLIL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
RSFVAEPYKIPSSSMMPNLLIGDFILVNKFAYGFRLPITNTKFIPTGEPKRGDVVVFKPP
HHHHCCCCCCCCCCCCCHHHHHHHHEEHHHHCEEECCCCCCEEECCCCCCCCCEEEECCC
HAPDQNWIKRVVGLPGDKIGFHGDTLYINDKPMHYTVKGEYIGKGKGAEMTGTTLLVEDL
CCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECEEEECCCCCCCCCCEEEEECC
PGRTHTVLEWLDRNMPAGQGDWTVPADSYFVMGDNRDNSEDSRFWTQTHFLPEANLRGKA
CCCHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCEEEEHEECCCCCCCCCCE
FLIWLNCEGWFCKGSFDPSRIGTGIQ
EEEEEECCCEEEECCCCHHHCCCCCC
>Mature Secondary Structure
MKWFEIILVVLTLGSGFIWLLDKLFLAKRRAARAGLLDSEPAIVDYSRAFFPVLAVVLIL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
RSFVAEPYKIPSSSMMPNLLIGDFILVNKFAYGFRLPITNTKFIPTGEPKRGDVVVFKPP
HHHHCCCCCCCCCCCCCHHHHHHHHEEHHHHCEEECCCCCCEEECCCCCCCCCEEEECCC
HAPDQNWIKRVVGLPGDKIGFHGDTLYINDKPMHYTVKGEYIGKGKGAEMTGTTLLVEDL
CCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECEEEECCCCCCCCCCEEEEECC
PGRTHTVLEWLDRNMPAGQGDWTVPADSYFVMGDNRDNSEDSRFWTQTHFLPEANLRGKA
CCCHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCEEEEHEECCCCCCCCCCE
FLIWLNCEGWFCKGSFDPSRIGTGIQ
EEEEEECCCEEEECCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]