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The map label for this gene is ffh [H]

Identifier: 21242042

GI number: 21242042

Start: 1477750

End: 1479126

Strand: Direct

Name: ffh [H]

Synonym: XAC1289

Alternate gene names: 21242042

Gene position: 1477750-1479126 (Clockwise)

Preceding gene: 21242040

Following gene: 21242043

Centisome position: 28.55

GC content: 65.21

Gene sequence:

>1377_bases
ATGTTCGAGTCTCTTACCCAACGTCTCTCCGGCACCATGGAGCGCCTGCGCGGCCGCGGCCGCCTGACCGAGGAGAACAT
CCGCGAAGCCACCCGCGAAGTACGCATCGCCCTGCTCGAGGCCGACGTGGCGCTGCCGGTGGTGCAGGCGCTGATCGAGC
GCATCAAGGTGCGCGCAGTCGGTCAGGAAGTGCTCAAGTCGCTGACCCCGGGCCAGGCGCTGATCAAGGTGGTACGCGAC
GAGCTCACCGCCGTCATGGGCGCGGCCGCCACCGACCTCAACCTCAACGTGCCGGCGCCGGCCATCGTCCTGATGGCGGG
CCTGCAGGGTGCAGGCAAGACCACCACGGTCGGCAAGCTCGCCAAGCACCTGAAAGAAAAGCGCAAGAAGAAGGTCATGG
TGGTCTCGGCCGACGTCTACCGCCCGGCCGCGATCGAGCAGCTCAAGACCTTGGCCGAACAGGTCGGGGTGCTGTTCTTC
GCCTCAGATGCGTCGCAGAAGCCGGTCGACATCGTGCGTGCCGCCATCAGCGATGCGCGCAAGTCCTTCGTCGACGTACT
GCTGGTCGATACCGCCGGCCGCCTGGCGATCGATGCGGCGATGATGGACGAGATCAAGGCGCTGCACGCCGCGGTCAACC
CCACCGAAACCCTGTTCGTGGTCGATGCCATGACCGGTCAGGACGCGGCCAACACCGCCAAGGCCTTCGGTGAGGCGCTG
CCGCTGACCGGCGTGGTGCTGACCAAGACCGACGGCGACGCCCGCGGCGGTGCCGCACTGAGCGTGCGCTACATCACCGG
CAAGCCGATCAAGTTCGTCGGTACCGGCGAAAAGATCGACGGCCTGGATGTTTTCCATCCCGACCGCGTCGCCAGCCGCA
TCCTGGACATGGGCGATGTGCTGTCGCTGGTGGAGCAGGTCGAGCACAGCGTCGACCAGGAAAAGGCCGCCAAGCTTGCG
GCCAAGGTCGCCAAGGGCAAGAAGTTCGACCTCAACGACATGAAGGAACAGCTCGAGCAGATGCAGAACATGGGCGGTAT
CCATGGGCTGATGGACAAGCTGCCTGGCATGGGCCAGATCCCGGACAACGTCAAACAGCAGGTCACCGGCAAGGAAGTGC
CGCGCATGATCGCCATCATCAATTCGATGACCAAGAAAGAGCGGCGCAACCCGGCGCTGCTCAACGGCTCGCGCCGTGCC
CGCATCGCACGCGGCTCGGGCATGCAGCCGGCCGACGTCAACAAGCTGATGAAGCAGTATCAGCAGATGGAAAAGATGAT
GGGCAAGCTGGCCGGCGGCGGCATGAAGGGCCTGATGCGCAACATGAAGGGCATGATGGGCGCCATGGGCGGCCGCGGCG
GCATGCCGTTCCGCTGA

Upstream 100 bases:

>100_bases
AGGGAGCGCCTGATCAAGCGGGGTGCGCCGGGCGCCGGGGCAGGCCGCCAGCCGGTGCCGCTATAATCGGCACCCGTTTC
CCCTCCGCGGTCCTTTGCGC

Downstream 100 bases:

>100_bases
GCAACCTGCGCACGCCGCGCTGCGAAGCCATTCGCAGGCGCCCAGTGCGTGCATCTTGCGCTGGCCTGGTGCTTGCGTGG
CAGGCCACATCAAAGTGGGC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFESLTQRLSGTMERLRGRGRLTEENIREATREVRIALLEADVALPVVQALIERIKVRAVGQEVLKSLTPGQALIKVVRD
ELTAVMGAAATDLNLNVPAPAIVLMAGLQGAGKTTTVGKLAKHLKEKRKKKVMVVSADVYRPAAIEQLKTLAEQVGVLFF
ASDASQKPVDIVRAAISDARKSFVDVLLVDTAGRLAIDAAMMDEIKALHAAVNPTETLFVVDAMTGQDAANTAKAFGEAL
PLTGVVLTKTDGDARGGAALSVRYITGKPIKFVGTGEKIDGLDVFHPDRVASRILDMGDVLSLVEQVEHSVDQEKAAKLA
AKVAKGKKFDLNDMKEQLEQMQNMGGIHGLMDKLPGMGQIPDNVKQQVTGKEVPRMIAIINSMTKKERRNPALLNGSRRA
RIARGSGMQPADVNKLMKQYQQMEKMMGKLAGGGMKGLMRNMKGMMGAMGGRGGMPFR

Sequences:

>Translated_458_residues
MFESLTQRLSGTMERLRGRGRLTEENIREATREVRIALLEADVALPVVQALIERIKVRAVGQEVLKSLTPGQALIKVVRD
ELTAVMGAAATDLNLNVPAPAIVLMAGLQGAGKTTTVGKLAKHLKEKRKKKVMVVSADVYRPAAIEQLKTLAEQVGVLFF
ASDASQKPVDIVRAAISDARKSFVDVLLVDTAGRLAIDAAMMDEIKALHAAVNPTETLFVVDAMTGQDAANTAKAFGEAL
PLTGVVLTKTDGDARGGAALSVRYITGKPIKFVGTGEKIDGLDVFHPDRVASRILDMGDVLSLVEQVEHSVDQEKAAKLA
AKVAKGKKFDLNDMKEQLEQMQNMGGIHGLMDKLPGMGQIPDNVKQQVTGKEVPRMIAIINSMTKKERRNPALLNGSRRA
RIARGSGMQPADVNKLMKQYQQMEKMMGKLAGGGMKGLMRNMKGMMGAMGGRGGMPFR
>Mature_458_residues
MFESLTQRLSGTMERLRGRGRLTEENIREATREVRIALLEADVALPVVQALIERIKVRAVGQEVLKSLTPGQALIKVVRD
ELTAVMGAAATDLNLNVPAPAIVLMAGLQGAGKTTTVGKLAKHLKEKRKKKVMVVSADVYRPAAIEQLKTLAEQVGVLFF
ASDASQKPVDIVRAAISDARKSFVDVLLVDTAGRLAIDAAMMDEIKALHAAVNPTETLFVVDAMTGQDAANTAKAFGEAL
PLTGVVLTKTDGDARGGAALSVRYITGKPIKFVGTGEKIDGLDVFHPDRVASRILDMGDVLSLVEQVEHSVDQEKAAKLA
AKVAKGKKFDLNDMKEQLEQMQNMGGIHGLMDKLPGMGQIPDNVKQQVTGKEVPRMIAIINSMTKKERRNPALLNGSRRA
RIARGSGMQPADVNKLMKQYQQMEKMMGKLAGGGMKGLMRNMKGMMGAMGGRGGMPFR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=30.3571428571429, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=351, Percent_Identity=32.4786324786325, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI23308697, Length=304, Percent_Identity=28.9473684210526, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=28.9473684210526, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI89061728, Length=140, Percent_Identity=35, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=446, Percent_Identity=68.3856502242152, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1789874, Length=229, Percent_Identity=37.117903930131, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=419, Percent_Identity=30.5489260143198, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=201, Percent_Identity=35.3233830845771, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=441, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=212, Percent_Identity=28.7735849056604, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=31.2217194570136, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24641198, Length=261, Percent_Identity=28.735632183908, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49343; Mature: 49343

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS00589 PTS_HPR_SER ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLTQRLSGTMERLRGRGRLTEENIREATREVRIALLEADVALPVVQALIERIKVRAV
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLKSLTPGQALIKVVRDELTAVMGAAATDLNLNVPAPAIVLMAGLQGAGKTTTVGKL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHH
AKHLKEKRKKKVMVVSADVYRPAAIEQLKTLAEQVGVLFFASDASQKPVDIVRAAISDAR
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHH
KSFVDVLLVDTAGRLAIDAAMMDEIKALHAAVNPTETLFVVDAMTGQDAANTAKAFGEAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKTDGDARGGAALSVRYITGKPIKFVGTGEKIDGLDVFHPDRVASRILDMGDV
CCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
LSLVEQVEHSVDQEKAAKLAAKVAKGKKFDLNDMKEQLEQMQNMGGIHGLMDKLPGMGQI
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PDNVKQQVTGKEVPRMIAIINSMTKKERRNPALLNGSRRARIARGSGMQPADVNKLMKQY
CHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCCHHHHHHHHHH
QQMEKMMGKLAGGGMKGLMRNMKGMMGAMGGRGGMPFR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFESLTQRLSGTMERLRGRGRLTEENIREATREVRIALLEADVALPVVQALIERIKVRAV
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLKSLTPGQALIKVVRDELTAVMGAAATDLNLNVPAPAIVLMAGLQGAGKTTTVGKL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHH
AKHLKEKRKKKVMVVSADVYRPAAIEQLKTLAEQVGVLFFASDASQKPVDIVRAAISDAR
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHH
KSFVDVLLVDTAGRLAIDAAMMDEIKALHAAVNPTETLFVVDAMTGQDAANTAKAFGEAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKTDGDARGGAALSVRYITGKPIKFVGTGEKIDGLDVFHPDRVASRILDMGDV
CCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
LSLVEQVEHSVDQEKAAKLAAKVAKGKKFDLNDMKEQLEQMQNMGGIHGLMDKLPGMGQI
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PDNVKQQVTGKEVPRMIAIINSMTKKERRNPALLNGSRRARIARGSGMQPADVNKLMKQY
CHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCCHHHHHHHHHH
QQMEKMMGKLAGGGMKGLMRNMKGMMGAMGGRGGMPFR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]