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The map label for this gene is lpxH

Identifier: 21241801

GI number: 21241801

Start: 1194972

End: 1195715

Strand: Reverse

Name: lpxH

Synonym: XAC1036

Alternate gene names: 21241801

Gene position: 1195715-1194972 (Counterclockwise)

Preceding gene: 21241802

Following gene: 21241788

Centisome position: 23.1

GC content: 67.34

Gene sequence:

>744_bases
ATGACGACCCTGTTCATTTCCGACCTGCATCTGGATCCGGCCCGGCCGGCGATCACCGAGTTGTTCCTGGAATTCCTGCG
CACGCAGGTCCCCGGTAGCGACGCGCTCTACATCCTGGGCGATCTGTTCGAAGCCTGGATCGGCGACGACACCCCATCCA
CCGCCGCCGATGCCGTGGCGGTGGCCCTGCATGCAGTGGCGGATTCCGGCGTGCCGGTGTTCTTCATGGCCGGCAACCGC
GACTTCCTGGTGGGCGAAACCTACGCGCAGCGGGCGGGCTTCCGGATCCTGCCCGACCCCACCGTGATCGATCTGTACGG
GCACACCACGCTGCTGATGCACGGCGATTTGCTGTGCACCGACGACACGGCCTACCAGGCCTTCCGCGCGCAGACGCGCG
ACCCGGTGTTCCAGGCGCAATTCCTGGCCCAGCCGCTGGCCGCACGCGTCGCGTTCGCGCAGCAGGCGCGCGCGGCAAGC
CAGGCGCGGCATGCAGAACTCAAGCAGGGCGACCAGTCGCGCTTCGAAACCGTCACCGACGTCTCGCCGGCCGAGGTGGA
AGCCACCTTCGTGCGTTACGGCCTGGATCGGCTGATCCACGGCCACACCCATCGCCCTGCCATCCATACCTTGCAGGCCG
GTGGTCACACCTGCACGCGCATCGTGCTGGGCGACTGGTACGAGCAAGGCTCGGTCTTGCGCGTGGATGCCGATGGCGCG
TCGCTGGAGCAGTTGGCGCTGTAA

Upstream 100 bases:

>100_bases
CGCCACGCCTGCATGATCTTTGAATCCTGACCCGAATCTCGCAACCCGAATTCCTGTCCCCGCCCCTGACCGCCCCGCGC
TGCCGCCGTACAATGGCGCA

Downstream 100 bases:

>100_bases
CGCGGCCGATCCCGTGCCTGCCATGGCAAGGCGCAGCGACGCAGTGCTGCACGCAAGGCGCACAGCAAGACCGAAAGCGC
GCCTGAGGCCACAGACGCGC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAVALHAVADSGVPVFFMAGNR
DFLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCTDDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAAS
QARHAELKQGDQSRFETVTDVSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGHTCTRIVLGDWYEQGSVLRVDADGA
SLEQLAL

Sequences:

>Translated_247_residues
MTTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAVALHAVADSGVPVFFMAGNR
DFLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCTDDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAAS
QARHAELKQGDQSRFETVTDVSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGHTCTRIVLGDWYEQGSVLRVDADGA
SLEQLAL
>Mature_246_residues
TTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVAVALHAVADSGVPVFFMAGNRD
FLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCTDDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQ
ARHAELKQGDQSRFETVTDVSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGHTCTRIVLGDWYEQGSVLRVDADGAS
LEQLAL

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=242, Percent_Identity=48.3471074380165, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_XANAC (P58975)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641383.1
- ProteinModelPortal:   P58975
- GeneID:   1155107
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1036
- NMPDR:   fig|190486.1.peg.1027
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   XAXO190486:XAC1036-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 26977; Mature: 26845

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVA
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
VALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCT
HHHHHHHCCCCEEEEEECCCCEEECCHHHHHCCCEECCCCCEEEECCCEEEEEECCEEEC
DDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
VSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGHTCTRIVLGDWYEQGSVLRVDADGA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCEEEEEEEECCCCCCCEEEEECCCC
SLEQLAL
CHHHHCC
>Mature Secondary Structure 
TTLFISDLHLDPARPAITELFLEFLRTQVPGSDALYILGDLFEAWIGDDTPSTAADAVA
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
VALHAVADSGVPVFFMAGNRDFLVGETYAQRAGFRILPDPTVIDLYGHTTLLMHGDLLCT
HHHHHHHCCCCEEEEEECCCCEEECCHHHHHCCCEECCCCCEEEECCCEEEEEECCEEEC
DDTAYQAFRAQTRDPVFQAQFLAQPLAARVAFAQQARAASQARHAELKQGDQSRFETVTD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
VSPAEVEATFVRYGLDRLIHGHTHRPAIHTLQAGGHTCTRIVLGDWYEQGSVLRVDADGA
CCCHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCEEEEEEEECCCCCCCEEEEECCCC
SLEQLAL
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217