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The map label for this gene is qor [C]

Identifier: 21241776

GI number: 21241776

Start: 1167056

End: 1168078

Strand: Reverse

Name: qor [C]

Synonym: XAC1011

Alternate gene names: 21241776

Gene position: 1168078-1167056 (Counterclockwise)

Preceding gene: 21241780

Following gene: 21241775

Centisome position: 22.57

GC content: 65.98

Gene sequence:

>1023_bases
ATGAAAGCTGTCGCCCTCACCCGCCATCTTCCGATCGACGATCCCGAATCGCTACTTGACGTGGAACTTCCGGCACCTGC
GGCGCCGTCGGGGTATGACTTATTGGTGCGGGTGGAGGCGATCTCGGTGAACCCGGTCGATACAAAGGTGCGCGCGCCCA
AGCCGCAGCCCCTGCAGGCGCCGAAGGTCCTGGGTTACGACGCAGCCGGAGTGATCGAGGCGGTCGGCCCGGAGGTCACC
GCCTTCGCGGTCGGCGACGAGGTCTACTATGCCGGCGATATCGGGCGGCCGGGCAGCAATGCGCAGTATCAGTTGGTGGA
CGCGCGGATTGCCGGATGCAAACCGACCTCGCTCAGCTTCGCGCAGGCGGCCGCGCTACCGCTGACCACCCTGACGGCGT
GGGAACTGCTGTTCCAGCGCATGCCCTATTCATTCGACGGTGCACGCAATCGCGGCAGGCATCTGCTCATCGTCGGCGGC
GCTGGCGGCGTGGGCTCCATCGCGATCCAGCTGGCGCGGCATGCCGGATTCACGGTGATTGCCACCGCATCGCGCCCGGA
GAGCATCGAATGGGTTCGCCAAATGGGCGCGCACCACGTGATCGATCATCATCAACCGCTGCAGCCGCAACTGCAGGCGC
TGGGATTGGAAACGGTGGACGCGGCGCTCAATCTGGCCGACACCGACCGCTACTGGCAGCCACTGGGCGAAGTGCTGGCG
CCGCAGGGCCATGTGGGCCTGATCGTGGAGCCGCGCGGGCCGTTGTCGATCGGCGACCCATACAAATCCAAGTGCATCGG
CATCCATTGGGAGCTAATGTTCACGCGCGCACGCTACGCGACCGAAGACATGGTCGAGCAGCACCGCATCCTCAACCGGG
CGGCCAGCCTGATCGATGCCGGCGAGCTGCGCACCACGCATACCGAGACGCTGTCGCCGATCAATGCGCAGCAGCTGCGC
GAGGCGCACCGTCGGCTGGAAAGCGGCAGCACGATCGGCAAGCTGGTGCTGGCCGGCTGGTAA

Upstream 100 bases:

>100_bases
TGGTGAACGCCAAGCCCCGTCCGAGCTGAATTGTGGGGTGGATGGTTGCGGACGACTTGCCCCACAACGCACCCTGAACC
TCCCGCTCAGGAGCGCTCCA

Downstream 100 bases:

>100_bases
GGCGGCGGTCTGGCTCACGTCGCTGCGGCGATGCATGGATGCGCGCGGCGCCTGCGTATCGGCGCGCGCCCGTGCGGGCG
ACAGCGAAGGCGTGTTACCT

Product: oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKAVALTRHLPIDDPESLLDVELPAPAAPSGYDLLVRVEAISVNPVDTKVRAPKPQPLQAPKVLGYDAAGVIEAVGPEVT
AFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSFAQAAALPLTTLTAWELLFQRMPYSFDGARNRGRHLLIVGG
AGGVGSIAIQLARHAGFTVIATASRPESIEWVRQMGAHHVIDHHQPLQPQLQALGLETVDAALNLADTDRYWQPLGEVLA
PQGHVGLIVEPRGPLSIGDPYKSKCIGIHWELMFTRARYATEDMVEQHRILNRAASLIDAGELRTTHTETLSPINAQQLR
EAHRRLESGSTIGKLVLAGW

Sequences:

>Translated_340_residues
MKAVALTRHLPIDDPESLLDVELPAPAAPSGYDLLVRVEAISVNPVDTKVRAPKPQPLQAPKVLGYDAAGVIEAVGPEVT
AFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSFAQAAALPLTTLTAWELLFQRMPYSFDGARNRGRHLLIVGG
AGGVGSIAIQLARHAGFTVIATASRPESIEWVRQMGAHHVIDHHQPLQPQLQALGLETVDAALNLADTDRYWQPLGEVLA
PQGHVGLIVEPRGPLSIGDPYKSKCIGIHWELMFTRARYATEDMVEQHRILNRAASLIDAGELRTTHTETLSPINAQQLR
EAHRRLESGSTIGKLVLAGW
>Mature_340_residues
MKAVALTRHLPIDDPESLLDVELPAPAAPSGYDLLVRVEAISVNPVDTKVRAPKPQPLQAPKVLGYDAAGVIEAVGPEVT
AFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSFAQAAALPLTTLTAWELLFQRMPYSFDGARNRGRHLLIVGG
AGGVGSIAIQLARHAGFTVIATASRPESIEWVRQMGAHHVIDHHQPLQPQLQALGLETVDAALNLADTDRYWQPLGEVLA
PQGHVGLIVEPRGPLSIGDPYKSKCIGIHWELMFTRARYATEDMVEQHRILNRAASLIDAGELRTTHTETLSPINAQQLR
EAHRRLESGSTIGKLVLAGW

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=333, Percent_Identity=29.1291291291291, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194239674, Length=348, Percent_Identity=29.5977011494253, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13236495, Length=348, Percent_Identity=29.5977011494253, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI194239676, Length=208, Percent_Identity=35.0961538461538, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI22538446, Length=336, Percent_Identity=27.6785714285714, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI22538444, Length=336, Percent_Identity=27.6785714285714, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24308257, Length=331, Percent_Identity=24.1691842900302, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI28557745, Length=227, Percent_Identity=29.5154185022026, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790485, Length=191, Percent_Identity=32.9842931937173, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71987554, Length=185, Percent_Identity=33.5135135135135, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17507255, Length=171, Percent_Identity=36.8421052631579, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324195, Length=230, Percent_Identity=29.5652173913043, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36726; Mature: 36726

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVALTRHLPIDDPESLLDVELPAPAAPSGYDLLVRVEAISVNPVDTKVRAPKPQPLQA
CCCEEEEECCCCCCCHHHEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCC
PKVLGYDAAGVIEAVGPEVTAFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSF
CCEECCCCHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHH
AQAAALPLTTLTAWELLFQRMPYSFDGARNRGRHLLIVGGAGGVGSIAIQLARHAGFTVI
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEE
ATASRPESIEWVRQMGAHHVIDHHQPLQPQLQALGLETVDAALNLADTDRYWQPLGEVLA
EECCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHC
PQGHVGLIVEPRGPLSIGDPYKSKCIGIHWELMFTRARYATEDMVEQHRILNRAASLIDA
CCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
GELRTTHTETLSPINAQQLREAHRRLESGSTIGKLVLAGW
CCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MKAVALTRHLPIDDPESLLDVELPAPAAPSGYDLLVRVEAISVNPVDTKVRAPKPQPLQA
CCCEEEEECCCCCCCHHHEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCC
PKVLGYDAAGVIEAVGPEVTAFAVGDEVYYAGDIGRPGSNAQYQLVDARIAGCKPTSLSF
CCEECCCCHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHH
AQAAALPLTTLTAWELLFQRMPYSFDGARNRGRHLLIVGGAGGVGSIAIQLARHAGFTVI
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEE
ATASRPESIEWVRQMGAHHVIDHHQPLQPQLQALGLETVDAALNLADTDRYWQPLGEVLA
EECCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHC
PQGHVGLIVEPRGPLSIGDPYKSKCIGIHWELMFTRARYATEDMVEQHRILNRAASLIDA
CCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
GELRTTHTETLSPINAQQLREAHRRLESGSTIGKLVLAGW
CCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA