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The map label for this gene is pntA [H]

Identifier: 21241688

GI number: 21241688

Start: 1082219

End: 1083115

Strand: Direct

Name: pntA [H]

Synonym: XAC0918

Alternate gene names: 21241688

Gene position: 1082219-1083115 (Clockwise)

Preceding gene: 21241687

Following gene: 21241689

Centisome position: 20.91

GC content: 70.12

Gene sequence:

>897_bases
ATGGCTGTGCAGGTGCTGGTACTGAAAGAGCAGGCCGCCGGCGAACGCCGTGTGGCCGCGACGCCGGAAACGGTCAAGAA
ACTGGTCGCGCTCGGTGCCGGCGTGTGGATCGAACCGGGGGCCGGCCGGGCCAGCAGCATGGACGATGACGCGTATCTGC
AGGCCGGTGCGCAGCCTGCCGGCGCCGACGCCGTGGCGCAGGCCGAGATGGTGCTGTGCGTGCAGGCGCCTTCTACCGAC
ACGTTGCTCCGGTGCAAGCCGCACGCGGTGGTGATCGGCATGCTGGCGCCGGATGCAGACCCTGCGCGTGCGCAGGCGTT
TGCCGCGCGGCAATTGATTGCGTTTCCACTGGAGCGCCTGCCGCGCACCACGCGCGCGCAGTCGATGGATGTGTTGAGCT
CGCAGGCCGGCATGGCCGGCTACAAGGCGATGCTGATTGCCGCGCAGCTGGCGCCGCGCTTTTTTCCGATGCTGACCACC
GCGGCCGGCACCATGCGCCCGTGCAAGGTGCTGGTGATCGGCGCGGGCGTGGCCGGCCTGCAGGCGATCGCCACCGCCAA
GCGGCTGGGCGCGCAGGTGGAAGGCTTCGATGTGCGGCCGGAAACGCGTGAGCAGATCGCCTCGCTGGGTGCGCGATTTC
TGGACCTGGGCGTGAGCGCTGCCGGCGAAGGCGGCTACGCGCGTCAACTCAGCGACGACGAACGCGCCGAACAGCAGCGT
CGTCTGGCCGAACACCTCACCGGTGTGGATGTGGTGGTGTGCACTGCAGCGGTTCCGGGCCGGCCGGCACCGAAGATCGT
GACCACCGAGATGGCACGCGGCATGCGCGCCGGCAGCGTGATCGTGGACCTGGCGGCGGAAACCGGCGGCAATTGCGCGG
CCACCCGCCCGGGGTAG

Upstream 100 bases:

>100_bases
ACTGACGCTCTCGCCGAGAGAATGATCCAAGCTTCGCTACCTGCGCGCGCACCGCGCTCTGCTAGCATCGCCGCGACTGG
GCGCAAGACCGGAGCAACCC

Downstream 100 bases:

>100_bases
ACGTATGACCTCGACGGCGTGGTCATCGCTGGCCCGCTCAATCTGGCCAGCCAGGGCGCAGTGCATGCCAGCGAGATGTT
CGCGCGCAACGTGTACGCCT

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha; Pyridine nucleotide transhydrogenase subunit alpha [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAVQVLVLKEQAAGERRVAATPETVKKLVALGAGVWIEPGAGRASSMDDDAYLQAGAQPAGADAVAQAEMVLCVQAPSTD
TLLRCKPHAVVIGMLAPDADPARAQAFAARQLIAFPLERLPRTTRAQSMDVLSSQAGMAGYKAMLIAAQLAPRFFPMLTT
AAGTMRPCKVLVIGAGVAGLQAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLSDDERAEQQR
RLAEHLTGVDVVVCTAAVPGRPAPKIVTTEMARGMRAGSVIVDLAAETGGNCAATRPG

Sequences:

>Translated_298_residues
MAVQVLVLKEQAAGERRVAATPETVKKLVALGAGVWIEPGAGRASSMDDDAYLQAGAQPAGADAVAQAEMVLCVQAPSTD
TLLRCKPHAVVIGMLAPDADPARAQAFAARQLIAFPLERLPRTTRAQSMDVLSSQAGMAGYKAMLIAAQLAPRFFPMLTT
AAGTMRPCKVLVIGAGVAGLQAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLSDDERAEQQR
RLAEHLTGVDVVVCTAAVPGRPAPKIVTTEMARGMRAGSVIVDLAAETGGNCAATRPG
>Mature_297_residues
AVQVLVLKEQAAGERRVAATPETVKKLVALGAGVWIEPGAGRASSMDDDAYLQAGAQPAGADAVAQAEMVLCVQAPSTDT
LLRCKPHAVVIGMLAPDADPARAQAFAARQLIAFPLERLPRTTRAQSMDVLSSQAGMAGYKAMLIAAQLAPRFFPMLTTA
AGTMRPCKVLVIGAGVAGLQAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLSDDERAEQQRR
LAEHLTGVDVVVCTAAVPGRPAPKIVTTEMARGMRAGSVIVDLAAETGGNCAATRPG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=298, Percent_Identity=41.2751677852349, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI122939153, Length=298, Percent_Identity=41.2751677852349, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI1787887, Length=292, Percent_Identity=46.9178082191781, Blast_Score=257, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17550456, Length=298, Percent_Identity=39.9328859060403, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR004571 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 30866; Mature: 30735

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQVLVLKEQAAGERRVAATPETVKKLVALGAGVWIEPGAGRASSMDDDAYLQAGAQPA
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHCCCCCC
GADAVAQAEMVLCVQAPSTDTLLRCKPHAVVIGMLAPDADPARAQAFAARQLIAFPLERL
CCHHHHHEEEEEEEECCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
PRTTRAQSMDVLSSQAGMAGYKAMLIAAQLAPRFFPMLTTAAGTMRPCKVLVIGAGVAGL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHH
QAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLSDDERAEQQR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHH
RLAEHLTGVDVVVCTAAVPGRPAPKIVTTEMARGMRAGSVIVDLAAETGGNCAATRPG
HHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCEECCCCC
>Mature Secondary Structure 
AVQVLVLKEQAAGERRVAATPETVKKLVALGAGVWIEPGAGRASSMDDDAYLQAGAQPA
EEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHCCCCCC
GADAVAQAEMVLCVQAPSTDTLLRCKPHAVVIGMLAPDADPARAQAFAARQLIAFPLERL
CCHHHHHEEEEEEEECCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHC
PRTTRAQSMDVLSSQAGMAGYKAMLIAAQLAPRFFPMLTTAAGTMRPCKVLVIGAGVAGL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHH
QAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLSDDERAEQQR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHH
RLAEHLTGVDVVVCTAAVPGRPAPKIVTTEMARGMRAGSVIVDLAAETGGNCAATRPG
HHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3525165; 1633824; 9097039; 9278503; 1932078 [H]