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The map label for this gene is glnS

Identifier: 21241663

GI number: 21241663

Start: 1054921

End: 1056660

Strand: Reverse

Name: glnS

Synonym: XAC0893

Alternate gene names: 21241663

Gene position: 1056660-1054921 (Counterclockwise)

Preceding gene: 21241666

Following gene: 21241662

Centisome position: 20.42

GC content: 64.77

Gene sequence:

>1740_bases
ATGTCCGAGACCCTAGCCACCGACGCCACCGCCCCGGCGGAGAAGAAAGACTTCATCCGCCAGATCGTCCGCGAGGATCT
GGCCAGCGGCAAGCACACGGTCATCCGCACCCGCTTCCCGCCCGAGCCCAATGGCTACCTGCATATTGGCCATGCCAAGG
CGATCTGCCTGGATTTCGGCCTGGCCGCCGAGTTCGGCGGGCTGTGCAACCTGCGCCTGGACGATACCAACCCGGCCAAG
GAAGACCCCGAGTTCGTGGTGGCCATCCAGGACGACGTGCGCTGGCTGGGCTATGACTGGGCGCAACTGCGCCACGCCTC
GGATTATTTCCAGGTGTATTACCTGGCCGCGCAGAAGCTGATCCGCGATGGCCATGCCTTCGTGTGCGACCTTTCCGCAG
AACAGGTGCGCCAATACCGTGGCACGCTGACCGAACCCGGCCGCAATTCGCCGTTCCGCGAGCGCAGCGTCGAAGAAAAC
CTGGACCTGTTCGCGCGCATGCGTGCCGGCGAATTCCCCGACGGCGCGCGTACGCTGCGCGCCAAGATCGACATGGCCAG
CGGCAATATCAACCTGCGCGACCCGGCGCTGTACCGCATCAAGCATGTGGAGCATCAGAACACCGGCAACGCCTGGCCGA
TCTACCCGATGTACGACTTCGCGCATTCGCTCGGCGATGCGGTGGAAGGCATCACCCACTCGCTGTGCACGCTGGAATTT
GAAGACCATCGCCCGCTGTACGACTGGTGCGTGGACAAGGTGGACCTGGTCGGCCATCCGGAACTGCTGCAGCCGCTGCT
GGACAAGGGCCTGCCGCGCGAAGCCGCCAAGCCGCGTCAGATCGAGTTTTCGCGCCTCAACATCAACTACACGGTGATGA
GCAAGCGCAAGCTCACCGCGCTGGTGGAAGAGCAGCTGGTGGACGGTTGGGACGACCCGCGCATGTACACGCTGCAGGGC
CTGCGCCGGCGTGGCTATACGCCGGCGGCGATGCGCCTGTTCGTGGACCGCGTGGGCATCAGCAAGCAGAACTCGCTGAT
CGATTTCTCGGTGCTGGAAGGTTGCCTGCGCGAGGATCTGGACGCAGCGGCGCCGCGCCGTATGGCCGTGATCGACCCGC
TCAAGCTGGTGCTGACCAACCTGCCGGAAGGCCACACCGAAACGCTGCAGTTTTCCAACCACCCCAAGGACGACAGCTTC
GGCACACGCGAGGTGCCGTTTGCGCGCGAGCTGTGGATCGAGCGCGAGGATTTCGCCGAGGTTCCGCCAAAGGGCTGGAA
GCGCCTGGTGCCGGGCGGCGAAATCCGCTTGCGCGGTGCAGGCATTGCGCGCGTGGACGAGGTGATCAAGAACGCTGACG
GCGAGATCGTCGAACTGCGCGGCTGGCTGGATCCGGAATCGCGCCCGGGCATGGAAGGCGCCAACCGCAAGGTCAAGGGC
ACCATCCACTGGGTCAGCGCGGCACACGCGGTGGAAGCGGAAATCCGCCTGTACGACCGCCTGTTTTCGGTGGAGAAGCC
TGACGACGAGTCCGAGGGCAAGACCTACCGCGATTACCTGAACCCCGAGTCCAAGCGCAACGTGCGCGGGTACGTAGAGC
CGAGCGCTGCGATGGCAGCGCCCGAGCAGGCGTTCCAGTTCGAACGCACCGGTTACTTCGTTGCCGACCGTCGCGACCAT
AGCGAAGCCACGCCGGTCTTCAATCGCAGCGTGACCTTGCGCGACACCTGGGCCAAGTAA

Upstream 100 bases:

>100_bases
CGCCGAAACCACTGCCCCCACGCCGCCCCTCCGCACCCGGCGCCTACCCCTAACCGGTGCCACCGCCTAAACTTGCGGTT
TACCTATTGCTGATGCGCGC

Downstream 100 bases:

>100_bases
CCGCGCAGGACAGCGGCGCCCTTGCAAGGCGGGCGTCGCTGCTACCGAGATCGGGCGGCGGGTGCGCGGCTGCAGAGGCG
GCATCTGCGTCATCACGCCC

Product: glutaminyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamine--tRNA ligase; GlnRS

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFGLAAEFGGLCNLRLDDTNPAK
EDPEFVVAIQDDVRWLGYDWAQLRHASDYFQVYYLAAQKLIRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEEN
LDLFARMRAGEFPDGARTLRAKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EDHRPLYDWCVDKVDLVGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTALVEEQLVDGWDDPRMYTLQG
LRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDLDAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDDSF
GTREVPFARELWIEREDFAEVPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
TIHWVSAAHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAAPEQAFQFERTGYFVADRRDH
SEATPVFNRSVTLRDTWAK

Sequences:

>Translated_579_residues
MSETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFGLAAEFGGLCNLRLDDTNPAK
EDPEFVVAIQDDVRWLGYDWAQLRHASDYFQVYYLAAQKLIRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEEN
LDLFARMRAGEFPDGARTLRAKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EDHRPLYDWCVDKVDLVGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTALVEEQLVDGWDDPRMYTLQG
LRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDLDAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDDSF
GTREVPFARELWIEREDFAEVPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
TIHWVSAAHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAAPEQAFQFERTGYFVADRRDH
SEATPVFNRSVTLRDTWAK
>Mature_578_residues
SETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFGLAAEFGGLCNLRLDDTNPAKE
DPEFVVAIQDDVRWLGYDWAQLRHASDYFQVYYLAAQKLIRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEENL
DLFARMRAGEFPDGARTLRAKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEFE
DHRPLYDWCVDKVDLVGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTALVEEQLVDGWDDPRMYTLQGL
RRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDLDAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDDSFG
TREVPFARELWIEREDFAEVPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKGT
IHWVSAAHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAAPEQAFQFERTGYFVADRRDHS
EATPVFNRSVTLRDTWAK

Specific function: Unknown

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI4826960, Length=545, Percent_Identity=42.9357798165138, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI62241042, Length=555, Percent_Identity=32.972972972973, Blast_Score=279, Evalue=6e-75,
Organism=Escherichia coli, GI1786895, Length=572, Percent_Identity=55.0699300699301, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1788743, Length=107, Percent_Identity=32.7102803738318, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17543332, Length=553, Percent_Identity=41.9529837251356, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17511007, Length=535, Percent_Identity=31.9626168224299, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324742, Length=583, Percent_Identity=36.0205831903945, Blast_Score=354, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6321192, Length=534, Percent_Identity=32.7715355805243, Blast_Score=270, Evalue=6e-73,
Organism=Drosophila melanogaster, GI17864488, Length=565, Percent_Identity=39.1150442477876, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24649466, Length=538, Percent_Identity=32.5278810408922, Blast_Score=251, Evalue=1e-66,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYQ_XANAC (Q8PNZ5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641245.1
- ProteinModelPortal:   Q8PNZ5
- SMR:   Q8PNZ5
- GeneID:   1154964
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0893
- NMPDR:   fig|190486.1.peg.889
- HOGENOM:   HBG334108
- OMA:   RMPTIAG
- ProtClustDB:   PRK05347
- BioCyc:   XAXO190486:XAC0893-MONOMER
- BRENDA:   6.1.1.18
- GO:   GO:0005737
- HAMAP:   MF_00126
- InterPro:   IPR001412
- InterPro:   IPR004514
- InterPro:   IPR022861
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR020059
- InterPro:   IPR020056
- InterPro:   IPR011035
- InterPro:   IPR014729
- Gene3D:   G3DSA:1.10.1160.10
- Gene3D:   G3DSA:2.40.240.10
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10119:SF3
- PANTHER:   PTHR10119
- PRINTS:   PR00987
- TIGRFAMs:   TIGR00440

Pfam domain/function: PF00749 tRNA-synt_1c; PF03950 tRNA-synt_1c_C; SSF50715 Ribosomal_L25rel

EC number: =6.1.1.18

Molecular weight: Translated: 65873; Mature: 65742

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS00435 PEROXIDASE_1

Important sites: BINDING 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCEEEEEHHC
LAAEFGGLCNLRLDDTNPAKEDPEFVVAIQDDVRWLGYDWAQLRHASDYFQVYYLAAQKL
HHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHH
IRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEENLDLFARMRAGEFPDGARTLR
HHCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEE
AKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
EDHRPLYDWCVDKVDLVGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTA
CCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCHHHHH
LVEEQLVDGWDDPRMYTLQGLRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDL
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHH
DAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDDSFGTREVPFARELWIEREDFAE
HHCCCCCEEHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHC
VPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
CCCHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEE
TIHWVSAAHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAA
EEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCEEECCHHHHCC
PEQAFQFERTGYFVADRRDHSEATPVFNRSVTLRDTWAK
CHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SETLATDATAPAEKKDFIRQIVREDLASGKHTVIRTRFPPEPNGYLHIGHAKAICLDFG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCEEEEEHHC
LAAEFGGLCNLRLDDTNPAKEDPEFVVAIQDDVRWLGYDWAQLRHASDYFQVYYLAAQKL
HHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHH
IRDGHAFVCDLSAEQVRQYRGTLTEPGRNSPFRERSVEENLDLFARMRAGEFPDGARTLR
HHCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEE
AKIDMASGNINLRDPALYRIKHVEHQNTGNAWPIYPMYDFAHSLGDAVEGITHSLCTLEF
EEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEE
EDHRPLYDWCVDKVDLVGHPELLQPLLDKGLPREAAKPRQIEFSRLNINYTVMSKRKLTA
CCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEECCHHHHH
LVEEQLVDGWDDPRMYTLQGLRRRGYTPAAMRLFVDRVGISKQNSLIDFSVLEGCLREDL
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHH
DAAAPRRMAVIDPLKLVLTNLPEGHTETLQFSNHPKDDSFGTREVPFARELWIEREDFAE
HHCCCCCEEHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHC
VPPKGWKRLVPGGEIRLRGAGIARVDEVIKNADGEIVELRGWLDPESRPGMEGANRKVKG
CCCHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEE
TIHWVSAAHAVEAEIRLYDRLFSVEKPDDESEGKTYRDYLNPESKRNVRGYVEPSAAMAA
EEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCEEECCHHHHCC
PEQAFQFERTGYFVADRRDHSEATPVFNRSVTLRDTWAK
CHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217