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The map label for this gene is dld [H]

Identifier: 21241533

GI number: 21241533

Start: 906905

End: 908290

Strand: Reverse

Name: dld [H]

Synonym: XAC0762

Alternate gene names: 21241533

Gene position: 908290-906905 (Counterclockwise)

Preceding gene: 21241534

Following gene: 21241532

Centisome position: 17.55

GC content: 68.33

Gene sequence:

>1386_bases
ATGACCGATGTACTTCCCACCGCACTTGCCGAGTTGTTGGCCGCGCGCCTGGGTACCGATGGATGGTTGACCGGCGACGA
TGCGCGCCGCCGCTATGGCGAAGACGATTCGCGCCGCTGGGCATTGCCGGCCGCGGTGGCGTTGCCGCGCGACACCGATG
AGGTGGTGGCGATCGTGCAGGCGTGCCGTGCGCACGGCGTGCCGATCGTGGCGCGCGGCGCCGGCACCGGCACCACCGGC
GCGGCGGTGCCGTTTTCCGGCGGGGTGGTGGTGTCGATGGCGCGCATGAACCAGATCCTGGCACTACGTCCGCAAGACCG
CTGCGCGGTGGTGCAACCGGGCCTGCTCAATGGCGACCTGCAACAGGCGCTGCAGCCGCATGGTTTGTTCTGGCCGCCGG
ATCCGTCCAGCGCGGACATCTGCAGCGTCGGCGGCAATCTATCCACCAACGCCGGCGGCCCGCGCGCGGTGAAATACGGC
GCCACCCGCGACAACGTGCTCGGCCTGGTGGCGGTGACCGGCACCGGCGAGGTGATCCGCTGCGGCGGCGCGTACACCAA
GAATTCCACCGGTTACGACCTCACCCACTTGCTGGTCGGCAGCGAGGGCACCCTGGCGATCATCGTCGAGGCGACCTTGA
AGCTGACCCCGCGCGCCATTGCGCAAGCCGGCCTGCGCGCGCTGTACCGCGATGCGTCCAGCGCCGCAGCCGCGGTGTCG
CGGCTGATGGCGCAACCGACCACGCCGACCATGCTGGAATTCATGGATGCCAGTGCGATTGCGCTGCTACGCCGCAATGG
CAGCGATGTGCCCGACGCTGGCGCCATGCTGTTGATCGAAGCCGACGGCGATCACGACACCTTGCCCTACGCGCTGCAAG
CCCTGCACGACGCGGCCGATGGCGAAGGCGTACTGAGCCTGGACGTGGCCGCCGATGGCAGCGCGCGCGACAAGTTGTGG
GCCGCACGCCGCGCCCTGTCGCCGGCCTTGCGCACCATCAAGCCGGGCAAGATCAATGAGGACGTGGTGGTGCCGGTGTC
GCGCATTCCCGAACTCGTCGCCGGCGTGGAAGCGCTCGCTGCGGAATTCGCACTGCCCATCGTCGCCTTCGGCCATGCCG
GCAACGGCAACCTGCACGTCAACATCATGTACGACCCGGCCGATGCCGACGAAAACGCCCGCGCGCATGCCGCCTTGCCA
CGACTGTTTACGCTGGTGCTGGCGCTGGAAGGCACGCTCTCCGGCGAGCACGGCATCGGCGTGGCCAAGCGCGATTTCAT
GAGCCAGGCCTTCAGCGCAGCAACGCTGGCCACCATGCGCGCAATCAAGGCCGCACTGGATCCGGACGGGATTCTCAACC
CGGGCAAGGTATTACCGCCTGCATGA

Upstream 100 bases:

>100_bases
GCACGTTGCTCTCCGAGCTGCGCTGGGTCTGGTTGCCGCTCACCGTCGCCGTGCTGGGGTGGAAATGCATCCAGCGCGCG
GCACCACAGGATCGCATGTC

Downstream 100 bases:

>100_bases
GTAAATGATGAGCACTCTTCGTTGCATAACGTCAACGTCATACCACAGCAACCACTTGATGAAATCAGACTTACATGGAT
AGCCTGATCATCCGAATAAG

Product: D-lactate dehydrogenase

Products: pyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTDVLPTALAELLAARLGTDGWLTGDDARRRYGEDDSRRWALPAAVALPRDTDEVVAIVQACRAHGVPIVARGAGTGTTG
AAVPFSGGVVVSMARMNQILALRPQDRCAVVQPGLLNGDLQQALQPHGLFWPPDPSSADICSVGGNLSTNAGGPRAVKYG
ATRDNVLGLVAVTGTGEVIRCGGAYTKNSTGYDLTHLLVGSEGTLAIIVEATLKLTPRAIAQAGLRALYRDASSAAAAVS
RLMAQPTTPTMLEFMDASAIALLRRNGSDVPDAGAMLLIEADGDHDTLPYALQALHDAADGEGVLSLDVAADGSARDKLW
AARRALSPALRTIKPGKINEDVVVPVSRIPELVAGVEALAAEFALPIVAFGHAGNGNLHVNIMYDPADADENARAHAALP
RLFTLVLALEGTLSGEHGIGVAKRDFMSQAFSAATLATMRAIKAALDPDGILNPGKVLPPA

Sequences:

>Translated_461_residues
MTDVLPTALAELLAARLGTDGWLTGDDARRRYGEDDSRRWALPAAVALPRDTDEVVAIVQACRAHGVPIVARGAGTGTTG
AAVPFSGGVVVSMARMNQILALRPQDRCAVVQPGLLNGDLQQALQPHGLFWPPDPSSADICSVGGNLSTNAGGPRAVKYG
ATRDNVLGLVAVTGTGEVIRCGGAYTKNSTGYDLTHLLVGSEGTLAIIVEATLKLTPRAIAQAGLRALYRDASSAAAAVS
RLMAQPTTPTMLEFMDASAIALLRRNGSDVPDAGAMLLIEADGDHDTLPYALQALHDAADGEGVLSLDVAADGSARDKLW
AARRALSPALRTIKPGKINEDVVVPVSRIPELVAGVEALAAEFALPIVAFGHAGNGNLHVNIMYDPADADENARAHAALP
RLFTLVLALEGTLSGEHGIGVAKRDFMSQAFSAATLATMRAIKAALDPDGILNPGKVLPPA
>Mature_460_residues
TDVLPTALAELLAARLGTDGWLTGDDARRRYGEDDSRRWALPAAVALPRDTDEVVAIVQACRAHGVPIVARGAGTGTTGA
AVPFSGGVVVSMARMNQILALRPQDRCAVVQPGLLNGDLQQALQPHGLFWPPDPSSADICSVGGNLSTNAGGPRAVKYGA
TRDNVLGLVAVTGTGEVIRCGGAYTKNSTGYDLTHLLVGSEGTLAIIVEATLKLTPRAIAQAGLRALYRDASSAAAAVSR
LMAQPTTPTMLEFMDASAIALLRRNGSDVPDAGAMLLIEADGDHDTLPYALQALHDAADGEGVLSLDVAADGSARDKLWA
ARRALSPALRTIKPGKINEDVVVPVSRIPELVAGVEALAAEFALPIVAFGHAGNGNLHVNIMYDPADADENARAHAALPR
LFTLVLALEGTLSGEHGIGVAKRDFMSQAFSAATLATMRAIKAALDPDGILNPGKVLPPA

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=457, Percent_Identity=34.1356673960613, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI37595754, Length=480, Percent_Identity=32.5, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI119964728, Length=426, Percent_Identity=32.1596244131455, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4501993, Length=226, Percent_Identity=29.2035398230088, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1789351, Length=423, Percent_Identity=37.3522458628842, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1787977, Length=521, Percent_Identity=28.4069097888676, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI48994907, Length=491, Percent_Identity=23.8289205702648, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI48994914, Length=140, Percent_Identity=34.2857142857143, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=455, Percent_Identity=31.6483516483516, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71992381, Length=455, Percent_Identity=30.989010989011, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992392, Length=380, Percent_Identity=31.8421052631579, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17534361, Length=454, Percent_Identity=27.7533039647577, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17556096, Length=225, Percent_Identity=26.2222222222222, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320023, Length=452, Percent_Identity=28.5398230088496, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6320027, Length=434, Percent_Identity=29.2626728110599, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320764, Length=436, Percent_Identity=28.8990825688073, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=30.3529411764706, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=30.3529411764706, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=30.3529411764706, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24653753, Length=242, Percent_Identity=29.3388429752066, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.1.28

Molecular weight: Translated: 47743; Mature: 47612

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVLPTALAELLAARLGTDGWLTGDDARRRYGEDDSRRWALPAAVALPRDTDEVVAIVQ
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEECCCEEECCCCHHHHHHHHH
ACRAHGVPIVARGAGTGTTGAAVPFSGGVVVSMARMNQILALRPQDRCAVVQPGLLNGDL
HHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHCCEEEECCCCCEEEECCCCCCCHH
QQALQPHGLFWPPDPSSADICSVGGNLSTNAGGPRAVKYGATRDNVLGLVAVTGTGEVIR
HHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCEEE
CGGAYTKNSTGYDLTHLLVGSEGTLAIIVEATLKLTPRAIAQAGLRALYRDASSAAAAVS
ECCCCCCCCCCCCEEEEEECCCCCEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RLMAQPTTPTMLEFMDASAIALLRRNGSDVPDAGAMLLIEADGDHDTLPYALQALHDAAD
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
GEGVLSLDVAADGSARDKLWAARRALSPALRTIKPGKINEDVVVPVSRIPELVAGVEALA
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHH
AEFALPIVAFGHAGNGNLHVNIMYDPADADENARAHAALPRLFTLVLALEGTLSGEHGIG
HHHHCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
VAKRDFMSQAFSAATLATMRAIKAALDPDGILNPGKVLPPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDVLPTALAELLAARLGTDGWLTGDDARRRYGEDDSRRWALPAAVALPRDTDEVVAIVQ
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEECCCEEECCCCHHHHHHHHH
ACRAHGVPIVARGAGTGTTGAAVPFSGGVVVSMARMNQILALRPQDRCAVVQPGLLNGDL
HHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHCCEEEECCCCCEEEECCCCCCCHH
QQALQPHGLFWPPDPSSADICSVGGNLSTNAGGPRAVKYGATRDNVLGLVAVTGTGEVIR
HHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCEEE
CGGAYTKNSTGYDLTHLLVGSEGTLAIIVEATLKLTPRAIAQAGLRALYRDASSAAAAVS
ECCCCCCCCCCCCEEEEEECCCCCEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RLMAQPTTPTMLEFMDASAIALLRRNGSDVPDAGAMLLIEADGDHDTLPYALQALHDAAD
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
GEGVLSLDVAADGSARDKLWAARRALSPALRTIKPGKINEDVVVPVSRIPELVAGVEALA
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHH
AEFALPIVAFGHAGNGNLHVNIMYDPADADENARAHAALPRLFTLVLALEGTLSGEHGIG
HHHHCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
VAKRDFMSQAFSAATLATMRAIKAALDPDGILNPGKVLPPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; NAD+

Specific reaction: (R)-lactate + NAD+ = pyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]