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The map label for this gene is frmB [H]

Identifier: 21241507

GI number: 21241507

Start: 875951

End: 876781

Strand: Direct

Name: frmB [H]

Synonym: XAC0736

Alternate gene names: 21241507

Gene position: 875951-876781 (Clockwise)

Preceding gene: 21241506

Following gene: 21241509

Centisome position: 16.92

GC content: 62.33

Gene sequence:

>831_bases
ATGGAACGTATCGAACACCGCGCCTGCTTCGGCGGCTGGCAGGATGTCTATCGGCATCAGTCGCACACCTTGAACTGCAG
CATGCAGGTGGGCGTTTACCTGCCGCCGCAAGCCGCGGACGGCCCGTTGCCGGTGCTGTACTGGTTGAGCGGTTTGACCT
GCACCGAACAGAATTTCATCAGCAAGGCCGGCGCGCAGCGCTATGCGGCCGAACATGGCGTGATCCTAATTGCGCCCGAC
ACCAGCCCACGGGGCGAGGATGTGGCGGATGCGGACGGTTACGACATCGGCAAGGGCGCCGGCTTCTACGTCGATGCCAC
GCAAGCGCCATGGGCGGCGCATTACCGCATGTACGATTACGTGGTGAACGAATTGCCGGCGTTGATCGAAGCGACTTTCG
CCACCACCGGTGCGCGTGCGATCAGTGGCCATTCGATGGGTGGGCACGGCGCCTTGACCATCGCACTGAAGAACCCGGGC
CGCTATCGCAGCGTGTCGGCGTTTTCGCCGATCGTGGCGCCCAGCCAGGTGCCGTGGGGCGAGAAAGCATTTGGCCAGTA
TCTGGGCAACGACCGCACGACCTGGAAAGCCTACGATGCCACCGCATTGATTGCCGACGCTCAGGAGCGTTTGCCGCTGC
TGATCGATCAGGGCGATGCGGACGAATTTCTGCAAAACCAGCTGAAAACCGCGCTATTTGAAGGCGCCGCCAAGGCCGCG
GGCTACCCGGTGACGGTGCGGCTGCAGCCCGGTTATGACCACAGCTACTACTTCATTTCCAGCTTCATCGGCGAGCACAT
TGCGCATCATGCTGCGGCCTTGCGTGGGTGA

Upstream 100 bases:

>100_bases
CTGTCGGCCCATGTGGCACGCAAGAAGGGTCTGTTGCATTGATGGTCCAACCCTGCAACCGGCGATCCGGCTGCAGGGTT
TTCTCTTCGTAAGGAATCTC

Downstream 100 bases:

>100_bases
GTGCAGGCGCTCGTGTGCATGACCTAAAGACGCGCAGCGCAGCTGGGAGTTGCATGACACAGGCATCGGTTGCGCCTGTA
CGCTGCCGCACCCTGGCTAT

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MERIEHRACFGGWQDVYRHQSHTLNCSMQVGVYLPPQAADGPLPVLYWLSGLTCTEQNFISKAGAQRYAAEHGVILIAPD
TSPRGEDVADADGYDIGKGAGFYVDATQAPWAAHYRMYDYVVNELPALIEATFATTGARAISGHSMGGHGALTIALKNPG
RYRSVSAFSPIVAPSQVPWGEKAFGQYLGNDRTTWKAYDATALIADAQERLPLLIDQGDADEFLQNQLKTALFEGAAKAA
GYPVTVRLQPGYDHSYYFISSFIGEHIAHHAAALRG

Sequences:

>Translated_276_residues
MERIEHRACFGGWQDVYRHQSHTLNCSMQVGVYLPPQAADGPLPVLYWLSGLTCTEQNFISKAGAQRYAAEHGVILIAPD
TSPRGEDVADADGYDIGKGAGFYVDATQAPWAAHYRMYDYVVNELPALIEATFATTGARAISGHSMGGHGALTIALKNPG
RYRSVSAFSPIVAPSQVPWGEKAFGQYLGNDRTTWKAYDATALIADAQERLPLLIDQGDADEFLQNQLKTALFEGAAKAA
GYPVTVRLQPGYDHSYYFISSFIGEHIAHHAAALRG
>Mature_276_residues
MERIEHRACFGGWQDVYRHQSHTLNCSMQVGVYLPPQAADGPLPVLYWLSGLTCTEQNFISKAGAQRYAAEHGVILIAPD
TSPRGEDVADADGYDIGKGAGFYVDATQAPWAAHYRMYDYVVNELPALIEATFATTGARAISGHSMGGHGALTIALKNPG
RYRSVSAFSPIVAPSQVPWGEKAFGQYLGNDRTTWKAYDATALIADAQERLPLLIDQGDADEFLQNQLKTALFEGAAKAA
GYPVTVRLQPGYDHSYYFISSFIGEHIAHHAAALRG

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=279, Percent_Identity=56.989247311828, Blast_Score=323, Evalue=1e-88,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=59.6363636363636, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=59.7826086956522, Blast_Score=350, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17510185, Length=280, Percent_Identity=47.8571428571429, Blast_Score=264, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=43.5810810810811, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI45551932, Length=281, Percent_Identity=52.3131672597865, Blast_Score=286, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24648347, Length=281, Percent_Identity=52.3131672597865, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 29995; Mature: 29995

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIEHRACFGGWQDVYRHQSHTLNCSMQVGVYLPPQAADGPLPVLYWLSGLTCTEQNFI
CCCCHHHHHHCCHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHH
SKAGAQRYAAEHGVILIAPDTSPRGEDVADADGYDIGKGAGFYVDATQAPWAAHYRMYDY
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
VVNELPALIEATFATTGARAISGHSMGGHGALTIALKNPGRYRSVSAFSPIVAPSQVPWG
HHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCC
EKAFGQYLGNDRTTWKAYDATALIADAQERLPLLIDQGDADEFLQNQLKTALFEGAAKAA
HHHHHHHHCCCCCEEEECCCEEEEECHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHC
GYPVTVRLQPGYDHSYYFISSFIGEHIAHHAAALRG
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERIEHRACFGGWQDVYRHQSHTLNCSMQVGVYLPPQAADGPLPVLYWLSGLTCTEQNFI
CCCCHHHHHHCCHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHH
SKAGAQRYAAEHGVILIAPDTSPRGEDVADADGYDIGKGAGFYVDATQAPWAAHYRMYDY
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
VVNELPALIEATFATTGARAISGHSMGGHGALTIALKNPGRYRSVSAFSPIVAPSQVPWG
HHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCC
EKAFGQYLGNDRTTWKAYDATALIADAQERLPLLIDQGDADEFLQNQLKTALFEGAAKAA
HHHHHHHHCCCCCEEEECCCEEEEECHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHC
GYPVTVRLQPGYDHSYYFISSFIGEHIAHHAAALRG
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA