Click here to switch to the map view.

The map label for this gene is betT [H]

Identifier: 21241491

GI number: 21241491

Start: 858843

End: 860822

Strand: Reverse

Name: betT [H]

Synonym: XAC0720

Alternate gene names: 21241491

Gene position: 860822-858843 (Counterclockwise)

Preceding gene: 21241492

Following gene: 21241490

Centisome position: 16.63

GC content: 63.28

Gene sequence:

>1980_bases
ATGAGTGCGACAGCGCCGCACATCTTGCCGGTACGCACCCTGCGCCCGGTGTTCGTACTGGCTGCCACTGTCGTGTGCAC
GTTTGCCTTGCTGGTGTCGTTGTTTCCGCTGGAATCAGGACGTGTGCTGCTGGATGCGCAGACCTGGGCGTCGCGCAATG
TCGGCTGGTACTACCTGCTGGCGACGACGCTGTATCTGGTGTTCGTGCTGGCCACGGCCCTGTCCAGCTACGGCAACATC
AAGCTCGGCGCCGATCACGACGAGCCGGAATTCAGTTACCTCTCCTGGGCCGGCATGCTGTTCGCCGCGGGCATCAGCAT
CACGCTGTTCTTCTTCTGCGTTTCCGAGCCGCTTACGCATTATCTGCAACCGCCACAGGGCGGCACCGGCAGTGGCGAAG
CCTCCGCACGCCAGGCGATGCAGCTGCTGTTCCTGCATTGGGGCCTGCATGGTTGGGGCGTGTTCGCGCTGGCGGCCATG
GCGCTGGCGTATTTCGCCTTCCGCCACAACCTGCCGCTGGCGCTGCGATCGGCGTTGTATCCGCTGATCGGCAAACGCAT
CAATGGGCCGATCGGCTACACCGTGGATGCGCTGGGCATCGTGGCCACCGTGTTCGGCCTGGGCGCTGACATGGGCTTTG
GCGTGCTGCATCTCAACGCCGGCCTGAGCACCTTGATGGACGTGCCGCATACGCACTGGGTGCAGGTGGCGCTGATCGTG
GCGATGATGGGCGCGGCCATTGTGGTGGCGGTCTCCGGCGTCGAAAAAGGCGTGCGCTGGATGTCGGACATCAACATGCT
GCTGGCCATGGCGCTGCTGTTGTTCATGCTGTTCGCCGGCCCGACGCAGTACCTGCTCAATGCGCTGATGCAAAACCTGG
GCGACTACCTGGGCAGCGTGGTCAACAAGAGTTTCGACGTGTATGCCTATGGTGGCCGCGCCGATTGGCTGGGCGACTGG
ACGGTGTTCTATTGGGCCTGGTGGATCGGTTGGGCGCCCTTCGTCGGGCTGTTCATCGCGCGCATCTCGCGCGGCCGCAC
CATTCGCGAATTCGTGTTGGGGGTGTTGCTGATCCCGCTCGGGTTTACGCTGGCATGGCTGTCGATCTTCGGCAACAGCG
CGCTGGATCAGCTGCTGCATCACGGCCAGACAGCATGGGCGCAGCAGGCCATCGATGCGCCGCAGACCGTGTTGTATGCG
TTGCTGCAGCGTTACCCGTGGAGCCGCACGGTCATCACGGTCACGGTGGCGATCAGTTTCGTGTTCTTCGTGACCTCCGC
CGATTCCGGCACGGTGGTGTTGTCCACGCTCTCCTCTCACGGCGGTGAACCGCACGACGACGGCCCGCGCTGGCTACGTG
TGTTCTGGGGCGTACTCACTGCCGTGGTCACGGCAGGCCTGTTGCTGGCCGGCAGCATGGACGCACTGAAATCGGCGGTG
GTGCTGGCCTCGCTGCCATTCTCTGCAGTGCTGCTGCTGATGGCCTGGGGCCTGTCGCGCGCACTCAGCGAAGAATCGCA
GCGCAAACGCGCGCAGCTTTACAGCCCCAGCCCGTTGATCGGGCAATCACGCCATCACGGCGGCTGGCGTCAGCGGTTGG
GCCAGGCGATGCACTTCCCGGCGCGCGATGAGGTGTATCGCTTCATGCACGACCAGGTGCGCCCGGCGATCGAAGCGGTC
ACCGCACAACTGCAAGAGGAAGGCTGGAAGGTGAGCAGCCGCATCGACGACGGCGACATGGAAATCAGCGTCGATCACGG
CGAACAGCAGGGCTTCCGCTATCAAATCGTGATGCGCGGGTATCTCACTCCGTCGTTTGCCGCGCAGCGCTTCCGTAACC
AGCGCTACTACCGCGCCGAGGTCTACCTGTACGAAGGCAGCCAGGACTACGACCTGGTGGGCTACAGCCGCGAACAGATC
ATCAACGACATCATCGATCAATACGAACGTCACCTGCAGTTTCTGCATCTCACCCGCTAA

Upstream 100 bases:

>100_bases
ACTCGACCGCTGACGCCCCCTCGACACCGCCTGTGCGATAACGCAGGCGGTTTTTCGTTGGGAGCGCAGCACGTGATATG
CAGCGTATGAGTGTGTCGCC

Downstream 100 bases:

>100_bases
AGGTGCGTCGCTGCGGCGACCGTCCCACAGGAGGTTTGTCATGCCACGTTTCCCCGACCAGTTGCTGTATATCGGCGGCC
GTTATGTTCCCGCCCGCGGC

Product: high-affinity choline transport

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MSATAPHILPVRTLRPVFVLAATVVCTFALLVSLFPLESGRVLLDAQTWASRNVGWYYLLATTLYLVFVLATALSSYGNI
KLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGGTGSGEASARQAMQLLFLHWGLHGWGVFALAAM
ALAYFAFRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLSTLMDVPHTHWVQVALIV
AMMGAAIVVAVSGVEKGVRWMSDINMLLAMALLLFMLFAGPTQYLLNALMQNLGDYLGSVVNKSFDVYAYGGRADWLGDW
TVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPLGFTLAWLSIFGNSALDQLLHHGQTAWAQQAIDAPQTVLYA
LLQRYPWSRTVITVTVAISFVFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYSPSPLIGQSRHHGGWRQRLGQAMHFPARDEVYRFMHDQVRPAIEAV
TAQLQEEGWKVSSRIDDGDMEISVDHGEQQGFRYQIVMRGYLTPSFAAQRFRNQRYYRAEVYLYEGSQDYDLVGYSREQI
INDIIDQYERHLQFLHLTR

Sequences:

>Translated_659_residues
MSATAPHILPVRTLRPVFVLAATVVCTFALLVSLFPLESGRVLLDAQTWASRNVGWYYLLATTLYLVFVLATALSSYGNI
KLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGGTGSGEASARQAMQLLFLHWGLHGWGVFALAAM
ALAYFAFRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLSTLMDVPHTHWVQVALIV
AMMGAAIVVAVSGVEKGVRWMSDINMLLAMALLLFMLFAGPTQYLLNALMQNLGDYLGSVVNKSFDVYAYGGRADWLGDW
TVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPLGFTLAWLSIFGNSALDQLLHHGQTAWAQQAIDAPQTVLYA
LLQRYPWSRTVITVTVAISFVFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYSPSPLIGQSRHHGGWRQRLGQAMHFPARDEVYRFMHDQVRPAIEAV
TAQLQEEGWKVSSRIDDGDMEISVDHGEQQGFRYQIVMRGYLTPSFAAQRFRNQRYYRAEVYLYEGSQDYDLVGYSREQI
INDIIDQYERHLQFLHLTR
>Mature_658_residues
SATAPHILPVRTLRPVFVLAATVVCTFALLVSLFPLESGRVLLDAQTWASRNVGWYYLLATTLYLVFVLATALSSYGNIK
LGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGGTGSGEASARQAMQLLFLHWGLHGWGVFALAAMA
LAYFAFRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLSTLMDVPHTHWVQVALIVA
MMGAAIVVAVSGVEKGVRWMSDINMLLAMALLLFMLFAGPTQYLLNALMQNLGDYLGSVVNKSFDVYAYGGRADWLGDWT
VFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPLGFTLAWLSIFGNSALDQLLHHGQTAWAQQAIDAPQTVLYAL
LQRYPWSRTVITVTVAISFVFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAVV
LASLPFSAVLLLMAWGLSRALSEESQRKRAQLYSPSPLIGQSRHHGGWRQRLGQAMHFPARDEVYRFMHDQVRPAIEAVT
AQLQEEGWKVSSRIDDGDMEISVDHGEQQGFRYQIVMRGYLTPSFAAQRFRNQRYYRAEVYLYEGSQDYDLVGYSREQII
NDIIDQYERHLQFLHLTR

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=656, Percent_Identity=45.4268292682927, Blast_Score=576, Evalue=1e-165,
Organism=Escherichia coli, GI1788102, Length=453, Percent_Identity=29.1390728476821, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1786224, Length=468, Percent_Identity=25.2136752136752, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 73163; Mature: 73031

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATAPHILPVRTLRPVFVLAATVVCTFALLVSLFPLESGRVLLDAQTWASRNVGWYYLL
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCHHHHH
ATTLYLVFVLATALSSYGNIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTH
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQPPQGGTGSGEASARQAMQLLFLHWGLHGWGVFALAAMALAYFAFRHNLPLALRSALY
HCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLSTLMDVPHTHWVQVALIV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHH
AMMGAAIVVAVSGVEKGVRWMSDINMLLAMALLLFMLFAGPTQYLLNALMQNLGDYLGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VNKSFDVYAYGGRADWLGDWTVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPL
HCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GFTLAWLSIFGNSALDQLLHHGQTAWAQQAIDAPQTVLYALLQRYPWSRTVITVTVAISF
HHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
VFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
HHHHCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYSPSPLIGQSRHHGGWRQRLGQAMHFP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCC
ARDEVYRFMHDQVRPAIEAVTAQLQEEGWKVSSRIDDGDMEISVDHGEQQGFRYQIVMRG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCCEEEEEEEC
YLTPSFAAQRFRNQRYYRAEVYLYEGSQDYDLVGYSREQIINDIIDQYERHLQFLHLTR
CCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SATAPHILPVRTLRPVFVLAATVVCTFALLVSLFPLESGRVLLDAQTWASRNVGWYYLL
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCHHHHH
ATTLYLVFVLATALSSYGNIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTH
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQPPQGGTGSGEASARQAMQLLFLHWGLHGWGVFALAAMALAYFAFRHNLPLALRSALY
HCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLSTLMDVPHTHWVQVALIV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHH
AMMGAAIVVAVSGVEKGVRWMSDINMLLAMALLLFMLFAGPTQYLLNALMQNLGDYLGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VNKSFDVYAYGGRADWLGDWTVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPL
HCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GFTLAWLSIFGNSALDQLLHHGQTAWAQQAIDAPQTVLYALLQRYPWSRTVITVTVAISF
HHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
VFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
HHHHCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYSPSPLIGQSRHHGGWRQRLGQAMHFP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCC
ARDEVYRFMHDQVRPAIEAVTAQLQEEGWKVSSRIDDGDMEISVDHGEQQGFRYQIVMRG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCCEEEEEEEC
YLTPSFAAQRFRNQRYYRAEVYLYEGSQDYDLVGYSREQIINDIIDQYERHLQFLHLTR
CCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]