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The map label for this gene is betA

Identifier: 21241489

GI number: 21241489

Start: 855538

End: 857208

Strand: Reverse

Name: betA

Synonym: XAC0718

Alternate gene names: 21241489

Gene position: 857208-855538 (Counterclockwise)

Preceding gene: 21241490

Following gene: 21241488

Centisome position: 16.56

GC content: 65.05

Gene sequence:

>1671_bases
ATGCAACGCGAATACGACTACATCATCATCGGTGCCGGCTCGGCAGGCAACGTGCTGGCGGCACGCCTGACCGAAGATCC
CGGCGTGACCGTGCTGCTGCTCGAAGCGGGCGGGCCGGATTACCGGGTGGATTTCCGCACGCAGATGCCGGCAGCATTGG
CCTTCCCGTTGCAGGGGCGCCGCTACAACTGGGCCTATGAAACCGAGCCGGAACCCTACATGGACAACCGGCGCATGGAA
TGCGGTCGCGGCAAGGGCCTGGGCGGCTCGTCGCTGATCAACGGCATGTGCTACATCCGCGGCAATGCGCTCGACTTCGA
TCATTGGGCCAAGCGCCCCGGCCTGGAGGACTGGAGCTACCGCGATGTGCTGCCGTACTTCCGCAAGGCAGAGACGCGCG
ATATCGGCGCCAACGACTATCACGGTGGCGACGGTCCGGTGAGCGTGGCAACGCCGAAGAACGACAACAACGTGTTGTTC
CATGCCATGGTCGAGGCAGGCGTACAGGCGGGCTACCCGCGCACCGGCGATCTCAACGGCTACCAGCAGGAAGGCTTCGG
ACCGATGGACCGCACGGTGACGCCACGCGGGCGCCGCGCCAGCACCGCGCGCGGCTACCTGGACATGGCCAAGCCGCGCG
ATGGCCTGCATATCGTCACCCACGCCACCACCGATCGCATTTTGTTTGCAGGCAAGCGCGCCATCGGCGTGCATTACCTG
GTGGGCAACAGCAGCGAAGGAATCGATGCGCATGCGCGCCGCGAAGTGCTGGTGTGCGCAGGTGCGATCGCCTCGCCGCA
GCTGCTGCAACGCTCCGGCGTGGGCGCACCCGATCTGCTGCGCGCCCTCGATGTGCAACTGGTGCACGATCTGCCCGGTG
TGGGCCAGAATCTGCAGGACCACCTGGAGGTGTATATCCAGTATGCGTGCACCAAACCGGTCTCGCTGTATCCGGCACTG
CAATGGTGGAACCAGCCGGCGATCGGCGCGCAATGGTTGTTCGCCGGCACCGGTACCGGCGCCAGCAATCAGTTCGAAGC
CGGCGGCTTCATCCGCACGCGCGAGGAATTCGACTGGCCCAACATCCAGTACCACTTCCTTCCGGTTGCCATCAATTACA
ACGGCAGCAATGCGGTCAAGGAGCACGGCTTCCAAGCGCACGTCGGCTCGATGCGCACACCCAGCCGCGGGCGTGTGCAC
GCCAAGTCGCGCGACCCGCGCCAGCATCCTTCGATCCTGTTCAACTACCAATCCACCGACCAGGACTGGCAGGAATTCCG
CGACGCGATCCGCATCACCCGCGAGATCATCGCGCAACCGGCGCTAGACGCTTACCGCGGCCGCGAGATCAGCCCCAGTG
CGGACTGCAAGACCGATGCGGAGCTGGACGCATTCGTCCGCTCTCGCGCAGAAACCGCCTATCACCCCTCCTGCTCCTGC
GCGATGGGCACCGACGCCATGGCGGTAGTCGACGGCCAGGGCCGGGTGCACGGCATGGAGGGTCTGCGCGTGATCGACGC
CTCGATCATGCCGCGCATCATCACTGGCAACCTCAACGCCACCACCATCATGATTGCCGAGAAAATCGCCGACCGCGTTC
GCGGTCGTACCCCATTGCCGCGCAGTACCGCCGATTACTACATTGCCGGCGATGCCCCTGTGCGCGGGTGA

Upstream 100 bases:

>100_bases
AGGCGCGGCGGCAGCGACGCGATCGCTTCCCGCGCGCACGCCCGCGTCTGCGCCATCCGCCTCGATCGCCACCGCACCGT
TACCGCATCAGGAGAACACC

Downstream 100 bases:

>100_bases
CTTTTCTACGGGTCGAGCGTGCGGTGCGCTAACCCTTTGGCATGTACCGTGAACCCGTCCATGAGCGCGTTAGCGGCGTC
CACGCCGCCAATGGTCCCGC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRVDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLF
HAMVEAGVQAGYPRTGDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPAL
QWWNQPAIGAQWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
AKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDAYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
AMGTDAMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRVRGRTPLPRSTADYYIAGDAPVRG

Sequences:

>Translated_556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRVDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLF
HAMVEAGVQAGYPRTGDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPAL
QWWNQPAIGAQWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
AKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDAYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
AMGTDAMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRVRGRTPLPRSTADYYIAGDAPVRG
>Mature_556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRVDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLF
HAMVEAGVQAGYPRTGDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPAL
QWWNQPAIGAQWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
AKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDAYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
AMGTDAMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRVRGRTPLPRSTADYYIAGDAPVRG

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=48.8029465930018, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1786503, Length=552, Percent_Identity=77.7173913043478, Blast_Score=910, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=44.404973357016, Blast_Score=460, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24642048, Length=592, Percent_Identity=36.1486486486487, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24642042, Length=573, Percent_Identity=35.9511343804538, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45549471, Length=580, Percent_Identity=33.448275862069, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI45551458, Length=580, Percent_Identity=33.448275862069, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=35.3765323992995, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24642055, Length=579, Percent_Identity=34.5423143350604, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=35.1254480286738, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI18859995, Length=571, Percent_Identity=34.6760070052539, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=34.2059336823735, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=32.0623916811092, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24642035, Length=576, Percent_Identity=33.6805555555556, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24642037, Length=577, Percent_Identity=33.1022530329289, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24642051, Length=575, Percent_Identity=31.1304347826087, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI18859993, Length=580, Percent_Identity=33.1034482758621, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24645930, Length=582, Percent_Identity=26.6323024054983, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24642057, Length=590, Percent_Identity=28.135593220339, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_XANAC (Q8PPG8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641071.1
- ProteinModelPortal:   Q8PPG8
- SMR:   Q8PPG8
- GeneID:   1154789
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0718
- NMPDR:   fig|190486.1.peg.715
- HOGENOM:   HBG734713
- OMA:   EISPGAH
- ProtClustDB:   PRK02106
- BioCyc:   XAXO190486:XAC0718-MONOMER
- BRENDA:   1.1.99.1
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 61267; Mature: 61267

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 475-475

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRVDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETEPEPYMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSY
EECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCH
RDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLFHAMVEAGVQAGYPRTGDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHHHCCCCCCCCCCC
YQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
CHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEEE
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQD
ECCCCCCCCHHHHCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
HLEVYIQYACTKPVSLYPALQWWNQPAIGAQWLFAGTGTGASNQFEAGGFIRTREEFDWP
HHHHHHHHHCCCCCEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEHHHCCCC
NIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHAKSRDPRQHPSILFNYQSTD
CEEEEEEEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCC
QDWQEFRDAIRITREIIAQPALDAYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCE
AMGTDAMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRVRGRTPLP
ECCCCEEEEEECCCCEECCCCEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHCCCCCCC
RSTADYYIAGDAPVRG
CCCCCEEEECCCCCCC
>Mature Secondary Structure
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRVDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETEPEPYMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSY
EECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCH
RDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLFHAMVEAGVQAGYPRTGDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHHHHHCCCCCCCCCCC
YQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYL
CHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEEE
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQD
ECCCCCCCCHHHHCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
HLEVYIQYACTKPVSLYPALQWWNQPAIGAQWLFAGTGTGASNQFEAGGFIRTREEFDWP
HHHHHHHHHCCCCCEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEHHHCCCC
NIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHAKSRDPRQHPSILFNYQSTD
CEEEEEEEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCC
QDWQEFRDAIRITREIIAQPALDAYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSC
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCE
AMGTDAMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRVRGRTPLP
ECCCCEEEEEECCCCEECCCCEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHCCCCCCC
RSTADYYIAGDAPVRG
CCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217