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The map label for this gene is adhC [H]

Identifier: 21241423

GI number: 21241423

Start: 769862

End: 770968

Strand: Direct

Name: adhC [H]

Synonym: XAC0652

Alternate gene names: 21241423

Gene position: 769862-770968 (Clockwise)

Preceding gene: 21241422

Following gene: 21241424

Centisome position: 14.87

GC content: 66.21

Gene sequence:

>1107_bases
ATGAAGACACGCGCTGCGGTGGCCTGGGGTCCGCACCAGCCGTTGACCATCGAAGAAGTAGACCTGCAGCCGCCGCGTCC
CGGCGAGGTGCTGGTGCGCCTGGTCGCCACCGGCATTTGCCAGGGCGATGCGCATGCGTTGGCGCATGGCCATGCCGGCA
GCTTTCCGGCGATCCTGGGGCAGGAGGGCGCCGGGGTTGTCGAAGACGTCGGGATCGGCGTCACCAGCGTGCGGCCCGGC
GATCACGTGATTCCGCTGTATATGCCCGAATGCGGCGTGTGCAAATTCTGCCGTTCCGGCCGTACAAATTTGTGCCAGGC
GATTCGCAGCAGCCAGGAACGTGGCCTGATGCCTGACGGCAGCAGCCGGTTTTCGTTGCATGGGCGGCCGATCCTGCATC
ACATGGGCACCAGCACGTTTTCCGAATACACCGTATTGCCGGAGATTGCAGTCGCACGCATCCATCCGGAGGCGCCGCTG
GAGCAGGCCTGCCTGCTCGGCTGCACGGTCACCACCGGCGTCGGTGCGGTGCTCAACAGCACGCATGTGCGGCCGGGCGA
TTGCGTGGCGGTGTTCGGGCTGGGCGGCATCGGATTGTCGGTGATACAGGGCGCGCTGCTGGCGCAGGCCGGCCGCATCA
TCGCGGTGGACATCGACCCTGCGAAATTCGCACTGGCACGTACGCTGGGCGCCACCGATTGCCTGGATCCGCGCGACTAC
GGTGCGCCGATCCAGCAGGTGATCGTGGACCTGACCGATGGCGGTGCCGACCACAGTTTCGAATGCGTCGGCGATGTCGG
CGCGATGCGGGCGGCGCTGGAGTGTTGCCACAAGGGCTGGGGCGAGAGCGTCATCCTGGGGATGGCCGACGACACGCAGG
AAATCAGCACGCGCCCGTTTCAATTGGTCACCGGGCGGGTGTGGCGCGGCAGCGCCTTCGGCGGCGTCAAAGGCCGCAGC
GAGCTACCCGGTTACGTCGAACGCTATCTGCACGGCGATATCCAGCTGGCGCCGTTGATCACGCGCACGCTGGCGCTGGA
TGACATCAACCAGGCGTTGACGGACCTGCGTGCGGCGCGCGGCATCAAATCCATCGTGGCGTATTGA

Upstream 100 bases:

>100_bases
AGCTTGCGCGAACTCAAACAGATCCCCGTGGGCGAGCTGCCGTGGGGCGTGATCATCGCGCGCTGAGCGGCCGGCAGGCC
GACGGCGTCAGGGAGGCCGG

Downstream 100 bases:

>100_bases
AGGAGATGCACATGGCAGCAGGCAGATGCAGGACAGCGACGCTGCATCGCACGGGATTGGCAGGCGCATGGGCCATGACC
CTGCTCGCACGCAGCGCATT

Product: alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKTRAAVAWGPHQPLTIEEVDLQPPRPGEVLVRLVATGICQGDAHALAHGHAGSFPAILGQEGAGVVEDVGIGVTSVRPG
DHVIPLYMPECGVCKFCRSGRTNLCQAIRSSQERGLMPDGSSRFSLHGRPILHHMGTSTFSEYTVLPEIAVARIHPEAPL
EQACLLGCTVTTGVGAVLNSTHVRPGDCVAVFGLGGIGLSVIQGALLAQAGRIIAVDIDPAKFALARTLGATDCLDPRDY
GAPIQQVIVDLTDGGADHSFECVGDVGAMRAALECCHKGWGESVILGMADDTQEISTRPFQLVTGRVWRGSAFGGVKGRS
ELPGYVERYLHGDIQLAPLITRTLALDDINQALTDLRAARGIKSIVAY

Sequences:

>Translated_368_residues
MKTRAAVAWGPHQPLTIEEVDLQPPRPGEVLVRLVATGICQGDAHALAHGHAGSFPAILGQEGAGVVEDVGIGVTSVRPG
DHVIPLYMPECGVCKFCRSGRTNLCQAIRSSQERGLMPDGSSRFSLHGRPILHHMGTSTFSEYTVLPEIAVARIHPEAPL
EQACLLGCTVTTGVGAVLNSTHVRPGDCVAVFGLGGIGLSVIQGALLAQAGRIIAVDIDPAKFALARTLGATDCLDPRDY
GAPIQQVIVDLTDGGADHSFECVGDVGAMRAALECCHKGWGESVILGMADDTQEISTRPFQLVTGRVWRGSAFGGVKGRS
ELPGYVERYLHGDIQLAPLITRTLALDDINQALTDLRAARGIKSIVAY
>Mature_368_residues
MKTRAAVAWGPHQPLTIEEVDLQPPRPGEVLVRLVATGICQGDAHALAHGHAGSFPAILGQEGAGVVEDVGIGVTSVRPG
DHVIPLYMPECGVCKFCRSGRTNLCQAIRSSQERGLMPDGSSRFSLHGRPILHHMGTSTFSEYTVLPEIAVARIHPEAPL
EQACLLGCTVTTGVGAVLNSTHVRPGDCVAVFGLGGIGLSVIQGALLAQAGRIIAVDIDPAKFALARTLGATDCLDPRDY
GAPIQQVIVDLTDGGADHSFECVGDVGAMRAALECCHKGWGESVILGMADDTQEISTRPFQLVTGRVWRGSAFGGVKGRS
ELPGYVERYLHGDIQLAPLITRTLALDDINQALTDLRAARGIKSIVAY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=53.4059945504087, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=45.9239130434783, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=45.1086956521739, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=45.9239130434783, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=44.5040214477212, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=43.8692098092643, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=44.0443213296399, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=41.7344173441734, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=41.7344173441734, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=24.9299719887955, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=60.4336043360434, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI87082125, Length=299, Percent_Identity=27.7591973244147, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87081918, Length=229, Percent_Identity=29.2576419213974, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=24.1758241758242, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=24.8571428571429, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786825, Length=258, Percent_Identity=26.7441860465116, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788075, Length=370, Percent_Identity=24.8648648648649, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI226510992, Length=296, Percent_Identity=26.6891891891892, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=48.2573726541555, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=48, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=48.1049562682216, Blast_Score=351, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17562876, Length=372, Percent_Identity=27.4193548387097, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=233, Percent_Identity=30.4721030042918, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=334, Percent_Identity=29.0419161676647, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=352, Percent_Identity=26.1363636363636, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=27.5757575757576, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=50.4043126684636, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319621, Length=292, Percent_Identity=29.4520547945205, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=290, Percent_Identity=26.551724137931, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=241, Percent_Identity=27.3858921161826, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=293, Percent_Identity=26.6211604095563, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=51.3586956521739, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17137530, Length=268, Percent_Identity=31.3432835820896, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737897, Length=269, Percent_Identity=30.8550185873606, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 38816; Mature: 38816

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRAAVAWGPHQPLTIEEVDLQPPRPGEVLVRLVATGICQGDAHALAHGHAGSFPAILG
CCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHC
QEGAGVVEDVGIGVTSVRPGDHVIPLYMPECGVCKFCRSGRTNLCQAIRSSQERGLMPDG
CCCCCCHHHCCCCEEECCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCC
SSRFSLHGRPILHHMGTSTFSEYTVLPEIAVARIHPEAPLEQACLLGCTVTTGVGAVLNS
CCEEEECCCHHHHHCCCCCHHHEEECCHHHHEEECCCCCHHHHHHHHCHHHHHHHHHHHC
THVRPGDCVAVFGLGGIGLSVIQGALLAQAGRIIAVDIDPAKFALARTLGATDCLDPRDY
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCC
GAPIQQVIVDLTDGGADHSFECVGDVGAMRAALECCHKGWGESVILGMADDTQEISTRPF
CCCHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCE
QLVTGRVWRGSAFGGVKGRSELPGYVERYLHGDIQLAPLITRTLALDDINQALTDLRAAR
EEEECCEECCCCCCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
GIKSIVAY
HHHHHHCC
>Mature Secondary Structure
MKTRAAVAWGPHQPLTIEEVDLQPPRPGEVLVRLVATGICQGDAHALAHGHAGSFPAILG
CCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHC
QEGAGVVEDVGIGVTSVRPGDHVIPLYMPECGVCKFCRSGRTNLCQAIRSSQERGLMPDG
CCCCCCHHHCCCCEEECCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCC
SSRFSLHGRPILHHMGTSTFSEYTVLPEIAVARIHPEAPLEQACLLGCTVTTGVGAVLNS
CCEEEECCCHHHHHCCCCCHHHEEECCHHHHEEECCCCCHHHHHHHHCHHHHHHHHHHHC
THVRPGDCVAVFGLGGIGLSVIQGALLAQAGRIIAVDIDPAKFALARTLGATDCLDPRDY
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCC
GAPIQQVIVDLTDGGADHSFECVGDVGAMRAALECCHKGWGESVILGMADDTQEISTRPF
CCCHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCE
QLVTGRVWRGSAFGGVKGRSELPGYVERYLHGDIQLAPLITRTLALDDINQALTDLRAAR
EEEECCEECCCCCCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
GIKSIVAY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]