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The map label for this gene is pdhA [H]

Identifier: 21241219

GI number: 21241219

Start: 531758

End: 532846

Strand: Reverse

Name: pdhA [H]

Synonym: XAC0446

Alternate gene names: 21241219

Gene position: 532846-531758 (Counterclockwise)

Preceding gene: 77748525

Following gene: 21241218

Centisome position: 10.3

GC content: 66.94

Gene sequence:

>1089_bases
ATGAGCGTAGCCGCGCAGTTCCAGATCGACTATCTGCAATACATGGACGCGGACGGCCAATGGGTCCGCGACGACCTTCC
GGCCGACGCCGCCAACCCGCAACACCTGCTCGCCCTGTTCAAGCGCATGTTGTTCGTGCGCACCTTCGACACCAAATCGG
TGGCCTTGCAGCGCACCGGCAAGCTGGGCACCTACGCGGCCTGCATCGGCCACGAGGCCACGCATGTGGGGATCGGCGCT
TCGATGCGCAGCGGCGATGTGTTCGCGCCCAGCTATCGCGAATACGGCACCATGTTCGAACGCGGCGTGCGCCCGCGCGA
TGTGCTGCTGTACTGGGGCGGCGACGAGCGCGGCAGCGACTATCCGCGCGATGCCGATGCGGCGATCGACTTCCCGATCT
GCGTACCGATTTCCACCCAGTGCCTGCACGCCGCCGGCTCGGCGCTGTCGTTCAAGCTGCAGGGCAAGCAGCACGTTGCG
GTGGCCTGCTGCGGCGACGGTGGCAGCTCCAAGACCGACTTCTATGCCGCGCTCAATTCGGCCGGCGCCTACAAGCTGCC
GCTGATCCTGTGCGTGATCAACAACGGCTGGGCGATCTCGGTGCCGCGCTCGGCGCAGACCGGCGCGCAGACGCTTGCGC
AGAAGGGCCTGGCTGGCGGCCTGCATTGCCTGCAGGTGGACGGCAACGACCTGGTTGCCGTGCTCGAAGCGATGCGTCAG
GCACGCGTGCGCGCACTGGCCGGCGAGGGCGGCACGGTGATCGAGTTTTTGACCTATCGCCTGTCCGACCACACCACCGC
CGACGATGCGCGGCGCTACCGCGGCGAAGAAGAGGTCAAGCAGGGCTGGGCGCGCGAACCGCTGCTGCGCCTGCGCCGCT
ATCTCACTGCGCAAGGCCTGTGGGACGAAGCGCAGGAAGACGCCTGGAAGGCCGACTGCAGCGCACGCGTGGACGAAGAG
GTCAACGCCTATCTCAACACGCCGGTGCAGCCGGTCGAAGCGATGTTCGATTATCTCTACGGCGACCCGCCGGCCGAGTT
GCTGGCACAGCGCGCCGAAGTGATGGCGCTGGAGTCGCGCCATGGATGA

Upstream 100 bases:

>100_bases
AGCATGATCGTCTGCTGCGGTGCAGGACAGCGTTTTGCTTCGCCGTCCTTAACATGGCAACTCATATCATTTGAAACTTC
TTGATGAAGGTGTCGTCGCA

Downstream 100 bases:

>100_bases
GCTCAAGCATGTGCCCGCGGACGCCTCGCAGCACGCCAGTGCCCCTTACAACGCTGCGGCAACGCGCGGAGAGATCGCCA
TGAGTTCGCCCATCACCCTG

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSVAAQFQIDYLQYMDADGQWVRDDLPADAANPQHLLALFKRMLFVRTFDTKSVALQRTGKLGTYAACIGHEATHVGIGA
SMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKQHVA
VACCGDGGSSKTDFYAALNSAGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLVAVLEAMRQ
ARVRALAGEGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGLWDEAQEDAWKADCSARVDEE
VNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESRHG

Sequences:

>Translated_362_residues
MSVAAQFQIDYLQYMDADGQWVRDDLPADAANPQHLLALFKRMLFVRTFDTKSVALQRTGKLGTYAACIGHEATHVGIGA
SMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKQHVA
VACCGDGGSSKTDFYAALNSAGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLVAVLEAMRQ
ARVRALAGEGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGLWDEAQEDAWKADCSARVDEE
VNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESRHG
>Mature_361_residues
SVAAQFQIDYLQYMDADGQWVRDDLPADAANPQHLLALFKRMLFVRTFDTKSVALQRTGKLGTYAACIGHEATHVGIGAS
MRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKQHVAV
ACCGDGGSSKTDFYAALNSAGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLVAVLEAMRQA
RVRALAGEGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGLWDEAQEDAWKADCSARVDEEV
NAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESRHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=363, Percent_Identity=31.6804407713499, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI258645172, Length=363, Percent_Identity=31.6804407713499, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI4505685, Length=327, Percent_Identity=28.1345565749235, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI291084742, Length=327, Percent_Identity=28.1345565749235, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI291084744, Length=334, Percent_Identity=26.9461077844311, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=25.6410256410256, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI86563357, Length=332, Percent_Identity=35.8433734939759, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI86563355, Length=332, Percent_Identity=35.8433734939759, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17536047, Length=321, Percent_Identity=24.6105919003115, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI32564172, Length=321, Percent_Identity=24.6105919003115, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=26.8370607028754, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355903, Length=357, Percent_Identity=31.9327731092437, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24639744, Length=289, Percent_Identity=26.9896193771626, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571106, Length=289, Percent_Identity=26.9896193771626, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639740, Length=289, Percent_Identity=26.9896193771626, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24639746, Length=255, Percent_Identity=28.6274509803922, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639748, Length=290, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39661; Mature: 39530

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAAQFQIDYLQYMDADGQWVRDDLPADAANPQHLLALFKRMLFVRTFDTKSVALQRTG
CCCCHHEEHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KLGTYAACIGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSD
CCCHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
YPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKQHVAVACCGDGGSSKTDFYAALNS
CCCCCCCEECCEEECCCCHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCHHHHHHCC
AGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLVAVLEAMRQ
CCCEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
ARVRALAGEGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCC
WDEAQEDAWKADCSARVDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESR
HHHHHHHHHHHCCCHHCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
HG
CC
>Mature Secondary Structure 
SVAAQFQIDYLQYMDADGQWVRDDLPADAANPQHLLALFKRMLFVRTFDTKSVALQRTG
CCCHHEEHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KLGTYAACIGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSD
CCCHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
YPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKQHVAVACCGDGGSSKTDFYAALNS
CCCCCCCEECCEEECCCCHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCHHHHHHCC
AGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLVAVLEAMRQ
CCCEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
ARVRALAGEGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCC
WDEAQEDAWKADCSARVDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESR
HHHHHHHHHHHCCCHHCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
HG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA