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The map label for this gene is pdhB [H]

Identifier: 21241218

GI number: 21241218

Start: 530695

End: 531678

Strand: Reverse

Name: pdhB [H]

Synonym: XAC0445

Alternate gene names: 21241218

Gene position: 531678-530695 (Counterclockwise)

Preceding gene: 21241219

Following gene: 21241217

Centisome position: 10.27

GC content: 66.97

Gene sequence:

>984_bases
ATGAGTTCGCCCATCACCCTGATCGAAGCCATCACCCAGGCCTTGGCCTGGGAACTGGAACACGACCCTGCGGTACTGGT
GCTGGGCGAAGATGTCGGCGTCAACGGCGGGGTGTTTCGTGCCACCGCCGGCCTGCAGCAACGCTTCGGCAGCGACCGCG
TGCTGGATACGCCACTGGACGAGACCACCATCGCCGGGCTGAGCGTCGGGCTGGCCGCGCAAGGCATGAAGCCGGTCGCC
GAAGCGCAGTTCGACGGCTTCGTGTATCCGATGGTCGACCATCTGATCTGCCACGCCGCCCGCCTGCGCAACCGCACCCG
CGGCCGCCTGCATTGCCCGATGGTGCTGCGCGTGCCGTGGGGTGGCGGCATCCGTGCGCCGGAACATCACAGCGAAGCCA
ACGAAGCCATCTTCACCAACGTGCCGGGCCTGCGCGTGGTGCTGCCGTCCTCGCCGCAACGCGCCTACGGCCTGTTGCTG
GCGGCGATCCGCGACCCGGATCCGGTCATCTACATGGAGCCCAAGCGCATCTATCGCCAGTACAAGGAAGTGGTGGCCAA
CGATGGCGAAGCGCTGCCGCTGGATGTGTGCTTCGTACTGCGCGACGGCACCGATGTCACCCTGGTGACCTGGGGCGCGC
AGGTGAAAGAAGCGCTGGAAGCGGCCGACAAACTCGCTGGCGAAGGCATCAGCGCCGAAGTCATCGACGTGGCCACGTTG
CGCCCGCTGGACTTCGACACCATCGCCGAATCGGTCGCAAAGACCGGCCGCTGCGTGATCGTGCAGGAAGCTCCGCGCAC
CGCCGGTTTCGGCGCGGAAATCGCCGCGCGCCTGGCCGAGCAGTCGATGTACGACCTGGTGGCGCCGGTCGAACGCGTCA
CCGGTTACGACACGCATATCCCGCTGTTCCGGCTGGAAATGAAGTTCCTGCCGAGCGTGGAGCGCATCGTCAGCGCGGCA
CGTCGCGCGGTGGCTGCCGGCTGA

Upstream 100 bases:

>100_bases
CTGGAGTCGCGCCATGGATGAGCTCAAGCATGTGCCCGCGGACGCCTCGCAGCACGCCAGTGCCCCTTACAACGCTGCGG
CAACGCGCGGAGAGATCGCC

Downstream 100 bases:

>100_bases
TATGCGCGCCCGTCTGCTTTGCGACCATCGCGCCGCCTACGCCAACCCGGTCCGCTTCCAGGCAGGCCAGCAGGTCGGCT
TAGGGGTGCGCGACGAAGAA

Product: pyruvate dehydrogenase E1 beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGSDRVLDTPLDETTIAGLSVGLAAQGMKPVA
EAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHSEANEAIFTNVPGLRVVLPSSPQRAYGLLL
AAIRDPDPVIYMEPKRIYRQYKEVVANDGEALPLDVCFVLRDGTDVTLVTWGAQVKEALEAADKLAGEGISAEVIDVATL
RPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVERVTGYDTHIPLFRLEMKFLPSVERIVSAA
RRAVAAG

Sequences:

>Translated_327_residues
MSSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGSDRVLDTPLDETTIAGLSVGLAAQGMKPVA
EAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHSEANEAIFTNVPGLRVVLPSSPQRAYGLLL
AAIRDPDPVIYMEPKRIYRQYKEVVANDGEALPLDVCFVLRDGTDVTLVTWGAQVKEALEAADKLAGEGISAEVIDVATL
RPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVERVTGYDTHIPLFRLEMKFLPSVERIVSAA
RRAVAAG
>Mature_326_residues
SSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGSDRVLDTPLDETTIAGLSVGLAAQGMKPVAE
AQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHSEANEAIFTNVPGLRVVLPSSPQRAYGLLLA
AIRDPDPVIYMEPKRIYRQYKEVVANDGEALPLDVCFVLRDGTDVTLVTWGAQVKEALEAADKLAGEGISAEVIDVATLR
PLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVERVTGYDTHIPLFRLEMKFLPSVERIVSAAR
RAVAAG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=41.1042944785276, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=41.1042944785276, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=34.4615384615385, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=33.2307692307692, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=42.1538461538462, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=37.5, Blast_Score=210, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6319698, Length=329, Percent_Identity=36.7781155015198, Blast_Score=208, Evalue=7e-55,
Organism=Drosophila melanogaster, GI160714832, Length=317, Percent_Identity=41.6403785488959, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI160714828, Length=317, Percent_Identity=41.6403785488959, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI21358145, Length=320, Percent_Identity=38.75, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24650940, Length=320, Percent_Identity=38.75, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=37.7777777777778, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=37.7777777777778, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35382; Mature: 35251

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGSDRVLDTPLD
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCC
ETTIAGLSVGLAAQGMKPVAEAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPW
CHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEECCEEEEECC
GGGIRAPEHHSEANEAIFTNVPGLRVVLPSSPQRAYGLLLAAIRDPDPVIYMEPKRIYRQ
CCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHEECCCCCEEEECHHHHHHH
YKEVVANDGEALPLDVCFVLRDGTDVTLVTWGAQVKEALEAADKLAGEGISAEVIDVATL
HHHHHHCCCCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEEC
RPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVERVTGYDTHI
CCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PLFRLEMKFLPSVERIVSAARRAVAAG
CCEEEHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGSDRVLDTPLD
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCC
ETTIAGLSVGLAAQGMKPVAEAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPW
CHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEECCEEEEECC
GGGIRAPEHHSEANEAIFTNVPGLRVVLPSSPQRAYGLLLAAIRDPDPVIYMEPKRIYRQ
CCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHEECCCCCEEEECHHHHHHH
YKEVVANDGEALPLDVCFVLRDGTDVTLVTWGAQVKEALEAADKLAGEGISAEVIDVATL
HHHHHHCCCCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEEC
RPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVERVTGYDTHI
CCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PLFRLEMKFLPSVERIVSAARRAVAAG
CCEEEHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]