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The map label for this gene is ggt [H]

Identifier: 21241079

GI number: 21241079

Start: 362876

End: 364456

Strand: Reverse

Name: ggt [H]

Synonym: XAC0305

Alternate gene names: 21241079

Gene position: 364456-362876 (Counterclockwise)

Preceding gene: 21241080

Following gene: 21241078

Centisome position: 7.04

GC content: 68.94

Gene sequence:

>1581_bases
ATGCTGCAGACCCTGCGCGCGCGCCGCGGCATGGTGGTCGCACCGCATCATCTTGCCGCACAGGCTGGACGCGATGTCTT
GCGCGACGGTGGCACTGCCATCGAAGCGGCCGTCGCCACCGCCGCCTGCCTGGCGGTGGTCTACCCACACATGACCGGCA
TCGGCGGCGATGGCTTCTGGCTCATCCACGAACCCGATGGCCGCGTGCATGCCATCGATGCCTGCGGCCGCGCGGCGCAG
GCGGCAACACTGGATTTCTATCGCGGCCACGCCCACATTCCGTGGCGCGGGCCAGGCGCGGCCAATACCGTGGCCGGCAC
CGTCTCCGGCTGGGCGCTGGCCCTGCAACAGGCAAACGGCAACTTGTCGCTGCAACGCCTGTTGAGCGATGCGATCCATC
ACGCCAGCGCCGGCGTGCCGGTCACGCTGGGCGGCGCGCAGATTGCCGCCAGCAAGGGCGCAGAACTGCGCCCACAACCC
GGCGCCTATCGCGAGATTTTCGAGCCGCACGCAGTTCCATTGCAGGAAGGCGCACTACTGCAGCAGCCGCAACTGGCGCG
CAGCTTGCAGCGGCTCGCCGACGAAGGGCTGGAGGGTTTCTATCGCGGTTCGCTCGCCCACGACATCGCTGCAGATCTGC
ACGCACTCGGCAGCCCGCTCAGCGCACACGATCTTGCCGCCCATCGCGCCGACGCCAGCGTGCCGTTATCGGTTGTCATC
CAGGGCGCGCGTCTCTACAACCACGCGCCACCCACGCAGGGGCTCGCCTCGCTGTTGATCCTGGCGCTATTCGATCGCCT
GAAGGTAGAAAGCGCAGACGGCCACGCACACCTGCACGGGCTGATCGAAGCCAGCAAGCAAGCGTTCCTGATCCGCGACG
CACACCTGGGCGACCCGGCCTGGATGACGCTCGACGCGCAGGCCCTGCTCGACGACAGCGCCGCACTCGATGCGCTCGCC
GCACGCATCGACATGAGCGCCGCATTGCCGTGGCCACAGCCCTCGCAGGCCGGCGACACCGTCTGGTTCGGCGCCATCGA
CGCGCACGGCCGCGCGGTCAGCTGCATCCAGTCCACCTACTTCGAATTCGGCTCGGGCCTGGTATTGCCGCGCACCGGCA
TCACCTGGCAGAACCGCGGCTGCAGCTTCCGCCTCGCCCCCGATGGCTGGAACGCGCTCGTCCCCGGGCGCAAGCCCTTC
CACACCCTCAACCCGGCGCTGGCCACCTTCGACGACGGCCGCGTCATGGCCTACGGCACCATGGGCGGCGAAGGCCAGCC
GCAAACACAGGCCGCGGTGTTCTCTCGCTACGCCCGCTTCGGCATGCCGCTGCAGCAGGCGGTCAGCGCACCGCGCTGGC
TGCTCGGCCGCACCTGGGGCGAAGACAGCACGTCGTTGAAGCTGGAAAACCGCTTCGACCCGGCAGTCGTGCAGGCCCTG
CGCAACGCCGGGCATGCGGTGGAACTGCTGCCGGCGTATAGCTCGGTGATGGGGCATGCAGGTGCCTTGGTGCGCGAGCG
AGATGGCGTCCTGAGTGGTGCCAGCGATCCGCGCTCGGATGGGGCGGTGGCGGCATGGTGA

Upstream 100 bases:

>100_bases
TGATCGCCGCGCCCGGCCGGGAAGACCGCCTGTTTGCGCTGGCCGCGCAACTCGAGCGCGACGGCCTGCTCGCCTTCAGC
CCGCCGCCGGAGCCACGCTG

Downstream 100 bases:

>100_bases
CCGCAGCGGTCGTTCCGCTACGGCCACTCGCCCCACGCGCGCATGGGCGCGCACCGGATGAAAGCGTCCATGTGTCGCAA
GACCGTCGTGCGGGAGCCTT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MLQTLRARRGMVVAPHHLAAQAGRDVLRDGGTAIEAAVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHAHIPWRGPGAANTVAGTVSGWALALQQANGNLSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRPQP
GAYREIFEPHAVPLQEGALLQQPQLARSLQRLADEGLEGFYRGSLAHDIAADLHALGSPLSAHDLAAHRADASVPLSVVI
QGARLYNHAPPTQGLASLLILALFDRLKVESADGHAHLHGLIEASKQAFLIRDAHLGDPAWMTLDAQALLDDSAALDALA
ARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTYFEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALVPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTSLKLENRFDPAVVQAL
RNAGHAVELLPAYSSVMGHAGALVRERDGVLSGASDPRSDGAVAAW

Sequences:

>Translated_526_residues
MLQTLRARRGMVVAPHHLAAQAGRDVLRDGGTAIEAAVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHAHIPWRGPGAANTVAGTVSGWALALQQANGNLSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRPQP
GAYREIFEPHAVPLQEGALLQQPQLARSLQRLADEGLEGFYRGSLAHDIAADLHALGSPLSAHDLAAHRADASVPLSVVI
QGARLYNHAPPTQGLASLLILALFDRLKVESADGHAHLHGLIEASKQAFLIRDAHLGDPAWMTLDAQALLDDSAALDALA
ARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTYFEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALVPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTSLKLENRFDPAVVQAL
RNAGHAVELLPAYSSVMGHAGALVRERDGVLSGASDPRSDGAVAAW
>Mature_526_residues
MLQTLRARRGMVVAPHHLAAQAGRDVLRDGGTAIEAAVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHAHIPWRGPGAANTVAGTVSGWALALQQANGNLSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRPQP
GAYREIFEPHAVPLQEGALLQQPQLARSLQRLADEGLEGFYRGSLAHDIAADLHALGSPLSAHDLAAHRADASVPLSVVI
QGARLYNHAPPTQGLASLLILALFDRLKVESADGHAHLHGLIEASKQAFLIRDAHLGDPAWMTLDAQALLDDSAALDALA
ARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTYFEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALVPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTSLKLENRFDPAVVQAL
RNAGHAVELLPAYSSVMGHAGALVRERDGVLSGASDPRSDGAVAAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=546, Percent_Identity=29.6703296703297, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI73915090, Length=546, Percent_Identity=29.6703296703297, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI73915096, Length=546, Percent_Identity=29.6703296703297, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI73915094, Length=546, Percent_Identity=29.6703296703297, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI113429324, Length=533, Percent_Identity=28.8930581613508, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI113429326, Length=541, Percent_Identity=29.0203327171904, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI109148539, Length=544, Percent_Identity=27.0220588235294, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI153266885, Length=559, Percent_Identity=24.1502683363148, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI153266901, Length=560, Percent_Identity=23.9285714285714, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=23.2304900181488, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789856, Length=540, Percent_Identity=30.3703703703704, Blast_Score=222, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI193208247, Length=487, Percent_Identity=26.8993839835729, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=487, Percent_Identity=26.8993839835729, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI212646519, Length=502, Percent_Identity=24.5019920318725, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=502, Percent_Identity=24.5019920318725, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=553, Percent_Identity=25.497287522604, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17542894, Length=504, Percent_Identity=24.8015873015873, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=514, Percent_Identity=22.1789883268482, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=26.0617760617761, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI161077880, Length=554, Percent_Identity=26.3537906137184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642670, Length=554, Percent_Identity=26.3537906137184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642666, Length=554, Percent_Identity=26.3537906137184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161077878, Length=554, Percent_Identity=26.3537906137184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45551474, Length=554, Percent_Identity=26.3537906137184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161077496, Length=465, Percent_Identity=23.4408602150538, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI18859741, Length=435, Percent_Identity=23.448275862069, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55544; Mature: 55544

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQTLRARRGMVVAPHHLAAQAGRDVLRDGGTAIEAAVATAACLAVVYPHMTGIGGDGFW
CCCCHHHCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LIHEPDGRVHAIDACGRAAQAATLDFYRGHAHIPWRGPGAANTVAGTVSGWALALQQANG
EEECCCCCEEEEHHHCCHHHHHHHHHCCCCEECCCCCCCCCCHHHHCHHHHEEEEECCCC
NLSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRPQPGAYREIFEPHAVPLQEGALL
CHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
QQPQLARSLQRLADEGLEGFYRGSLAHDIAADLHALGSPLSAHDLAAHRADASVPLSVVI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHEE
QGARLYNHAPPTQGLASLLILALFDRLKVESADGHAHLHGLIEASKQAFLIRDAHLGDPA
ECHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
WMTLDAQALLDDSAALDALAARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTY
EEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
FEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALVPGRKPFHTLNPALATFDDGRVMAYGT
HHHCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEC
MGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTSLKLENRFDPAVVQAL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHH
RNAGHAVELLPAYSSVMGHAGALVRERDGVLSGASDPRSDGAVAAW
HCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MLQTLRARRGMVVAPHHLAAQAGRDVLRDGGTAIEAAVATAACLAVVYPHMTGIGGDGFW
CCCCHHHCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LIHEPDGRVHAIDACGRAAQAATLDFYRGHAHIPWRGPGAANTVAGTVSGWALALQQANG
EEECCCCCEEEEHHHCCHHHHHHHHHCCCCEECCCCCCCCCCHHHHCHHHHEEEEECCCC
NLSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRPQPGAYREIFEPHAVPLQEGALL
CHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
QQPQLARSLQRLADEGLEGFYRGSLAHDIAADLHALGSPLSAHDLAAHRADASVPLSVVI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHEE
QGARLYNHAPPTQGLASLLILALFDRLKVESADGHAHLHGLIEASKQAFLIRDAHLGDPA
ECHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
WMTLDAQALLDDSAALDALAARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTY
EEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
FEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALVPGRKPFHTLNPALATFDDGRVMAYGT
HHHCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEC
MGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTSLKLENRFDPAVVQAL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHH
RNAGHAVELLPAYSSVMGHAGALVRERDGVLSGASDPRSDGAVAAW
HCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]