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The map label for this gene is yahK [H]

Identifier: 21240805

GI number: 21240805

Start: 35929

End: 36987

Strand: Direct

Name: yahK [H]

Synonym: XAC0031

Alternate gene names: 21240805

Gene position: 35929-36987 (Clockwise)

Preceding gene: 21240800

Following gene: 21240809

Centisome position: 0.69

GC content: 64.78

Gene sequence:

>1059_bases
ATGAGCACAGCCCACGCCTACGCTGCCCAGGCCGCCGATCAACCACTTGCCCCATTCGTGTTCGAACGCCGTGCGCCCGG
CCCCAACGACGTGCAGATCGACATCGCCTACTGTGGCGTGTGTCACTCGGACCTGCATACCGCACGCAACGAATGGCACA
ACACGCTGTACCCCTCGGTGCCCGGCCACGAGATCGTCGGCCGCGTCACGGCGGTGGGCAATGCGGTCACCGGCTTCAAG
GTCGGCGACCTGGCCGGTGTTGGCTGCATGGTCGACAGCTGCCGCAGCTGCGCCTCCTGCCAGGAAGGCGAAGAACAGTA
TTGCGAAGCCGGCTTCACCGGCACCTACAACGGGCCGATGTTCGGCGGCGGCGAGAACACCTACGGCGGCTATTCCGACC
ATATCGTGGTCGACCAGAAGTACGTGCTGCGCATCACCCACAGCGACAACCTGGCCGCGGTGGCACCGCTGCTGTGCGCC
GGCATCACCACCTATTCGCCGCTGGCGCACTGGAAGGTAGGCCCGGGCCAGAAGGTGGGCGTGGTCGGTCTCGGCGGCCT
GGGCCATATGGCGGTGAAGATCGCCAAGGCGATGGGCGCTACCGTGGTGCTGTTCACCACCTCCGAAAGCAAGCGCGCCG
ATGCGCTGCGCCTGGGCGCCAGCGAAGTGGTGATTTCCAAGGACGAAGCGCAGATGGCCGCGCAGTACAACACCCTGGAT
TTCATCCTCAACACCGTGGCCGCGCCGCATAACCTGGACCCGTTCCTCAACGCGCTCAAGCGCGATGGCGCCATTGTGCT
GGTCGGCGTGCCCGAGCAGTCGCACCCGTCGCCGGCGGTGTTCAACCTGGTGATGAAGCGCCGCACGCTGGCCGGTTCGC
TGATCGGCGGCATCCGCCAGACCCAGGAAATGCTGGATTTCTGCGCCAAGCACAACATCGTCTCGGACATCGAAACCATC
CGCGCCGACCAGATCAACGAGGCCTACGAGCGCATGCTCAAGAGCGACGTGAAGTACCGCTTCGTGATCGATATGGCGAC
CTTGGATCAGGCGGCTTGA

Upstream 100 bases:

>100_bases
ACTGTCGCAGGAGTGCGACATCTGCGCGTTTTAAGCTAGCGATCCTTCTTTTCCGTTGTTGGCGCAGCTTGCCGACGACG
CAACACCCCGGAGTTTTCCC

Downstream 100 bases:

>100_bases
TCAAGATTGCATCAAATGTATGAAATGCCACCGCTTGCGTTGTTGTTAGACGCAGGCGGTGGCGCGCGGCAGTTTGTTAC
CAGCGCAGCTTGATGCGCTT

Product: alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSTAHAYAAQAADQPLAPFVFERRAPGPNDVQIDIAYCGVCHSDLHTARNEWHNTLYPSVPGHEIVGRVTAVGNAVTGFK
VGDLAGVGCMVDSCRSCASCQEGEEQYCEAGFTGTYNGPMFGGGENTYGGYSDHIVVDQKYVLRITHSDNLAAVAPLLCA
GITTYSPLAHWKVGPGQKVGVVGLGGLGHMAVKIAKAMGATVVLFTTSESKRADALRLGASEVVISKDEAQMAAQYNTLD
FILNTVAAPHNLDPFLNALKRDGAIVLVGVPEQSHPSPAVFNLVMKRRTLAGSLIGGIRQTQEMLDFCAKHNIVSDIETI
RADQINEAYERMLKSDVKYRFVIDMATLDQAA

Sequences:

>Translated_352_residues
MSTAHAYAAQAADQPLAPFVFERRAPGPNDVQIDIAYCGVCHSDLHTARNEWHNTLYPSVPGHEIVGRVTAVGNAVTGFK
VGDLAGVGCMVDSCRSCASCQEGEEQYCEAGFTGTYNGPMFGGGENTYGGYSDHIVVDQKYVLRITHSDNLAAVAPLLCA
GITTYSPLAHWKVGPGQKVGVVGLGGLGHMAVKIAKAMGATVVLFTTSESKRADALRLGASEVVISKDEAQMAAQYNTLD
FILNTVAAPHNLDPFLNALKRDGAIVLVGVPEQSHPSPAVFNLVMKRRTLAGSLIGGIRQTQEMLDFCAKHNIVSDIETI
RADQINEAYERMLKSDVKYRFVIDMATLDQAA
>Mature_351_residues
STAHAYAAQAADQPLAPFVFERRAPGPNDVQIDIAYCGVCHSDLHTARNEWHNTLYPSVPGHEIVGRVTAVGNAVTGFKV
GDLAGVGCMVDSCRSCASCQEGEEQYCEAGFTGTYNGPMFGGGENTYGGYSDHIVVDQKYVLRITHSDNLAAVAPLLCAG
ITTYSPLAHWKVGPGQKVGVVGLGGLGHMAVKIAKAMGATVVLFTTSESKRADALRLGASEVVISKDEAQMAAQYNTLDF
ILNTVAAPHNLDPFLNALKRDGAIVLVGVPEQSHPSPAVFNLVMKRRTLAGSLIGGIRQTQEMLDFCAKHNIVSDIETIR
ADQINEAYERMLKSDVKYRFVIDMATLDQAA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=28.0555555555556, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=28.099173553719, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=27.5568181818182, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=27.5568181818182, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI71743840, Length=360, Percent_Identity=25, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=360, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI71565152, Length=361, Percent_Identity=24.6537396121884, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71565154, Length=356, Percent_Identity=25.561797752809, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=344, Percent_Identity=66.2790697674419, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI87082401, Length=345, Percent_Identity=32.7536231884058, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=29.1666666666667, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=296, Percent_Identity=28.7162162162162, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI226510992, Length=282, Percent_Identity=28.3687943262411, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788075, Length=261, Percent_Identity=26.0536398467433, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786552, Length=360, Percent_Identity=27.5, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788407, Length=282, Percent_Identity=28.0141843971631, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=267, Percent_Identity=26.5917602996255, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082125, Length=187, Percent_Identity=27.807486631016, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=365, Percent_Identity=28.2191780821918, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=323, Percent_Identity=27.2445820433437, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=356, Percent_Identity=28.6516853932584, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=27.5482093663912, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=365, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=334, Percent_Identity=27.2455089820359, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=267, Percent_Identity=28.4644194756554, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=29.1866028708134, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=321, Percent_Identity=37.3831775700935, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319949, Length=334, Percent_Identity=34.7305389221557, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319621, Length=330, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=33.434650455927, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=32.6283987915408, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=30.6990881458967, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=28.4153005464481, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=319, Percent_Identity=25.0783699059561, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=27.3458445040214, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37673; Mature: 37542

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAHAYAAQAADQPLAPFVFERRAPGPNDVQIDIAYCGVCHSDLHTARNEWHNTLYPSV
CCCCHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCC
PGHEIVGRVTAVGNAVTGFKVGDLAGVGCMVDSCRSCASCQEGEEQYCEAGFTGTYNGPM
CCHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCE
FGGGENTYGGYSDHIVVDQKYVLRITHSDNLAAVAPLLCAGITTYSPLAHWKVGPGQKVG
ECCCCCCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECCCCCEEE
VVGLGGLGHMAVKIAKAMGATVVLFTTSESKRADALRLGASEVVISKDEAQMAAQYNTLD
EEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCEEEECHHHHHHHHHHHHH
FILNTVAAPHNLDPFLNALKRDGAIVLVGVPEQSHPSPAVFNLVMKRRTLAGSLIGGIRQ
HHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCAKHNIVSDIETIRADQINEAYERMLKSDVKYRFVIDMATLDQAA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCC
>Mature Secondary Structure 
STAHAYAAQAADQPLAPFVFERRAPGPNDVQIDIAYCGVCHSDLHTARNEWHNTLYPSV
CCCHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCC
PGHEIVGRVTAVGNAVTGFKVGDLAGVGCMVDSCRSCASCQEGEEQYCEAGFTGTYNGPM
CCHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCE
FGGGENTYGGYSDHIVVDQKYVLRITHSDNLAAVAPLLCAGITTYSPLAHWKVGPGQKVG
ECCCCCCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECCCCCEEE
VVGLGGLGHMAVKIAKAMGATVVLFTTSESKRADALRLGASEVVISKDEAQMAAQYNTLD
EEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCEEEECHHHHHHHHHHHHH
FILNTVAAPHNLDPFLNALKRDGAIVLVGVPEQSHPSPAVFNLVMKRRTLAGSLIGGIRQ
HHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCAKHNIVSDIETIRADQINEAYERMLKSDVKYRFVIDMATLDQAA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]