Click here to switch to the map view.

The map label for this gene is dnaA [H]

Identifier: 21240775

GI number: 21240775

Start: 42

End: 1370

Strand: Direct

Name: dnaA [H]

Synonym: XAC0001

Alternate gene names: 21240775

Gene position: 42-1370 (Clockwise)

Preceding gene: NA

Following gene: 21240776

Centisome position: 0.0

GC content: 65.24

Gene sequence:

>1329_bases
ATGGATGCTTGGCCCCGCTGTCTGGAACGTCTCGAAGCCGAATTCCCGCCCGAAGATGTCCACACCTGGTTGAAACCCCT
GCAAGCCGAAGATCGCGGCGACAGCATCGTGCTGTACGCTCCGAACGCCTTCATCGTCGACCAGGTGCGCGAACGTTACC
TGCCGCGCATTCGCGAATTGCTGGCGTATTTCGTCGGCAATGGCGACGTCGCGCTGGCGGTCGGTTCGCGTCCACGCGCG
CCCGAGCCGGCCCCTGCACCCGTGGCCGTGCCGAGCGCGCCGCAGGCTGCACCGATCGTGCCGTTCGCCGGCAACCTGGA
TTCGCATTACACCTTCGCCAACTTCGTGGAAGGCCGCAGCAACCAGTTGGGCCTGGCGGCCGCGATCCAGGCTGCACAGA
AGCCCGGCGACCGTGCACACAACCCGTTGCTGCTGTACGGCAGCACCGGTCTGGGCAAGACCCACCTGATGTTCGCGGCC
GGCAATGCGCTGCGTCAGGCCAATCCGGCCGCCAAGGTGATGTATCTGCGTTCGGAGCAGTTCTTCAGCGCGATGATCCG
GGCGCTGCAGGACAAGGCGATGGACCAGTTCAAGCGCCAGTTCCAGCAGATCGATGCGCTGCTGATCGACGACATCCAGT
TCTTCGCCGGCAAGGACCGCACCCAGGAAGAGTTCTTCCACACCTTCAACGCGCTGTTCGATGGCCGCCAACAGATCATC
CTGACCTGCGACCGCTACCCGCGCGAGGTCGAAGGCCTGGAGCCGCGGCTGAAGTCGCGCCTGGCCTGGGGCCTGTCGGT
GGCGATCGACCCGCCGGACTTCGAGACCCGCGCGGCCATCGTGCTGGCCAAGGCGCGCGAGCGCGGCGCCGAAATTCCCG
ACGACGTGGCATTCCTGATCGCCAAGAAGATGCGCTCCAACGTGCGCGACCTTGAAGGCGCGCTCAACACGCTGGTGGCG
CGTGCCAACTTCACCGGGCGCTCGATCACGGTGGAATTTGCCCAGGAGACGCTGCGCGACCTGCTGCGCGCCCAGCAACA
GGCGATCGGCATTCCCAATATCCAGAAGACTGTGGCCGATTACTACGGCTTGCAAATGAAGGATCTGCTGTCCAAGCGGC
GCACCCGCTCGCTGGCGCGCCCGCGCCAGGTGGCGATGGCGCTGGCCAAGGAACTCACCGAGCACAGCCTGCCGGAGATC
GGCGATGCCTTCGCTGGCCGCGACCACACCACCGTGCTGCATGCGTGCCGTCAGATCCGCACGTTGATGGAGGCCGACGG
CAAGCTCCGCGAGGACTGGGAAAAGCTGATTCGCAAGCTCAGCGAGTAA

Upstream 100 bases:

>100_bases
CTGCCCTCGGTGCTAGGCTGGTCCATCCTCTTTTCACTACCGGGCTGCGAGCACGGCGCTTTTCTGCGCGCCGCAGCCAG
CAACAGATGATCATACTTTG

Downstream 100 bases:

>100_bases
GCCATCGGCTGCCATCGGGTCCAGGCTGGAAAAAAGCGTGGAAACGTTGGGGTCAAATGCGGGAGAATCTGTGGATAACG
TTGCGCCGCAGTCGGGCTCG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIRELLAYFVGNGDVALAVGSRPRA
PEPAPAPVAVPSAPQAAPIVPFAGNLDSHYTFANFVEGRSNQLGLAAAIQAAQKPGDRAHNPLLLYGSTGLGKTHLMFAA
GNALRQANPAAKVMYLRSEQFFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQII
LTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLIAKKMRSNVRDLEGALNTLVA
RANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVADYYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEI
GDAFAGRDHTTVLHACRQIRTLMEADGKLREDWEKLIRKLSE

Sequences:

>Translated_442_residues
MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIRELLAYFVGNGDVALAVGSRPRA
PEPAPAPVAVPSAPQAAPIVPFAGNLDSHYTFANFVEGRSNQLGLAAAIQAAQKPGDRAHNPLLLYGSTGLGKTHLMFAA
GNALRQANPAAKVMYLRSEQFFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQII
LTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLIAKKMRSNVRDLEGALNTLVA
RANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVADYYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEI
GDAFAGRDHTTVLHACRQIRTLMEADGKLREDWEKLIRKLSE
>Mature_442_residues
MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIRELLAYFVGNGDVALAVGSRPRA
PEPAPAPVAVPSAPQAAPIVPFAGNLDSHYTFANFVEGRSNQLGLAAAIQAAQKPGDRAHNPLLLYGSTGLGKTHLMFAA
GNALRQANPAAKVMYLRSEQFFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQII
LTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLIAKKMRSNVRDLEGALNTLVA
RANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVADYYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEI
GDAFAGRDHTTVLHACRQIRTLMEADGKLREDWEKLIRKLSE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=55.0537634408602, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI226510964, Length=231, Percent_Identity=27.7056277056277, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 49539; Mature: 49539

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIREL
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LAYFVGNGDVALAVGSRPRAPEPAPAPVAVPSAPQAAPIVPFAGNLDSHYTFANFVEGRS
HHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
NQLGLAAAIQAAQKPGDRAHNPLLLYGSTGLGKTHLMFAAGNALRQANPAAKVMYLRSEQ
CCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHH
FFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEE
LTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLI
EECCCCCCHHCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
AKKMRSNVRDLEGALNTLVARANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVAD
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEIGDAFAGRDHTTVLHACRQIR
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHH
TLMEADGKLREDWEKLIRKLSE
HHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIREL
CCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
LAYFVGNGDVALAVGSRPRAPEPAPAPVAVPSAPQAAPIVPFAGNLDSHYTFANFVEGRS
HHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
NQLGLAAAIQAAQKPGDRAHNPLLLYGSTGLGKTHLMFAAGNALRQANPAAKVMYLRSEQ
CCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHH
FFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEE
LTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLI
EECCCCCCHHCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
AKKMRSNVRDLEGALNTLVARANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVAD
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEIGDAFAGRDHTTVLHACRQIR
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHH
TLMEADGKLREDWEKLIRKLSE
HHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA