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The map label for this gene is nuoH

Identifier: 161485711

GI number: 161485711

Start: 3157216

End: 3158307

Strand: Reverse

Name: nuoH

Synonym: XAC2697

Alternate gene names: 161485711

Gene position: 3158307-3157216 (Counterclockwise)

Preceding gene: 21243426

Following gene: 21243424

Centisome position: 61.02

GC content: 60.44

Gene sequence:

>1092_bases
ATGAACGAATTGCTGTTGAACCTGGTCGACCCGTTGCACCAGTGGTTCCTGGGACTGGGCGATGGCGGCGCAGTGCTCTG
GTCGGTATTGAAGATCCTGCTGATCGCCGTGCCGGTGATCGTGACGGTGGCCTTCTACGTGGTCTGGGAGCGCAAGCTGA
TCGGCTGGATGCACGTGCGCCACGGGCCCATGTACGTGGGTATGGGCATCTTCCAGGCCTTCGCCGACGTGTTCAAACTC
CTGTTCAAGGAGATCGTGCAACCGGCCAGCTCGCACAAGGCGATGTTCGTCATCGCACCGCTGCTGACACTGGCGCCGGC
CTTCGCCGCGTGGTCGGTGGTGCCGTTCGATGCGAAGCTTGTGTTGTCCAATGCCAACGTCGGCCTGCTGTATCTGCTGG
CGATGACCTCGCTGGGCGTGTACGGCATCATCCTGGCCGGCTGGGCGTCGAACTCGAAGTACGCCTTCCTGGGCGCGATG
CGTTCGGCCGCGCAGGTGGTCAGCTACGAAATTGCGATGGGCTTTGCGCTGGTCGGTGTGATGATTGCCTCCGGCAGCGT
CAACCTGAGCCAGATCGTGTTCGCTCAGGCCGGCAATTCCGGCTTCTTCGACTGGTTCCTGATTCCGCTGTTCCCGTTGT
TCATCGTGTACTGGGTTTCTGGCGTCGCCGAAACCAACCGCGCGCCGTTCGACGTGGTGGAAGGCGAATCGGAAATCGTC
GCCGGTCACATGGTGGAATATTCGGGCGGTGCGTTCGCACTGTTCTTCCTGGCCGAATACGCCAACATGATCCTGGTCAG
CTTCCTGATCTCGATCTTCTTCCTCGGCGGTTGGTTGAGCCCGATCCAGGGCTGGGTCAATGCGGACATTTCGCCGTGGA
TCGACTGGTTGTGGAAGGGCGGCTGGCCGTGGCTGCTGATGAAGGTGTTCTTCTTCGCCAGCGCCTATATCTGGTTCCGC
GCCAGCTTCCCGCGTTACCGCTACGACCAGATCATGCGTCTGGGCTGGAAGGTCTTCATTCCGCTCACGATCGTGTGGAT
CGCAGTGACGGCGTTGATGGTGTTTTACGGCGTGATCCAGAAGGGCGTGTAA

Upstream 100 bases:

>100_bases
TGGTGCTGGACAAGCGCGTCGCACCGGGCACGGTGTGGATCGAATCCGGCCATGGTGCAACCGCACCGCTCGGTGCCGGT
CGTGTAACGGTGGTGGCTGC

Downstream 100 bases:

>100_bases
TCGATGAACAAGATCACCCATTACTTCAAGAGCCTGCTGCTGCTCGAATTGCTCGGCGGTTTGTGGCTGACGTTGAAATA
CACGTTCAAGCCCAAGTACA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNELLLNLVDPLHQWFLGLGDGGAVLWSVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKL
LFKEIVQPASSHKAMFVIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVNADISPWIDWLWKGGWPWLLMKVFFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV

Sequences:

>Translated_363_residues
MNELLLNLVDPLHQWFLGLGDGGAVLWSVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKL
LFKEIVQPASSHKAMFVIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVNADISPWIDWLWKGGWPWLLMKVFFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV
>Mature_363_residues
MNELLLNLVDPLHQWFLGLGDGGAVLWSVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKL
LFKEIVQPASSHKAMFVIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVNADISPWIDWLWKGGWPWLLMKVFFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=303, Percent_Identity=39.6039603960396, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1788618, Length=331, Percent_Identity=38.9728096676737, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_XANAC (Q8PJ47)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643007.2
- GeneID:   1156768
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2697
- NMPDR:   fig|190486.1.peg.2651
- HOGENOM:   HBG727670
- OMA:   SSHKAMF
- ProtClustDB:   PRK06076
- BioCyc:   XAXO190486:XAC2697-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 40449; Mature: 40449

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10b01314)-; HASH(0x11310360)-; HASH(0x11308984)-; HASH(0x10a51f58)-; HASH(0x11305f88)-; HASH(0x1130aeb0)-; HASH(0x10f1e498)-; HASH(0x112d87d4)-; HASH(0x10d3b834)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELLLNLVDPLHQWFLGLGDGGAVLWSVLKILLIAVPVIVTVAFYVVWERKLIGWMHVR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGPMYVGMGIFQAFADVFKLLFKEIVQPASSHKAMFVIAPLLTLAPAFAAWSVVPFDAKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEECCCCCEE
VLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGV
EEECCCHHHHHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
HHHCCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEE
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVNADISPWIDWLWKG
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
GWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQ
CCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGV
HCH
>Mature Secondary Structure
MNELLLNLVDPLHQWFLGLGDGGAVLWSVLKILLIAVPVIVTVAFYVVWERKLIGWMHVR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGPMYVGMGIFQAFADVFKLLFKEIVQPASSHKAMFVIAPLLTLAPAFAAWSVVPFDAKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEECCCCCEE
VLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGV
EEECCCHHHHHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MIASGSVNLSQIVFAQAGNSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
HHHCCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEE
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVNADISPWIDWLWKG
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
GWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQ
CCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGV
HCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217