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The map label for this gene is algC [H]

Identifier: 57238444

GI number: 57238444

Start: 1494240

End: 1495610

Strand: Reverse

Name: algC [H]

Synonym: CJE1594

Alternate gene names: 57238444

Gene position: 1495610-1494240 (Counterclockwise)

Preceding gene: 57238447

Following gene: 57238443

Centisome position: 84.13

GC content: 31.87

Gene sequence:

>1371_bases
ATGTTAGATGTGATTTTTAGAGAATATGATATAAGAGGACTTTATGGCAAAGAACTGAATGAAAAAAGCGTTAAAGCTAT
AGGTTTTTGCTTGGGACAAACCATGCTAAATAAAGGCTGTAAAAATGTAAGTGTGGGCTATGATGCAAGATATAGTGCAA
ATGAGCTTTTTAATTATCTGGTGAGTGGACTTAACAAAGCGGGAATAAAAATCTATGATATAGGGCTTGCGCCAACTCCA
TTGGGGTATTTTAGTCTTTATGAGGGCTTGAAATTTGATGCAAATGTTATGATAACAGGCTCTCATAACCCAAAAGATTA
TAATGGTTTTAAAATCACTATCAATAAAGAAAGTTTTTTTGGCGTAGAGTTAAAAGAGTTTTCAAAAGAAGTTTATAAGC
ATTTAAATGATGATATTGAAGAAAATTTAGAAGTAGAAAAATACGATATTTTAAGCCTTTATGTGAAATTTATATGTGAG
CAATTTAGCTTTTTAAAGGATTTTAATTATAAATTTGGTGTTGATTGTACAAATGGTGCGGCTGGAGTAGTGATAGAGCC
TTTAATCAAGGCTTTAAATTTAAAAGCTCATGTAATGTTTGCAGAGCCTGATGGACAGTTTCCAAACCATGCCCCAGATC
CTACAGAAGAAGAAAACTTAAGTGCGATTAGAGAATTTTTAAATCAAAATCAAGATTATTCTTTGGCTTTTGCTTTTGAT
GGGGATGCTGATAGAATGGTTGCTTTAAGTAAAACTCATGTATTTTGTGGGGATGAGCTTTGTTATTTGTTTGCTAAAAA
TATCCCTAATCCACGCATTTTAGGCGAGGTAAAATGTTCTAAAAATCTTTTTGATGAAGTGGCTAAATTTGGAACTATTT
TTATGGGAAAAACAGGACATTCTAATATCAAAAAAATGATGAAAGAAAAAGATATTGATTTAGCTGCTGAGGTGAGTGGG
CATATTTTCTTTAAACATAGATATTTTGGTTATGATGATGGAATTTATGCATTTTTAAGAGCCTTGGAGCTTGTTTATAA
AGGTTTTGATCTAGAAAGTATGATTAGAGCTTTACCAAAACTTTATACTACACCTGAAATTAAAATTCCTGTAAATGAAG
AAGAAAAATTCAAACTTGTGGAAGAATTTCAAAAAGAGATTGAAAAAGGAGCTTTAAAAGGTGTTAAAAGTCTTTGTGAA
ATTGATGGAGCTAGGATAGATTTTGGCGATGGATGGGCTTTACTTCGTGCATCTAACACCAGCCCTTATCTTATCACACG
CTTTGAGGCAACGTCTTTAGAAAGAGCAAAAGAGCTTGAAAGTATGGTATTTACTTTATTTGATGATATAAAAGCTAGAT
TTAAGAATTGA

Upstream 100 bases:

>100_bases
AATTAATGTAAAATTGTAGCAAAAATTTCTTTTCTATCCAAATTTGCTTTAGAAAAACGATAAATTTAGGTTAAAGAAGA
GATGAATTTGAAGGAAAAAA

Downstream 100 bases:

>100_bases
TGAGATAATATTTCGCGATTTAAATTTATCTTAAAAAGGAATAAAAAATGAAAAAAATACTTGTTCTACTTACGCTATGT
GCTTTTGCTTTTGGTGCAAG

Product: phosphomannomutase/phosphoglucomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLDVIFREYDIRGLYGKELNEKSVKAIGFCLGQTMLNKGCKNVSVGYDARYSANELFNYLVSGLNKAGIKIYDIGLAPTP
LGYFSLYEGLKFDANVMITGSHNPKDYNGFKITINKESFFGVELKEFSKEVYKHLNDDIEENLEVEKYDILSLYVKFICE
QFSFLKDFNYKFGVDCTNGAAGVVIEPLIKALNLKAHVMFAEPDGQFPNHAPDPTEEENLSAIREFLNQNQDYSLAFAFD
GDADRMVALSKTHVFCGDELCYLFAKNIPNPRILGEVKCSKNLFDEVAKFGTIFMGKTGHSNIKKMMKEKDIDLAAEVSG
HIFFKHRYFGYDDGIYAFLRALELVYKGFDLESMIRALPKLYTTPEIKIPVNEEEKFKLVEEFQKEIEKGALKGVKSLCE
IDGARIDFGDGWALLRASNTSPYLITRFEATSLERAKELESMVFTLFDDIKARFKN

Sequences:

>Translated_456_residues
MLDVIFREYDIRGLYGKELNEKSVKAIGFCLGQTMLNKGCKNVSVGYDARYSANELFNYLVSGLNKAGIKIYDIGLAPTP
LGYFSLYEGLKFDANVMITGSHNPKDYNGFKITINKESFFGVELKEFSKEVYKHLNDDIEENLEVEKYDILSLYVKFICE
QFSFLKDFNYKFGVDCTNGAAGVVIEPLIKALNLKAHVMFAEPDGQFPNHAPDPTEEENLSAIREFLNQNQDYSLAFAFD
GDADRMVALSKTHVFCGDELCYLFAKNIPNPRILGEVKCSKNLFDEVAKFGTIFMGKTGHSNIKKMMKEKDIDLAAEVSG
HIFFKHRYFGYDDGIYAFLRALELVYKGFDLESMIRALPKLYTTPEIKIPVNEEEKFKLVEEFQKEIEKGALKGVKSLCE
IDGARIDFGDGWALLRASNTSPYLITRFEATSLERAKELESMVFTLFDDIKARFKN
>Mature_456_residues
MLDVIFREYDIRGLYGKELNEKSVKAIGFCLGQTMLNKGCKNVSVGYDARYSANELFNYLVSGLNKAGIKIYDIGLAPTP
LGYFSLYEGLKFDANVMITGSHNPKDYNGFKITINKESFFGVELKEFSKEVYKHLNDDIEENLEVEKYDILSLYVKFICE
QFSFLKDFNYKFGVDCTNGAAGVVIEPLIKALNLKAHVMFAEPDGQFPNHAPDPTEEENLSAIREFLNQNQDYSLAFAFD
GDADRMVALSKTHVFCGDELCYLFAKNIPNPRILGEVKCSKNLFDEVAKFGTIFMGKTGHSNIKKMMKEKDIDLAAEVSG
HIFFKHRYFGYDDGIYAFLRALELVYKGFDLESMIRALPKLYTTPEIKIPVNEEEKFKLVEEFQKEIEKGALKGVKSLCE
IDGARIDFGDGWALLRASNTSPYLITRFEATSLERAKELESMVFTLFDDIKARFKN

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=464, Percent_Identity=29.5258620689655, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789566, Length=465, Percent_Identity=25.1612903225806, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51844; Mature: 51844

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVIFREYDIRGLYGKELNEKSVKAIGFCLGQTMLNKGCKNVSVGYDARYSANELFNYL
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
VSGLNKAGIKIYDIGLAPTPLGYFSLYEGLKFDANVMITGSHNPKDYNGFKITINKESFF
HHCCCCCCEEEEECCCCCCCCHHHHHHCCCEECCEEEEECCCCCCCCCCEEEEEECCCCC
GVELKEFSKEVYKHLNDDIEENLEVEKYDILSLYVKFICEQFSFLKDFNYKFGVDCTNGA
CCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
AGVVIEPLIKALNLKAHVMFAEPDGQFPNHAPDPTEEENLSAIREFLNQNQDYSLAFAFD
CCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
GDADRMVALSKTHVFCGDELCYLFAKNIPNPRILGEVKCSKNLFDEVAKFGTIFMGKTGH
CCCCCEEEEECCEEEECCHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCEEEECCCCH
SNIKKMMKEKDIDLAAEVSGHIFFKHRYFGYDDGIYAFLRALELVYKGFDLESMIRALPK
HHHHHHHHHCCCCEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LYTTPEIKIPVNEEEKFKLVEEFQKEIEKGALKGVKSLCEIDGARIDFGDGWALLRASNT
HCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCC
SPYLITRFEATSLERAKELESMVFTLFDDIKARFKN
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDVIFREYDIRGLYGKELNEKSVKAIGFCLGQTMLNKGCKNVSVGYDARYSANELFNYL
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
VSGLNKAGIKIYDIGLAPTPLGYFSLYEGLKFDANVMITGSHNPKDYNGFKITINKESFF
HHCCCCCCEEEEECCCCCCCCHHHHHHCCCEECCEEEEECCCCCCCCCCEEEEEECCCCC
GVELKEFSKEVYKHLNDDIEENLEVEKYDILSLYVKFICEQFSFLKDFNYKFGVDCTNGA
CCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
AGVVIEPLIKALNLKAHVMFAEPDGQFPNHAPDPTEEENLSAIREFLNQNQDYSLAFAFD
CCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
GDADRMVALSKTHVFCGDELCYLFAKNIPNPRILGEVKCSKNLFDEVAKFGTIFMGKTGH
CCCCCEEEEECCEEEECCHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCEEEECCCCH
SNIKKMMKEKDIDLAAEVSGHIFFKHRYFGYDDGIYAFLRALELVYKGFDLESMIRALPK
HHHHHHHHHCCCCEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LYTTPEIKIPVNEEEKFKLVEEFQKEIEKGALKGVKSLCEIDGARIDFGDGWALLRASNT
HCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCC
SPYLITRFEATSLERAKELESMVFTLFDDIKARFKN
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]