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The map label for this gene is glmS [H]

Identifier: 57238410

GI number: 57238410

Start: 1456083

End: 1457879

Strand: Reverse

Name: glmS [H]

Synonym: CJE1558

Alternate gene names: 57238410

Gene position: 1457879-1456083 (Counterclockwise)

Preceding gene: 57238411

Following gene: 57238409

Centisome position: 82.0

GC content: 34.45

Gene sequence:

>1797_bases
ATGTGTGGAATCGTAGGTTATATAGGAAATAATGAAAAAAAACAAATTATACTAAATGGACTTAAAGAATTGGAATATCG
TGGCTATGATAGTGCGGGTATGGCAGTGATGCAAGAAGGAGAGCTCAGTTTTTTTAAAGCTGTAGGAAAGCTTGAAAATT
TGGCGAATAAATGCACGGATTTTGAAAGTCAAGGTTATGGTTTTGCTATAGGTCATACAAGATGGGCAACTCATGGTAAG
CCTACTGAAATCAACGCACATCCTCATTTAGGACAGTATTCTTGTGTGATTCACAATGGTATTATAGAAAATTATAAAGA
AATCAAAGATAAACTTGAAAAAGAAGGCGTGAGTTTTTTAAGTCAAACCGATACAGAAGTTATTGTCCAGCTTTTTGAAT
TATATGCAAGAAATTTGGGAGTTTTTGAAGCTTGGCAAAAAACCATCAAAGAACTTCGCGGTGCTTTTGCTACTTTGTTG
GTAACAAAAAAAGATCCCAATCATGTGTATTTTGCAAAAAATGCTGCTCCTTTGATTATCGGTAAAAATGCAAATAAAGA
ATGGTATTTTTCTTCAGGTGATGCGCCTTTGATAGGAAGTTGTGATGAGGTAATGTATCTTGAAGATTTAAGCTTGGGAT
ACGCGAGTAAAGATGAGCTTGTCGTTTATGAAAATGATATTTTAAAATCACTTTGTTTTTCTAAGCTTTCAGGCGATAAG
GCTTATGCAAAAAAAGACGGCTTTCGTTTTTTTATGGAAAAAGAAATTTATGAACAAAGTCGCGTGATGAGTGAAGTTTT
AATGGGGCGTATTCAAGGCGATGAAGTCGTTTTTGATGAGCTAAACAATGAAGATTTAAGTCAAGTAGATGAAATCACGC
TTTGTGCTTGTGGAACAAGCTATCATGCTGCAATGGCAAGTGCTTATTTGTTTGAAAGAATTGCTAAAGTTAAAGCTAAA
GTAGAAATTGCAAGTGAATTTCGCTACCGTGAAGCAATTATAAAAAAGGATTCTTTATTTATCGTTATTTCTCAAAGTGG
AGAAACAGCAGACACTTTAGAGGCTTTAAAGATTGCAAAAGAGCAGAGTGCTAAGACTTTTGCAATTTGCAATGTGGATA
ATTCTAATATAGTGCGTTTAGCACACCTAAGTCTTTTAACTCGTGCAGGTATAGAAAAAGGAGTTGCTTCAACTAAAGCT
TTTGCGACTCAAGTTTTAACCCTTTGGATGTTTGCTATTTTTATGGCACAAAAAAGAAATTTAAATGTTTCTGCTGAAAT
TAAAGCACTTTTGCATACTCCAAATTGCGTGAGTGTAAAACAGGCTTTACATGAAAAAATTCATCGTTTATCCAAGCGTT
ATTTAGATGGACATGGCTTTTTCTTTATAGGCAGAGATGTGTTTTATCCTTTGGCTTTAGAAGGAGCTTTGAAACTTAAA
GAATTATCTTATCTTCACGCTGAGGGTTATCCTGCAGGAGAGATGAAACATGGCCCTATTGCTTTGGCTGATTCTAAGCT
TTATACTATAGCTTTAATGCCAAAGCACATGCTTTATGAAAAAACAAAATCAAATGTTGAAGAGCTTATTGCTAGGGATT
CTACAGTGCTTAGCATTTCACCTTTAGAATTTGATTTAAGTGATGATTTTATAAAAACCAATGAGCAAGATCATTATATG
TGTGAATTTTTTGAAATGATGGTCATTACTCAACTTTTGGCGATGGAAATTTCCATAAGACTTGGCAATGATGTGGATAT
GCCAAGAAATTTGGCTAAAAGCGTAACGGTAGAATAG

Upstream 100 bases:

>100_bases
ATAAGACAAAGGACGCGTAATATTTTTATTTTTCAAAAGAATGAAAAATTAGAACATAGCGAGCAAAAGTTAGTTAATTT
ATTAATAAGTGAGTAAAAAA

Downstream 100 bases:

>100_bases
AAATGAAAAAATTTTTTTGTTTAACTTTAGTTTGTAAACTTTTTGCTTTAAGCGAATTTGAACTTCATCATATTGATAAA
GTACATAAGCTAGGGTATAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCTDFESQGYGFAIGHTRWATHGK
PTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFLSQTDTEVIVQLFELYARNLGVFEAWQKTIKELRGAFATLL
VTKKDPNHVYFAKNAAPLIIGKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVVYENDILKSLCFSKLSGDK
AYAKKDGFRFFMEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTSYHAAMASAYLFERIAKVKAK
VEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAKEQSAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKA
FATQVLTLWMFAIFMAQKRNLNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
ELSYLHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSISPLEFDLSDDFIKTNEQDHYM
CEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE

Sequences:

>Translated_598_residues
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCTDFESQGYGFAIGHTRWATHGK
PTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFLSQTDTEVIVQLFELYARNLGVFEAWQKTIKELRGAFATLL
VTKKDPNHVYFAKNAAPLIIGKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVVYENDILKSLCFSKLSGDK
AYAKKDGFRFFMEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTSYHAAMASAYLFERIAKVKAK
VEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAKEQSAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKA
FATQVLTLWMFAIFMAQKRNLNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
ELSYLHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSISPLEFDLSDDFIKTNEQDHYM
CEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE
>Mature_598_residues
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCTDFESQGYGFAIGHTRWATHGK
PTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFLSQTDTEVIVQLFELYARNLGVFEAWQKTIKELRGAFATLL
VTKKDPNHVYFAKNAAPLIIGKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVVYENDILKSLCFSKLSGDK
AYAKKDGFRFFMEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTSYHAAMASAYLFERIAKVKAK
VEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAKEQSAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKA
FATQVLTLWMFAIFMAQKRNLNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
ELSYLHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSISPLEFDLSDDFIKTNEQDHYM
CEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=32.4599708879185, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=31.4868804664723, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=41.0339256865913, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1788651, Length=201, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=427, Percent_Identity=33.4894613583138, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17532897, Length=427, Percent_Identity=33.4894613583138, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=32.3325635103926, Blast_Score=204, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322745, Length=442, Percent_Identity=32.8054298642534, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=30.4449648711944, Blast_Score=167, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=33.8164251207729, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=31.9884726224784, Blast_Score=321, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67219; Mature: 67219

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCTD
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCC
FESQGYGFAIGHTRWATHGKPTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFL
CCCCCCEEEECCCEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIVQLFELYARNLGVFEAWQKTIKELRGAFATLLVTKKDPNHVYFAKNAAPLII
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCEEEE
GKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVVYENDILKSLCFSKLSGDK
ECCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCH
AYAKKDGFRFFMEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHEEEEECCCH
YHAAMASAYLFERIAKVKAKVEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
EQSAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKAFATQVLTLWMFAIFMAQKRN
HCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
CCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCHHHHH
ELSYLHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSIS
HHHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEE
PLEFDLSDDFIKTNEQDHYMCEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE
CCEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCTD
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCC
FESQGYGFAIGHTRWATHGKPTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFL
CCCCCCEEEECCCEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIVQLFELYARNLGVFEAWQKTIKELRGAFATLLVTKKDPNHVYFAKNAAPLII
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCEEEE
GKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVVYENDILKSLCFSKLSGDK
ECCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCH
AYAKKDGFRFFMEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTS
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHEEEEECCCH
YHAAMASAYLFERIAKVKAKVEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
EQSAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKAFATQVLTLWMFAIFMAQKRN
HCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
CCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCHHHHH
ELSYLHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSIS
HHHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEE
PLEFDLSDDFIKTNEQDHYMCEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE
CCEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]