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The map label for this gene is fumC [H]

Identifier: 57238408

GI number: 57238408

Start: 1451508

End: 1452899

Strand: Reverse

Name: fumC [H]

Synonym: CJE1556

Alternate gene names: 57238408

Gene position: 1452899-1451508 (Counterclockwise)

Preceding gene: 57238409

Following gene: 57238405

Centisome position: 81.72

GC content: 36.35

Gene sequence:

>1392_bases
ATGGAATACAGAGTTGAACATGATACCATGGGTGAAGTTAAGGTCCCAAATGACAAATATTGGGGAGCTCAAACTGAAAG
AAGTTTTGAAAATTTCAAAATCGGTTGCGAGAAAATGCCAAAGGTTTTAATCTATGCTTTTACAAATCTTAAAAAATCTT
TAGCTTTGGTCAATAACAAACTTGGCAAACTTGATGATGCTAAGAAAAATGCTATAGTTCAAGCTTGCGATGAGATTATC
GCAGGTAAATTTGATGATAATTTTCCACTTGCGATTTGGCAAACAGGTTCAGGCACACAAAGCAATATGAATATGAATGA
AGTTATTGCAAATCGTGCCACTGAAATCATGGGCGGGGATTTTCGCAAAGAAAAGCTTGTACATCCAAATGATCATGTTA
ATATGAGTCAAAGTTCAAATGATACTTTTCCAACAGCTATGAGTATCGTTGCGGTTGAGCAAGTAGAGAAAAAGCTTATC
CCTGCGCTTGATGAGCTTATTGCAACTTTTGAAAAAAAAGTAAAAGAATTTGATAGTATTATCAAGATAGGACGCACGCA
TTTACAAGATGCTACTCCACTTACTCTAGCACAAGAATTTAGTGGATATCTTTCTATGCTTTTGCATTCAAAAGAGCAAA
TCATCGCTTCTTTACCAACTTTAAGAGAACTTGCCATAGGAGGAACCGCAGTAGGAACAGGGCTTAATGCGCATCCAGAA
TTAAGCCAAAAAGTAAGTGAAGAGCTAACTCAACTTATAGGTACGAAATTTGTTTCAAGTCCAAATAAATTTCATGCTTT
AACAAGTCATGATGCGATCAATTTTACTCATGGAGCTATGAAGGGTTTGGCTGCAAATTTAATGAAAATTGCAAATGATA
TAAGATGGTTAGCTTCAGGCCCAAGATGCGGTCTTGGTGAGCTTATCATCCCTGAAAATGAGCCAGGAAGTTCGATTATG
CCAGGTAAGGTAAATCCTACCCAGTGTGAAGCTGTTACTATGGTTGCTGTACAAGTGATGGGAAATGATGCAGCTATCGG
ATTTGCAGCAAGTCAAGGAAATTTTGAACTTAATGTGTTTAAGCCTGTGATTATTTATAATTTCTTGCAAAGTCTTGATT
TGTTAGCTGATTCTATGCATTCATTCAATATCCATTGTGCTGTAGGCATAGAACCAAATCGTGCAAAAATCGATCATAAT
CTTCATAATTCTTTAATGCTAGTTACCGCTCTAAACCCATACATAGGTTATGAAAACGCTGCTAAAGTAGCCAAAAATGC
CCATAAAAAAGGTATTTCTTTAAAAGAAAGCGCAATGGAGCTTGGTTTGGTTAGCGAAGAAGATTTCAATAAATTTGTTG
ATCCTACTAAAATGATAGGTCCAAAAGCCTAG

Upstream 100 bases:

>100_bases
GCCTATGAATTGCATTTAATGAGTTCAGTAGGAAAACGTTTTTGAAAGTATTTATTTTTTTAGCTTATAATAAATAAAAT
TTTAATCAAAGGAAAAAATT

Downstream 100 bases:

>100_bases
AACATAAAACTTGCCTTTTTTAAGGCAAGTTAAATTAAATTCTTATCTTTTAAAATCACATACATTCTTAAAGTTGATAC
AAAAAAAGTTAAAATCGCAG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MEYRVEHDTMGEVKVPNDKYWGAQTERSFENFKIGCEKMPKVLIYAFTNLKKSLALVNNKLGKLDDAKKNAIVQACDEII
AGKFDDNFPLAIWQTGSGTQSNMNMNEVIANRATEIMGGDFRKEKLVHPNDHVNMSQSSNDTFPTAMSIVAVEQVEKKLI
PALDELIATFEKKVKEFDSIIKIGRTHLQDATPLTLAQEFSGYLSMLLHSKEQIIASLPTLRELAIGGTAVGTGLNAHPE
LSQKVSEELTQLIGTKFVSSPNKFHALTSHDAINFTHGAMKGLAANLMKIANDIRWLASGPRCGLGELIIPENEPGSSIM
PGKVNPTQCEAVTMVAVQVMGNDAAIGFAASQGNFELNVFKPVIIYNFLQSLDLLADSMHSFNIHCAVGIEPNRAKIDHN
LHNSLMLVTALNPYIGYENAAKVAKNAHKKGISLKESAMELGLVSEEDFNKFVDPTKMIGPKA

Sequences:

>Translated_463_residues
MEYRVEHDTMGEVKVPNDKYWGAQTERSFENFKIGCEKMPKVLIYAFTNLKKSLALVNNKLGKLDDAKKNAIVQACDEII
AGKFDDNFPLAIWQTGSGTQSNMNMNEVIANRATEIMGGDFRKEKLVHPNDHVNMSQSSNDTFPTAMSIVAVEQVEKKLI
PALDELIATFEKKVKEFDSIIKIGRTHLQDATPLTLAQEFSGYLSMLLHSKEQIIASLPTLRELAIGGTAVGTGLNAHPE
LSQKVSEELTQLIGTKFVSSPNKFHALTSHDAINFTHGAMKGLAANLMKIANDIRWLASGPRCGLGELIIPENEPGSSIM
PGKVNPTQCEAVTMVAVQVMGNDAAIGFAASQGNFELNVFKPVIIYNFLQSLDLLADSMHSFNIHCAVGIEPNRAKIDHN
LHNSLMLVTALNPYIGYENAAKVAKNAHKKGISLKESAMELGLVSEEDFNKFVDPTKMIGPKA
>Mature_463_residues
MEYRVEHDTMGEVKVPNDKYWGAQTERSFENFKIGCEKMPKVLIYAFTNLKKSLALVNNKLGKLDDAKKNAIVQACDEII
AGKFDDNFPLAIWQTGSGTQSNMNMNEVIANRATEIMGGDFRKEKLVHPNDHVNMSQSSNDTFPTAMSIVAVEQVEKKLI
PALDELIATFEKKVKEFDSIIKIGRTHLQDATPLTLAQEFSGYLSMLLHSKEQIIASLPTLRELAIGGTAVGTGLNAHPE
LSQKVSEELTQLIGTKFVSSPNKFHALTSHDAINFTHGAMKGLAANLMKIANDIRWLASGPRCGLGELIIPENEPGSSIM
PGKVNPTQCEAVTMVAVQVMGNDAAIGFAASQGNFELNVFKPVIIYNFLQSLDLLADSMHSFNIHCAVGIEPNRAKIDHN
LHNSLMLVTALNPYIGYENAAKVAKNAHKKGISLKESAMELGLVSEEDFNKFVDPTKMIGPKA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.6580086580087, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=52.3809523809524, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=61.925601750547, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.8286334056399, Blast_Score=320, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=59.4360086767896, Blast_Score=559, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=58.5365853658537, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=61.038961038961, Blast_Score=569, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.6810344827586, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.6810344827586, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=54.9568965517241, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=55.0537634408602, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=49.4623655913978, Blast_Score=459, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50725; Mature: 50725

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRVEHDTMGEVKVPNDKYWGAQTERSFENFKIGCEKMPKVLIYAFTNLKKSLALVNNK
CCEECCCCCCCCEECCCCCCCCCCHHCCHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHH
LGKLDDAKKNAIVQACDEIIAGKFDDNFPLAIWQTGSGTQSNMNMNEVIANRATEIMGGD
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FRKEKLVHPNDHVNMSQSSNDTFPTAMSIVAVEQVEKKLIPALDELIATFEKKVKEFDSI
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKIGRTHLQDATPLTLAQEFSGYLSMLLHSKEQIIASLPTLRELAIGGTAVGTGLNAHPE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCCCHH
LSQKVSEELTQLIGTKFVSSPNKFHALTSHDAINFTHGAMKGLAANLMKIANDIRWLASG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PRCGLGELIIPENEPGSSIMPGKVNPTQCEAVTMVAVQVMGNDAAIGFAASQGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHEEHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLDLLADSMHSFNIHCAVGIEPNRAKIDHNLHNSLMLVTALNPYIGYENA
HHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHCCCCCCCCEEEEEECCCCCCCHHH
AKVAKNAHKKGISLKESAMELGLVSEEDFNKFVDPTKMIGPKA
HHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEYRVEHDTMGEVKVPNDKYWGAQTERSFENFKIGCEKMPKVLIYAFTNLKKSLALVNNK
CCEECCCCCCCCEECCCCCCCCCCHHCCHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHH
LGKLDDAKKNAIVQACDEIIAGKFDDNFPLAIWQTGSGTQSNMNMNEVIANRATEIMGGD
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FRKEKLVHPNDHVNMSQSSNDTFPTAMSIVAVEQVEKKLIPALDELIATFEKKVKEFDSI
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKIGRTHLQDATPLTLAQEFSGYLSMLLHSKEQIIASLPTLRELAIGGTAVGTGLNAHPE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCCCHH
LSQKVSEELTQLIGTKFVSSPNKFHALTSHDAINFTHGAMKGLAANLMKIANDIRWLASG
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PRCGLGELIIPENEPGSSIMPGKVNPTQCEAVTMVAVQVMGNDAAIGFAASQGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHEEHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLDLLADSMHSFNIHCAVGIEPNRAKIDHNLHNSLMLVTALNPYIGYENA
HHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHCCCCCCCCEEEEEECCCCCCCHHH
AKVAKNAHKKGISLKESAMELGLVSEEDFNKFVDPTKMIGPKA
HHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]