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The map label for this gene is hemH [H]

Identifier: 57238294

GI number: 57238294

Start: 545084

End: 545995

Strand: Reverse

Name: hemH [H]

Synonym: CJE0610

Alternate gene names: 57238294

Gene position: 545995-545084 (Counterclockwise)

Preceding gene: 57238293

Following gene: 57237588

Centisome position: 30.71

GC content: 27.74

Gene sequence:

>912_bases
GTGAAATTAGTTTTATTTTTAAATATGGGCGGAGCTACGAATTTACAAGATTGTGAAGTTTTTTTAAAAAATATGTTTAA
TGATCCTTATATTTTAGGAATCAAAAATCGATTTTTAAGAAAATTTGTAGCATGGATCATAACAAAGGCTCGCGTTAAAG
CCATGCAAGAAAACTATAAAAAAATGGGCGGAAAATCCCCTTTAAACGAACTTACTCAAAGCCTGTGTGACAAGCTTAAT
TTAAAACAAGATGAATTTAAATTTGATTTTGTAAATCTTTATGTTCCTCCTTTTGCCACAGAAATTTTGCAAAAATACAC
TTTAAATGCAAGTGATGAAATCATTCTTTTTCCACTTTATCCGCACCATTCTTGCACCACAGTAACTTCATCTTTAGAAG
TTCTGCAAAATGAAATTTCAAAGCAAAAAATTCAAGCAAAAGTAAAAACTATAGATATTTTTTATAAAAATGAGCTTTAT
AATGAGATGATAGTTTCGCACATTTTGGATAAAAAAAGTAAATTTGATGCCAAAATTTTGATTTTTTCAGCGCATTCTTT
GCCACAAAGCATTATTGACAAAGGTGATTTATATGAAAAGCATGTAAATGATCATGTAGAAATTTTAAAAGAAAAACTAA
AAGATCATTTTGATGAATTTATTTTAGCTTATCAGTCTAAACTAGGCCCTGTAAAATGGCTTGAACCAAATACAAGCGAT
GTTTTGGCAAATTTAAACGATAAAGCTTTGATTTATCCTATTTCTTTTTGCATTGATTGTTCTGAAACGATTTTTGAACT
AGGTATGGAGTATAAACATTTAGCAAAATGTGATTATGATTTGATAAGTTGTCCTAATAATAGTGATGAATTTATGAAAT
TTATTTTAAAGTATTTATCTGATCTTAACTAA

Upstream 100 bases:

>100_bases
CAGAACACGAAGCTTTGTTAAAACTTATCGATAATCAACCCAATCATTTAGCCAGCACGAGCGATGCTTACAAAGTTCAA
GAAATTTTAGAAAGGTTTGC

Downstream 100 bases:

>100_bases
GAATGAATTTGAGATCCTTGTCTATCATTTTTTTAAACTTTTTTGGTAAAAATTTAGCCGACTAAACCAAAGTATAAGCT
TTTTCTCCGTGCAAACTCAC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKLVLFLNMGGATNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLN
LKQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLYPHHSCTTVTSSLEVLQNEISKQKIQAKVKTIDIFYKNELY
NEMIVSHILDKKSKFDAKILIFSAHSLPQSIIDKGDLYEKHVNDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNNSDEFMKFILKYLSDLN

Sequences:

>Translated_303_residues
MKLVLFLNMGGATNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLN
LKQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLYPHHSCTTVTSSLEVLQNEISKQKIQAKVKTIDIFYKNELY
NEMIVSHILDKKSKFDAKILIFSAHSLPQSIIDKGDLYEKHVNDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNNSDEFMKFILKYLSDLN
>Mature_303_residues
MKLVLFLNMGGATNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLN
LKQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLYPHHSCTTVTSSLEVLQNEISKQKIQAKVKTIDIFYKNELY
NEMIVSHILDKKSKFDAKILIFSAHSLPQSIIDKGDLYEKHVNDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNNSDEFMKFILKYLSDLN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=295, Percent_Identity=32.5423728813559, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI60499025, Length=292, Percent_Identity=31.8493150684932, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786681, Length=305, Percent_Identity=21.3114754098361, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324750, Length=283, Percent_Identity=27.9151943462898, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17864156, Length=321, Percent_Identity=26.1682242990654, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=26.8482490272374, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552018, Length=193, Percent_Identity=26.4248704663212, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35169; Mature: 35169

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLFLNMGGATNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYK
CEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMGGKSPLNELTQSLCDKLNLKQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLY
HCCCCCCHHHHHHHHHHHCCCCCHHCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEECC
PHHSCTTVTSSLEVLQNEISKQKIQAKVKTIDIFYKNELYNEMIVSHILDKKSKFDAKIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCEEEE
IFSAHSLPQSIIDKGDLYEKHVNDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
EEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHH
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNNSDEFMKFILKYLS
HHHCCCCCEEEEEHHHHHCCHHHHHHHCCHHHHHHHCCCHHEECCCCHHHHHHHHHHHHH
DLN
CCC
>Mature Secondary Structure
MKLVLFLNMGGATNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYK
CEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMGGKSPLNELTQSLCDKLNLKQDEFKFDFVNLYVPPFATEILQKYTLNASDEIILFPLY
HCCCCCCHHHHHHHHHHHCCCCCHHCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEECC
PHHSCTTVTSSLEVLQNEISKQKIQAKVKTIDIFYKNELYNEMIVSHILDKKSKFDAKIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCEEEE
IFSAHSLPQSIIDKGDLYEKHVNDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
EEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHH
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNNSDEFMKFILKYLS
HHHCCCCCEEEEEHHHHHCCHHHHHHHCCHHHHHHHCCCHHEECCCCHHHHHHHHHHHHH
DLN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA