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The map label for this gene is purC [H]

Identifier: 57238285

GI number: 57238285

Start: 557524

End: 558234

Strand: Direct

Name: purC [H]

Synonym: CJE0619

Alternate gene names: 57238285

Gene position: 557524-558234 (Clockwise)

Preceding gene: 57238286

Following gene: 57238284

Centisome position: 31.36

GC content: 29.54

Gene sequence:

>711_bases
ATGACAAAAAAAGAAATGCTCTACGAAGGAAAAGGTAAAAAACTTTTCAAAACTGATGATGAAAATTTACTAATTAGTGA
GTTTAAAGATGATTTAACCGCTTTTAATGCAGAAAAAAGAGGCAATGAAAGTGGAAAAGGTGCATTAAACTGTAGAATCA
GTACTGAAATTTTTCATTTGCTCGAAAAAAATGGGATTAAAACCCATTTGGTAGAAACTATAAGCGATACAGAACAAGTG
GTTAAAAAATGTAAAATTGTTCCTATTGAAGTTATAGTACGCAATGTTGCAACAGGTTCTCTTACAAAAAGACTGGGCAT
TAAAGATGGCACTGTGCTACCTTTTGCTTTGGTGGAATTTTGTCTTAAAGATGATGCCTTAGGCGATCCTTTTATCAATG
ATGAGCATTGTTTGATTTTAAATTTAGTGCAAAATGAAGCTCAAATTAGTGAAATTAAAAATATGGCTAGAAAGATTAAC
TCTATTTTAACTCCATTTTTTGACAATAAAAATTTAAGGCTGATTGACTTTAAAATCGAACTGGGTTTAACTAAAGATAA
TGAACTTGTTTTAGCCGATGAAATAAGCCCTGATAGTTGTAGATTTTGGGATAAATTTAGTAATGAAAAATTAGACAAAG
ATAGATTTCGTCAAGATCTAGGTAATGTAAAAATGGCTTATGAAGAAGTTTTAAAAAGAATATTAAATTAA

Upstream 100 bases:

>100_bases
AATAAAAATCTAATCAGTCAAAAACAAATCAATGATGATGCACAGTTAAATTCAGCTATTGATACTATTAAAATTTTAAA
TATCAAACAAGGACGATAAA

Downstream 100 bases:

>100_bases
GGAAAAATATGGAAGTTATTGTAAATATTTCTTTAAAAAATGGGGTTTTAGATCCACAAGGCAAAGCGGTGGAAAAAGCT
TTGCATTCTTTAAATTTTAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCRISTEIFHLLEKNGIKTHLVETISDTEQV
VKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEFCLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKIN
SILTPFFDNKNLRLIDFKIELGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN

Sequences:

>Translated_236_residues
MTKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCRISTEIFHLLEKNGIKTHLVETISDTEQV
VKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEFCLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKIN
SILTPFFDNKNLRLIDFKIELGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN
>Mature_235_residues
TKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCRISTEIFHLLEKNGIKTHLVETISDTEQVV
KKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEFCLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKINS
ILTPFFDNKNLRLIDFKIELGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=244, Percent_Identity=32.3770491803279, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI5453539, Length=244, Percent_Identity=32.3770491803279, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI119220559, Length=251, Percent_Identity=31.4741035856574, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=42.7350427350427, Blast_Score=187, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=239, Percent_Identity=36.4016736401674, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI18860083, Length=238, Percent_Identity=28.9915966386555, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=31.5789473684211, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26954; Mature: 26823

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCRISTEIFHL
CCCHHHEECCCCCEEEECCCCCEEHHHHHHHHHHHCCHHCCCCCCCCEEEEEEHHHHHHH
LEKNGIKTHLVETISDTEQVVKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEF
HHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHH
CLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKINSILTPFFDNKNLRLIDFKIE
HHHCCCCCCCCCCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
LGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN
EECCCCCCEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKKEMLYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGALNCRISTEIFHL
CCHHHEECCCCCEEEECCCCCEEHHHHHHHHHHHCCHHCCCCCCCCEEEEEEHHHHHHH
LEKNGIKTHLVETISDTEQVVKKCKIVPIEVIVRNVATGSLTKRLGIKDGTVLPFALVEF
HHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHH
CLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKINSILTPFFDNKNLRLIDFKIE
HHHCCCCCCCCCCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
LGLTKDNELVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN
EECCCCCCEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA