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The map label for this gene is hemC [H]

Identifier: 57238255

GI number: 57238255

Start: 585744

End: 586667

Strand: Direct

Name: hemC [H]

Synonym: CJE0649

Alternate gene names: 57238255

Gene position: 585744-586667 (Clockwise)

Preceding gene: 57238256

Following gene: 57238254

Centisome position: 32.95

GC content: 32.47

Gene sequence:

>924_bases
ATGAAGCTTATTATTGCAACAAGAAAAAGTCAATTAGCTCTTTGGCAAAGTGAACATGTAGCCCAAATTTTAAAAAATAC
ACATCAAATTGAAGTGCTTTTAGAAGGTTTTAAAACAAAAGGCGATGTTTTGCTTGATTCTCCTTTGGCAAAAATTGGTG
GTAAAGGACTTTTTACAAAAGAACTTGAAGAAAGTATGTTAAGAAAAGAAGCACACTTAGCGGTGCATAGTTTAAAAGAT
GTGCCTAGTTTTTTTCCTCAAGGTTTAGTTTTGGCAGCGGTAAGTAAAAGAGAGCAAAGCAATGATGCTATGCTAAGTCA
AAATTATAAAGATTTTCTTTCTTTGCCAAAAGGTGCAAAAATAGGCACTACTAGTCTTAGACGCAAGATGCAGCTTTTAT
TATTAAGACCTGATTTAGATATTATTTCTTTGCGTGGTAATGTCAATTCTCGTATAGAGAAATTAAAAAATAATGATTTT
GATGCGATTATTTTGGCAATGGCGGGAATTAAACGCTTAAACTTAGATAAGCAAGTGAATTTTGTTTATGAATTTAGCAA
AGATGAGCTTATTCCTGCGGCTTCTCAAGGAGCTTTAGGTATAGAAAGCATAAATGATGAAAAAATTTTAGAACTTTTAA
AATGTTTAAATGATGAAAATGCTTTGATTGAAACAAGCATTGAAAGAGAATTTATTGCTACTTTAGAAGGAGGTTGTCAA
GTTCCTATAGGTATTAACGCAGAGCTCTTGGGAGATGAAATTTGTGTGCGTGCGGTACTTGGACTACCCGATGGAAGTGA
AATTTTAAAAGATAAGAGAATGATTAAAAAGAATGATTTTAAAGGTTTTGGAGAGAGTTTGGCTAAGGAGTTTATTGCTA
AAGGTGCTAAAGAACTTTTAAAAAAAGCTGAGAGTATGATATGA

Upstream 100 bases:

>100_bases
CTTTGAAATTAATAACTAAATCAAAATATCAATACACCAAGCAAGAGTATCAAAATTCTAATGAAGAAATTATTGATGTT
GAAATTATAGAGGATAGAAA

Downstream 100 bases:

>100_bases
AAGAATTTATTCAAATTTTAAAAGAAAATGATCTTTTAAGGGTAATTGAAGAACCTGTAGATGTAGATCTTGAAATCGCT
CATTTAGCCTATATAGAAGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKLIIATRKSQLALWQSEHVAQILKNTHQIEVLLEGFKTKGDVLLDSPLAKIGGKGLFTKELEESMLRKEAHLAVHSLKD
VPSFFPQGLVLAAVSKREQSNDAMLSQNYKDFLSLPKGAKIGTTSLRRKMQLLLLRPDLDIISLRGNVNSRIEKLKNNDF
DAIILAMAGIKRLNLDKQVNFVYEFSKDELIPAASQGALGIESINDEKILELLKCLNDENALIETSIEREFIATLEGGCQ
VPIGINAELLGDEICVRAVLGLPDGSEILKDKRMIKKNDFKGFGESLAKEFIAKGAKELLKKAESMI

Sequences:

>Translated_307_residues
MKLIIATRKSQLALWQSEHVAQILKNTHQIEVLLEGFKTKGDVLLDSPLAKIGGKGLFTKELEESMLRKEAHLAVHSLKD
VPSFFPQGLVLAAVSKREQSNDAMLSQNYKDFLSLPKGAKIGTTSLRRKMQLLLLRPDLDIISLRGNVNSRIEKLKNNDF
DAIILAMAGIKRLNLDKQVNFVYEFSKDELIPAASQGALGIESINDEKILELLKCLNDENALIETSIEREFIATLEGGCQ
VPIGINAELLGDEICVRAVLGLPDGSEILKDKRMIKKNDFKGFGESLAKEFIAKGAKELLKKAESMI
>Mature_307_residues
MKLIIATRKSQLALWQSEHVAQILKNTHQIEVLLEGFKTKGDVLLDSPLAKIGGKGLFTKELEESMLRKEAHLAVHSLKD
VPSFFPQGLVLAAVSKREQSNDAMLSQNYKDFLSLPKGAKIGTTSLRRKMQLLLLRPDLDIISLRGNVNSRIEKLKNNDF
DAIILAMAGIKRLNLDKQVNFVYEFSKDELIPAASQGALGIESINDEKILELLKCLNDENALIETSIEREFIATLEGGCQ
VPIGINAELLGDEICVRAVLGLPDGSEILKDKRMIKKNDFKGFGESLAKEFIAKGAKELLKKAESMI

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=280, Percent_Identity=38.5714285714286, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI66933009, Length=280, Percent_Identity=38.5714285714286, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=48.6754966887417, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6319996, Length=315, Percent_Identity=36.1904761904762, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20130425, Length=260, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34037; Mature: 34037

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIIATRKSQLALWQSEHVAQILKNTHQIEVLLEGFKTKGDVLLDSPLAKIGGKGLFTK
CEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCHHHHCCCCCHHH
ELEESMLRKEAHLAVHSLKDVPSFFPQGLVLAAVSKREQSNDAMLSQNYKDFLSLPKGAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCCC
IGTTSLRRKMQLLLLRPDLDIISLRGNVNSRIEKLKNNDFDAIILAMAGIKRLNLDKQVN
CCHHHHHHHHHHHEECCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
FVYEFSKDELIPAASQGALGIESINDEKILELLKCLNDENALIETSIEREFIATLEGGCQ
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
VPIGINAELLGDEICVRAVLGLPDGSEILKDKRMIKKNDFKGFGESLAKEFIAKGAKELL
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KKAESMI
HHHHHCC
>Mature Secondary Structure
MKLIIATRKSQLALWQSEHVAQILKNTHQIEVLLEGFKTKGDVLLDSPLAKIGGKGLFTK
CEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCHHHHCCCCCHHH
ELEESMLRKEAHLAVHSLKDVPSFFPQGLVLAAVSKREQSNDAMLSQNYKDFLSLPKGAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCCC
IGTTSLRRKMQLLLLRPDLDIISLRGNVNSRIEKLKNNDFDAIILAMAGIKRLNLDKQVN
CCHHHHHHHHHHHEECCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
FVYEFSKDELIPAASQGALGIESINDEKILELLKCLNDENALIETSIEREFIATLEGGCQ
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
VPIGINAELLGDEICVRAVLGLPDGSEILKDKRMIKKNDFKGFGESLAKEFIAKGAKELL
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KKAESMI
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA