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The map label for this gene is kefBC [H]

Identifier: 57238103

GI number: 57238103

Start: 1279948

End: 1281573

Strand: Direct

Name: kefBC [H]

Synonym: CJE1366

Alternate gene names: 57238103

Gene position: 1279948-1281573 (Clockwise)

Preceding gene: 57238102

Following gene: 57238104

Centisome position: 71.99

GC content: 30.87

Gene sequence:

>1626_bases
ATGGATAATTTTTTAGAAATTTTTTTAATCACCGTTGCTATAGCTATAGTTTTAAATGTCATATTTAAAAAATTTGAAAT
TCCAACTATCATTGGATATATAGCTGCTGGAGAAATCATTTCTGAAATTTATCATTTAAGTGGCAAAGGCGAAATCACTC
ATATAGCCGAATTTGGTATAGTGTTTTTAATGTTTACTATAGGGCTTGAATTTTCTTTTAAGCATTTAATGGCAATGAAA
CAAGAAGTTTTTTTAAACGGCTCTTTGCAGATGCTTACTTGTGGCTTTGTTTTTATGTTACTTGCTATAGGAATTTTAGG
ACTTGGAGATAAAAGCGCTACTATAGTAGGCTTTGCACTAGCGCTTTCTTCAACCGCAGTGGTGCTTAAAATTTTAAATG
ATAATGGCGATATCAATGAGCAATATGGTAGAAAAGCATTGGGAATTTTGCTTTTTCAAGATATAGCCGTTATTCCTTTG
CTTTTGCTTGTAGATATTTTTTCATCCAACAATCAAAACATAGAAAAACTCCTTTTTACCACTTTAATTTCAGCGCTTAT
TTTAATCACTTTATTATTTTTCATAGGTAAATATCTAGTGGATAGAATTTTTAGACTCATTATCCACACTTCTTCTCAAG
AAATTTTTATTAGTACTGTTTTATTTATGGTTATTGGAGCAAGTTTTTTAGCAAATTATTTTGGATTTTCTTATTCTTTG
GGTGCTTTTATAGCAGGTGCTTTGATAGCAGAAACAAAATATAAACACAAAATAGAAGCGGACTTGATCCCATTTAGAGA
TTTGCTTTTAGGGCTTTTTTTCATAACTGTAGGCATGCAAATTCAACTTGATGTAGTGGCACAAAATTGGTTTTTAATCA
TAGTTTTAACCCTTCTTGTAATGGCTTTAAAATTTGGCATAGTTTTTGGCTTTTTATTTCTTTACACCAAAAAAAGAGTA
GCGCTTAAAACAGCTTTTGCCATAGCTCAAATTGGCGAATTCGCCCTAGCAATTTTTTCTCTTTTACAAGCAAAAAATAT
GCTTGATATCAAAACTTCACAAATTTTAATTGTTGTTTCTATTTTAACCATGATTATCACACCTTTTATTTTAAACAATA
TAAGAAAAATTACCAATGTTGTAGAAGATATAGCACTTAATACCAACGCTGTGCAAAATATTGACAGCAATATCAAGCTT
AAAAATCATCTTGTTGTTTTTGGCTACGGACGCTTAGGACAAGAAGTCGTACAAAAAATCAAAAACACAGGCGTACCTTA
TCTTGTTTTAGAAAGTGATTTAAATTTAGTAGAACTTGGAGTTAGTCGAGGTGAAAATGTCGTTTTTGCCAATGCTGCTC
AAGAAGAAACCTTAAAAATTGCCAATATAGAAGAATGTGCCGTAGCTATTATCACAGTTACAAATGAAGCTAAACTTGAA
ATTTTATGTCAAGTGCTAGCTAATTATCCAAAACCTATAGACACCATCATTCATGTAAATGGAACTTTAAAAAAGATGCT
TTTTTCTAGCATAGATGAAAATATACGCATCATTCGCTCTGAAAAAGTAATCGCTAGAAATTTAGTTCAAGAAGCACTAG
AATGCCGCATTCATAAAAATACCTAA

Upstream 100 bases:

>100_bases
AGAATTAAGCAAACAACAAAATAAAGAAGCGGCTAGTAAAGCCGTTGTTAAGCATAAAAATAGCTTTGATTTGATTTTTT
ATGAGAAAAAATAAAAAATA

Downstream 100 bases:

>100_bases
GGAAGAATTTTGACAAAAAATGAAGAAAAAGCCTTACGCGTAAAATACCTAAGAAATCTTGAAAAATTTTTCAATGGCGC
TATATCTGCACTTAAAAAAG

Product: sodium/hydrogen exchanger family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MDNFLEIFLITVAIAIVLNVIFKKFEIPTIIGYIAAGEIISEIYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLMAMK
QEVFLNGSLQMLTCGFVFMLLAIGILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPL
LLLVDIFSSNNQNIEKLLFTTLISALILITLLFFIGKYLVDRIFRLIIHTSSQEIFISTVLFMVIGASFLANYFGFSYSL
GAFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLDVVAQNWFLIIVLTLLVMALKFGIVFGFLFLYTKKRV
ALKTAFAIAQIGEFALAIFSLLQAKNMLDIKTSQILIVVSILTMIITPFILNNIRKITNVVEDIALNTNAVQNIDSNIKL
KNHLVVFGYGRLGQEVVQKIKNTGVPYLVLESDLNLVELGVSRGENVVFANAAQEETLKIANIEECAVAIITVTNEAKLE
ILCQVLANYPKPIDTIIHVNGTLKKMLFSSIDENIRIIRSEKVIARNLVQEALECRIHKNT

Sequences:

>Translated_541_residues
MDNFLEIFLITVAIAIVLNVIFKKFEIPTIIGYIAAGEIISEIYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLMAMK
QEVFLNGSLQMLTCGFVFMLLAIGILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPL
LLLVDIFSSNNQNIEKLLFTTLISALILITLLFFIGKYLVDRIFRLIIHTSSQEIFISTVLFMVIGASFLANYFGFSYSL
GAFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLDVVAQNWFLIIVLTLLVMALKFGIVFGFLFLYTKKRV
ALKTAFAIAQIGEFALAIFSLLQAKNMLDIKTSQILIVVSILTMIITPFILNNIRKITNVVEDIALNTNAVQNIDSNIKL
KNHLVVFGYGRLGQEVVQKIKNTGVPYLVLESDLNLVELGVSRGENVVFANAAQEETLKIANIEECAVAIITVTNEAKLE
ILCQVLANYPKPIDTIIHVNGTLKKMLFSSIDENIRIIRSEKVIARNLVQEALECRIHKNT
>Mature_541_residues
MDNFLEIFLITVAIAIVLNVIFKKFEIPTIIGYIAAGEIISEIYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLMAMK
QEVFLNGSLQMLTCGFVFMLLAIGILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPL
LLLVDIFSSNNQNIEKLLFTTLISALILITLLFFIGKYLVDRIFRLIIHTSSQEIFISTVLFMVIGASFLANYFGFSYSL
GAFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLDVVAQNWFLIIVLTLLVMALKFGIVFGFLFLYTKKRV
ALKTAFAIAQIGEFALAIFSLLQAKNMLDIKTSQILIVVSILTMIITPFILNNIRKITNVVEDIALNTNAVQNIDSNIKL
KNHLVVFGYGRLGQEVVQKIKNTGVPYLVLESDLNLVELGVSRGENVVFANAAQEETLKIANIEECAVAIITVTNEAKLE
ILCQVLANYPKPIDTIIHVNGTLKKMLFSSIDENIRIIRSEKVIARNLVQEALECRIHKNT

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=344, Percent_Identity=27.3255813953488, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1786232, Length=494, Percent_Identity=30.3643724696356, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1789749, Length=494, Percent_Identity=29.3522267206478, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786685, Length=536, Percent_Identity=26.3059701492537, Blast_Score=169, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 60099; Mature: 60099

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNFLEIFLITVAIAIVLNVIFKKFEIPTIIGYIAAGEIISEIYHLSGKGEITHIAEFGI
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VFLMFTIGLEFSFKHLMAMKQEVFLNGSLQMLTCGFVFMLLAIGILGLGDKSATIVGFAL
HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLVDIFSSNNQNIEKLLFT
HHHCHHHEEEEECCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TLISALILITLLFFIGKYLVDRIFRLIIHTSSQEIFISTVLFMVIGASFLANYFGFSYSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
GAFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLDVVAQNWFLIIVLTLLV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEHHCCHHHHHHHHHHH
MALKFGIVFGFLFLYTKKRVALKTAFAIAQIGEFALAIFSLLQAKNMLDIKTSQILIVVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILTMIITPFILNNIRKITNVVEDIALNTNAVQNIDSNIKLKNHLVVFGYGRLGQEVVQKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEECEEEEEECHHHHHHHHHHH
KNTGVPYLVLESDLNLVELGVSRGENVVFANAAQEETLKIANIEECAVAIITVTNEAKLE
HHCCCCEEEEECCCCEEEECCCCCCCEEEECCCCHHHEECCCHHHHEEEEEEECCCHHHH
ILCQVLANYPKPIDTIIHVNGTLKKMLFSSIDENIRIIRSEKVIARNLVQEALECRIHKN
HHHHHHHCCCCCCHHEEECCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
T
C
>Mature Secondary Structure
MDNFLEIFLITVAIAIVLNVIFKKFEIPTIIGYIAAGEIISEIYHLSGKGEITHIAEFGI
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VFLMFTIGLEFSFKHLMAMKQEVFLNGSLQMLTCGFVFMLLAIGILGLGDKSATIVGFAL
HHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLVDIFSSNNQNIEKLLFT
HHHCHHHEEEEECCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TLISALILITLLFFIGKYLVDRIFRLIIHTSSQEIFISTVLFMVIGASFLANYFGFSYSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
GAFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLDVVAQNWFLIIVLTLLV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEHHCCHHHHHHHHHHH
MALKFGIVFGFLFLYTKKRVALKTAFAIAQIGEFALAIFSLLQAKNMLDIKTSQILIVVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILTMIITPFILNNIRKITNVVEDIALNTNAVQNIDSNIKLKNHLVVFGYGRLGQEVVQKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEECEEEEEECHHHHHHHHHHH
KNTGVPYLVLESDLNLVELGVSRGENVVFANAAQEETLKIANIEECAVAIITVTNEAKLE
HHCCCCEEEEECCCCEEEECCCCCCCEEEECCCCHHHEECCCHHHHEEEEEEECCCHHHH
ILCQVLANYPKPIDTIIHVNGTLKKMLFSSIDENIRIIRSEKVIARNLVQEALECRIHKN
HHHHHHHCCCCCCHHEEECCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]