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The map label for this gene is argH [H]

Identifier: 57237759

GI number: 57237759

Start: 942972

End: 944354

Strand: Reverse

Name: argH [H]

Synonym: CJE1009

Alternate gene names: 57237759

Gene position: 944354-942972 (Counterclockwise)

Preceding gene: 57237760

Following gene: 57237752

Centisome position: 53.12

GC content: 30.73

Gene sequence:

>1383_bases
ATGAAAAATGAAATGTGGTCAGGACGTTTTAGTGGTGCAAGTGATGAGCTTTTAAAAGAATTTAATGCAAGTTTAAATGT
AGATAAAACTTTGTTCAATGAAGATATACAAGGTTCTATAGCACACGCTACAATGCTTGAAAGTTGTGGTATTTTAAAAA
AAGAAGAATTAGATGCTATTATAAAAGGTTTAGAGCAGGTTAGAAGTGAAATAGAGCAAGGTAAATTTGTTTTTGATATC
AAAGATGAAGATATTCATATGGCTATAGAAAAGCGTTTAAGCGAGATTATAGGTAGTGAAATTGGCGGAAGACTACATAC
TGCAAGAAGTAGAAATGACCAAGTGGCTACTGATTTTAAACTTTTTGTAAAAAAATCTCATATTGAACTTATAAAGCTTT
TAAAAGAATTGATTCAAACCATGCTTAAACATGCTAAAGCGCATAAAAAAACTATTATGCCAAGTTTTACACATTTACAA
CACGCTCAGCCTGTGAGTTTTTCTTTTTATATCTTAGCTTATGCTTTTATGTTAATGCGAGATATTAAGCGTTTGCAAAA
TAGCCTAGAACTTGCAGACTTTTCACCACTTGGATCTTGTGCATGTGCAGGAACAAGCTATGCTACCAATCGTGAGTTGA
GTGCTAAAATTTTAGGATTTAAAGATATTATGTCAAATGCTATGGATGGAGTGAGTGATAGGGATTTTGCTCTTGATTTG
CTTTATGATATAGCAGTTATTTTTACACACACTTCAAGACTTTGTGAGGAAATGATTTTATTTTCAAGCTCAGAATTTTC
TTTTATAACCATAAGTGATAGTTTTTCAACGGGAAGTTCTATTATGCCTCAGAAAAAAAATCCTGATGTTTGTGAACTTA
TACGTGGAAAAACAGGGCGTGTTTATGGAAATTTAATTTCTCTTTTAACTATAATGAAAGCTTTACCTTTAGCTTATAAT
AAAGATATGCAAGAAGATAAAGAGGGGATTTTTGATAGTGTAAAAACCGCTAAAGATAGCTTAATTATCTTAAATGCAAT
GTTAAAAGAAATACAAATCAACAAAGAAAATATGCTTAATGCTTGTAAAAAAGGTCATATGTTGGCTACCGATTTGGCAG
ATTATTTGGTGCGTGAAAAAAATATTCCTTTTAGAAAAGCACATTTTATAGTGGGAAATGTTGTTGCACAAGCTGAAGCA
CAAGGCATTGATATAAGTGAAATTAAAGATCTTTCAAAAATAGATCCTGTATTTGATGAAAAAGCTATGGAACTTTTAAA
TTTTGAATTTTCTTTAAATTCTAAGCAAAGTGAAGGCTCAAGTTCTATTGCAAGCGTAGAAAAGCAAATTCAAATTTTGG
AAGGTTTTATTCAAAATTTATAA

Upstream 100 bases:

>100_bases
TAAATTAGCACATATGTTTATACAAAATTTTAAACGTTATGAAGATGTCAAAGAAGGCATTGAATTTAGCAAATTTGGAC
CAAAAATTTAAGGCATTTAA

Downstream 100 bases:

>100_bases
ATATTGTTTAGGCTATTTTGCCTAAACATTGAATCTAAAATGCATTACATCGCCATCTAAAACGATATAGTCTTTTCCTT
CAAGGCGTAGCTTTCCTGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIIKGLEQVRSEIEQGKFVFDI
KDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKLLKELIQTMLKHAKAHKKTIMPSFTHLQ
HAQPVSFSFYILAYAFMLMRDIKRLQNSLELADFSPLGSCACAGTSYATNRELSAKILGFKDIMSNAMDGVSDRDFALDL
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGRVYGNLISLLTIMKALPLAYN
KDMQEDKEGIFDSVKTAKDSLIILNAMLKEIQINKENMLNACKKGHMLATDLADYLVREKNIPFRKAHFIVGNVVAQAEA
QGIDISEIKDLSKIDPVFDEKAMELLNFEFSLNSKQSEGSSSIASVEKQIQILEGFIQNL

Sequences:

>Translated_460_residues
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIIKGLEQVRSEIEQGKFVFDI
KDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKLLKELIQTMLKHAKAHKKTIMPSFTHLQ
HAQPVSFSFYILAYAFMLMRDIKRLQNSLELADFSPLGSCACAGTSYATNRELSAKILGFKDIMSNAMDGVSDRDFALDL
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGRVYGNLISLLTIMKALPLAYN
KDMQEDKEGIFDSVKTAKDSLIILNAMLKEIQINKENMLNACKKGHMLATDLADYLVREKNIPFRKAHFIVGNVVAQAEA
QGIDISEIKDLSKIDPVFDEKAMELLNFEFSLNSKQSEGSSSIASVEKQIQILEGFIQNL
>Mature_460_residues
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIIKGLEQVRSEIEQGKFVFDI
KDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKLLKELIQTMLKHAKAHKKTIMPSFTHLQ
HAQPVSFSFYILAYAFMLMRDIKRLQNSLELADFSPLGSCACAGTSYATNRELSAKILGFKDIMSNAMDGVSDRDFALDL
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGRVYGNLISLLTIMKALPLAYN
KDMQEDKEGIFDSVKTAKDSLIILNAMLKEIQINKENMLNACKKGHMLATDLADYLVREKNIPFRKAHFIVGNVVAQAEA
QGIDISEIKDLSKIDPVFDEKAMELLNFEFSLNSKQSEGSSSIASVEKQIQILEGFIQNL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=43.2314410480349, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=43.2314410480349, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=41.2663755458515, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=41.0480349344978, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=43.3628318584071, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321806, Length=455, Percent_Identity=41.978021978022, Blast_Score=382, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=39.6514161220044, Blast_Score=351, Evalue=5e-97,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=39.6514161220044, Blast_Score=351, Evalue=5e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51627; Mature: 51627

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAI
CCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHH
IKGLEQVRSEIEQGKFVFDIKDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFK
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHH
LFVKKSHIELIKLLKELIQTMLKHAKAHKKTIMPSFTHLQHAQPVSFSFYILAYAFMLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
DIKRLQNSLELADFSPLGSCACAGTSYATNRELSAKILGFKDIMSNAMDGVSDRDFALDL
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGNLISLLTIMKALPLAYNKDMQEDKEGIFDSVKTAKDSLIILNAMLKEIQINKENMLN
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ACKKGHMLATDLADYLVREKNIPFRKAHFIVGNVVAQAEAQGIDISEIKDLSKIDPVFDE
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
KAMELLNFEFSLNSKQSEGSSSIASVEKQIQILEGFIQNL
HHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAI
CCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHH
IKGLEQVRSEIEQGKFVFDIKDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFK
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHH
LFVKKSHIELIKLLKELIQTMLKHAKAHKKTIMPSFTHLQHAQPVSFSFYILAYAFMLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
DIKRLQNSLELADFSPLGSCACAGTSYATNRELSAKILGFKDIMSNAMDGVSDRDFALDL
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGNLISLLTIMKALPLAYNKDMQEDKEGIFDSVKTAKDSLIILNAMLKEIQINKENMLN
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ACKKGHMLATDLADYLVREKNIPFRKAHFIVGNVVAQAEAQGIDISEIKDLSKIDPVFDE
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
KAMELLNFEFSLNSKQSEGSSSIASVEKQIQILEGFIQNL
HHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA