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The map label for this gene is moeA [H]

Identifier: 57237698

GI number: 57237698

Start: 880884

End: 882044

Strand: Reverse

Name: moeA [H]

Synonym: CJE0944

Alternate gene names: 57237698

Gene position: 882044-880884 (Counterclockwise)

Preceding gene: 57237699

Following gene: 57237695

Centisome position: 49.61

GC content: 30.4

Gene sequence:

>1161_bases
ATGAAAAATATCTTTAAAACCTTAAAAGACTTAGAAAATCAAATTTCATGCTTAGATGAAAGTGAGCTTATTAGCCTTGA
AAAAGCAAAGGATAGAATTTTAGCTAAAGATTTATACGCTAGAAAAAATTTACCTAGTTTTGACAATGCTGCTCTTGATG
GCTATGCTTTTAATTATACTGATATCAATGAGGCTTTGGAGATTAAAGGGACTATTTTTGCAGGAGATAAAAATTTTTAT
ACAGTTGCTAAGAATGAATGCTATAAAATCATGACAGGGGCTAAAATGCCCAAAAATGCTGATACTATCTTAATGTTAGA
AGATGAGTATATAGAAGAAAATAAACTCATCATTAAAAAAGCCCCTAAACAATACAATGCCTATCGCTATAAAGGCGAAG
AATTAAAAAAAGGTGAAATTTTACTTCAAAAAGGCACCAAACTTAATGATAAACATATCGCCCTGCTTGCTTCTCAAGGG
CTTTATAAAATAGAAGTCATAAGAAAAATTCGCATAGGTATTTTTTCAAGTGGAAATGAGCTAAAAGAACCTTGGCAAGA
ATGCGATGAAGAAAGTATTTATAATGCTAATGCTTTGCCTTTACTAACCATGCTTCAAAATGCTTCTTATTTAGGTATTA
TCAAAGATAATTTTAAAAGCACTAAAGAGGCTTTAGAAAATACAAATTTTGATCTTTTAATCACTTCAGGAGGTGCAAGC
GTTGGCGAGGCTGATTTTATGGAAAAAGCTTTAGATGAATTAGGCTTTACTCCGCTTTTTAAAGGACTAAAAGCACGCCC
TGCAAGACCTACTAAGCTTTATAGAAAGGGTGAGAATTTCGTATTGATTTTACCAGGAAATCCCATGGCGGCCTATCTTT
CTTGTTTTATTTTTGCTAAAAAAATTATTGCTTTATTAAGTGGAAACCTAGACAATCCTTTAACATTTTATGGCAAAATG
GGTATGGATTTAAAGCTTAAAAGCGGAAGAAATAATCTCATCTTAGGAAATTTAGAAAAAGATATTTTTACACCATTTAA
TGAAAATAAATTTGGATCTGGTATGATACTTCCACTTATTAAAAGTGAATTTTTACTTATAAGTGAAGAAAATATAAGCA
AATTAAAAAAAGGTGATGAAATCACGCTTTTAAAAATATAA

Upstream 100 bases:

>100_bases
GCACAAGCAAAGTCCATAGAATTTATCATCTTGATAGAGGTTATGAAAATTTAGAAGAAAAATTTAAAGGTTTAGGTGTT
AAAATCACAAGGCTTGAAGA

Downstream 100 bases:

>100_bases
TGTTTGTGTTTTTCACAAACATTAGCTTAATTTATCCTCATCATCATGATCATGGATATATTGTTCATCATTTTCCAAGG
TATCAACAAAACGCCCTATC

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKNIFKTLKDLENQISCLDESELISLEKAKDRILAKDLYARKNLPSFDNAALDGYAFNYTDINEALEIKGTIFAGDKNFY
TVAKNECYKIMTGAKMPKNADTILMLEDEYIEENKLIIKKAPKQYNAYRYKGEELKKGEILLQKGTKLNDKHIALLASQG
LYKIEVIRKIRIGIFSSGNELKEPWQECDEESIYNANALPLLTMLQNASYLGIIKDNFKSTKEALENTNFDLLITSGGAS
VGEADFMEKALDELGFTPLFKGLKARPARPTKLYRKGENFVLILPGNPMAAYLSCFIFAKKIIALLSGNLDNPLTFYGKM
GMDLKLKSGRNNLILGNLEKDIFTPFNENKFGSGMILPLIKSEFLLISEENISKLKKGDEITLLKI

Sequences:

>Translated_386_residues
MKNIFKTLKDLENQISCLDESELISLEKAKDRILAKDLYARKNLPSFDNAALDGYAFNYTDINEALEIKGTIFAGDKNFY
TVAKNECYKIMTGAKMPKNADTILMLEDEYIEENKLIIKKAPKQYNAYRYKGEELKKGEILLQKGTKLNDKHIALLASQG
LYKIEVIRKIRIGIFSSGNELKEPWQECDEESIYNANALPLLTMLQNASYLGIIKDNFKSTKEALENTNFDLLITSGGAS
VGEADFMEKALDELGFTPLFKGLKARPARPTKLYRKGENFVLILPGNPMAAYLSCFIFAKKIIALLSGNLDNPLTFYGKM
GMDLKLKSGRNNLILGNLEKDIFTPFNENKFGSGMILPLIKSEFLLISEENISKLKKGDEITLLKI
>Mature_386_residues
MKNIFKTLKDLENQISCLDESELISLEKAKDRILAKDLYARKNLPSFDNAALDGYAFNYTDINEALEIKGTIFAGDKNFY
TVAKNECYKIMTGAKMPKNADTILMLEDEYIEENKLIIKKAPKQYNAYRYKGEELKKGEILLQKGTKLNDKHIALLASQG
LYKIEVIRKIRIGIFSSGNELKEPWQECDEESIYNANALPLLTMLQNASYLGIIKDNFKSTKEALENTNFDLLITSGGAS
VGEADFMEKALDELGFTPLFKGLKARPARPTKLYRKGENFVLILPGNPMAAYLSCFIFAKKIIALLSGNLDNPLTFYGKM
GMDLKLKSGRNNLILGNLEKDIFTPFNENKFGSGMILPLIKSEFLLISEENISKLKKGDEITLLKI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=331, Percent_Identity=31.7220543806647, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI10880983, Length=331, Percent_Identity=31.7220543806647, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1787049, Length=344, Percent_Identity=31.1046511627907, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147659, Length=323, Percent_Identity=26.0061919504644, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562606, Length=348, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136978, Length=286, Percent_Identity=29.020979020979, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=286, Percent_Identity=29.020979020979, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43486; Mature: 43486

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIFKTLKDLENQISCLDESELISLEKAKDRILAKDLYARKNLPSFDNAALDGYAFNYT
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC
DINEALEIKGTIFAGDKNFYTVAKNECYKIMTGAKMPKNADTILMLEDEYIEENKLIIKK
CCCCEEEEEEEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEE
APKQYNAYRYKGEELKKGEILLQKGTKLNDKHIALLASQGLYKIEVIRKIRIGIFSSGNE
CCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEHHHHHHEEECCCHH
LKEPWQECDEESIYNANALPLLTMLQNASYLGIIKDNFKSTKEALENTNFDLLITSGGAS
HHHHHHHCCHHHCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCC
VGEADFMEKALDELGFTPLFKGLKARPARPTKLYRKGENFVLILPGNPMAAYLSCFIFAK
CCHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHHHH
KIIALLSGNLDNPLTFYGKMGMDLKLKSGRNNLILGNLEKDIFTPFNENKFGSGMILPLI
HHHHHHCCCCCCCEEEEECCCCEEEEECCCCCEEEECCCHHHCCCCCCCCCCCCEEEHHH
KSEFLLISEENISKLKKGDEITLLKI
CCCEEEEECCCHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKNIFKTLKDLENQISCLDESELISLEKAKDRILAKDLYARKNLPSFDNAALDGYAFNYT
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC
DINEALEIKGTIFAGDKNFYTVAKNECYKIMTGAKMPKNADTILMLEDEYIEENKLIIKK
CCCCEEEEEEEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEE
APKQYNAYRYKGEELKKGEILLQKGTKLNDKHIALLASQGLYKIEVIRKIRIGIFSSGNE
CCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEEHHHHHHEEECCCHH
LKEPWQECDEESIYNANALPLLTMLQNASYLGIIKDNFKSTKEALENTNFDLLITSGGAS
HHHHHHHCCHHHCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCC
VGEADFMEKALDELGFTPLFKGLKARPARPTKLYRKGENFVLILPGNPMAAYLSCFIFAK
CCHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHHHH
KIIALLSGNLDNPLTFYGKMGMDLKLKSGRNNLILGNLEKDIFTPFNENKFGSGMILPLI
HHHHHHCCCCCCCEEEEECCCCEEEEECCCCCEEEECCCHHHCCCCCCCCCCCCEEEHHH
KSEFLLISEENISKLKKGDEITLLKI
CCCEEEEECCCHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]