Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 57237499

GI number: 57237499

Start: 448230

End: 449444

Strand: Direct

Name: fabF [H]

Synonym: CJE0494

Alternate gene names: 57237499

Gene position: 448230-449444 (Clockwise)

Preceding gene: 57237498

Following gene: 57237500

Centisome position: 25.21

GC content: 36.54

Gene sequence:

>1215_bases
TTGAAAAGAGTTGTAGTTACAGGTATTGGTATGATCAATGCCCTTGGTTTAGATAAAGAAAGTTCATTTAAAGCAATTTG
CAATGGAGAAAGCGGAGTAAATAAAATTACTCTTTTTGATGCTACGGACTTTCCTGTTCAAATTGCAGCTGAAGTTAAAA
ATTTTGATCCATTAGAGGTTGTTGATGGCAAAGAAGTAAAAAAAATTGACCGTTTCATACAACTTGGAATTAAAGCAGCA
AGAGAAGCAATGCAGGATGCTGGATTTAGTGAAGAATTAGATAAAGAAGAATTTGGCATTGTTTCGGCTTCTGGTATTGG
AGGTTTGCCTAACATAGAAAAAAATTCCATTATTTGTTCCGAGCGAGGTCCGCGTAAAATTTCCCCTTTTTTCATACCTT
CAGCACTTGTAAATATGTTAGGAGGTTTGATTTCTATAGAGCATGGGCTTAAAGGGCCAAATATTTCTTGTGTTACAGCT
TGTGCAGCAGGAACTCATGCTATAGGAGAAGCTTATAAAAGTATAGCTTTGGGAAATGCTAAAAAGATGTTAGTCATAGG
TGCAGAAGCTGCGATTTGTCCTGTAGGTATAGGTGGTTTTGCTTCAATGAAAGCTTTATCAACTAGAAATGAAGATCCAG
AGCATGCTTCAAGACCATTTGACAAAGAAAGAGATGGTTTTGTCATGGGAGAAGGTGCTGGAGCTTTAGTTTTTGAGGAA
TATGAAGAGGCTAAAAAACGCGGTGCTACGATTTATGCTGAATTAATTGGATTTGGAGAAAGTGCAGATGCGCATCATAT
TACTTCACCAACTTTAGATGGGCCTTTAAGAGCTATGAAAAAAGCTTTAAATATGGCAGGGAATCCAAAGGTAGATTATA
TCAATGCACATGGAACTTCAACCCCTGTAAATGACAAAAATGAAACAGCAGCAATTAAAGAGCTTTTTGGCAATAATATC
CCGCTTATAAGTTCCACCAAAGGACAAACAGGTCATTGCTTGGGTGCTGCAGGTGCAATTGAAGCAGTTGTTAGTGTTAT
GGCTTTAAGAGATGGGGTAGTTCCACCTACAATCAATCAGCTTGTAAAAGATGATGAATGTGATCTTGATTATATTCCAA
ATATATCAAGAAAAGTAGATTTAAAAGTGGTGATGAGTAATTCTTTTGGTTTTGGTGGCACAAATGGCTGTGTTGTATTT
AAAAAAGTAGATTAA

Upstream 100 bases:

>100_bases
TTCCAGATAGTGATGCTGAAAAATTAATTAAAATTGAAGATGTTGTAAATTATATTGACAATCTAAAAAAATAATTTTTT
TTCTTGCAAGGAGCTTATTC

Downstream 100 bases:

>100_bases
TATGGCTTCTTATTTAGATTTTGAAAAAAATATTCAGCAAATTGACGAGGACATTATCAATGCTCAGATTAAAGGAGATA
CTGAAGCTGTATCGATTTTA

Product: 3-oxoacyl-ACP synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKRVVVTGIGMINALGLDKESSFKAICNGESGVNKITLFDATDFPVQIAAEVKNFDPLEVVDGKEVKKIDRFIQLGIKAA
REAMQDAGFSEELDKEEFGIVSASGIGGLPNIEKNSIICSERGPRKISPFFIPSALVNMLGGLISIEHGLKGPNISCVTA
CAAGTHAIGEAYKSIALGNAKKMLVIGAEAAICPVGIGGFASMKALSTRNEDPEHASRPFDKERDGFVMGEGAGALVFEE
YEEAKKRGATIYAELIGFGESADAHHITSPTLDGPLRAMKKALNMAGNPKVDYINAHGTSTPVNDKNETAAIKELFGNNI
PLISSTKGQTGHCLGAAGAIEAVVSVMALRDGVVPPTINQLVKDDECDLDYIPNISRKVDLKVVMSNSFGFGGTNGCVVF
KKVD

Sequences:

>Translated_404_residues
MKRVVVTGIGMINALGLDKESSFKAICNGESGVNKITLFDATDFPVQIAAEVKNFDPLEVVDGKEVKKIDRFIQLGIKAA
REAMQDAGFSEELDKEEFGIVSASGIGGLPNIEKNSIICSERGPRKISPFFIPSALVNMLGGLISIEHGLKGPNISCVTA
CAAGTHAIGEAYKSIALGNAKKMLVIGAEAAICPVGIGGFASMKALSTRNEDPEHASRPFDKERDGFVMGEGAGALVFEE
YEEAKKRGATIYAELIGFGESADAHHITSPTLDGPLRAMKKALNMAGNPKVDYINAHGTSTPVNDKNETAAIKELFGNNI
PLISSTKGQTGHCLGAAGAIEAVVSVMALRDGVVPPTINQLVKDDECDLDYIPNISRKVDLKVVMSNSFGFGGTNGCVVF
KKVD
>Mature_404_residues
MKRVVVTGIGMINALGLDKESSFKAICNGESGVNKITLFDATDFPVQIAAEVKNFDPLEVVDGKEVKKIDRFIQLGIKAA
REAMQDAGFSEELDKEEFGIVSASGIGGLPNIEKNSIICSERGPRKISPFFIPSALVNMLGGLISIEHGLKGPNISCVTA
CAAGTHAIGEAYKSIALGNAKKMLVIGAEAAICPVGIGGFASMKALSTRNEDPEHASRPFDKERDGFVMGEGAGALVFEE
YEEAKKRGATIYAELIGFGESADAHHITSPTLDGPLRAMKKALNMAGNPKVDYINAHGTSTPVNDKNETAAIKELFGNNI
PLISSTKGQTGHCLGAAGAIEAVVSVMALRDGVVPPTINQLVKDDECDLDYIPNISRKVDLKVVMSNSFGFGGTNGCVVF
KKVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=411, Percent_Identity=41.3625304136253, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI223972627, Length=187, Percent_Identity=32.620320855615, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI41872631, Length=360, Percent_Identity=25.2777777777778, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=51.9512195121951, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788663, Length=408, Percent_Identity=36.0294117647059, Blast_Score=246, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=33.8199513381995, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=38.9312977099237, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=367, Percent_Identity=27.5204359673025, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=26.865671641791, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=33.7078651685393, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=42.512077294686, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI19920632, Length=375, Percent_Identity=26.4, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221330659, Length=375, Percent_Identity=26.4, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=372, Percent_Identity=24.7311827956989, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42674; Mature: 42674

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVVTGIGMINALGLDKESSFKAICNGESGVNKITLFDATDFPVQIAAEVKNFDPLEV
CCEEEEECCCHHHHCCCCCCCCCCEEECCCCCCCEEEEEECCCCCEEEEEHHCCCCCCEE
VDGKEVKKIDRFIQLGIKAAREAMQDAGFSEELDKEEFGIVSASGIGGLPNIEKNSIICS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCEEEECCCCCCCCCCCCCEEEC
ERGPRKISPFFIPSALVNMLGGLISIEHGLKGPNISCVTACAAGTHAIGEAYKSIALGNA
CCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHCCHHHHHHHHHHHHCCCC
KKMLVIGAEAAICPVGIGGFASMKALSTRNEDPEHASRPFDKERDGFVMGEGAGALVFEE
CEEEEEECCCCEEECCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCEEHHHH
YEEAKKRGATIYAELIGFGESADAHHITSPTLDGPLRAMKKALNMAGNPKVDYINAHGTS
HHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
TPVNDKNETAAIKELFGNNIPLISSTKGQTGHCLGAAGAIEAVVSVMALRDGVVPPTINQ
CCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCEECHHHHHHHHHHHHHHHCCCCCHHHHH
LVKDDECDLDYIPNISRKVDLKVVMSNSFGFGGTNGCVVFKKVD
HHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKRVVVTGIGMINALGLDKESSFKAICNGESGVNKITLFDATDFPVQIAAEVKNFDPLEV
CCEEEEECCCHHHHCCCCCCCCCCEEECCCCCCCEEEEEECCCCCEEEEEHHCCCCCCEE
VDGKEVKKIDRFIQLGIKAAREAMQDAGFSEELDKEEFGIVSASGIGGLPNIEKNSIICS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCEEEECCCCCCCCCCCCCEEEC
ERGPRKISPFFIPSALVNMLGGLISIEHGLKGPNISCVTACAAGTHAIGEAYKSIALGNA
CCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHCCHHHHHHHHHHHHCCCC
KKMLVIGAEAAICPVGIGGFASMKALSTRNEDPEHASRPFDKERDGFVMGEGAGALVFEE
CEEEEEECCCCEEECCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCCCEEHHHH
YEEAKKRGATIYAELIGFGESADAHHITSPTLDGPLRAMKKALNMAGNPKVDYINAHGTS
HHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
TPVNDKNETAAIKELFGNNIPLISSTKGQTGHCLGAAGAIEAVVSVMALRDGVVPPTINQ
CCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCEECHHHHHHHHHHHHHHHCCCCCHHHHH
LVKDDECDLDYIPNISRKVDLKVVMSNSFGFGGTNGCVVFKKVD
HHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]