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The map label for this gene is aroE [H]

Identifier: 57237460

GI number: 57237460

Start: 407537

End: 408325

Strand: Direct

Name: aroE [H]

Synonym: CJE0454

Alternate gene names: 57237460

Gene position: 407537-408325 (Clockwise)

Preceding gene: 57237459

Following gene: 57237462

Centisome position: 22.92

GC content: 29.28

Gene sequence:

>789_bases
ATGAAATTTTTAGCAGTTATAGGCGATCCTATTTCTCACTCTAAATCGCCTAGAATGCATAATAATGCTATTAAAGCCTT
AGGGCTTGATAGCATTTATACACGCTATCATTTAAGAAATGCTAACTGTTTAAGAGAAGATTTTTTTAAATTAGGACTTA
GTGGAGCTAATATTACTTTGCCTTTTAAGGAAAAAGCTTTAGATATTGCTGATGTGAAGGATGATTTTGCTAGAAATATT
GGCTCTGCAAATACTTTATGCTTAAAAGAAGATAAAATTTACGCTTATAATACTGATGCTTTAGGTTTTTTAGAAGCTAT
TAAGGATTTTGATAATATAAAAAAAGCTTTGATTTTGGGTGCTGGAGGTACAGCTTTGGCGCTTGCTTATGCATTAAAAC
AAAAAGGCGTAGAAGTGTATATAGCTAATCGTAGTAAAGAAAGATTTAAAGATTTTTTAGCTTATCCAACTTATCTTTAT
AAAAACTTGCAAGATTTTGACTTTGATTTGGTTATAAATTCAACTTCTGCTGGATTAAAAGATGAAAATTTACCTTGTGA
TAGAGAGCTTTTAGATAGAATTTTACCTAAAGCTAAATTTGCTTTTGAGGTAATTTATGGCAGAGAAACACCTTTTTATA
GATTATGTAAAGAGTATCATTTAAAAATTAAAGATGGACTTGATATGCTTTTATGGCAAGGAGTTTTTGCTTTTGAACTT
TTTTTTGAAATACAAGATAAAAGAGAGATGATAAAAAATGCAATGCAACAGGCATTGATTTTAAAGTAG

Upstream 100 bases:

>100_bases
CCAAGGTTTTAATAGGGCCATTTGAAAAGGCAGATATTGCAGCAGAACTTGCTAAAATCCGTAAGGATATTGCAAAAGAT
GCTTTTTCTTTTACTTTAAA

Downstream 100 bases:

>100_bases
AATGATAGTTATTTTTCTTGTATAAGAAAATCTTATTTTTTGTGTGAGAAAGTTTAATTTTCCCACAAGTTTTATCATTC
AAATATTTCTACCCCATCTT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKFLAVIGDPISHSKSPRMHNNAIKALGLDSIYTRYHLRNANCLREDFFKLGLSGANITLPFKEKALDIADVKDDFARNI
GSANTLCLKEDKIYAYNTDALGFLEAIKDFDNIKKALILGAGGTALALAYALKQKGVEVYIANRSKERFKDFLAYPTYLY
KNLQDFDFDLVINSTSAGLKDENLPCDRELLDRILPKAKFAFEVIYGRETPFYRLCKEYHLKIKDGLDMLLWQGVFAFEL
FFEIQDKREMIKNAMQQALILK

Sequences:

>Translated_262_residues
MKFLAVIGDPISHSKSPRMHNNAIKALGLDSIYTRYHLRNANCLREDFFKLGLSGANITLPFKEKALDIADVKDDFARNI
GSANTLCLKEDKIYAYNTDALGFLEAIKDFDNIKKALILGAGGTALALAYALKQKGVEVYIANRSKERFKDFLAYPTYLY
KNLQDFDFDLVINSTSAGLKDENLPCDRELLDRILPKAKFAFEVIYGRETPFYRLCKEYHLKIKDGLDMLLWQGVFAFEL
FFEIQDKREMIKNAMQQALILK
>Mature_262_residues
MKFLAVIGDPISHSKSPRMHNNAIKALGLDSIYTRYHLRNANCLREDFFKLGLSGANITLPFKEKALDIADVKDDFARNI
GSANTLCLKEDKIYAYNTDALGFLEAIKDFDNIKKALILGAGGTALALAYALKQKGVEVYIANRSKERFKDFLAYPTYLY
KNLQDFDFDLVINSTSAGLKDENLPCDRELLDRILPKAKFAFEVIYGRETPFYRLCKEYHLKIKDGLDMLLWQGVFAFEL
FFEIQDKREMIKNAMQQALILK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=274, Percent_Identity=29.9270072992701, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787983, Length=281, Percent_Identity=28.4697508896797, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29950; Mature: 29950

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLAVIGDPISHSKSPRMHNNAIKALGLDSIYTRYHLRNANCLREDFFKLGLSGANITL
CCEEEEECCCCCCCCCCCHHCCHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEE
PFKEKALDIADVKDDFARNIGSANTLCLKEDKIYAYNTDALGFLEAIKDFDNIKKALILG
CCHHHHCHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHEEEC
AGGTALALAYALKQKGVEVYIANRSKERFKDFLAYPTYLYKNLQDFDFDLVINSTSAGLK
CCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
DENLPCDRELLDRILPKAKFAFEVIYGRETPFYRLCKEYHLKIKDGLDMLLWQGVFAFEL
CCCCCCCHHHHHHHCCCHHHHEEEEECCCCCHHHHHHHHCCHHHCCHHHHHHHHHHHHHH
FFEIQDKREMIKNAMQQALILK
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFLAVIGDPISHSKSPRMHNNAIKALGLDSIYTRYHLRNANCLREDFFKLGLSGANITL
CCEEEEECCCCCCCCCCCHHCCHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEE
PFKEKALDIADVKDDFARNIGSANTLCLKEDKIYAYNTDALGFLEAIKDFDNIKKALILG
CCHHHHCHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHEEEC
AGGTALALAYALKQKGVEVYIANRSKERFKDFLAYPTYLYKNLQDFDFDLVINSTSAGLK
CCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
DENLPCDRELLDRILPKAKFAFEVIYGRETPFYRLCKEYHLKIKDGLDMLLWQGVFAFEL
CCCCCCCHHHHHHHCCCHHHHEEEEECCCCCHHHHHHHHCCHHHCCHHHHHHHHHHHHHH
FFEIQDKREMIKNAMQQALILK
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954 [H]