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The map label for this gene is ndk

Identifier: 57237383

GI number: 57237383

Start: 337200

End: 337613

Strand: Reverse

Name: ndk

Synonym: CJE0377

Alternate gene names: 57237383

Gene position: 337613-337200 (Counterclockwise)

Preceding gene: 57237384

Following gene: 57237382

Centisome position: 18.99

GC content: 31.16

Gene sequence:

>414_bases
ATGGAAAAAACTTTATCTATAATTAAACCTGATGCTGTTAAAAAAGGTGTTATAGGAAAAATTTTAGATCGTTTTGAAAG
CAATGGATTAAGAATCGCTGCAATGAAAAAAGTTCAACTTAGTAAAGAACAAGCTGAAAATTTTTATGCTGTTCATAAAG
AAAGACCTTTTTTTAAAGACTTGGTTGAATTTATGATTAGCGGTCCTGTTGTTGTTTCTGTACTAGAAGGAGAAGGTGCT
GTATTAAAAAATAGAGATTTAATGGGAGCGACAAATCCTAAAGAAGCTAAAGCAGGAACAATTAGAGCCGATTTTGCTGA
GAGTATTGATGCTAATGCTGTTCATGGAAGTGACAGCTTGGAAAATGCAAAAATAGAAATTGATTTTTTCTTTAAACCAA
ATGAAATTTGCTAA

Upstream 100 bases:

>100_bases
AAAAAGCTAGAGATTCCTAGCTTTTTCTTTTAATTTAACTTTCTTTAAACAAATTCAAGTATAATTTTAAGCTTTATTAA
AATAAGGAGTTATTACAAAG

Downstream 100 bases:

>100_bases
ATGAAAATCCCTTTTTCTAAGATTAATACAAAGGAATATCCTTTTAAACTTAATCTTGAAAATATGATTTTTGAGGGAAA
TTTAGTAAAAATAAATCCTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKDLVEFMISGPVVVSVLEGEGA
VLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSLENAKIEIDFFFKPNEIC

Sequences:

>Translated_137_residues
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKDLVEFMISGPVVVSVLEGEGA
VLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSLENAKIEIDFFFKPNEIC
>Mature_137_residues
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKDLVEFMISGPVVVSVLEGEGA
VLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSLENAKIEIDFFFKPNEIC

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=46.3235294117647, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=46.3235294117647, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=46.3235294117647, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=46.3235294117647, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=46.3235294117647, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=45.1851851851852, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=45.1851851851852, Blast_Score=130, Evalue=2e-31,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=45.1851851851852, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=38.5185185185185, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI7019465, Length=144, Percent_Identity=34.7222222222222, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI37574614, Length=144, Percent_Identity=34.7222222222222, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=36.2962962962963, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=37.3134328358209, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI148839372, Length=135, Percent_Identity=35.5555555555556, Blast_Score=73, Evalue=9e-14,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=58.3941605839416, Blast_Score=170, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=44.4444444444444, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=42.2222222222222, Blast_Score=124, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=8e-31,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=36.5671641791045, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24645457, Length=137, Percent_Identity=31.3868613138686, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CAMJ8 (A8FKC1)

Other databases:

- EMBL:   CP000814
- RefSeq:   YP_001481885.1
- ProteinModelPortal:   A8FKC1
- SMR:   A8FKC1
- STRING:   A8FKC1
- GeneID:   5618272
- GenomeReviews:   CP000814_GR
- KEGG:   cju:C8J_0309
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   CJEJ407148:C8J_0309-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15114; Mature: 15114

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKD
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEEHHHHHCHHHHHHEEEECCCCCHHHH
LVEFMISGPVVVSVLEGEGAVLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSL
HHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCC
ENAKIEIDFFFKPNEIC
CCCEEEEEEEECCCCCC
>Mature Secondary Structure
MEKTLSIIKPDAVKKGVIGKILDRFESNGLRIAAMKKVQLSKEQAENFYAVHKERPFFKD
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEEHHHHHCHHHHHHEEEECCCCCHHHH
LVEFMISGPVVVSVLEGEGAVLKNRDLMGATNPKEAKAGTIRADFAESIDANAVHGSDSL
HHHHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCC
ENAKIEIDFFFKPNEIC
CCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA