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The map label for this gene is dxs [H]

Identifier: 57237372

GI number: 57237372

Start: 327832

End: 329679

Strand: Direct

Name: dxs [H]

Synonym: CJE0366

Alternate gene names: 57237372

Gene position: 327832-329679 (Clockwise)

Preceding gene: 57237371

Following gene: 57237373

Centisome position: 18.44

GC content: 33.55

Gene sequence:

>1848_bases
ATGAGTAAAAAATTTGTCCATACTCAAGAAGAGTTAGAAAAGCTAAGTTTAAAAGAATTAGAAAATTTAGCAGCATCTAT
GCGTGAAAAAATCATACAAGTTGTGAGTAAAAATGGTGGGCATTTAAGTTCAAATTTGGGTGCTGTAGAACTTAGTATAG
CAATGCATTTGGTTTTTGATGCAAAAAAAGATCCTTTTATTTTTGATGTGTCGCATCAGTCTTATACACACAAGCTTTTA
AGCGGAAAAGAAGAAATATTTGATACTTTAAGACAAATCAATGGTTTAAGTGGTTATACAAAACCTAGCGAGGGAGATTA
TTTTGTAGCAGGGCATTCTAGCACCTCTATTTCTTTGGCAGTAGGTGCTTGTAAGGCCATTGCTTTAAAAGGTGAAAAGC
GTATTCCTGTTGCTTTGATTGGAGATGGTGCTTTAAGTGCGGGTATGGCCTATGAGGCTTTAAATGAATTGGGTGATTCT
AAATTTCCTTGCGTAATACTTTTAAATGATAATGAAATGAGTATTTCAAAACCAATTGGAGCAATTTCAAAGTATCTTTC
TCAGGCTATGGCAACGCAGTTTTATCAAAGTTTTAAAAAGCGTATTGCTAAAATGTTGGATATATTGCCTGATAGTGCTA
CTTATATGGCCAAGCGTTTTGAAGAGAGTTTTAAACTTATTACTCCTGGACTTTTGTTTGAAGAATTAGGGCTTGAATAT
ATAGGGCCTATTGATGGACATAATTTAGGTGAAATTATTTCTGCATTAAAACAAGCAAAAGCTATGCAAAAGCCTTGTGT
GATACATGCTCAAACCATAAAGGGTAAAGGCTATGTTTTAGCCGAAGGAAAACATGCTAAATGGCACGGGGTGGGAGCTT
TTGATATAGATAGTGGAGAGAGTGTTAAAAAAAGTGATACTAAAAAATCTGCTACTGAAATTTTTTCTAAGAATTTGCTT
GATTTAGCCTCAAAATATGAAAATATTGTTGGGGTTACGGCAGCTATGCCAAGTGGAACAGGTCTTGATAAGCTTATAGA
AAAATATCCAAATCGTTTTTGGGATGTGGCTATTGCAGAACAGCATGCAGTAACTTCTATGGCCGCTATGGCAAAAGAAG
GATTTAAACCTTTTATTGCAATATATAGCACTTTTTTGCAGCGTGCTTATGATCAAGTGATCCATGATTGTGCGATTATG
AATTTAAATGTGGTTTTTGCTATGGATAGGGCAGGGATAGTAGGCGAAGATGGGGAGACGCATCAAGGTGTTTTTGATCT
TAGTTTTTTAGCTCCTTTGCCAAATTTCACTCTTTTAGCCCCAAGAGATGAACAAATGATGCAAAATATAATGGAGTATG
CTTATTTACATCAAGGACCTATTGCTTTTCGTTATCCTAGAGGGAGTTTTATTTTGGATAAAGAATTTAATCCTTGTGAG
ATAAAACTTGGTAAGGCGCAATGGCTTGTAAAAAATAGTAGTGAAATTGCTTTTTTAGGTTATGGACAAGGTGTGGCAAA
AGCGTGGCAAGTCTTAAGAGCCTTGCAAGAAATGAATAATAATGCTAATTTGATTGATTTAATTTTTGCTAAACCTTTAG
ATGAAGAGCTTTTGTGTGAGCTTGCTAAAAAAAGTAAAATTTGGTTTATTTTTAGTGAAAATGTTAAAATTGGCGGTATA
GAAAGTTTAATTAATAATTTTTTACAAAAATATGATTTGCATGTAAAAGTTGTTAGCTTTGAATATGAAGACAAATTTAT
TGAACATGGAAAAACAAGTGAGGTGGAAAAAAATCTAGAAAAAGATGTCAATAGCTTGTTGACGAAAGTTTTAAAATTTT
ATCATTAA

Upstream 100 bases:

>100_bases
GATGCAATTAGCAAAGGAAGTGTTGTTATTATAAGTGACGCAGGTAATATAGAATCCAATCTTAACTCTCGTCTAGCTAA
AATTAAAAAAATGGTGAATA

Downstream 100 bases:

>100_bases
ATAATAAAAAATATTATTTAATATAAACTTCTTTTAATAAAAATTTTATTATTATTTTTACTTAAAAAAGTAAGGAATAA
ATAAAATGGAATTACTACAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSKKFVHTQEELEKLSLKELENLAASMREKIIQVVSKNGGHLSSNLGAVELSIAMHLVFDAKKDPFIFDVSHQSYTHKLL
SGKEEIFDTLRQINGLSGYTKPSEGDYFVAGHSSTSISLAVGACKAIALKGEKRIPVALIGDGALSAGMAYEALNELGDS
KFPCVILLNDNEMSISKPIGAISKYLSQAMATQFYQSFKKRIAKMLDILPDSATYMAKRFEESFKLITPGLLFEELGLEY
IGPIDGHNLGEIISALKQAKAMQKPCVIHAQTIKGKGYVLAEGKHAKWHGVGAFDIDSGESVKKSDTKKSATEIFSKNLL
DLASKYENIVGVTAAMPSGTGLDKLIEKYPNRFWDVAIAEQHAVTSMAAMAKEGFKPFIAIYSTFLQRAYDQVIHDCAIM
NLNVVFAMDRAGIVGEDGETHQGVFDLSFLAPLPNFTLLAPRDEQMMQNIMEYAYLHQGPIAFRYPRGSFILDKEFNPCE
IKLGKAQWLVKNSSEIAFLGYGQGVAKAWQVLRALQEMNNNANLIDLIFAKPLDEELLCELAKKSKIWFIFSENVKIGGI
ESLINNFLQKYDLHVKVVSFEYEDKFIEHGKTSEVEKNLEKDVNSLLTKVLKFYH

Sequences:

>Translated_615_residues
MSKKFVHTQEELEKLSLKELENLAASMREKIIQVVSKNGGHLSSNLGAVELSIAMHLVFDAKKDPFIFDVSHQSYTHKLL
SGKEEIFDTLRQINGLSGYTKPSEGDYFVAGHSSTSISLAVGACKAIALKGEKRIPVALIGDGALSAGMAYEALNELGDS
KFPCVILLNDNEMSISKPIGAISKYLSQAMATQFYQSFKKRIAKMLDILPDSATYMAKRFEESFKLITPGLLFEELGLEY
IGPIDGHNLGEIISALKQAKAMQKPCVIHAQTIKGKGYVLAEGKHAKWHGVGAFDIDSGESVKKSDTKKSATEIFSKNLL
DLASKYENIVGVTAAMPSGTGLDKLIEKYPNRFWDVAIAEQHAVTSMAAMAKEGFKPFIAIYSTFLQRAYDQVIHDCAIM
NLNVVFAMDRAGIVGEDGETHQGVFDLSFLAPLPNFTLLAPRDEQMMQNIMEYAYLHQGPIAFRYPRGSFILDKEFNPCE
IKLGKAQWLVKNSSEIAFLGYGQGVAKAWQVLRALQEMNNNANLIDLIFAKPLDEELLCELAKKSKIWFIFSENVKIGGI
ESLINNFLQKYDLHVKVVSFEYEDKFIEHGKTSEVEKNLEKDVNSLLTKVLKFYH
>Mature_614_residues
SKKFVHTQEELEKLSLKELENLAASMREKIIQVVSKNGGHLSSNLGAVELSIAMHLVFDAKKDPFIFDVSHQSYTHKLLS
GKEEIFDTLRQINGLSGYTKPSEGDYFVAGHSSTSISLAVGACKAIALKGEKRIPVALIGDGALSAGMAYEALNELGDSK
FPCVILLNDNEMSISKPIGAISKYLSQAMATQFYQSFKKRIAKMLDILPDSATYMAKRFEESFKLITPGLLFEELGLEYI
GPIDGHNLGEIISALKQAKAMQKPCVIHAQTIKGKGYVLAEGKHAKWHGVGAFDIDSGESVKKSDTKKSATEIFSKNLLD
LASKYENIVGVTAAMPSGTGLDKLIEKYPNRFWDVAIAEQHAVTSMAAMAKEGFKPFIAIYSTFLQRAYDQVIHDCAIMN
LNVVFAMDRAGIVGEDGETHQGVFDLSFLAPLPNFTLLAPRDEQMMQNIMEYAYLHQGPIAFRYPRGSFILDKEFNPCEI
KLGKAQWLVKNSSEIAFLGYGQGVAKAWQVLRALQEMNNNANLIDLIFAKPLDEELLCELAKKSKIWFIFSENVKIGGIE
SLINNFLQKYDLHVKVVSFEYEDKFIEHGKTSEVEKNLEKDVNSLLTKVLKFYH

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=601, Percent_Identity=22.4625623960067, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4507521, Length=601, Percent_Identity=22.4625623960067, Blast_Score=93, Evalue=8e-19,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=40.9165302782324, Blast_Score=452, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17539652, Length=621, Percent_Identity=24.3156199677939, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45551847, Length=613, Percent_Identity=24.7960848287113, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550715, Length=613, Percent_Identity=24.7960848287113, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666278, Length=372, Percent_Identity=24.4623655913978, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=25.3164556962025, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68391; Mature: 68259

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKFVHTQEELEKLSLKELENLAASMREKIIQVVSKNGGHLSSNLGAVELSIAMHLVFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEHHHHEEEEEE
AKKDPFIFDVSHQSYTHKLLSGKEEIFDTLRQINGLSGYTKPSEGDYFVAGHSSTSISLA
CCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEE
VGACKAIALKGEKRIPVALIGDGALSAGMAYEALNELGDSKFPCVILLNDNEMSISKPIG
HHHHHHHEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHCHHH
AISKYLSQAMATQFYQSFKKRIAKMLDILPDSATYMAKRFEESFKLITPGLLFEELGLEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHH
IGPIDGHNLGEIISALKQAKAMQKPCVIHAQTIKGKGYVLAEGKHAKWHGVGAFDIDSGE
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCEEECCEEEECCCCC
SVKKSDTKKSATEIFSKNLLDLASKYENIVGVTAAMPSGTGLDKLIEKYPNRFWDVAIAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCHHEEHHHHH
QHAVTSMAAMAKEGFKPFIAIYSTFLQRAYDQVIHDCAIMNLNVVFAMDRAGIVGEDGET
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCC
HQGVFDLSFLAPLPNFTLLAPRDEQMMQNIMEYAYLHQGPIAFRYPRGSFILDKEFNPCE
CCCEEEEHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCE
IKLGKAQWLVKNSSEIAFLGYGQGVAKAWQVLRALQEMNNNANLIDLIFAKPLDEELLCE
EEECCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
LAKKSKIWFIFSENVKIGGIESLINNFLQKYDLHVKVVSFEYEDKFIEHGKTSEVEKNLE
HHHCCCEEEEEECCEEECCHHHHHHHHHHHHCCEEEEEEEEHHHHHHHCCCHHHHHHHHH
KDVNSLLTKVLKFYH
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKKFVHTQEELEKLSLKELENLAASMREKIIQVVSKNGGHLSSNLGAVELSIAMHLVFD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEHHHHEEEEEE
AKKDPFIFDVSHQSYTHKLLSGKEEIFDTLRQINGLSGYTKPSEGDYFVAGHSSTSISLA
CCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEE
VGACKAIALKGEKRIPVALIGDGALSAGMAYEALNELGDSKFPCVILLNDNEMSISKPIG
HHHHHHHEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHCHHH
AISKYLSQAMATQFYQSFKKRIAKMLDILPDSATYMAKRFEESFKLITPGLLFEELGLEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHH
IGPIDGHNLGEIISALKQAKAMQKPCVIHAQTIKGKGYVLAEGKHAKWHGVGAFDIDSGE
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCEEECCEEEECCCCC
SVKKSDTKKSATEIFSKNLLDLASKYENIVGVTAAMPSGTGLDKLIEKYPNRFWDVAIAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCHHEEHHHHH
QHAVTSMAAMAKEGFKPFIAIYSTFLQRAYDQVIHDCAIMNLNVVFAMDRAGIVGEDGET
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCC
HQGVFDLSFLAPLPNFTLLAPRDEQMMQNIMEYAYLHQGPIAFRYPRGSFILDKEFNPCE
CCCEEEEHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCE
IKLGKAQWLVKNSSEIAFLGYGQGVAKAWQVLRALQEMNNNANLIDLIFAKPLDEELLCE
EEECCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
LAKKSKIWFIFSENVKIGGIESLINNFLQKYDLHVKVVSFEYEDKFIEHGKTSEVEKNLE
HHHCCCEEEEEECCEEECCHHHHHHHHHHHHCCEEEEEEEEHHHHHHHCCCHHHHHHHHH
KDVNSLLTKVLKFYH
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA