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The map label for this gene is pbpC [H]

Identifier: 57236965

GI number: 57236965

Start: 688312

End: 690111

Strand: Direct

Name: pbpC [H]

Synonym: CJE0755

Alternate gene names: 57236965

Gene position: 688312-690111 (Clockwise)

Preceding gene: 57236964

Following gene: 57236976

Centisome position: 38.72

GC content: 31.28

Gene sequence:

>1800_bases
ATGCGTTTAGTTGTTGGATTTATACTATTGTTTTTTATATTTTTATTAAGTCGTGTGTATTATTTGAGTATAAAATCAAA
TGTATATTATGAAGAGCTTGCTAAACAAAATGCCATAAAAACTGAATTTTTACCACCTGTTAGGGGTCAAATTACAGATA
GAAATGGAACTTTATTGGCTATTAATGATTTGGGTTTTAGTATTTCTATTAAACCTTATTTAAGTATTAAAAAGTCAAAT
AAAGGAATTTTAGATAAAGAATTATCTGAACTTACAAATTTATTTCCCGATTTAAATGCTAGTAAATTAGCAGAAATTTA
TAAGAGAAATGATTCTTACTATAATCAAGATTTTATTAAAGTTGTAGATTTTATACCCTACGATGAGATTATTCCGCATT
ATTCAGAGTTAAATCTTAATAAAACAATAAAAATAGATCCTGTTGTAAAAAGAAAATATCCTTTTGGAAAATTGGCTTCG
CATATTATTGGGTATGTAGGTAAGGCAAATTTGCAAGATGTTCAAGAAAATGAAATAGCAAAACTTTCTAACTATACGGG
AAAAAGCGGTATAGAACGCTATTATAATGATATTTTACAAGGAGAAAAAGGAACTAGGGTTTATAAGGTTAATGCCTTAA
ATCAAGAAGTAGAACAGCTTTCTTACACTCCTGCTATGTCTAATGATATAGAACTTACGATAGATATAGAGCTTCAGTCT
TATTTAACTTCATTGTTTGAAGGGAATGCTGGAGCTGCTATAATTATGAATGTAAATGATGGATCTATTTTAGCTGCAGG
GAGTTTCCCTGAATATGATCTTAATCCTTTTGTAACAGGGATTTCTTTTAAGGATTGGGATGAGCTTTCAAATAGTCTTG
ATCATCCTTTTACAAATAAACTTATAAATGGATATTATCCTCCAGGTTCTGTTGTAAAAATGGGAGTAGGGCTTTCTTTT
TTAAATTCTAAAAATATTAGCCCGTCGACTCAATATGTTTGCAATGGAAGCATTGAGCTTGGAGGCAGGTTTTTTAGATG
TTGGAATCGATCAGGCCATGGACCTGTGGATTTAAAACATGCGATAAAATATAGTTGTGATGTTTATTTTTATAATGGCA
GTTTGCAAGTTGGAATCGATCAAATAAGTGAAACTTTATCTCGCATTGGCTTTGGAACGAAAACAGGGGTAGATTTACCT
AGTGAATTTGTAGGAACTTTACCAAGCAAAGAATGGAAGATGCAAAGATATAGACAATCTTGGTTTCAAGGTGATACTTT
AAATACAGCCATAGGTCAAGGTAATTTTCTTGCAACACCTATGCAAATTGCTAGATATACGGCTCAAATCGCAAAAGGTG
GAGAGGTTATACCTCATTTTTTAAAAAGCATAGAAAATAATAATACAACTATAGAAAATCAAATGGATGAAAATAAAAAA
GAAATTTTTACTTTATTTGAAAAGAGTCAATTGCCTTATATAAGAGATGCAATGTATGCCGTTGCCAATGAGCAAGGAGG
AACCTCTTATCGTTATTTGCATAATCTTGATGTGAAAGTTGCAGCAAAAACAGGAACCGCTCAGGTTGTGGGATTTTCAC
AAACAGATAAAAATAGGGTCGATGAAAAACAATTTGAGTATTATACTAGATCTCATGCGTGGCTTACTTCTTATGCTCCT
TATTCTAAGCCAAAATATGTAGTTACCGTTCTTTTGGAGCATGGTGGGAGAAATATTACTTCAGGGGCAACTGTAGCTAA
AATTTATCAAAAAATGATTGATCTTGGATATTTTAAATAA

Upstream 100 bases:

>100_bases
AGATGAAAAAATTAAAATTTTAGGATGGGCGTATATTGTTTCAGTTTTTATAGAATGTTGTTTAGCTTATGTGTTTTTTA
AAGGTAAAATTTAAATGAGA

Downstream 100 bases:

>100_bases
TTTTTAGTTGTAAATTGAGTTTTTCAAAAAAAACTTTTTTAGCAATTGGTTTAAAAACCTTGTATTAAATAAATTATAAG
TTTAATACAAGGAAAATTTA

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MRLVVGFILLFFIFLLSRVYYLSIKSNVYYEELAKQNAIKTEFLPPVRGQITDRNGTLLAINDLGFSISIKPYLSIKKSN
KGILDKELSELTNLFPDLNASKLAEIYKRNDSYYNQDFIKVVDFIPYDEIIPHYSELNLNKTIKIDPVVKRKYPFGKLAS
HIIGYVGKANLQDVQENEIAKLSNYTGKSGIERYYNDILQGEKGTRVYKVNALNQEVEQLSYTPAMSNDIELTIDIELQS
YLTSLFEGNAGAAIIMNVNDGSILAAGSFPEYDLNPFVTGISFKDWDELSNSLDHPFTNKLINGYYPPGSVVKMGVGLSF
LNSKNISPSTQYVCNGSIELGGRFFRCWNRSGHGPVDLKHAIKYSCDVYFYNGSLQVGIDQISETLSRIGFGTKTGVDLP
SEFVGTLPSKEWKMQRYRQSWFQGDTLNTAIGQGNFLATPMQIARYTAQIAKGGEVIPHFLKSIENNNTTIENQMDENKK
EIFTLFEKSQLPYIRDAMYAVANEQGGTSYRYLHNLDVKVAAKTGTAQVVGFSQTDKNRVDEKQFEYYTRSHAWLTSYAP
YSKPKYVVTVLLEHGGRNITSGATVAKIYQKMIDLGYFK

Sequences:

>Translated_599_residues
MRLVVGFILLFFIFLLSRVYYLSIKSNVYYEELAKQNAIKTEFLPPVRGQITDRNGTLLAINDLGFSISIKPYLSIKKSN
KGILDKELSELTNLFPDLNASKLAEIYKRNDSYYNQDFIKVVDFIPYDEIIPHYSELNLNKTIKIDPVVKRKYPFGKLAS
HIIGYVGKANLQDVQENEIAKLSNYTGKSGIERYYNDILQGEKGTRVYKVNALNQEVEQLSYTPAMSNDIELTIDIELQS
YLTSLFEGNAGAAIIMNVNDGSILAAGSFPEYDLNPFVTGISFKDWDELSNSLDHPFTNKLINGYYPPGSVVKMGVGLSF
LNSKNISPSTQYVCNGSIELGGRFFRCWNRSGHGPVDLKHAIKYSCDVYFYNGSLQVGIDQISETLSRIGFGTKTGVDLP
SEFVGTLPSKEWKMQRYRQSWFQGDTLNTAIGQGNFLATPMQIARYTAQIAKGGEVIPHFLKSIENNNTTIENQMDENKK
EIFTLFEKSQLPYIRDAMYAVANEQGGTSYRYLHNLDVKVAAKTGTAQVVGFSQTDKNRVDEKQFEYYTRSHAWLTSYAP
YSKPKYVVTVLLEHGGRNITSGATVAKIYQKMIDLGYFK
>Mature_599_residues
MRLVVGFILLFFIFLLSRVYYLSIKSNVYYEELAKQNAIKTEFLPPVRGQITDRNGTLLAINDLGFSISIKPYLSIKKSN
KGILDKELSELTNLFPDLNASKLAEIYKRNDSYYNQDFIKVVDFIPYDEIIPHYSELNLNKTIKIDPVVKRKYPFGKLAS
HIIGYVGKANLQDVQENEIAKLSNYTGKSGIERYYNDILQGEKGTRVYKVNALNQEVEQLSYTPAMSNDIELTIDIELQS
YLTSLFEGNAGAAIIMNVNDGSILAAGSFPEYDLNPFVTGISFKDWDELSNSLDHPFTNKLINGYYPPGSVVKMGVGLSF
LNSKNISPSTQYVCNGSIELGGRFFRCWNRSGHGPVDLKHAIKYSCDVYFYNGSLQVGIDQISETLSRIGFGTKTGVDLP
SEFVGTLPSKEWKMQRYRQSWFQGDTLNTAIGQGNFLATPMQIARYTAQIAKGGEVIPHFLKSIENNNTTIENQMDENKK
EIFTLFEKSQLPYIRDAMYAVANEQGGTSYRYLHNLDVKVAAKTGTAQVVGFSQTDKNRVDEKQFEYYTRSHAWLTSYAP
YSKPKYVVTVLLEHGGRNITSGATVAKIYQKMIDLGYFK

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=608, Percent_Identity=32.5657894736842, Blast_Score=312, Evalue=4e-86,
Organism=Escherichia coli, GI1786272, Length=580, Percent_Identity=22.7586206896552, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67644; Mature: 67644

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVVGFILLFFIFLLSRVYYLSIKSNVYYEELAKQNAIKTEFLPPVRGQITDRNGTLLA
CHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHCCCCCHHCCCCCCCEEECCCCCEEE
INDLGFSISIKPYLSIKKSNKGILDKELSELTNLFPDLNASKLAEIYKRNDSYYNQDFIK
EECCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHH
VVDFIPYDEIIPHYSELNLNKTIKIDPVVKRKYPFGKLASHIIGYVGKANLQDVQENEIA
HHHCCCHHHHCCCHHHCCCCCEEEECCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
KLSNYTGKSGIERYYNDILQGEKGTRVYKVNALNQEVEQLSYTPAMSNDIELTIDIELQS
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCEEEEEEEEHHH
YLTSLFEGNAGAAIIMNVNDGSILAAGSFPEYDLNPFVTGISFKDWDELSNSLDHPFTNK
HHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCEEECCCCCCHHHHHHHCCCCHHHH
LINGYYPPGSVVKMGVGLSFLNSKNISPSTQYVCNGSIELGGRFFRCWNRSGHGPVDLKH
HHCCCCCCCCCEEECCCEEECCCCCCCCCCEEEECCCEEECCEEEEEECCCCCCCCCHHH
AIKYSCDVYFYNGSLQVGIDQISETLSRIGFGTKTGVDLPSEFVGTLPSKEWKMQRYRQS
HHEEEEEEEEECCEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
WFQGDTLNTAIGQGNFLATPMQIARYTAQIAKGGEVIPHFLKSIENNNTTIENQMDENKK
HHCCCCCCHHCCCCCEEECHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCHHCCCHH
EIFTLFEKSQLPYIRDAMYAVANEQGGTSYRYLHNLDVKVAAKTGTAQVVGFSQTDKNRV
HHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCEEEEEECCCCCCCC
DEKQFEYYTRSHAWLTSYAPYSKPKYVVTVLLEHGGRNITSGATVAKIYQKMIDLGYFK
CHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRLVVGFILLFFIFLLSRVYYLSIKSNVYYEELAKQNAIKTEFLPPVRGQITDRNGTLLA
CHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHCCCCCHHCCCCCCCEEECCCCCEEE
INDLGFSISIKPYLSIKKSNKGILDKELSELTNLFPDLNASKLAEIYKRNDSYYNQDFIK
EECCCEEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHH
VVDFIPYDEIIPHYSELNLNKTIKIDPVVKRKYPFGKLASHIIGYVGKANLQDVQENEIA
HHHCCCHHHHCCCHHHCCCCCEEEECCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
KLSNYTGKSGIERYYNDILQGEKGTRVYKVNALNQEVEQLSYTPAMSNDIELTIDIELQS
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCEEEEEEEEHHH
YLTSLFEGNAGAAIIMNVNDGSILAAGSFPEYDLNPFVTGISFKDWDELSNSLDHPFTNK
HHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCEEECCCCCCHHHHHHHCCCCHHHH
LINGYYPPGSVVKMGVGLSFLNSKNISPSTQYVCNGSIELGGRFFRCWNRSGHGPVDLKH
HHCCCCCCCCCEEECCCEEECCCCCCCCCCEEEECCCEEECCEEEEEECCCCCCCCCHHH
AIKYSCDVYFYNGSLQVGIDQISETLSRIGFGTKTGVDLPSEFVGTLPSKEWKMQRYRQS
HHEEEEEEEEECCEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
WFQGDTLNTAIGQGNFLATPMQIARYTAQIAKGGEVIPHFLKSIENNNTTIENQMDENKK
HHCCCCCCHHCCCCCEEECHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCHHCCCHH
EIFTLFEKSQLPYIRDAMYAVANEQGGTSYRYLHNLDVKVAAKTGTAQVVGFSQTDKNRV
HHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCEEEEEECCCCCCCC
DEKQFEYYTRSHAWLTSYAPYSKPKYVVTVLLEHGGRNITSGATVAKIYQKMIDLGYFK
CHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 8930920 [H]