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The map label for this gene is ilvC [H]

Identifier: 57236945

GI number: 57236945

Start: 671555

End: 672577

Strand: Direct

Name: ilvC [H]

Synonym: CJE0735

Alternate gene names: 57236945

Gene position: 671555-672577 (Clockwise)

Preceding gene: 57236942

Following gene: 57236946

Centisome position: 37.77

GC content: 35.58

Gene sequence:

>1023_bases
ATGGCTATTACAGTATATTATGATAAAGATTGTGATTTAAATTTAATCAAATCAAAAAAAGTAGCAATTATAGGCTTTGG
CTCTCAAGGGCACGCTCATGCGATGAATTTAAGAGATAATGGCGTAAATGTAACTATCGGACTTCGTGAAGGTAGTGTAA
GTGCTGTTAAAGCAAAAAATGCTGGTTTTGAAGTAATGAGTGTGAGTGAGGCTTCTAAGATAGCGGATGTGATTATGATT
TTAGCTCCTGATGAAATTCAAGCAGATATTTTTAATGTCGAAATAAAACCAAATTTAAGTGAAGGCAAGGCTATAGCTTT
TGCACACGGTTTTAATATCCATTATGGTCAAATTGTTGTTCCAAAAGGTGTAGATGTTATCATGATAGCACCTAAAGCAC
CAGGTCATACAGTAAGAAATGAATTTACTCTAGGTGGTGGCACTCCTTGTTTAATAGCTATCCATCAAGATGAAAGCAAA
AATGCTAAAAATTTAGCCTTAAGTTATGCAAGTGCGATCGGGGGTGGACGTACAGGTATTATAGAAACAACCTTTAAAGC
CGAAACAGAAACAGATCTTTTTGGTGAGCAAGCTGTGCTTTGTGGTGGACTTAGTGCTTTGATTCAAGCAGGTTTTGAAA
CTTTGGTTGAAGCAGGTTATGAACCTGAAATGGCTTATTTTGAGTGTTTGCATGAAATGAAACTCATTGTGGATTTGATT
TATCAAGGTGGTATTGCAGATATGCGTTATTCTATTTCAAATACTGCAGAATACGGCGATTACATCACAGGGCCAAAGAT
TATCACTGAAGAGACTAAAAAAGCGATGAAAGGTGTTTTAAAAGATATACAAAATGGTGTTTTTGCAAAAGATTTTATCT
TAGAACGCCGTGCAGGTTTTGCTAGAATGCATGCAGAACGCAAAAATATGAATGATTCTTTGATAGAAAAAACAGGACGC
AATTTGCGTGCTATGATGCCTTGGATCAGTGCTAAAAAATTAGTAGATAAAGATAAGAACTAA

Upstream 100 bases:

>100_bases
TTTTGTAAAATTCTTACATAAAGTTTATAAAAAAAATATGAAATTTATACTTTAATTGCTATAATAATACCTTTAATTTT
TGAATTTTTAAGGAGTGAAT

Downstream 100 bases:

>100_bases
ACATTGTCAAAGAAAAAATTAGTTCAAATTCAGCGTTATTTAATCATAGCTATACTTTTTTTACTTTGCATAGCTTTAGC
TTTGGGAATTTTAGTAAAAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAITVYYDKDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKNAGFEVMSVSEASKIADVIMI
LAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESK
NAKNLALSYASAIGGGRTGIIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLI
YQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDFILERRAGFARMHAERKNMNDSLIEKTGR
NLRAMMPWISAKKLVDKDKN

Sequences:

>Translated_340_residues
MAITVYYDKDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKNAGFEVMSVSEASKIADVIMI
LAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESK
NAKNLALSYASAIGGGRTGIIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLI
YQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDFILERRAGFARMHAERKNMNDSLIEKTGR
NLRAMMPWISAKKLVDKDKN
>Mature_339_residues
AITVYYDKDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKNAGFEVMSVSEASKIADVIMIL
APDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKN
AKNLALSYASAIGGGRTGIIETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLIY
QGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDFILERRAGFARMHAERKNMNDSLIEKTGRN
LRAMMPWISAKKLVDKDKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=329, Percent_Identity=32.8267477203647, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=342, Percent_Identity=31.8713450292398, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36967; Mature: 36836

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITVYYDKDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKN
CEEEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCEEEEEECC
AGFEVMSVSEASKIADVIMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVV
CCEEEEEHHHHHHHEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCEEEECEEEE
PKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGGGRTGI
CCCCCEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCE
IETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLI
EEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
YQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDFILERRAGF
HCCCCCCEEEECCCCHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
ARMHAERKNMNDSLIEKTGRNLRAMMPWISAKKLVDKDKN
HHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AITVYYDKDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVKAKN
EEEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCEEEEEECC
AGFEVMSVSEASKIADVIMILAPDEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVV
CCEEEEEHHHHHHHEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCEEEECEEEE
PKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGGGRTGI
CCCCCEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCE
IETTFKAETETDLFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLI
EEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
YQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDFILERRAGF
HCCCCCCEEEECCCCHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
ARMHAERKNMNDSLIEKTGRNLRAMMPWISAKKLVDKDKN
HHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA